YJL179W / PFD1

Subunit of heterohexameric prefoldin, which binds cytosolic chaperonin and transfers target proteins to it; involved in the biogenesis of actin and of alpha- and gamma-tubulin

Zygosity: Homozygous strain
fixedexpanded
Profile for YJL179W / PFD1

Click on Significant Values for Screen Details ID:SGTC_7|Compound:0192-1582|FD-Score:3.45|P-value:3.89E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:4.81|P-value:1.44E-6 ID:SGTC_103|Compound:0844-0104|FD-Score:-5.10|P-value:3.23E-7 ID:SGTC_129|Compound:0088-0017|FD-Score:4.31|P-value:1.38E-5 ID:SGTC_138|Compound:0850-0259|FD-Score:4.83|P-value:1.28E-6 ID:SGTC_146|Compound:3448-8650|FD-Score:4.12|P-value:2.99E-5 ID:SGTC_163|Compound:1327-0036|FD-Score:5.46|P-value:5.18E-8 ID:SGTC_210|Compound:3551-0445|FD-Score:4.86|P-value:1.10E-6 ID:SGTC_212|Compound:3807-4682|FD-Score:6.78|P-value:2.06E-11 ID:SGTC_310|Compound:1273-0058|FD-Score:-5.14|P-value:2.76E-7 ID:SGTC_422|Compound:cantharidin|FD-Score:4.29|P-value:1.49E-5 ID:SGTC_426|Compound:0988-0037|FD-Score:-3.36|P-value:5.29E-4 ID:SGTC_438|Compound:sphingosine|FD-Score:3.19|P-value:9.66E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-4.71|P-value:2.23E-6 ID:SGTC_525|Compound:k781-2675|FD-Score:-3.42|P-value:4.29E-4 ID:SGTC_535|Compound:2293-4129|FD-Score:4.01|P-value:4.75E-5 ID:SGTC_568|Compound:1193-0097|FD-Score:-3.75|P-value:1.29E-4 ID:SGTC_582|Compound:0987-0078|FD-Score:3.29|P-value:6.81E-4 ID:SGTC_735|Compound:3076-0345|FD-Score:3.27|P-value:7.39E-4 ID:SGTC_849|Compound:0386-0493|FD-Score:4.17|P-value:2.47E-5 ID:SGTC_980|Compound:1473-0395|FD-Score:4.27|P-value:1.62E-5 ID:SGTC_1114|Compound:scopoletin|FD-Score:-3.22|P-value:8.50E-4 ID:SGTC_1298|Compound:1079-1278|FD-Score:3.88|P-value:7.97E-5 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:4.24|P-value:1.82E-5 ID:SGTC_1643|Compound:st009866|FD-Score:14.30|P-value:1.69E-44 ID:SGTC_1683|Compound:st010134|FD-Score:-3.45|P-value:3.84E-4 ID:SGTC_1702|Compound:st027038|FD-Score:3.20|P-value:9.35E-4 ID:SGTC_1754|Compound:st042065|FD-Score:3.52|P-value:3.07E-4 ID:SGTC_1789|Compound:tunicamycin|FD-Score:-3.51|P-value:3.07E-4 ID:SGTC_1803|Compound:st050068|FD-Score:6.81|P-value:1.72E-11 ID:SGTC_1820|Compound:st053765|FD-Score:-3.60|P-value:2.25E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:3.76|P-value:1.28E-4 ID:SGTC_1875|Compound:nocodazole|FD-Score:5.14|P-value:2.79E-7 ID:SGTC_2168|Compound:5727979|FD-Score:3.68|P-value:1.71E-4 ID:SGTC_2437|Compound:5741531|FD-Score:3.48|P-value:3.52E-4 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:5.72|P-value:1.28E-8 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:4.61|P-value:3.57E-6 ID:SGTC_2582|Compound:agaric acid|FD-Score:7.02|P-value:4.21E-12 ID:SGTC_2602|Compound:kawain|FD-Score:-3.37|P-value:5.04E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:3.58|P-value:2.45E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:7.27|P-value:7.18E-13 ID:SGTC_2785|Compound:7756463|FD-Score:3.40|P-value:4.67E-4 ID:SGTC_2932|Compound:9016711|FD-Score:-4.58|P-value:4.07E-6 ID:SGTC_2957|Compound:9076800|FD-Score:3.44|P-value:4.07E-4 ID:SGTC_2971|Compound:9092186|FD-Score:4.12|P-value:3.01E-5 ID:SGTC_3037|Compound:9091026|FD-Score:4.01|P-value:4.77E-5 ID:SGTC_3152|Compound:9099253|FD-Score:3.18|P-value:9.84E-4 ID:SGTC_3262|Compound:9137218|FD-Score:-3.27|P-value:7.07E-4 ID:SGTC_7|Compound:0192-1582|FD-Score:3.45|P-value:3.89E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:4.81|P-value:1.44E-6 ID:SGTC_103|Compound:0844-0104|FD-Score:-5.10|P-value:3.23E-7 ID:SGTC_129|Compound:0088-0017|FD-Score:4.31|P-value:1.38E-5 ID:SGTC_138|Compound:0850-0259|FD-Score:4.83|P-value:1.28E-6 ID:SGTC_146|Compound:3448-8650|FD-Score:4.12|P-value:2.99E-5 ID:SGTC_163|Compound:1327-0036|FD-Score:5.46|P-value:5.18E-8 ID:SGTC_210|Compound:3551-0445|FD-Score:4.86|P-value:1.10E-6 ID:SGTC_212|Compound:3807-4682|FD-Score:6.78|P-value:2.06E-11 ID:SGTC_310|Compound:1273-0058|FD-Score:-5.14|P-value:2.76E-7 ID:SGTC_422|Compound:cantharidin|FD-Score:4.29|P-value:1.49E-5 ID:SGTC_426|Compound:0988-0037|FD-Score:-3.36|P-value:5.29E-4 ID:SGTC_438|Compound:sphingosine|FD-Score:3.19|P-value:9.66E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-4.71|P-value:2.23E-6 ID:SGTC_525|Compound:k781-2675|FD-Score:-3.42|P-value:4.29E-4 ID:SGTC_535|Compound:2293-4129|FD-Score:4.01|P-value:4.75E-5 ID:SGTC_568|Compound:1193-0097|FD-Score:-3.75|P-value:1.29E-4 ID:SGTC_582|Compound:0987-0078|FD-Score:3.29|P-value:6.81E-4 ID:SGTC_735|Compound:3076-0345|FD-Score:3.27|P-value:7.39E-4 ID:SGTC_849|Compound:0386-0493|FD-Score:4.17|P-value:2.47E-5 ID:SGTC_980|Compound:1473-0395|FD-Score:4.27|P-value:1.62E-5 ID:SGTC_1114|Compound:scopoletin|FD-Score:-3.22|P-value:8.50E-4 ID:SGTC_1298|Compound:1079-1278|FD-Score:3.88|P-value:7.97E-5 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:4.24|P-value:1.82E-5 ID:SGTC_1643|Compound:st009866|FD-Score:14.30|P-value:1.69E-44 ID:SGTC_1683|Compound:st010134|FD-Score:-3.45|P-value:3.84E-4 ID:SGTC_1702|Compound:st027038|FD-Score:3.20|P-value:9.35E-4 ID:SGTC_1754|Compound:st042065|FD-Score:3.52|P-value:3.07E-4 ID:SGTC_1789|Compound:tunicamycin|FD-Score:-3.51|P-value:3.07E-4 ID:SGTC_1803|Compound:st050068|FD-Score:6.81|P-value:1.72E-11 ID:SGTC_1820|Compound:st053765|FD-Score:-3.60|P-value:2.25E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:3.76|P-value:1.28E-4 ID:SGTC_1875|Compound:nocodazole|FD-Score:5.14|P-value:2.79E-7 ID:SGTC_2168|Compound:5727979|FD-Score:3.68|P-value:1.71E-4 ID:SGTC_2437|Compound:5741531|FD-Score:3.48|P-value:3.52E-4 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:5.72|P-value:1.28E-8 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:4.61|P-value:3.57E-6 ID:SGTC_2582|Compound:agaric acid|FD-Score:7.02|P-value:4.21E-12 ID:SGTC_2602|Compound:kawain|FD-Score:-3.37|P-value:5.04E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:3.58|P-value:2.45E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:7.27|P-value:7.18E-13 ID:SGTC_2785|Compound:7756463|FD-Score:3.40|P-value:4.67E-4 ID:SGTC_2932|Compound:9016711|FD-Score:-4.58|P-value:4.07E-6 ID:SGTC_2957|Compound:9076800|FD-Score:3.44|P-value:4.07E-4 ID:SGTC_2971|Compound:9092186|FD-Score:4.12|P-value:3.01E-5 ID:SGTC_3037|Compound:9091026|FD-Score:4.01|P-value:4.77E-5 ID:SGTC_3152|Compound:9099253|FD-Score:3.18|P-value:9.84E-4 ID:SGTC_3262|Compound:9137218|FD-Score:-3.27|P-value:7.07E-4

Top fitness defect scores for YJL179W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1643 st009866 14.30 20.2 µM 1.69E-44 4 8.62E-47
2 SGTC_2688 kanamycin b 7.27 96.7 µM 7.18E-13 calcium & mitochondrial duress 95 1.78E-13
3 SGTC_2582 agaric acid 7.02 100.0 µM 4.21E-12 redox potentiating 127 1.15E-12
4 SGTC_1803 st050068 6.81 52.4 µM 1.72E-11 NEO1-PIK1 58 5.04E-12
5 SGTC_212 3807-4682 6.78 38.8 µM 2.06E-11 tubulin folding & SWR complex 20 6.11E-12
6 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 5.72 63.6 µM 1.28E-8 17 5.31E-9
7 SGTC_163 1327-0036 5.46 7.5 µM 5.18E-8 57 2.32E-8
8 SGTC_1875 nocodazole 5.14 6.0 µM 2.79E-7 tubulin folding & SWR complex 36 1.36E-7
9 SGTC_210 3551-0445 4.86 56.8 µM 1.10E-6 39 5.80E-7
10 SGTC_138 0850-0259 4.83 40.9 µM 1.28E-6 cell wall 153 6.80E-7
11 SGTC_58 0957-0393 4.81 9.0 µM 1.44E-6 cell wall 305 7.68E-7
12 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 4.61 92.6 µM 3.57E-6 16 2.00E-6
13 SGTC_129 0088-0017 4.31 176.6 µM 1.38E-5 62 8.29E-6
14 SGTC_422 cantharidin 4.29 155.0 µM 1.49E-5 cell wall signaling 47 8.97E-6
15 SGTC_980 1473-0395 4.27 201.0 µM 1.62E-5 8 9.80E-6
16 SGTC_1597 7-benzyloxygramine 4.24 47.5 µM 1.82E-5 calcium & mitochondrial duress 103 1.10E-5
17 SGTC_849 0386-0493 4.17 241.0 µM 2.47E-5 15 1.53E-5
18 SGTC_146 3448-8650 4.12 53.1 µM 2.99E-5 NEO1-PIK1 128 1.86E-5
19 SGTC_2971 9092186 4.12 9.9 µM 3.01E-5 ergosterol biosynthesis 26 1.88E-5
20 SGTC_535 2293-4129 4.01 48.2 µM 4.75E-5 NEO1 58 3.04E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.306 1.85E-73 YLR200W YKE2 hom Subunit of the heterohexameric Gim/prefoldin protein complex involved in the folding of alpha-tubulin, beta-tubulin, and actin
0.285 1.17E-63 YML094C-A_d YML094C-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene GIM5/YML094W; deletion confers sensitivity to GSAO
0.237 6.82E-44 YGR078C PAC10 hom Part of the heteromeric co-chaperone GimC/prefoldin complex, which promotes efficient protein folding
0.233 1.25E-42 YDR334W SWR1 hom Swi2/Snf2-related ATPase that is the structural component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A
0.225 9.96E-40 YML103C NUP188 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188
0.223 6.14E-39 YML121W GTR1 hom Cytoplasmic GTP binding protein and negative regulator of the Ran/Tc4 GTPase cycle; component of GSE complex, which is required for sorting of Gap1p; involved in phosphate transport and telomeric silencing; similar to human RagA and RagB
0.221 2.24E-38 YNL246W VPS75 hom NAP family histone chaperone; binds to histones and Rtt109p, stimulating histone acetyltransferase activity; possesses nucleosome assembly activity in vitro; proposed role in vacuolar protein sorting and in double-strand break repair; protein abundance increases in response to DNA replication stress
0.215 1.70E-36 YBR231C SWC5 hom Component of the SWR1 complex; complex exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; protein abundance increases in response to DNA replication stress
0.203 1.70E-32 YKL176C LST4 hom Protein possibly involved in a post-Golgi secretory pathway; required for the transport of nitrogen-regulated amino acid permease Gap1p from the Golgi to the cell surface
0.199 2.03E-31 YER007W PAC2 hom Microtubule effector required for tubulin heterodimer formation, binds alpha-tubulin, required for normal microtubule function, null mutant exhibits cold-sensitive microtubules and sensitivity to benomyl
0.193 1.82E-29 YAL011W SWC3 hom Protein of unknown function, component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for formation of nuclear-associated array of smooth endoplasmic reticulum known as karmellae
0.192 2.42E-29 YGL043W DST1 hom General transcription elongation factor TFIIS, enables RNA polymerase II to read through blocks to elongation by stimulating cleavage of nascent transcripts stalled at transcription arrest sites; maintains RNAPII elongation activity on ribosomal protein genes during conditions of transcriptional stress
0.191 9.91E-29 YML041C VPS71 hom Nucleosome-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting
0.190 1.61E-28 YDR335W MSN5 hom Karyopherin involved in nuclear import and export of proteins, including import of replication protein A and export of Swi6p, Far1p, and Pho4p; required for re-export of mature tRNAs after their retrograde import from the cytoplasm
0.189 2.83E-28 YPL241C CIN2 hom GTPase-activating protein (GAP) for Cin4p; tubulin folding factor C involved in beta-tubulin (Tub2p) folding; mutants display increased chromosome loss and benomyl sensitivity; deletion complemented by human GAP, retinitis pigmentosa 2