YJL180C / ATP12

Conserved protein required for assembly of alpha and beta subunits into the F1 sector of mitochondrial F1F0 ATP synthase; mutation of human ATP12 reduces active ATP synthase levels and is associated with the disorder ATPAF2 deficiency

Zygosity: Homozygous strain
fixedexpanded
Profile for YJL180C / ATP12

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:5.00|P-value:8.23E-7 ID:SGTC_149|Compound:3970-0822|FD-Score:4.44|P-value:1.02E-5 ID:SGTC_168|Compound:3970-0862|FD-Score:3.26|P-value:8.53E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:4.57|P-value:5.81E-6 ID:SGTC_236|Compound:1509-0011|FD-Score:18.40|P-value:3.91E-69 ID:SGTC_256|Compound:clotrimazole|FD-Score:-3.84|P-value:1.37E-4 ID:SGTC_263|Compound:alizarin|FD-Score:-4.33|P-value:2.05E-5 ID:SGTC_275|Compound:trichlorophene|FD-Score:12.00|P-value:1.02E-30 ID:SGTC_310|Compound:1273-0058|FD-Score:5.66|P-value:2.88E-8 ID:SGTC_350|Compound:k064-0020|FD-Score:3.52|P-value:3.57E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:7.30|P-value:1.37E-12 ID:SGTC_441|Compound:propafenone|FD-Score:3.69|P-value:1.92E-4 ID:SGTC_455|Compound:paf C-16|FD-Score:3.34|P-value:6.60E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-4.06|P-value:6.06E-5 ID:SGTC_514|Compound:4466-0038|FD-Score:8.11|P-value:4.13E-15 ID:SGTC_515|Compound:4092-1064|FD-Score:-3.97|P-value:8.50E-5 ID:SGTC_576|Compound:1073-0113|FD-Score:5.94|P-value:6.23E-9 ID:SGTC_586|Compound:0957-0265|FD-Score:4.11|P-value:3.96E-5 ID:SGTC_607|Compound:4491-0986|FD-Score:4.85|P-value:1.63E-6 ID:SGTC_744|Compound:1594-0068|FD-Score:5.61|P-value:3.76E-8 ID:SGTC_745|Compound:0469-0705|FD-Score:4.35|P-value:1.51E-5 ID:SGTC_880|Compound:0833-0487|FD-Score:4.79|P-value:2.17E-6 ID:SGTC_907|Compound:3448-6986|FD-Score:-4.00|P-value:7.45E-5 ID:SGTC_908|Compound:3448-7491|FD-Score:11.90|P-value:1.64E-30 ID:SGTC_917|Compound:harmaline|FD-Score:4.53|P-value:6.74E-6 ID:SGTC_918|Compound:glabranin|FD-Score:3.27|P-value:8.18E-4 ID:SGTC_995|Compound:3931-2021|FD-Score:6.99|P-value:1.08E-11 ID:SGTC_1003|Compound:4049-0218|FD-Score:3.45|P-value:4.47E-4 ID:SGTC_1063|Compound:disulfiram|FD-Score:3.68|P-value:2.00E-4 ID:SGTC_1073|Compound:triclabendazole|FD-Score:4.37|P-value:1.35E-5 ID:SGTC_1145|Compound:3546-0597|FD-Score:3.25|P-value:8.97E-4 ID:SGTC_1353|Compound:1498-1206|FD-Score:4.98|P-value:8.97E-7 ID:SGTC_1374|Compound:2889-5571|FD-Score:3.43|P-value:4.80E-4 ID:SGTC_1435|Compound:4092-0789|FD-Score:3.79|P-value:1.36E-4 ID:SGTC_1635|Compound:st007035|FD-Score:17.10|P-value:2.41E-60 ID:SGTC_1641|Compound:st009299|FD-Score:4.55|P-value:6.41E-6 ID:SGTC_1758|Compound:st042942|FD-Score:3.94|P-value:7.63E-5 ID:SGTC_1787|Compound:fluconazole|FD-Score:-6.10|P-value:3.50E-9 ID:SGTC_1797|Compound:st048695|FD-Score:3.28|P-value:8.12E-4 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:6.06|P-value:3.13E-9 ID:SGTC_2011|Compound:4012611|FD-Score:8.62|P-value:8.10E-17 ID:SGTC_2016|Compound:5121758|FD-Score:3.64|P-value:2.37E-4 ID:SGTC_2093|Compound:5331342|FD-Score:-3.82|P-value:1.52E-4 ID:SGTC_2177|Compound:5811945|FD-Score:3.39|P-value:5.59E-4 ID:SGTC_2218|Compound:6965428|FD-Score:3.36|P-value:6.15E-4 ID:SGTC_2310|Compound:7668677|FD-Score:5.96|P-value:5.70E-9 ID:SGTC_2316|Compound:5844804|FD-Score:-3.91|P-value:1.05E-4 ID:SGTC_2326|Compound:6164455|FD-Score:7.90|P-value:1.97E-14 ID:SGTC_2328|Compound:6201408|FD-Score:-3.32|P-value:8.39E-4 ID:SGTC_2349|Compound:9023730|FD-Score:4.73|P-value:2.88E-6 ID:SGTC_2370|Compound:9071495|FD-Score:4.74|P-value:2.72E-6 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.77|P-value:1.44E-4 ID:SGTC_2546|Compound:rhodinyl acetate|FD-Score:3.22|P-value:9.88E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:4.23|P-value:2.43E-5 ID:SGTC_2619|Compound:obliquin|FD-Score:4.77|P-value:2.38E-6 ID:SGTC_2630|Compound:antimycin a|FD-Score:4.38|P-value:1.33E-5 ID:SGTC_2834|Compound:9001755|FD-Score:-3.39|P-value:6.66E-4 ID:SGTC_3208|Compound:9114115|FD-Score:3.27|P-value:8.24E-4 ID:SGTC_3299|Compound:9121982|FD-Score:-3.40|P-value:6.45E-4 ID:SGTC_6|Compound:0844-0013|FD-Score:5.00|P-value:8.23E-7 ID:SGTC_149|Compound:3970-0822|FD-Score:4.44|P-value:1.02E-5 ID:SGTC_168|Compound:3970-0862|FD-Score:3.26|P-value:8.53E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:4.57|P-value:5.81E-6 ID:SGTC_236|Compound:1509-0011|FD-Score:18.40|P-value:3.91E-69 ID:SGTC_256|Compound:clotrimazole|FD-Score:-3.84|P-value:1.37E-4 ID:SGTC_263|Compound:alizarin|FD-Score:-4.33|P-value:2.05E-5 ID:SGTC_275|Compound:trichlorophene|FD-Score:12.00|P-value:1.02E-30 ID:SGTC_310|Compound:1273-0058|FD-Score:5.66|P-value:2.88E-8 ID:SGTC_350|Compound:k064-0020|FD-Score:3.52|P-value:3.57E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:7.30|P-value:1.37E-12 ID:SGTC_441|Compound:propafenone|FD-Score:3.69|P-value:1.92E-4 ID:SGTC_455|Compound:paf C-16|FD-Score:3.34|P-value:6.60E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-4.06|P-value:6.06E-5 ID:SGTC_514|Compound:4466-0038|FD-Score:8.11|P-value:4.13E-15 ID:SGTC_515|Compound:4092-1064|FD-Score:-3.97|P-value:8.50E-5 ID:SGTC_576|Compound:1073-0113|FD-Score:5.94|P-value:6.23E-9 ID:SGTC_586|Compound:0957-0265|FD-Score:4.11|P-value:3.96E-5 ID:SGTC_607|Compound:4491-0986|FD-Score:4.85|P-value:1.63E-6 ID:SGTC_744|Compound:1594-0068|FD-Score:5.61|P-value:3.76E-8 ID:SGTC_745|Compound:0469-0705|FD-Score:4.35|P-value:1.51E-5 ID:SGTC_880|Compound:0833-0487|FD-Score:4.79|P-value:2.17E-6 ID:SGTC_907|Compound:3448-6986|FD-Score:-4.00|P-value:7.45E-5 ID:SGTC_908|Compound:3448-7491|FD-Score:11.90|P-value:1.64E-30 ID:SGTC_917|Compound:harmaline|FD-Score:4.53|P-value:6.74E-6 ID:SGTC_918|Compound:glabranin|FD-Score:3.27|P-value:8.18E-4 ID:SGTC_995|Compound:3931-2021|FD-Score:6.99|P-value:1.08E-11 ID:SGTC_1003|Compound:4049-0218|FD-Score:3.45|P-value:4.47E-4 ID:SGTC_1063|Compound:disulfiram|FD-Score:3.68|P-value:2.00E-4 ID:SGTC_1073|Compound:triclabendazole|FD-Score:4.37|P-value:1.35E-5 ID:SGTC_1145|Compound:3546-0597|FD-Score:3.25|P-value:8.97E-4 ID:SGTC_1353|Compound:1498-1206|FD-Score:4.98|P-value:8.97E-7 ID:SGTC_1374|Compound:2889-5571|FD-Score:3.43|P-value:4.80E-4 ID:SGTC_1435|Compound:4092-0789|FD-Score:3.79|P-value:1.36E-4 ID:SGTC_1635|Compound:st007035|FD-Score:17.10|P-value:2.41E-60 ID:SGTC_1641|Compound:st009299|FD-Score:4.55|P-value:6.41E-6 ID:SGTC_1758|Compound:st042942|FD-Score:3.94|P-value:7.63E-5 ID:SGTC_1787|Compound:fluconazole|FD-Score:-6.10|P-value:3.50E-9 ID:SGTC_1797|Compound:st048695|FD-Score:3.28|P-value:8.12E-4 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:6.06|P-value:3.13E-9 ID:SGTC_2011|Compound:4012611|FD-Score:8.62|P-value:8.10E-17 ID:SGTC_2016|Compound:5121758|FD-Score:3.64|P-value:2.37E-4 ID:SGTC_2093|Compound:5331342|FD-Score:-3.82|P-value:1.52E-4 ID:SGTC_2177|Compound:5811945|FD-Score:3.39|P-value:5.59E-4 ID:SGTC_2218|Compound:6965428|FD-Score:3.36|P-value:6.15E-4 ID:SGTC_2310|Compound:7668677|FD-Score:5.96|P-value:5.70E-9 ID:SGTC_2316|Compound:5844804|FD-Score:-3.91|P-value:1.05E-4 ID:SGTC_2326|Compound:6164455|FD-Score:7.90|P-value:1.97E-14 ID:SGTC_2328|Compound:6201408|FD-Score:-3.32|P-value:8.39E-4 ID:SGTC_2349|Compound:9023730|FD-Score:4.73|P-value:2.88E-6 ID:SGTC_2370|Compound:9071495|FD-Score:4.74|P-value:2.72E-6 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.77|P-value:1.44E-4 ID:SGTC_2546|Compound:rhodinyl acetate|FD-Score:3.22|P-value:9.88E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:4.23|P-value:2.43E-5 ID:SGTC_2619|Compound:obliquin|FD-Score:4.77|P-value:2.38E-6 ID:SGTC_2630|Compound:antimycin a|FD-Score:4.38|P-value:1.33E-5 ID:SGTC_2834|Compound:9001755|FD-Score:-3.39|P-value:6.66E-4 ID:SGTC_3208|Compound:9114115|FD-Score:3.27|P-value:8.24E-4 ID:SGTC_3299|Compound:9121982|FD-Score:-3.40|P-value:6.45E-4

Top fitness defect scores for YJL180C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_236 1509-0011 18.40 5.3 µM 3.91E-69 66 1.51E-75
2 SGTC_1635 st007035 17.10 42.4 µM 2.41E-60 27 6.66E-66
3 SGTC_275 trichlorophene 12.00 5.7 µM 1.02E-30 mitochondrial stress 20 2.03E-33
4 SGTC_908 3448-7491 11.90 47.7 µM 1.64E-30 mitochondrial stress 3 3.42E-33
5 SGTC_2011 4012611 8.62 177.0 µM 8.10E-17 mitochondrial processes 2 3.40E-18
6 SGTC_514 4466-0038 8.11 2.6 nM 4.13E-15 cell wall 37 2.51E-16
7 SGTC_2326 6164455 7.90 177.6 µM 1.97E-14 mitochondrial processes 1 1.39E-15
8 SGTC_386 1509-0011 7.30 3.1 µM 1.37E-12 75 1.43E-13
9 SGTC_995 3931-2021 6.99 34.6 µM 1.08E-11 RPP1 & pyrimidine depletion 5 1.37E-12
10 SGTC_1883 5-benzylidenerhodanine 6.06 20.0 µM 3.13E-9 TRP & mitochondrial translation 19 6.70E-10
11 SGTC_2310 7668677 5.96 200.0 µM 5.70E-9 5 1.29E-9
12 SGTC_576 1073-0113 5.94 22.7 µM 6.23E-9 redox potentiating 19 1.42E-9
13 SGTC_310 1273-0058 5.66 1.1 µM 2.88E-8 mitochondrial stress 153 7.57E-9
14 SGTC_744 1594-0068 5.61 283.0 µM 3.76E-8 amide catabolism 5 1.01E-8
15 SGTC_6 0844-0013 5.00 19.8 µM 8.23E-7 35 2.92E-7
16 SGTC_1353 1498-1206 4.98 8.1 µM 8.97E-7 mitochondrial response to ROS 29 3.21E-7
17 SGTC_607 4491-0986 4.85 66.8 µM 1.63E-6 heme requiring 12 6.15E-7
18 SGTC_880 0833-0487 4.79 87.2 µM 2.17E-6 mitochondrial processes 6 8.40E-7
19 SGTC_2619 obliquin 4.77 87.9 µM 2.38E-6 cell wall 104 9.31E-7
20 SGTC_2370 9071495 4.74 200.0 µM 2.72E-6 mitochondrial processes 12 1.08E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.535 4.62E-248 YPL013C MRPS16 hom Mitochondrial ribosomal protein of the small subunit
0.530 5.34E-242 YDR518W EUG1 hom Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER
0.516 3.17E-228 YJL023C PET130 hom Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.516 1.39E-227 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.508 5.71E-220 YNL213C RRG9 hom Protein of unknown function; null mutant lacks mitochondrial DNA and cannot grow on glycerol; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.507 2.14E-218 YDR375C BCS1 hom Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases
0.505 4.92E-216 YDR230W_d YDR230W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.503 4.54E-215 YGR220C MRPL9 hom Mitochondrial ribosomal protein of the large subunit
0.500 1.57E-211 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.487 7.72E-200 YPL215W CBP3 hom Mitochondrial protein required for assembly of cytochrome bc1 complex; forms a complex with Cbp6p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.483 5.28E-196 YKL194C MST1 hom Mitochondrial threonyl-tRNA synthetase; aminoacylates both the canonical threonine tRNA tT(UGU)Q1 and the unusual threonine tRNA tT(XXX)Q2 in vitro
0.481 4.78E-194 YMR151W_d YIM2_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1
0.480 2.05E-193 YNL252C MRPL17 hom Mitochondrial ribosomal protein of the large subunit
0.459 2.95E-174 YJR120W YJR120W hom Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p
0.457 3.40E-173 YJL022W_d YJL022W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PET130