YJL182C_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized ORF YJL181W

Zygosity: Homozygous strain
fixedexpanded
Profile for YJL182C / YJL182C

Click on Significant Values for Screen Details ID:SGTC_33|Compound:0986-0033|FD-Score:3.13|P-value:7.66E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:-3.52|P-value:1.70E-4 ID:SGTC_203|Compound:k066-0004|FD-Score:3.21|P-value:5.82E-4 ID:SGTC_855|Compound:0428-0020|FD-Score:3.33|P-value:3.74E-4 ID:SGTC_869|Compound:0564-0080|FD-Score:5.12|P-value:1.05E-7 ID:SGTC_871|Compound:0574-0004|FD-Score:3.81|P-value:5.68E-5 ID:SGTC_943|Compound:3253-1379|FD-Score:3.72|P-value:8.16E-5 ID:SGTC_1010|Compound:4112-3296|FD-Score:4.23|P-value:9.04E-6 ID:SGTC_1106|Compound:tegaserod maleate|FD-Score:3.89|P-value:4.04E-5 ID:SGTC_1377|Compound:2944-0135|FD-Score:3.24|P-value:5.11E-4 ID:SGTC_1405|Compound:3909-7894|FD-Score:3.35|P-value:3.52E-4 ID:SGTC_1519|Compound:esterone|FD-Score:3.78|P-value:6.35E-5 ID:SGTC_1523|Compound:st012844|FD-Score:3.77|P-value:6.67E-5 ID:SGTC_1528|Compound:arabinosylhypoxanthine|FD-Score:3.85|P-value:4.86E-5 ID:SGTC_1534|Compound:6-azauridine|FD-Score:3.19|P-value:6.19E-4 ID:SGTC_1720|Compound:st037298|FD-Score:-3.29|P-value:4.11E-4 ID:SGTC_1721|Compound:st082152|FD-Score:3.92|P-value:3.54E-5 ID:SGTC_1733|Compound:st037357|FD-Score:3.23|P-value:5.38E-4 ID:SGTC_1757|Compound:st041620|FD-Score:3.11|P-value:8.16E-4 ID:SGTC_1764|Compound:st044502|FD-Score:4.55|P-value:2.06E-6 ID:SGTC_1778|Compound:st046819|FD-Score:3.85|P-value:4.93E-5 ID:SGTC_1790|Compound:st045711|FD-Score:5.77|P-value:2.50E-9 ID:SGTC_1798|Compound:st045719|FD-Score:8.10|P-value:1.04E-16 ID:SGTC_1871|Compound:st057448|FD-Score:-3.24|P-value:4.86E-4 ID:SGTC_2033|Compound:5192550|FD-Score:-3.40|P-value:2.70E-4 ID:SGTC_2125|Compound:5246583|FD-Score:-3.10|P-value:7.95E-4 ID:SGTC_2136|Compound:5328288|FD-Score:-4.83|P-value:4.49E-7 ID:SGTC_2185|Compound:6113692|FD-Score:-3.60|P-value:1.23E-4 ID:SGTC_2274|Compound:7947094|FD-Score:-3.21|P-value:5.37E-4 ID:SGTC_2326|Compound:6164455|FD-Score:-3.33|P-value:3.45E-4 ID:SGTC_2349|Compound:9023730|FD-Score:3.57|P-value:1.51E-4 ID:SGTC_2351|Compound:9026858|FD-Score:3.18|P-value:6.34E-4 ID:SGTC_2357|Compound:9067248|FD-Score:-4.02|P-value:2.14E-5 ID:SGTC_2461|Compound:5755302|FD-Score:3.37|P-value:3.19E-4 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:3.10|P-value:8.55E-4 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:4.83|P-value:4.87E-7 ID:SGTC_2622|Compound:2-methoxyxanthone|FD-Score:-3.14|P-value:6.92E-4 ID:SGTC_2628|Compound:lathosterol|FD-Score:3.08|P-value:9.02E-4 ID:SGTC_2699|Compound:st077704|FD-Score:3.53|P-value:1.75E-4 ID:SGTC_2842|Compound:9000675|FD-Score:3.43|P-value:2.53E-4 ID:SGTC_2845|Compound:9003024|FD-Score:-3.52|P-value:1.72E-4 ID:SGTC_2885|Compound:9057732|FD-Score:3.22|P-value:5.50E-4 ID:SGTC_2888|Compound:9058547|FD-Score:4.22|P-value:9.52E-6 ID:SGTC_2944|Compound:9067346|FD-Score:4.59|P-value:1.64E-6 ID:SGTC_3054|Compound:9094397|FD-Score:-3.16|P-value:6.46E-4 ID:SGTC_3058|Compound:9093861|FD-Score:3.34|P-value:3.56E-4 ID:SGTC_3106|Compound:9121286|FD-Score:4.58|P-value:1.72E-6 ID:SGTC_3204|Compound:9114183|FD-Score:4.03|P-value:2.26E-5 ID:SGTC_3222|Compound:9128301|FD-Score:4.47|P-value:2.99E-6 ID:SGTC_3236|Compound:9132701|FD-Score:3.69|P-value:9.28E-5 ID:SGTC_3281|Compound:9140613|FD-Score:4.05|P-value:2.06E-5 ID:SGTC_3320|Compound:9137005|FD-Score:3.15|P-value:7.10E-4 ID:SGTC_33|Compound:0986-0033|FD-Score:3.13|P-value:7.66E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:-3.52|P-value:1.70E-4 ID:SGTC_203|Compound:k066-0004|FD-Score:3.21|P-value:5.82E-4 ID:SGTC_855|Compound:0428-0020|FD-Score:3.33|P-value:3.74E-4 ID:SGTC_869|Compound:0564-0080|FD-Score:5.12|P-value:1.05E-7 ID:SGTC_871|Compound:0574-0004|FD-Score:3.81|P-value:5.68E-5 ID:SGTC_943|Compound:3253-1379|FD-Score:3.72|P-value:8.16E-5 ID:SGTC_1010|Compound:4112-3296|FD-Score:4.23|P-value:9.04E-6 ID:SGTC_1106|Compound:tegaserod maleate|FD-Score:3.89|P-value:4.04E-5 ID:SGTC_1377|Compound:2944-0135|FD-Score:3.24|P-value:5.11E-4 ID:SGTC_1405|Compound:3909-7894|FD-Score:3.35|P-value:3.52E-4 ID:SGTC_1519|Compound:esterone|FD-Score:3.78|P-value:6.35E-5 ID:SGTC_1523|Compound:st012844|FD-Score:3.77|P-value:6.67E-5 ID:SGTC_1528|Compound:arabinosylhypoxanthine|FD-Score:3.85|P-value:4.86E-5 ID:SGTC_1534|Compound:6-azauridine|FD-Score:3.19|P-value:6.19E-4 ID:SGTC_1720|Compound:st037298|FD-Score:-3.29|P-value:4.11E-4 ID:SGTC_1721|Compound:st082152|FD-Score:3.92|P-value:3.54E-5 ID:SGTC_1733|Compound:st037357|FD-Score:3.23|P-value:5.38E-4 ID:SGTC_1757|Compound:st041620|FD-Score:3.11|P-value:8.16E-4 ID:SGTC_1764|Compound:st044502|FD-Score:4.55|P-value:2.06E-6 ID:SGTC_1778|Compound:st046819|FD-Score:3.85|P-value:4.93E-5 ID:SGTC_1790|Compound:st045711|FD-Score:5.77|P-value:2.50E-9 ID:SGTC_1798|Compound:st045719|FD-Score:8.10|P-value:1.04E-16 ID:SGTC_1871|Compound:st057448|FD-Score:-3.24|P-value:4.86E-4 ID:SGTC_2033|Compound:5192550|FD-Score:-3.40|P-value:2.70E-4 ID:SGTC_2125|Compound:5246583|FD-Score:-3.10|P-value:7.95E-4 ID:SGTC_2136|Compound:5328288|FD-Score:-4.83|P-value:4.49E-7 ID:SGTC_2185|Compound:6113692|FD-Score:-3.60|P-value:1.23E-4 ID:SGTC_2274|Compound:7947094|FD-Score:-3.21|P-value:5.37E-4 ID:SGTC_2326|Compound:6164455|FD-Score:-3.33|P-value:3.45E-4 ID:SGTC_2349|Compound:9023730|FD-Score:3.57|P-value:1.51E-4 ID:SGTC_2351|Compound:9026858|FD-Score:3.18|P-value:6.34E-4 ID:SGTC_2357|Compound:9067248|FD-Score:-4.02|P-value:2.14E-5 ID:SGTC_2461|Compound:5755302|FD-Score:3.37|P-value:3.19E-4 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:3.10|P-value:8.55E-4 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:4.83|P-value:4.87E-7 ID:SGTC_2622|Compound:2-methoxyxanthone|FD-Score:-3.14|P-value:6.92E-4 ID:SGTC_2628|Compound:lathosterol|FD-Score:3.08|P-value:9.02E-4 ID:SGTC_2699|Compound:st077704|FD-Score:3.53|P-value:1.75E-4 ID:SGTC_2842|Compound:9000675|FD-Score:3.43|P-value:2.53E-4 ID:SGTC_2845|Compound:9003024|FD-Score:-3.52|P-value:1.72E-4 ID:SGTC_2885|Compound:9057732|FD-Score:3.22|P-value:5.50E-4 ID:SGTC_2888|Compound:9058547|FD-Score:4.22|P-value:9.52E-6 ID:SGTC_2944|Compound:9067346|FD-Score:4.59|P-value:1.64E-6 ID:SGTC_3054|Compound:9094397|FD-Score:-3.16|P-value:6.46E-4 ID:SGTC_3058|Compound:9093861|FD-Score:3.34|P-value:3.56E-4 ID:SGTC_3106|Compound:9121286|FD-Score:4.58|P-value:1.72E-6 ID:SGTC_3204|Compound:9114183|FD-Score:4.03|P-value:2.26E-5 ID:SGTC_3222|Compound:9128301|FD-Score:4.47|P-value:2.99E-6 ID:SGTC_3236|Compound:9132701|FD-Score:3.69|P-value:9.28E-5 ID:SGTC_3281|Compound:9140613|FD-Score:4.05|P-value:2.06E-5 ID:SGTC_3320|Compound:9137005|FD-Score:3.15|P-value:7.10E-4

Top fitness defect scores for YJL182C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1798 st045719 8.10 61.0 µM 1.04E-16 1 2.66E-16
2 SGTC_1790 st045711 5.77 43.5 µM 2.50E-9 2 4.00E-9
3 SGTC_869 0564-0080 5.12 44.1 µM 1.05E-7 7 1.51E-7
4 SGTC_2565 isoliquiritigenin 4.83 100.0 µM 4.87E-7 20 6.73E-7
5 SGTC_2944 9067346 4.59 25.6 µM 1.64E-6 13 2.20E-6
6 SGTC_3106 9121286 4.58 49.5 µM 1.72E-6 6 2.30E-6
7 SGTC_1764 st044502 4.55 93.5 µM 2.06E-6 21 2.73E-6
8 SGTC_3222 9128301 4.47 49.5 µM 2.99E-6 60S ribosome export 14 3.94E-6
9 SGTC_1010 4112-3296 4.23 15.2 µM 9.04E-6 13 1.16E-5
10 SGTC_2888 9058547 4.22 13.0 µM 9.52E-6 4 1.22E-5
11 SGTC_3281 9140613 4.05 49.5 µM 2.06E-5 RPP1 & pyrimidine depletion 19 2.57E-5
12 SGTC_3204 9114183 4.03 49.5 µM 2.26E-5 30 2.82E-5
13 SGTC_1721 st082152 3.92 9.3 µM 3.54E-5 60S ribosome export 20 4.36E-5
14 SGTC_1106 tegaserod maleate 3.89 11.7 µM 4.04E-5 18 4.97E-5
15 SGTC_1528 arabinosylhypoxanthine 3.85 74.6 µM 4.86E-5 26 5.94E-5
16 SGTC_1778 st046819 3.85 58.9 µM 4.93E-5 28 6.03E-5
17 SGTC_871 0574-0004 3.81 149.0 µM 5.68E-5 52 6.91E-5
18 SGTC_1519 esterone 3.78 74.0 µM 6.35E-5 DNA intercalators 19 7.72E-5
19 SGTC_1523 st012844 3.77 44.7 µM 6.67E-5 60S ribosome export 27 8.09E-5
20 SGTC_943 3253-1379 3.72 105.0 µM 8.16E-5 31 9.85E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.105 1.08E-9 YKL101W HSL1 hom Nim1p-related protein kinase that regulates the morphogenesis and septin checkpoints; associates with the assembled septin filament; required along with Hsl7p for bud neck recruitment, phosphorylation, and degradation of Swe1p
0.103 2.29E-9 YBL098W BNA4 hom Kynurenine 3-mono oxygenase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p; putative therapeutic target for Huntington disease
0.082 1.72E-6 YLR361C DCR2 hom Phosphoesterase involved in downregulation of the unfolded protein response, at least in part via dephosphorylation of Ire1p; dosage-dependent positive regulator of the G1/S phase transition through control of the timing of START
0.082 2.08E-6 YDL161W ENT1 hom Epsin-like protein involved in endocytosis and actin patch assembly; functionally redundant with Ent2p; binds clathrin via a clathrin-binding domain motif at C-terminus; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.082 2.28E-6 YBL106C SRO77 hom Protein with roles in exocytosis and cation homeostasis; functions in docking and fusion of post-Golgi vesicles with plasma membrane; homolog of Drosophila lethal giant larvae tumor suppressor; interacts with SNARE protein Sec9p; SRO77 has a paralog, SRO7, that arose from the whole genome duplication
0.074 1.58E-5 YGR001C_p YGR001C_p hom Putative protein of unknown function with similarity to methyltransferase family members; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; required for replication of Brome mosaic virus in S. cerevisiae
0.074 1.60E-5 YNL010W_p YNL010W_p hom Putative protein of unknown function with similarity to phosphoserine phosphatases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; homozygous diploid mutant shows an increase in glycogen accumulation
0.073 2.37E-5 YOR149C SMP3 het Alpha 1,2-mannosyltransferase involved in glycosyl phosphatidyl inositol (GPI) biosynthesis; required for addition of the fourth, side branching mannose to the GPI core structure
0.067 9.27E-5 YPL037C EGD1 hom Subunit beta1 of the nascent polypeptide-associated complex (NAC) involved in protein targeting, associated with cytoplasmic ribosomes; enhances DNA binding of the Gal4p activator; homolog of human BTF3b
0.066 1.16E-4 YIL092W_p YIL092W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to the nucleus
0.065 1.50E-4 YPR052C NHP6A hom High-mobility group (HMG) protein, binds to and remodels nucleosomes; involved in recruiting FACT and other chromatin remodelling complexes to chromosomes; functionally redundant with Nhp6Bp; homologous to mammalian HMGB1 and HMGB2; NHP6A has a paralog, NHP6B, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.064 1.90E-4 YGL099W LSG1 het Putative GTPase involved in 60S ribosomal subunit biogenesis; required for the release of Nmd3p from 60S subunits in the cytoplasm
0.064 2.17E-4 YML023C NSE5 het Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair
0.064 2.25E-4 YBR046C ZTA1 hom NADPH-dependent quinone reductase, GFP-tagged protein localizes to the cytoplasm and nucleus; has similarity to E. coli quinone oxidoreductase and to human zeta-crystallin
0.063 2.48E-4 YGR210C_p YGR210C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm