YJL183W / MNN11

Subunit of a Golgi mannosyltransferase complex that also contains Anp1p, Mnn9p, Mnn10p, and Hoc1p, and mediates elongation of the polysaccharide mannan backbone; has homology to Mnn10p

Zygosity: Homozygous strain
fixedexpanded
Profile for YJL183W / MNN11

Click on Significant Values for Screen Details ID:SGTC_18|Compound:0111-0177|FD-Score:5.39|P-value:1.22E-6 ID:SGTC_119|Compound:0121-0043|FD-Score:6.95|P-value:6.01E-10 ID:SGTC_121|Compound:0557-0495|FD-Score:5.73|P-value:2.73E-7 ID:SGTC_124|Compound:0136-0217|FD-Score:3.91|P-value:3.19E-4 ID:SGTC_131|Compound:0141-0277|FD-Score:4.16|P-value:1.39E-4 ID:SGTC_132|Compound:0417-1715|FD-Score:4.24|P-value:1.05E-4 ID:SGTC_179|Compound:1273-0063|FD-Score:4.62|P-value:2.69E-5 ID:SGTC_206|Compound:4546-0025|FD-Score:3.60|P-value:8.22E-4 ID:SGTC_435|Compound:c-PAF|FD-Score:3.69|P-value:6.21E-4 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:3.93|P-value:2.93E-4 ID:SGTC_663|Compound:1486-0733|FD-Score:4.85|P-value:1.10E-5 ID:SGTC_800|Compound:3448-7362|FD-Score:4.24|P-value:1.06E-4 ID:SGTC_878|Compound:0828-0289|FD-Score:6.14|P-value:3.82E-8 ID:SGTC_911|Compound:3456-4043|FD-Score:6.95|P-value:5.97E-10 ID:SGTC_951|Compound:1171-0579|FD-Score:3.75|P-value:5.26E-4 ID:SGTC_975|Compound:1335-0046|FD-Score:4.48|P-value:4.46E-5 ID:SGTC_976|Compound:1348-1067|FD-Score:4.62|P-value:2.66E-5 ID:SGTC_989|Compound:1501-0895|FD-Score:4.63|P-value:2.57E-5 ID:SGTC_1097|Compound:itavastatin|FD-Score:5.66|P-value:3.68E-7 ID:SGTC_1099|Compound:5-nonyloxytryptamine|FD-Score:4.04|P-value:2.05E-4 ID:SGTC_1100|Compound:amiodarone|FD-Score:3.58|P-value:8.74E-4 ID:SGTC_1247|Compound:0448-0043|FD-Score:3.79|P-value:4.61E-4 ID:SGTC_1280|Compound:0880-0253|FD-Score:-4.61|P-value:2.68E-5 ID:SGTC_1316|Compound:1272-0050|FD-Score:3.90|P-value:3.23E-4 ID:SGTC_1388|Compound:3346-4487|FD-Score:4.41|P-value:5.68E-5 ID:SGTC_1457|Compound:k015-0032|FD-Score:5.00|P-value:6.10E-6 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:3.88|P-value:3.47E-4 ID:SGTC_1712|Compound:st032288|FD-Score:3.65|P-value:7.10E-4 ID:SGTC_1853|Compound:st056710|FD-Score:6.09|P-value:4.99E-8 ID:SGTC_1905|Compound:st060207|FD-Score:3.85|P-value:3.82E-4 ID:SGTC_1908|Compound:st060353|FD-Score:3.85|P-value:3.81E-4 ID:SGTC_2007|Compound:4011539|FD-Score:4.12|P-value:1.59E-4 ID:SGTC_2009|Compound:4012297|FD-Score:3.58|P-value:8.75E-4 ID:SGTC_2137|Compound:5261020|FD-Score:4.24|P-value:1.06E-4 ID:SGTC_2242|Compound:6630449|FD-Score:3.75|P-value:5.22E-4 ID:SGTC_2286|Compound:7945697|FD-Score:3.59|P-value:8.45E-4 ID:SGTC_2342|Compound:7990637|FD-Score:-4.58|P-value:2.96E-5 ID:SGTC_2350|Compound:9023895|FD-Score:8.78|P-value:8.00E-15 ID:SGTC_2352|Compound:9027995|FD-Score:-4.01|P-value:2.20E-4 ID:SGTC_2357|Compound:9067248|FD-Score:4.10|P-value:1.68E-4 ID:SGTC_2391|Compound:6285546|FD-Score:4.16|P-value:1.39E-4 ID:SGTC_2399|Compound:5884133|FD-Score:15.00|P-value:1.70E-39 ID:SGTC_2460|Compound:5552655|FD-Score:4.59|P-value:3.01E-5 ID:SGTC_2508|Compound:celastrol|FD-Score:3.82|P-value:4.17E-4 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:3.66|P-value:6.94E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:5.48|P-value:8.10E-7 ID:SGTC_2829|Compound:7992743|FD-Score:5.81|P-value:1.85E-7 ID:SGTC_2851|Compound:9015922|FD-Score:4.66|P-value:2.32E-5 ID:SGTC_2888|Compound:9058547|FD-Score:3.92|P-value:3.05E-4 ID:SGTC_2924|Compound:9010168|FD-Score:5.06|P-value:4.78E-6 ID:SGTC_2925|Compound:9010536|FD-Score:3.88|P-value:3.44E-4 ID:SGTC_2971|Compound:9092186|FD-Score:-3.80|P-value:4.24E-4 ID:SGTC_2999|Compound:9069765|FD-Score:3.56|P-value:9.24E-4 ID:SGTC_3202|Compound:9113761|FD-Score:3.89|P-value:3.38E-4 ID:SGTC_3296|Compound:9122258|FD-Score:-3.93|P-value:2.85E-4 ID:SGTC_3333|Compound:9141820|FD-Score:4.32|P-value:7.96E-5 ID:SGTC_18|Compound:0111-0177|FD-Score:5.39|P-value:1.22E-6 ID:SGTC_119|Compound:0121-0043|FD-Score:6.95|P-value:6.01E-10 ID:SGTC_121|Compound:0557-0495|FD-Score:5.73|P-value:2.73E-7 ID:SGTC_124|Compound:0136-0217|FD-Score:3.91|P-value:3.19E-4 ID:SGTC_131|Compound:0141-0277|FD-Score:4.16|P-value:1.39E-4 ID:SGTC_132|Compound:0417-1715|FD-Score:4.24|P-value:1.05E-4 ID:SGTC_179|Compound:1273-0063|FD-Score:4.62|P-value:2.69E-5 ID:SGTC_206|Compound:4546-0025|FD-Score:3.60|P-value:8.22E-4 ID:SGTC_435|Compound:c-PAF|FD-Score:3.69|P-value:6.21E-4 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:3.93|P-value:2.93E-4 ID:SGTC_663|Compound:1486-0733|FD-Score:4.85|P-value:1.10E-5 ID:SGTC_800|Compound:3448-7362|FD-Score:4.24|P-value:1.06E-4 ID:SGTC_878|Compound:0828-0289|FD-Score:6.14|P-value:3.82E-8 ID:SGTC_911|Compound:3456-4043|FD-Score:6.95|P-value:5.97E-10 ID:SGTC_951|Compound:1171-0579|FD-Score:3.75|P-value:5.26E-4 ID:SGTC_975|Compound:1335-0046|FD-Score:4.48|P-value:4.46E-5 ID:SGTC_976|Compound:1348-1067|FD-Score:4.62|P-value:2.66E-5 ID:SGTC_989|Compound:1501-0895|FD-Score:4.63|P-value:2.57E-5 ID:SGTC_1097|Compound:itavastatin|FD-Score:5.66|P-value:3.68E-7 ID:SGTC_1099|Compound:5-nonyloxytryptamine|FD-Score:4.04|P-value:2.05E-4 ID:SGTC_1100|Compound:amiodarone|FD-Score:3.58|P-value:8.74E-4 ID:SGTC_1247|Compound:0448-0043|FD-Score:3.79|P-value:4.61E-4 ID:SGTC_1280|Compound:0880-0253|FD-Score:-4.61|P-value:2.68E-5 ID:SGTC_1316|Compound:1272-0050|FD-Score:3.90|P-value:3.23E-4 ID:SGTC_1388|Compound:3346-4487|FD-Score:4.41|P-value:5.68E-5 ID:SGTC_1457|Compound:k015-0032|FD-Score:5.00|P-value:6.10E-6 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:3.88|P-value:3.47E-4 ID:SGTC_1712|Compound:st032288|FD-Score:3.65|P-value:7.10E-4 ID:SGTC_1853|Compound:st056710|FD-Score:6.09|P-value:4.99E-8 ID:SGTC_1905|Compound:st060207|FD-Score:3.85|P-value:3.82E-4 ID:SGTC_1908|Compound:st060353|FD-Score:3.85|P-value:3.81E-4 ID:SGTC_2007|Compound:4011539|FD-Score:4.12|P-value:1.59E-4 ID:SGTC_2009|Compound:4012297|FD-Score:3.58|P-value:8.75E-4 ID:SGTC_2137|Compound:5261020|FD-Score:4.24|P-value:1.06E-4 ID:SGTC_2242|Compound:6630449|FD-Score:3.75|P-value:5.22E-4 ID:SGTC_2286|Compound:7945697|FD-Score:3.59|P-value:8.45E-4 ID:SGTC_2342|Compound:7990637|FD-Score:-4.58|P-value:2.96E-5 ID:SGTC_2350|Compound:9023895|FD-Score:8.78|P-value:8.00E-15 ID:SGTC_2352|Compound:9027995|FD-Score:-4.01|P-value:2.20E-4 ID:SGTC_2357|Compound:9067248|FD-Score:4.10|P-value:1.68E-4 ID:SGTC_2391|Compound:6285546|FD-Score:4.16|P-value:1.39E-4 ID:SGTC_2399|Compound:5884133|FD-Score:15.00|P-value:1.70E-39 ID:SGTC_2460|Compound:5552655|FD-Score:4.59|P-value:3.01E-5 ID:SGTC_2508|Compound:celastrol|FD-Score:3.82|P-value:4.17E-4 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:3.66|P-value:6.94E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:5.48|P-value:8.10E-7 ID:SGTC_2829|Compound:7992743|FD-Score:5.81|P-value:1.85E-7 ID:SGTC_2851|Compound:9015922|FD-Score:4.66|P-value:2.32E-5 ID:SGTC_2888|Compound:9058547|FD-Score:3.92|P-value:3.05E-4 ID:SGTC_2924|Compound:9010168|FD-Score:5.06|P-value:4.78E-6 ID:SGTC_2925|Compound:9010536|FD-Score:3.88|P-value:3.44E-4 ID:SGTC_2971|Compound:9092186|FD-Score:-3.80|P-value:4.24E-4 ID:SGTC_2999|Compound:9069765|FD-Score:3.56|P-value:9.24E-4 ID:SGTC_3202|Compound:9113761|FD-Score:3.89|P-value:3.38E-4 ID:SGTC_3296|Compound:9122258|FD-Score:-3.93|P-value:2.85E-4 ID:SGTC_3333|Compound:9141820|FD-Score:4.32|P-value:7.96E-5

Top fitness defect scores for YJL183W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2399 5884133 15.00 200.0 µM 1.70E-39 cell wall signaling 5 6.49E-51
2 SGTC_2350 9023895 8.78 38.9 µM 8.00E-15 ergosterol biosynthesis 2 8.50E-19
3 SGTC_911 3456-4043 6.95 236.0 µM 5.97E-10 mitochondrial processes 1 1.82E-12
4 SGTC_119 0121-0043 6.95 24.8 µM 6.01E-10 mitochondrial stress 17 1.83E-12
5 SGTC_878 0828-0289 6.14 13.7 µM 3.82E-8 13 4.00E-10
6 SGTC_1853 st056710 6.09 91.2 µM 4.99E-8 amide catabolism 3 5.66E-10
7 SGTC_2829 7992743 5.81 58.4 µM 1.85E-7 8 3.09E-9
8 SGTC_121 0557-0495 5.73 61.3 µM 2.73E-7 calcium & mitochondrial duress 21 5.10E-9
9 SGTC_1097 itavastatin 5.66 7.2 µM 3.68E-7 azole & statin 8 7.51E-9
10 SGTC_2582 agaric acid 5.48 100.0 µM 8.10E-7 redox potentiating 190 2.09E-8
11 SGTC_18 0111-0177 5.39 500.0 nM 1.22E-6 28 3.55E-8
12 SGTC_2924 9010168 5.06 62.8 µM 4.78E-6 cell wall signaling 15 2.08E-7
13 SGTC_1457 k015-0032 5.00 57.3 µM 6.10E-6 14 2.85E-7
14 SGTC_663 1486-0733 4.85 13.9 µM 1.10E-5 cell wall signaling 33 6.07E-7
15 SGTC_2851 9015922 4.66 71.4 µM 2.32E-5 21 1.60E-6
16 SGTC_989 1501-0895 4.63 10.3 µM 2.57E-5 3 1.82E-6
17 SGTC_976 1348-1067 4.62 47.6 µM 2.66E-5 60S ribosome export 15 1.91E-6
18 SGTC_179 1273-0063 4.62 6.8 µM 2.69E-5 15 1.94E-6
19 SGTC_2460 5552655 4.59 174.2 µM 3.01E-5 amide catabolism 17 2.23E-6
20 SGTC_975 1335-0046 4.48 28.5 µM 4.46E-5 RPP1 & pyrimidine depletion 21 3.71E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.268 3.22E-56 YBR260C RGD1 hom GTPase-activating protein (RhoGAP) for Rho3p and Rho4p, possibly involved in control of actin cytoskeleton organization
0.255 9.27E-51 YAL053W FLC2 hom Putative FAD transporter; required for uptake of FAD into endoplasmic reticulum; involved in cell wall maintenance; FLC2 has a paralog, YOR365C, that arose from the whole genome duplication
0.229 5.81E-41 YAL056C-A_d YAL056C-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.227 1.37E-40 YNL322C KRE1 hom Cell wall glycoprotein involved in beta-glucan assembly; serves as a K1 killer toxin membrane receptor
0.207 1.03E-33 YGR196C FYV8 hom Protein of unknown function, required for survival upon exposure to K1 killer toxin
0.207 1.16E-33 YNL084C END3 hom EH domain-containing protein involved in endocytosis, actin cytoskeletal organization and cell wall morphogenesis; forms a complex with Sla1p and Pan1p
0.205 4.47E-33 YEL036C ANP1 hom Subunit of the alpha-1,6 mannosyltransferase complex; type II membrane protein; has a role in retention of glycosyltransferases in the Golgi; involved in osmotic sensitivity and resistance to aminonitrophenyl propanediol
0.199 3.62E-31 YMR200W ROT1 het Molecular chaperone involved in protein folding in the ER; mutation causes defects in cell wall synthesis and in lysis of autophagic bodies, suppresses tor2 mutations, and is synthetically lethal with kar2-1 and with rot2 mutations; involved in N-linked glycosylation and O-mannosylation
0.191 6.70E-29 YAL058W CNE1 hom Calnexin; integral membrane ER chaperone involved in folding and quality control of glycoproteins; chaperone activity is inhibited by Mpd1p, with which Cne1p interacts; 24% identical to mammalian calnexin; Ca+ binding not yet shown in yeast
0.176 1.25E-24 YMR238W DFG5 hom Putative mannosidase, essential glycosylphosphatidylinositol (GPI)-anchored membrane protein required for cell wall biogenesis in bud formation, involved in filamentous growth, homologous to Dcw1p
0.172 1.14E-23 YBR229C ROT2 hom Glucosidase II catalytic subunit required for normal cell wall synthesis; mutations in rot2 suppress tor2 mutations, and are synthetically lethal with rot1 mutations
0.168 1.05E-22 YGL027C CWH41 hom Processing alpha glucosidase I, ER type II integral membrane N-glycoprotein involved in assembly of cell wall beta 1,6 glucan and asparagine-linked protein glycosylation; also involved in ER protein quality control and sensing of ER stress
0.163 2.25E-21 YDR245W MNN10 hom Subunit of a Golgi mannosyltransferase complex also containing Anp1p, Mnn9p, Mnn11p, and Hoc1p that mediates elongation of the polysaccharide mannan backbone; membrane protein of the mannosyltransferase family
0.160 1.24E-20 YJR075W HOC1 hom Alpha-1,6-mannosyltransferase involved in cell wall mannan biosynthesis; subunit of a Golgi-localized complex that also contains Anp1p, Mnn9p, Mnn11p, and Mnn10p; identified as a suppressor of a cell lysis sensitive pkc1-371 allele
0.143 6.77E-17 YLR332W MID2 hom O-glycosylated plasma membrane protein that acts as a sensor for cell wall integrity signaling and activates the pathway; interacts with Rom2p, a guanine nucleotide exchange factor for Rho1p, and with cell integrity pathway protein Zeo1p