Pex3p interacting protein, required for pexophagy; interacts with Atg8p and Atg11p; mRNA is weakly cell cycle regulated, peaking in G2 phase; YJL185C is a non-essential gene
Zygosity: Homozygous strain
fixedexpanded
![]() ![]() Click on Significant Values for Screen Details |
Top fitness defect scores for YJL185C deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Correlation | pval | ORF | Gene | Zygosity | Description |
---|---|---|---|---|---|
0.137 | 1.62E-15 | YJL171C | YJL171C | hom | GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress |
0.122 | 1.13E-12 | YFL014W | HSP12 | hom | Plasma membrane protein involved in maintaining membrane organization in stress conditions; induced by heat shock, oxidative stress, osmostress, stationary phase, glucose depletion, oleate and alcohol; protein abundance increased in response to DNA replication stress and dietary restriction; regulated by the HOG and Ras-Pka pathways; required for dietary restriction-induced lifespan extension |
0.121 | 2.16E-12 | YGR077C | PEX8 | hom | Intraperoxisomal organizer of the peroxisomal import machinery; organizes the formation of the importomer complex, bridging the docking complex with the RING finger complex; tightly associated with the lumenal face of the peroxisomal membrane; essential for peroxisome biogenesis; binds PTS1-signal receptor Pex5p, and PTS2-signal receptor Pex7p |
0.114 | 3.18E-11 | YGR022C_d | YGR022C_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W |
0.109 | 2.42E-10 | YNL166C | BNI5 | hom | Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner |
0.108 | 3.95E-10 | YLR400W_d | YLR400W_d | hom | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
0.107 | 4.91E-10 | YPR180W | AOS1 | het | Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability |
0.107 | 4.57E-10 | YLR213C | CRR1 | hom | Putative glycoside hydrolase of the spore wall envelope; required for normal spore wall assembly, possibly for cross-linking between the glucan and chitosan layers; expressed during sporulation |
0.104 | 1.54E-9 | YDR521W_d | YDR521W_d | hom | Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol |
0.103 | 2.48E-9 | YDL197C | ASF2 | hom | Anti-silencing protein that causes derepression of silent loci when overexpressed |
0.100 | 6.13E-9 | YGR278W | CWC22 | het | Spliceosome-associated protein that is required for pre-mRNA splicing; necessary for Prp2p function at the first catalytic step of splicing; has similarity to S. pombe Cwf22p; CWC22 is an essential protein |
0.097 | 1.65E-8 | YDL157C_p | YDL157C_p | hom | Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies |
0.097 | 1.68E-8 | YDR528W | HLR1 | hom | Protein involved in regulation of cell wall composition and integrity and response to osmotic stress; overproduction suppresses a lysis sensitive PKC mutation; similar to Lre1p, which functions antagonistically to protein kinase A; HLR1 has a paralog, LRE1, that arose from the whole genome duplication |
0.094 | 5.47E-8 | YOR050C_d | YOR050C_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutation is viable |
0.091 | 1.11E-7 | YLR107W | REX3 | hom | RNA exonuclease; required for maturation of the RNA component of RNase MRP; functions redundantly with Rnh70p and Rex2p in processing of U5 snRNA and RNase P RNA; member of RNase D family of exonucleases |