YJL185C / ATG36

Pex3p interacting protein, required for pexophagy; interacts with Atg8p and Atg11p; mRNA is weakly cell cycle regulated, peaking in G2 phase; YJL185C is a non-essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YJL185C / ATG36

Click on Significant Values for Screen Details ID:SGTC_38|Compound:0929-0051|FD-Score:5.71|P-value:1.47E-9 ID:SGTC_41|Compound:0478-0632|FD-Score:3.41|P-value:1.96E-4 ID:SGTC_44|Compound:0929-0055|FD-Score:6.68|P-value:1.90E-12 ID:SGTC_75|Compound:0159-0059|FD-Score:3.96|P-value:1.90E-5 ID:SGTC_153|Compound:4077-0274|FD-Score:3.14|P-value:5.40E-4 ID:SGTC_441|Compound:propafenone|FD-Score:-4.43|P-value:2.17E-6 ID:SGTC_522|Compound:1273-0010|FD-Score:4.38|P-value:2.62E-6 ID:SGTC_530|Compound:4358-1714|FD-Score:4.71|P-value:4.81E-7 ID:SGTC_562|Compound:3772-2733|FD-Score:3.57|P-value:9.96E-5 ID:SGTC_642|Compound:0335-0876|FD-Score:-3.22|P-value:4.33E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:3.42|P-value:1.88E-4 ID:SGTC_864|Compound:0469-0573|FD-Score:4.08|P-value:1.10E-5 ID:SGTC_868|Compound:0527-0199|FD-Score:-4.56|P-value:1.17E-6 ID:SGTC_870|Compound:0573-2213|FD-Score:3.06|P-value:7.31E-4 ID:SGTC_879|Compound:0831-1030|FD-Score:-3.07|P-value:7.53E-4 ID:SGTC_940|Compound:3232-1287|FD-Score:4.07|P-value:1.12E-5 ID:SGTC_983|Compound:1491-0821|FD-Score:3.62|P-value:8.34E-5 ID:SGTC_988|Compound:1497-1057|FD-Score:4.91|P-value:1.61E-7 ID:SGTC_1095|Compound:3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran|FD-Score:-3.21|P-value:4.46E-4 ID:SGTC_1189|Compound:1431-2119|FD-Score:3.12|P-value:5.84E-4 ID:SGTC_1293|Compound:1000-1278|FD-Score:4.06|P-value:1.19E-5 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.42|P-value:2.01E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.40|P-value:2.13E-4 ID:SGTC_1567|Compound:st069303|FD-Score:3.00|P-value:8.93E-4 ID:SGTC_1689|Compound:st020265|FD-Score:3.66|P-value:7.07E-5 ID:SGTC_1712|Compound:st032288|FD-Score:3.10|P-value:6.23E-4 ID:SGTC_1716|Compound:st033144|FD-Score:-3.68|P-value:7.04E-5 ID:SGTC_1767|Compound:st044992|FD-Score:-3.07|P-value:7.48E-4 ID:SGTC_1795|Compound:st049545|FD-Score:3.87|P-value:2.87E-5 ID:SGTC_1827|Compound:berberine|FD-Score:3.49|P-value:1.39E-4 ID:SGTC_1891|Compound:st059073|FD-Score:3.04|P-value:7.84E-4 ID:SGTC_2011|Compound:4012611|FD-Score:4.13|P-value:8.54E-6 ID:SGTC_2273|Compound:7815444|FD-Score:5.21|P-value:3.02E-8 ID:SGTC_2316|Compound:5844804|FD-Score:-3.29|P-value:3.25E-4 ID:SGTC_2336|Compound:9001819|FD-Score:3.29|P-value:3.07E-4 ID:SGTC_2340|Compound:7987427|FD-Score:-3.90|P-value:2.73E-5 ID:SGTC_2411|Compound:st077133|FD-Score:3.98|P-value:1.71E-5 ID:SGTC_2467|Compound:5474540|FD-Score:-3.25|P-value:3.89E-4 ID:SGTC_2475|Compound:5812728|FD-Score:3.75|P-value:4.70E-5 ID:SGTC_2557|Compound:derrustone|FD-Score:3.68|P-value:6.36E-5 ID:SGTC_2629|Compound:bisabolol|FD-Score:3.23|P-value:3.87E-4 ID:SGTC_2632|Compound:3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone|FD-Score:3.41|P-value:1.90E-4 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:-4.19|P-value:7.02E-6 ID:SGTC_2729|Compound:fluphenazine|FD-Score:3.34|P-value:2.56E-4 ID:SGTC_2790|Compound:5423970|FD-Score:-3.13|P-value:5.98E-4 ID:SGTC_2792|Compound:7535235|FD-Score:2.97|P-value:9.89E-4 ID:SGTC_2838|Compound:9002687|FD-Score:4.54|P-value:1.16E-6 ID:SGTC_2840|Compound:9008771|FD-Score:-3.79|P-value:4.26E-5 ID:SGTC_2841|Compound:9004761|FD-Score:3.95|P-value:1.96E-5 ID:SGTC_2844|Compound:9010103|FD-Score:-5.38|P-value:1.21E-8 ID:SGTC_2878|Compound:9043973|FD-Score:-3.79|P-value:4.32E-5 ID:SGTC_2951|Compound:9072950|FD-Score:3.41|P-value:1.91E-4 ID:SGTC_2982|Compound:9019404|FD-Score:4.90|P-value:1.74E-7 ID:SGTC_3111|Compound:9122088|FD-Score:-3.07|P-value:7.33E-4 ID:SGTC_3144|Compound:9087057|FD-Score:3.07|P-value:6.94E-4 ID:SGTC_3158|Compound:9100007|FD-Score:-3.17|P-value:5.14E-4 ID:SGTC_3166|Compound:9102297|FD-Score:2.97|P-value:9.80E-4 ID:SGTC_3225|Compound:9130819|FD-Score:4.34|P-value:3.23E-6 ID:SGTC_3237|Compound:9133362|FD-Score:5.25|P-value:2.44E-8 ID:SGTC_3322|Compound:9139058|FD-Score:3.34|P-value:2.56E-4 ID:SGTC_3351|Compound:9150312|FD-Score:3.57|P-value:1.03E-4 ID:SGTC_38|Compound:0929-0051|FD-Score:5.71|P-value:1.47E-9 ID:SGTC_41|Compound:0478-0632|FD-Score:3.41|P-value:1.96E-4 ID:SGTC_44|Compound:0929-0055|FD-Score:6.68|P-value:1.90E-12 ID:SGTC_75|Compound:0159-0059|FD-Score:3.96|P-value:1.90E-5 ID:SGTC_153|Compound:4077-0274|FD-Score:3.14|P-value:5.40E-4 ID:SGTC_441|Compound:propafenone|FD-Score:-4.43|P-value:2.17E-6 ID:SGTC_522|Compound:1273-0010|FD-Score:4.38|P-value:2.62E-6 ID:SGTC_530|Compound:4358-1714|FD-Score:4.71|P-value:4.81E-7 ID:SGTC_562|Compound:3772-2733|FD-Score:3.57|P-value:9.96E-5 ID:SGTC_642|Compound:0335-0876|FD-Score:-3.22|P-value:4.33E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:3.42|P-value:1.88E-4 ID:SGTC_864|Compound:0469-0573|FD-Score:4.08|P-value:1.10E-5 ID:SGTC_868|Compound:0527-0199|FD-Score:-4.56|P-value:1.17E-6 ID:SGTC_870|Compound:0573-2213|FD-Score:3.06|P-value:7.31E-4 ID:SGTC_879|Compound:0831-1030|FD-Score:-3.07|P-value:7.53E-4 ID:SGTC_940|Compound:3232-1287|FD-Score:4.07|P-value:1.12E-5 ID:SGTC_983|Compound:1491-0821|FD-Score:3.62|P-value:8.34E-5 ID:SGTC_988|Compound:1497-1057|FD-Score:4.91|P-value:1.61E-7 ID:SGTC_1095|Compound:3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran|FD-Score:-3.21|P-value:4.46E-4 ID:SGTC_1189|Compound:1431-2119|FD-Score:3.12|P-value:5.84E-4 ID:SGTC_1293|Compound:1000-1278|FD-Score:4.06|P-value:1.19E-5 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.42|P-value:2.01E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.40|P-value:2.13E-4 ID:SGTC_1567|Compound:st069303|FD-Score:3.00|P-value:8.93E-4 ID:SGTC_1689|Compound:st020265|FD-Score:3.66|P-value:7.07E-5 ID:SGTC_1712|Compound:st032288|FD-Score:3.10|P-value:6.23E-4 ID:SGTC_1716|Compound:st033144|FD-Score:-3.68|P-value:7.04E-5 ID:SGTC_1767|Compound:st044992|FD-Score:-3.07|P-value:7.48E-4 ID:SGTC_1795|Compound:st049545|FD-Score:3.87|P-value:2.87E-5 ID:SGTC_1827|Compound:berberine|FD-Score:3.49|P-value:1.39E-4 ID:SGTC_1891|Compound:st059073|FD-Score:3.04|P-value:7.84E-4 ID:SGTC_2011|Compound:4012611|FD-Score:4.13|P-value:8.54E-6 ID:SGTC_2273|Compound:7815444|FD-Score:5.21|P-value:3.02E-8 ID:SGTC_2316|Compound:5844804|FD-Score:-3.29|P-value:3.25E-4 ID:SGTC_2336|Compound:9001819|FD-Score:3.29|P-value:3.07E-4 ID:SGTC_2340|Compound:7987427|FD-Score:-3.90|P-value:2.73E-5 ID:SGTC_2411|Compound:st077133|FD-Score:3.98|P-value:1.71E-5 ID:SGTC_2467|Compound:5474540|FD-Score:-3.25|P-value:3.89E-4 ID:SGTC_2475|Compound:5812728|FD-Score:3.75|P-value:4.70E-5 ID:SGTC_2557|Compound:derrustone|FD-Score:3.68|P-value:6.36E-5 ID:SGTC_2629|Compound:bisabolol|FD-Score:3.23|P-value:3.87E-4 ID:SGTC_2632|Compound:3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone|FD-Score:3.41|P-value:1.90E-4 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:-4.19|P-value:7.02E-6 ID:SGTC_2729|Compound:fluphenazine|FD-Score:3.34|P-value:2.56E-4 ID:SGTC_2790|Compound:5423970|FD-Score:-3.13|P-value:5.98E-4 ID:SGTC_2792|Compound:7535235|FD-Score:2.97|P-value:9.89E-4 ID:SGTC_2838|Compound:9002687|FD-Score:4.54|P-value:1.16E-6 ID:SGTC_2840|Compound:9008771|FD-Score:-3.79|P-value:4.26E-5 ID:SGTC_2841|Compound:9004761|FD-Score:3.95|P-value:1.96E-5 ID:SGTC_2844|Compound:9010103|FD-Score:-5.38|P-value:1.21E-8 ID:SGTC_2878|Compound:9043973|FD-Score:-3.79|P-value:4.32E-5 ID:SGTC_2951|Compound:9072950|FD-Score:3.41|P-value:1.91E-4 ID:SGTC_2982|Compound:9019404|FD-Score:4.90|P-value:1.74E-7 ID:SGTC_3111|Compound:9122088|FD-Score:-3.07|P-value:7.33E-4 ID:SGTC_3144|Compound:9087057|FD-Score:3.07|P-value:6.94E-4 ID:SGTC_3158|Compound:9100007|FD-Score:-3.17|P-value:5.14E-4 ID:SGTC_3166|Compound:9102297|FD-Score:2.97|P-value:9.80E-4 ID:SGTC_3225|Compound:9130819|FD-Score:4.34|P-value:3.23E-6 ID:SGTC_3237|Compound:9133362|FD-Score:5.25|P-value:2.44E-8 ID:SGTC_3322|Compound:9139058|FD-Score:3.34|P-value:2.56E-4 ID:SGTC_3351|Compound:9150312|FD-Score:3.57|P-value:1.03E-4

Top fitness defect scores for YJL185C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_44 0929-0055 6.68 61.2 µM 1.90E-12 6 1.19E-11
2 SGTC_38 0929-0051 5.71 58.3 µM 1.47E-9 4 5.70E-9
3 SGTC_3237 9133362 5.25 49.5 µM 2.44E-8 14 7.76E-8
4 SGTC_2273 7815444 5.21 169.1 µM 3.02E-8 4 9.46E-8
5 SGTC_988 1497-1057 4.91 103.0 µM 1.61E-7 3 4.49E-7
6 SGTC_2982 9019404 4.90 26.0 µM 1.74E-7 12 4.81E-7
7 SGTC_530 4358-1714 4.71 28.0 µM 4.81E-7 24 1.24E-6
8 SGTC_2838 9002687 4.54 71.4 µM 1.16E-6 fatty acid desaturase (OLE1) 13 2.80E-6
9 SGTC_522 1273-0010 4.38 11.6 µM 2.62E-6 60S ribosome export 17 5.96E-6
10 SGTC_3225 9130819 4.34 49.5 µM 3.23E-6 amide catabolism 21 7.26E-6
11 SGTC_2011 4012611 4.13 177.0 µM 8.54E-6 mitochondrial processes 25 1.79E-5
12 SGTC_864 0469-0573 4.08 172.0 µM 1.10E-5 15 2.27E-5
13 SGTC_940 3232-1287 4.07 54.8 µM 1.12E-5 NEO1 34 2.30E-5
14 SGTC_1293 1000-1278 4.06 195.0 µM 1.19E-5 8 2.44E-5
15 SGTC_2411 st077133 3.98 39.9 µM 1.71E-5 RNA pol III & RNase P/MRP 32 3.41E-5
16 SGTC_75 0159-0059 3.96 199.0 µM 1.90E-5 fatty acid desaturase (OLE1) 19 3.77E-5
17 SGTC_2841 9004761 3.95 39.0 µM 1.96E-5 amide catabolism 28 3.87E-5
18 SGTC_1795 st049545 3.87 62.3 µM 2.87E-5 TSC3-RPN4 11 5.52E-5
19 SGTC_2475 5812728 3.75 15.0 µM 4.70E-5 mitochondrial processes 26 8.74E-5
20 SGTC_2557 derrustone 3.68 83.8 µM 6.36E-5 47 1.16E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.137 1.62E-15 YJL171C YJL171C hom GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress
0.122 1.13E-12 YFL014W HSP12 hom Plasma membrane protein involved in maintaining membrane organization in stress conditions; induced by heat shock, oxidative stress, osmostress, stationary phase, glucose depletion, oleate and alcohol; protein abundance increased in response to DNA replication stress and dietary restriction; regulated by the HOG and Ras-Pka pathways; required for dietary restriction-induced lifespan extension
0.121 2.16E-12 YGR077C PEX8 hom Intraperoxisomal organizer of the peroxisomal import machinery; organizes the formation of the importomer complex, bridging the docking complex with the RING finger complex; tightly associated with the lumenal face of the peroxisomal membrane; essential for peroxisome biogenesis; binds PTS1-signal receptor Pex5p, and PTS2-signal receptor Pex7p
0.114 3.18E-11 YGR022C_d YGR022C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
0.109 2.42E-10 YNL166C BNI5 hom Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner
0.108 3.95E-10 YLR400W_d YLR400W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.107 4.91E-10 YPR180W AOS1 het Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability
0.107 4.57E-10 YLR213C CRR1 hom Putative glycoside hydrolase of the spore wall envelope; required for normal spore wall assembly, possibly for cross-linking between the glucan and chitosan layers; expressed during sporulation
0.104 1.54E-9 YDR521W_d YDR521W_d hom Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol
0.103 2.48E-9 YDL197C ASF2 hom Anti-silencing protein that causes derepression of silent loci when overexpressed
0.100 6.13E-9 YGR278W CWC22 het Spliceosome-associated protein that is required for pre-mRNA splicing; necessary for Prp2p function at the first catalytic step of splicing; has similarity to S. pombe Cwf22p; CWC22 is an essential protein
0.097 1.65E-8 YDL157C_p YDL157C_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.097 1.68E-8 YDR528W HLR1 hom Protein involved in regulation of cell wall composition and integrity and response to osmotic stress; overproduction suppresses a lysis sensitive PKC mutation; similar to Lre1p, which functions antagonistically to protein kinase A;
HLR1 has a paralog, LRE1, that arose from the whole genome duplication
0.094 5.47E-8 YOR050C_d YOR050C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutation is viable
0.091 1.11E-7 YLR107W REX3 hom RNA exonuclease; required for maturation of the RNA component of RNase MRP; functions redundantly with Rnh70p and Rex2p in processing of U5 snRNA and RNase P RNA; member of RNase D family of exonucleases