HIPHOP chemogenomics database

YJL185C / ATG36

Pex3p interacting protein, required for pexophagy; interacts with Atg8p and Atg11p; mRNA is weakly cell cycle regulated, peaking in G2 phase; YJL185C is a non-essential gene

Zygosity: Homozygous strain

fixedexpanded
Profile for YJL185C / ATG36

Click on Significant Values for Screen Details

Top fitness defect scores for YJL185C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_44	0929-0055	6.68	61.2 µM	1.90E-12		6	1.19E-11
2	SGTC_38	0929-0051	5.71	58.3 µM	1.47E-9		4	5.70E-9
3	SGTC_3237	9133362	5.25	49.5 µM	2.44E-8		14	7.76E-8
4	SGTC_2273	7815444	5.21	169.1 µM	3.02E-8		4	9.46E-8
5	SGTC_988	1497-1057	4.91	103.0 µM	1.61E-7		3	4.49E-7
6	SGTC_2982	9019404	4.90	26.0 µM	1.74E-7		12	4.81E-7
7	SGTC_530	4358-1714	4.71	28.0 µM	4.81E-7		24	1.24E-6
8	SGTC_2838	9002687	4.54	71.4 µM	1.16E-6	fatty acid desaturase (OLE1)	13	2.80E-6
9	SGTC_522	1273-0010	4.38	11.6 µM	2.62E-6	60S ribosome export	17	5.96E-6
10	SGTC_3225	9130819	4.34	49.5 µM	3.23E-6	amide catabolism	21	7.26E-6
11	SGTC_2011	4012611	4.13	177.0 µM	8.54E-6	mitochondrial processes	25	1.79E-5
12	SGTC_864	0469-0573	4.08	172.0 µM	1.10E-5		15	2.27E-5
13	SGTC_940	3232-1287	4.07	54.8 µM	1.12E-5	NEO1	34	2.30E-5
14	SGTC_1293	1000-1278	4.06	195.0 µM	1.19E-5		8	2.44E-5
15	SGTC_2411	st077133	3.98	39.9 µM	1.71E-5	RNA pol III & RNase P/MRP	32	3.41E-5
16	SGTC_75	0159-0059	3.96	199.0 µM	1.90E-5	fatty acid desaturase (OLE1)	19	3.77E-5
17	SGTC_2841	9004761	3.95	39.0 µM	1.96E-5	amide catabolism	28	3.87E-5
18	SGTC_1795	st049545	3.87	62.3 µM	2.87E-5	TSC3-RPN4	11	5.52E-5
19	SGTC_2475	5812728	3.75	15.0 µM	4.70E-5	mitochondrial processes	26	8.74E-5
20	SGTC_2557	derrustone	3.68	83.8 µM	6.36E-5		47	1.16E-4

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.137	1.62E-15	YJL171C	YJL171C	hom	GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress
0.122	1.13E-12	YFL014W	HSP12	hom	Plasma membrane protein involved in maintaining membrane organization in stress conditions; induced by heat shock, oxidative stress, osmostress, stationary phase, glucose depletion, oleate and alcohol; protein abundance increased in response to DNA replication stress and dietary restriction; regulated by the HOG and Ras-Pka pathways; required for dietary restriction-induced lifespan extension
0.121	2.16E-12	YGR077C	PEX8	hom	Intraperoxisomal organizer of the peroxisomal import machinery; organizes the formation of the importomer complex, bridging the docking complex with the RING finger complex; tightly associated with the lumenal face of the peroxisomal membrane; essential for peroxisome biogenesis; binds PTS1-signal receptor Pex5p, and PTS2-signal receptor Pex7p
0.114	3.18E-11	YGR022C_d	YGR022C_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
0.109	2.42E-10	YNL166C	BNI5	hom	Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner
0.108	3.95E-10	YLR400W_d	YLR400W_d	hom	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.107	4.91E-10	YPR180W	AOS1	het	Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability
0.107	4.57E-10	YLR213C	CRR1	hom	Putative glycoside hydrolase of the spore wall envelope; required for normal spore wall assembly, possibly for cross-linking between the glucan and chitosan layers; expressed during sporulation
0.104	1.54E-9	YDR521W_d	YDR521W_d	hom	Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol
0.103	2.48E-9	YDL197C	ASF2	hom	Anti-silencing protein that causes derepression of silent loci when overexpressed
0.100	6.13E-9	YGR278W	CWC22	het	Spliceosome-associated protein that is required for pre-mRNA splicing; necessary for Prp2p function at the first catalytic step of splicing; has similarity to S. pombe Cwf22p; CWC22 is an essential protein
0.097	1.65E-8	YDL157C_p	YDL157C_p	hom	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.097	1.68E-8	YDR528W	HLR1	hom	Protein involved in regulation of cell wall composition and integrity and response to osmotic stress; overproduction suppresses a lysis sensitive PKC mutation; similar to Lre1p, which functions antagonistically to protein kinase A; HLR1 has a paralog, LRE1, that arose from the whole genome duplication
0.094	5.47E-8	YOR050C_d	YOR050C_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutation is viable
0.091	1.11E-7	YLR107W	REX3	hom	RNA exonuclease; required for maturation of the RNA component of RNase MRP; functions redundantly with Rnh70p and Rex2p in processing of U5 snRNA and RNase P RNA; member of RNase D family of exonucleases