YJL189W / RPL39

Ribosomal 60S subunit protein L39; required for ribosome biogenesis; loss of both Rpl31p and Rpl39p confers lethality; also exhibits genetic interactions with SIS1 and PAB1; homologous to mammalian ribosomal protein L39, no bacterial homolog

Zygosity: Homozygous strain
fixedexpanded
Profile for YJL189W / RPL39

Click on Significant Values for Screen Details ID:SGTC_59|Compound:0330-0160|FD-Score:3.43|P-value:5.15E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:5.82|P-value:1.65E-8 ID:SGTC_599|Compound:1935-0052|FD-Score:4.54|P-value:7.68E-6 ID:SGTC_800|Compound:3448-7362|FD-Score:8.02|P-value:1.47E-14 ID:SGTC_831|Compound:k061-1017|FD-Score:3.56|P-value:3.40E-4 ID:SGTC_956|Compound:1185-0240|FD-Score:4.21|P-value:3.03E-5 ID:SGTC_960|Compound:1222-0186|FD-Score:4.15|P-value:3.87E-5 ID:SGTC_1252|Compound:0493-0875|FD-Score:3.94|P-value:8.40E-5 ID:SGTC_1272|Compound:0839-0021|FD-Score:-4.51|P-value:1.34E-5 ID:SGTC_1276|Compound:0871-0068|FD-Score:5.01|P-value:9.41E-7 ID:SGTC_1650|Compound:st011916|FD-Score:-3.83|P-value:1.88E-4 ID:SGTC_1652|Compound:st011932|FD-Score:-5.70|P-value:5.25E-8 ID:SGTC_1675|Compound:st018485|FD-Score:4.16|P-value:3.60E-5 ID:SGTC_1718|Compound:roemerine|FD-Score:-5.51|P-value:1.40E-7 ID:SGTC_1849|Compound:st056239|FD-Score:3.42|P-value:5.39E-4 ID:SGTC_1967|Compound:st070177|FD-Score:-3.84|P-value:1.84E-4 ID:SGTC_1969|Compound:st069479|FD-Score:4.69|P-value:3.96E-6 ID:SGTC_2006|Compound:4011487|FD-Score:-3.58|P-value:4.57E-4 ID:SGTC_2093|Compound:5331342|FD-Score:3.26|P-value:9.11E-4 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:3.78|P-value:1.57E-4 ID:SGTC_2289|Compound:7946404|FD-Score:-7.12|P-value:1.46E-11 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:-4.05|P-value:8.35E-5 ID:SGTC_2523|Compound:spermine|FD-Score:-3.82|P-value:1.92E-4 ID:SGTC_2537|Compound:larixol|FD-Score:3.63|P-value:2.65E-4 ID:SGTC_2548|Compound:3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin|FD-Score:-3.41|P-value:7.78E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.53|P-value:8.05E-6 ID:SGTC_2701|Compound:st077767|FD-Score:-3.39|P-value:8.43E-4 ID:SGTC_2704|Compound:st078022|FD-Score:-3.40|P-value:8.26E-4 ID:SGTC_2848|Compound:9016370|FD-Score:-4.04|P-value:8.81E-5 ID:SGTC_2896|Compound:9052656|FD-Score:-3.52|P-value:5.54E-4 ID:SGTC_2964|Compound:9083345|FD-Score:3.28|P-value:8.60E-4 ID:SGTC_3104|Compound:9120930|FD-Score:3.40|P-value:5.75E-4 ID:SGTC_3216|Compound:9129716|FD-Score:-3.76|P-value:2.40E-4 ID:SGTC_3219|Compound:9131112|FD-Score:-4.98|P-value:1.78E-6 ID:SGTC_59|Compound:0330-0160|FD-Score:3.43|P-value:5.15E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:5.82|P-value:1.65E-8 ID:SGTC_599|Compound:1935-0052|FD-Score:4.54|P-value:7.68E-6 ID:SGTC_800|Compound:3448-7362|FD-Score:8.02|P-value:1.47E-14 ID:SGTC_831|Compound:k061-1017|FD-Score:3.56|P-value:3.40E-4 ID:SGTC_956|Compound:1185-0240|FD-Score:4.21|P-value:3.03E-5 ID:SGTC_960|Compound:1222-0186|FD-Score:4.15|P-value:3.87E-5 ID:SGTC_1252|Compound:0493-0875|FD-Score:3.94|P-value:8.40E-5 ID:SGTC_1272|Compound:0839-0021|FD-Score:-4.51|P-value:1.34E-5 ID:SGTC_1276|Compound:0871-0068|FD-Score:5.01|P-value:9.41E-7 ID:SGTC_1650|Compound:st011916|FD-Score:-3.83|P-value:1.88E-4 ID:SGTC_1652|Compound:st011932|FD-Score:-5.70|P-value:5.25E-8 ID:SGTC_1675|Compound:st018485|FD-Score:4.16|P-value:3.60E-5 ID:SGTC_1718|Compound:roemerine|FD-Score:-5.51|P-value:1.40E-7 ID:SGTC_1849|Compound:st056239|FD-Score:3.42|P-value:5.39E-4 ID:SGTC_1967|Compound:st070177|FD-Score:-3.84|P-value:1.84E-4 ID:SGTC_1969|Compound:st069479|FD-Score:4.69|P-value:3.96E-6 ID:SGTC_2006|Compound:4011487|FD-Score:-3.58|P-value:4.57E-4 ID:SGTC_2093|Compound:5331342|FD-Score:3.26|P-value:9.11E-4 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:3.78|P-value:1.57E-4 ID:SGTC_2289|Compound:7946404|FD-Score:-7.12|P-value:1.46E-11 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:-4.05|P-value:8.35E-5 ID:SGTC_2523|Compound:spermine|FD-Score:-3.82|P-value:1.92E-4 ID:SGTC_2537|Compound:larixol|FD-Score:3.63|P-value:2.65E-4 ID:SGTC_2548|Compound:3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin|FD-Score:-3.41|P-value:7.78E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.53|P-value:8.05E-6 ID:SGTC_2701|Compound:st077767|FD-Score:-3.39|P-value:8.43E-4 ID:SGTC_2704|Compound:st078022|FD-Score:-3.40|P-value:8.26E-4 ID:SGTC_2848|Compound:9016370|FD-Score:-4.04|P-value:8.81E-5 ID:SGTC_2896|Compound:9052656|FD-Score:-3.52|P-value:5.54E-4 ID:SGTC_2964|Compound:9083345|FD-Score:3.28|P-value:8.60E-4 ID:SGTC_3104|Compound:9120930|FD-Score:3.40|P-value:5.75E-4 ID:SGTC_3216|Compound:9129716|FD-Score:-3.76|P-value:2.40E-4 ID:SGTC_3219|Compound:9131112|FD-Score:-4.98|P-value:1.78E-6

Top fitness defect scores for YJL189W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_800 3448-7362 8.02 155.0 µM 1.47E-14 translation 16 5.20E-16
2 SGTC_118 0083-0097 5.82 135.3 µM 1.65E-8 translation 26 3.01E-9
3 SGTC_1276 0871-0068 5.01 94.2 µM 9.41E-7 5 2.72E-7
4 SGTC_1969 st069479 4.69 40.1 µM 3.96E-6 5 1.34E-6
5 SGTC_599 1935-0052 4.54 86.5 µM 7.68E-6 8 2.81E-6
6 SGTC_2688 kanamycin b 4.53 96.7 µM 8.05E-6 calcium & mitochondrial duress 296 2.95E-6
7 SGTC_956 1185-0240 4.21 191.0 µM 3.03E-5 16 1.29E-5
8 SGTC_1675 st018485 4.16 24.5 µM 3.60E-5 60S ribosome export 21 1.56E-5
9 SGTC_960 1222-0186 4.15 7.7 µM 3.87E-5 29 1.69E-5
10 SGTC_1252 0493-0875 3.94 34.8 µM 8.40E-5 28 3.99E-5
11 SGTC_2232 chlorophetanol 3.78 41.5 µM 1.57E-4 TRP & mitochondrial translation 134 7.98E-5
12 SGTC_2537 larixol 3.63 68.9 µM 2.65E-4 32 1.43E-4
13 SGTC_831 k061-1017 3.56 217.0 µM 3.40E-4 translation 88 1.88E-4
14 SGTC_59 0330-0160 3.43 1.3 µM 5.15E-4 156 2.97E-4
15 SGTC_1849 st056239 3.42 19.2 µM 5.39E-4 RPP1 & pyrimidine depletion 47 3.12E-4
16 SGTC_3104 9120930 3.40 49.5 µM 5.75E-4 24 3.36E-4
17 SGTC_2964 9083345 3.28 53.4 µM 8.60E-4 42 5.23E-4
18 SGTC_2093 5331342 3.26 194.4 µM 9.11E-4 41 5.58E-4
19 SGTC_843 0310-0051 3.21 143.0 µM 0.00106 37 6.62E-4
20 SGTC_2224 6650123 3.21 117.7 µM 0.00107 12 6.68E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.226 5.57E-40 YLR048W RPS0B hom Protein component of the small (40S) ribosomal subunit; RPS0B has a paralog, RPS0A, that arose from the whole genome duplication; required for maturation of 18S rRNA along with Rps0Ap; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal; homologous to human ribosomal protein SA and bacterial S2
0.216 1.36E-36 YGL246C RAI1 hom Nuclear protein with decapping endonuclease activity targeted toward mRNAs with unmethylated 7-methylguanosine cap structures; binds to and stabilizes the exoribonuclease Rat1p; required for pre-rRNA processing; homologous to human DOM3Z
0.207 7.28E-34 YEL054C RPL12A hom Ribosomal 60S subunit protein L12A; rpl12a rpl12b double mutant exhibits slow growth and slow translation; homologous to mammalian ribosomal protein L12 and bacterial L11; RPL12A has a paralog, RPL12B, that arose from the whole genome duplication
0.205 4.41E-33 YJL188C_d BUD19_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 88% of ORF overlaps the verified gene RPL39; diploid mutant displays a weak budding pattern phenotype in a systematic assay
0.191 7.32E-29 YOR309C_d YOR309C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NOP58
0.181 4.34E-26 YDR140W MTQ2 hom S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; subunit of complex with Trm112p that methylates translation release factor Sup45p (eRF1) in the ternary complex eRF1-eRF3-GTP; similar to E.coli PrmC
0.172 1.45E-23 YML073C RPL6A hom Ribosomal 60S subunit protein L6A; N-terminally acetylated; binds 5.8S rRNA; homologous to mammalian ribosomal protein L6, no bacterial homolog; RPL6A has a paralog, RPL6B, that arose from the whole genome duplication
0.168 1.25E-22 YGL135W RPL1B hom Ribosomal 60S subunit protein L1B; N-terminally acetylated; homologous to mammalian ribosomal protein L10A and bacterial L1; RPL1B has a paralog, RPL1A, that arose from the whole genome duplication; rpl1a rpl1b double null mutation is lethal
0.163 2.31E-21 YLR068W FYV7 hom Essential protein required for maturation of 18S rRNA; required for survival upon exposure to K1 killer toxin
0.161 6.80E-21 YDL061C RPS29B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S29 and bacterial S14; RPS29B has a paralog, RPS29A, that arose from the whole genome duplication
0.158 3.28E-20 YGR162W TIF4631 hom Translation initiation factor eIF4G; subunit of the mRNA cap-binding protein complex (eIF4F) that also contains eIF4E (Cdc33p); interacts with Pab1p and with eIF4A (Tif1p); also has a role in biogenesis of the large ribosomal subunit; TIF4631 has a paralog, TIF4632, that arose from the whole genome duplication
0.156 8.72E-20 YJR145C RPS4A hom Protein component of the small (40S) ribosomal subunit; mutation affects 20S pre-rRNA processing; homologous to mammalian ribosomal protein S4, no bacterial homolog; RPS4A has a paralog, RPS4B, that arose from the whole genome duplication
0.155 1.76E-19 YLR287C-A RPS30A hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S30, no bacterial homolog; RPS30A has a paralog, RPS30B, that arose from the whole genome duplication
0.152 7.07E-19 YPL249C-A RPL36B hom Ribosomal 60S subunit protein L36B; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L36, no bacterial homolog; RPL36B has a paralog, RPL36A, that arose from the whole genome duplication
0.152 9.44E-19 YGR271C-A EFG1 hom Essential protein required for maturation of 18S rRNA; null mutant is sensitive to hydroxyurea and is delayed in recovering from alpha-factor arrest; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus