YJL190C / RPS22A

Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15A and bacterial S8; RPS22A has a paralog, RPS22B, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YJL190C / RPS22A

Click on Significant Values for Screen Details ID:SGTC_35|Compound:0133-0054|FD-Score:4.51|P-value:6.27E-6 ID:SGTC_66|Compound:0109-0187|FD-Score:4.08|P-value:3.81E-5 ID:SGTC_140|Compound:0062-0056|FD-Score:4.50|P-value:6.52E-6 ID:SGTC_356|Compound:1634-0012|FD-Score:3.92|P-value:7.24E-5 ID:SGTC_390|Compound:dec-rvkr-cmk|FD-Score:3.31|P-value:6.53E-4 ID:SGTC_393|Compound:acivicin|FD-Score:3.97|P-value:5.93E-5 ID:SGTC_501|Compound:nsc-95397|FD-Score:3.25|P-value:8.13E-4 ID:SGTC_595|Compound:3909-8003|FD-Score:3.32|P-value:6.37E-4 ID:SGTC_630|Compound:4356-0227|FD-Score:3.30|P-value:6.91E-4 ID:SGTC_639|Compound:0833-0042|FD-Score:3.53|P-value:3.13E-4 ID:SGTC_651|Compound:3253-0966|FD-Score:3.40|P-value:4.91E-4 ID:SGTC_663|Compound:1486-0733|FD-Score:3.45|P-value:4.14E-4 ID:SGTC_687|Compound:k029-0044|FD-Score:4.20|P-value:2.34E-5 ID:SGTC_716|Compound:1683-5115|FD-Score:-3.64|P-value:2.34E-4 ID:SGTC_913|Compound:3487-1245|FD-Score:4.44|P-value:8.38E-6 ID:SGTC_979|Compound:1426-2828|FD-Score:3.30|P-value:6.80E-4 ID:SGTC_1030|Compound:k029-0042|FD-Score:4.73|P-value:2.26E-6 ID:SGTC_1035|Compound:k081-0041|FD-Score:5.15|P-value:3.06E-7 ID:SGTC_1039|Compound:k821-0043|FD-Score:5.93|P-value:4.66E-9 ID:SGTC_1043|Compound:0916-0009|FD-Score:3.89|P-value:8.15E-5 ID:SGTC_1091|Compound:telmisartan|FD-Score:3.56|P-value:2.80E-4 ID:SGTC_1231|Compound:0242-0792|FD-Score:4.45|P-value:8.26E-6 ID:SGTC_1255|Compound:0566-0045|FD-Score:3.20|P-value:9.61E-4 ID:SGTC_1647|Compound:st011722|FD-Score:3.41|P-value:4.66E-4 ID:SGTC_1655|Compound:st012546|FD-Score:4.74|P-value:2.25E-6 ID:SGTC_1717|Compound:st033143|FD-Score:3.85|P-value:9.45E-5 ID:SGTC_1732|Compound:st034308|FD-Score:4.84|P-value:1.37E-6 ID:SGTC_1808|Compound:st050063|FD-Score:-3.83|P-value:1.19E-4 ID:SGTC_1864|Compound:st057645|FD-Score:3.37|P-value:5.32E-4 ID:SGTC_1866|Compound:st057638|FD-Score:5.36|P-value:1.08E-7 ID:SGTC_1876|Compound:myriocin|FD-Score:-3.28|P-value:8.15E-4 ID:SGTC_1916|Compound:st067606|FD-Score:3.71|P-value:1.62E-4 ID:SGTC_1929|Compound:genistein trimethyl ether|FD-Score:-3.89|P-value:9.40E-5 ID:SGTC_2010|Compound:4012422|FD-Score:6.23|P-value:8.35E-10 ID:SGTC_2128|Compound:5255449|FD-Score:4.54|P-value:5.35E-6 ID:SGTC_2136|Compound:5328288|FD-Score:-6.02|P-value:3.37E-9 ID:SGTC_2310|Compound:7668677|FD-Score:-3.43|P-value:5.00E-4 ID:SGTC_2329|Compound:6138490|FD-Score:3.44|P-value:4.20E-4 ID:SGTC_2392|Compound:N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide|FD-Score:5.27|P-value:1.66E-7 ID:SGTC_2486|Compound:5283202|FD-Score:4.81|P-value:1.56E-6 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:3.46|P-value:3.93E-4 ID:SGTC_2714|Compound:st079313|FD-Score:5.05|P-value:4.91E-7 ID:SGTC_2803|Compound:7707263|FD-Score:6.14|P-value:1.37E-9 ID:SGTC_2873|Compound:9040596|FD-Score:3.75|P-value:1.39E-4 ID:SGTC_2881|Compound:9058953|FD-Score:3.75|P-value:1.39E-4 ID:SGTC_2929|Compound:9013348|FD-Score:3.23|P-value:8.57E-4 ID:SGTC_2952|Compound:9073731|FD-Score:4.05|P-value:4.26E-5 ID:SGTC_2994|Compound:9053520|FD-Score:3.76|P-value:1.34E-4 ID:SGTC_3013|Compound:9080133|FD-Score:4.09|P-value:3.64E-5 ID:SGTC_3269|Compound:9137823|FD-Score:3.48|P-value:3.66E-4 ID:SGTC_35|Compound:0133-0054|FD-Score:4.51|P-value:6.27E-6 ID:SGTC_66|Compound:0109-0187|FD-Score:4.08|P-value:3.81E-5 ID:SGTC_140|Compound:0062-0056|FD-Score:4.50|P-value:6.52E-6 ID:SGTC_356|Compound:1634-0012|FD-Score:3.92|P-value:7.24E-5 ID:SGTC_390|Compound:dec-rvkr-cmk|FD-Score:3.31|P-value:6.53E-4 ID:SGTC_393|Compound:acivicin|FD-Score:3.97|P-value:5.93E-5 ID:SGTC_501|Compound:nsc-95397|FD-Score:3.25|P-value:8.13E-4 ID:SGTC_595|Compound:3909-8003|FD-Score:3.32|P-value:6.37E-4 ID:SGTC_630|Compound:4356-0227|FD-Score:3.30|P-value:6.91E-4 ID:SGTC_639|Compound:0833-0042|FD-Score:3.53|P-value:3.13E-4 ID:SGTC_651|Compound:3253-0966|FD-Score:3.40|P-value:4.91E-4 ID:SGTC_663|Compound:1486-0733|FD-Score:3.45|P-value:4.14E-4 ID:SGTC_687|Compound:k029-0044|FD-Score:4.20|P-value:2.34E-5 ID:SGTC_716|Compound:1683-5115|FD-Score:-3.64|P-value:2.34E-4 ID:SGTC_913|Compound:3487-1245|FD-Score:4.44|P-value:8.38E-6 ID:SGTC_979|Compound:1426-2828|FD-Score:3.30|P-value:6.80E-4 ID:SGTC_1030|Compound:k029-0042|FD-Score:4.73|P-value:2.26E-6 ID:SGTC_1035|Compound:k081-0041|FD-Score:5.15|P-value:3.06E-7 ID:SGTC_1039|Compound:k821-0043|FD-Score:5.93|P-value:4.66E-9 ID:SGTC_1043|Compound:0916-0009|FD-Score:3.89|P-value:8.15E-5 ID:SGTC_1091|Compound:telmisartan|FD-Score:3.56|P-value:2.80E-4 ID:SGTC_1231|Compound:0242-0792|FD-Score:4.45|P-value:8.26E-6 ID:SGTC_1255|Compound:0566-0045|FD-Score:3.20|P-value:9.61E-4 ID:SGTC_1647|Compound:st011722|FD-Score:3.41|P-value:4.66E-4 ID:SGTC_1655|Compound:st012546|FD-Score:4.74|P-value:2.25E-6 ID:SGTC_1717|Compound:st033143|FD-Score:3.85|P-value:9.45E-5 ID:SGTC_1732|Compound:st034308|FD-Score:4.84|P-value:1.37E-6 ID:SGTC_1808|Compound:st050063|FD-Score:-3.83|P-value:1.19E-4 ID:SGTC_1864|Compound:st057645|FD-Score:3.37|P-value:5.32E-4 ID:SGTC_1866|Compound:st057638|FD-Score:5.36|P-value:1.08E-7 ID:SGTC_1876|Compound:myriocin|FD-Score:-3.28|P-value:8.15E-4 ID:SGTC_1916|Compound:st067606|FD-Score:3.71|P-value:1.62E-4 ID:SGTC_1929|Compound:genistein trimethyl ether|FD-Score:-3.89|P-value:9.40E-5 ID:SGTC_2010|Compound:4012422|FD-Score:6.23|P-value:8.35E-10 ID:SGTC_2128|Compound:5255449|FD-Score:4.54|P-value:5.35E-6 ID:SGTC_2136|Compound:5328288|FD-Score:-6.02|P-value:3.37E-9 ID:SGTC_2310|Compound:7668677|FD-Score:-3.43|P-value:5.00E-4 ID:SGTC_2329|Compound:6138490|FD-Score:3.44|P-value:4.20E-4 ID:SGTC_2392|Compound:N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide|FD-Score:5.27|P-value:1.66E-7 ID:SGTC_2486|Compound:5283202|FD-Score:4.81|P-value:1.56E-6 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:3.46|P-value:3.93E-4 ID:SGTC_2714|Compound:st079313|FD-Score:5.05|P-value:4.91E-7 ID:SGTC_2803|Compound:7707263|FD-Score:6.14|P-value:1.37E-9 ID:SGTC_2873|Compound:9040596|FD-Score:3.75|P-value:1.39E-4 ID:SGTC_2881|Compound:9058953|FD-Score:3.75|P-value:1.39E-4 ID:SGTC_2929|Compound:9013348|FD-Score:3.23|P-value:8.57E-4 ID:SGTC_2952|Compound:9073731|FD-Score:4.05|P-value:4.26E-5 ID:SGTC_2994|Compound:9053520|FD-Score:3.76|P-value:1.34E-4 ID:SGTC_3013|Compound:9080133|FD-Score:4.09|P-value:3.64E-5 ID:SGTC_3269|Compound:9137823|FD-Score:3.48|P-value:3.66E-4

Top fitness defect scores for YJL190C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2010 4012422 6.23 159.0 µM 8.35E-10 4 2.37E-10
2 SGTC_2803 7707263 6.14 71.4 µM 1.37E-9 4 4.04E-10
3 SGTC_1039 k821-0043 5.93 94.0 µM 4.66E-9 Golgi 5 1.49E-9
4 SGTC_1866 st057638 5.36 64.0 µM 1.08E-7 4 4.28E-8
5 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 5.27 200.0 µM 1.66E-7 2 6.77E-8
6 SGTC_1035 k081-0041 5.15 55.2 µM 3.06E-7 Golgi 10 1.30E-7
7 SGTC_2714 st079313 5.05 56.9 µM 4.91E-7 2 2.16E-7
8 SGTC_1732 st034308 4.84 51.8 µM 1.37E-6 13 6.43E-7
9 SGTC_2486 5283202 4.81 22.4 µM 1.56E-6 24 7.39E-7
10 SGTC_1655 st012546 4.74 55.1 µM 2.25E-6 11 1.09E-6
11 SGTC_1030 k029-0042 4.73 36.7 µM 2.26E-6 TSC3-RPN4 9 1.10E-6
12 SGTC_2128 5255449 4.54 168.5 µM 5.35E-6 20 2.76E-6
13 SGTC_35 0133-0054 4.51 64.1 µM 6.27E-6 17 3.27E-6
14 SGTC_140 0062-0056 4.50 502.5 µM 6.52E-6 11 3.41E-6
15 SGTC_1231 0242-0792 4.45 125.0 µM 8.26E-6 11 4.38E-6
16 SGTC_913 3487-1245 4.44 167.0 µM 8.38E-6 16 4.45E-6
17 SGTC_687 k029-0044 4.20 34.9 µM 2.34E-5 PDR1 15 1.33E-5
18 SGTC_3013 9080133 4.09 71.4 µM 3.64E-5 18 2.13E-5
19 SGTC_66 0109-0187 4.08 42.4 µM 3.81E-5 37 2.24E-5
20 SGTC_2952 9073731 4.05 13.8 µM 4.26E-5 tubulin folding & SWR complex 38 2.52E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.105 1.05E-9 YLR416C_d YLR416C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.095 3.70E-8 YNL137C NAM9 het Mitochondrial ribosomal component of the small subunit
0.092 8.81E-8 YGR198W YPP1 het Cargo-transport protein involved in endocytosis; interacts with phosphatidylinositol-4-kinase Stt4; GFP-fusion protein localizes to the cytoplasm; YGR198W is an essential gene
0.087 5.13E-7 YLR018C POM34 hom Subunit of the transmembrane ring of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport, NPC biogenesis and spindle pole body duplication
0.082 2.09E-6 YLR401C DUS3 hom Dihydrouridine synthase; member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus4p; contains a consensus oleate response element (ORE) in its promoter region; forms nuclear foci upon DNA replication stress
0.081 2.63E-6 YDL182W LYS20 hom Homocitrate synthase isozyme; catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate to form homocitrate, which is the first step in the lysine biosynthesis pathway; LYS20 has a paralog, LYS21, that arose from the whole genome duplication
0.076 1.10E-5 YIL016W SNL1 hom Ribosome-associated protein proposed to act in protein synthesis and nuclear pore complex biogenesis and maintenance as well as protein folding; has similarity to the mammalian BAG-1 protein
0.073 2.38E-5 YCL025C AGP1 hom Low-affinity amino acid permease with broad substrate range; involved in uptake of asparagine, glutamine, and other amino acids; expression regulated by SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p); AGP1 has a paralog, GNP1, that arose from the whole genome duplication
0.070 4.55E-5 YML010W SPT5 het Component of the universally conserved Spt4/5 complex (DSIF complex); the complex has multiple roles in concert with RNA polymerases I and II, including regulation of transcription elongation, RNA processing, quality control, and transcription-coupled DNA repair
0.069 6.89E-5 YDR355C_d YDR355C_d het Dubious: Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified essential ORF SPC110/YDR356W
0.069 6.91E-5 YMR283C RIT1 hom 2'-O-ribosyl phosphate transferase, modifies the initiator methionine tRNA at position 64 to distinguish it from elongator methionine tRNA
0.068 7.74E-5 YNL151C RPC31 het RNA polymerase III subunit C31
0.068 8.27E-5 YCL048W SPS22 hom Protein of unknown function; SPS22 has a paralog, SPS2, that arose from the whole genome duplication; redundant with Sps2p for the organization of the beta-glucan layer of the spore wall
0.068 8.95E-5 YBL074C AAR2 het Component of the U5 snRNP, required for splicing of U3 precursors; originally described as a splicing factor specifically required for splicing pre-mRNA of the MATa1 cistron
0.067 9.26E-5 YPR062W FCY1 hom Cytosine deaminase, zinc metalloenzyme that catalyzes the hydrolytic deamination of cytosine to uracil; of biomedical interest because it also catalyzes the deamination of 5-fluorocytosine (5FC) to form anticancer drug 5-fluorouracil (5FU)