YJL191W / RPS14B

Protein component of the small (40S) ribosomal subunit; required for ribosome assembly and 20S pre-rRNA processing; mutations confer cryptopleurine resistance; homologous to mammalian ribosomal protein S14 and bacterial S11; RPS14B has a paralog, RPS14A, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YJL191W / RPS14B

Click on Significant Values for Screen Details ID:SGTC_48|Compound:0382-0018|FD-Score:3.73|P-value:2.27E-4 ID:SGTC_147|Compound:4466-0538|FD-Score:3.71|P-value:2.47E-4 ID:SGTC_162|Compound:k030-0015|FD-Score:4.25|P-value:3.24E-5 ID:SGTC_171|Compound:k064-0041|FD-Score:-3.31|P-value:9.18E-4 ID:SGTC_277|Compound:nystatin|FD-Score:-4.65|P-value:5.90E-6 ID:SGTC_333|Compound:3486-0131|FD-Score:4.02|P-value:7.85E-5 ID:SGTC_391|Compound:gliotoxin|FD-Score:3.55|P-value:4.21E-4 ID:SGTC_429|Compound:1112-0049|FD-Score:3.67|P-value:2.82E-4 ID:SGTC_479|Compound:n-linoleoylglycine|FD-Score:4.33|P-value:2.32E-5 ID:SGTC_548|Compound:1436-0017|FD-Score:-3.97|P-value:9.11E-5 ID:SGTC_870|Compound:0573-2213|FD-Score:3.34|P-value:8.36E-4 ID:SGTC_931|Compound:2812-0076|FD-Score:4.25|P-value:3.27E-5 ID:SGTC_1018|Compound:4259-0013|FD-Score:3.98|P-value:9.03E-5 ID:SGTC_1285|Compound:0929-0069|FD-Score:6.05|P-value:6.42E-9 ID:SGTC_1286|Compound:0929-0070|FD-Score:6.76|P-value:1.04E-10 ID:SGTC_1347|Compound:1493-0251|FD-Score:-3.54|P-value:4.27E-4 ID:SGTC_1363|Compound:1636-0063|FD-Score:3.86|P-value:1.43E-4 ID:SGTC_1410|Compound:3909-8106|FD-Score:-3.65|P-value:2.95E-4 ID:SGTC_1608|Compound:st001473|FD-Score:3.44|P-value:6.12E-4 ID:SGTC_1770|Compound:st043884|FD-Score:3.63|P-value:3.26E-4 ID:SGTC_1950|Compound:st077106|FD-Score:-3.87|P-value:1.31E-4 ID:SGTC_1967|Compound:st070177|FD-Score:3.88|P-value:1.30E-4 ID:SGTC_1982|Compound:st072467|FD-Score:-3.29|P-value:9.79E-4 ID:SGTC_2016|Compound:5121758|FD-Score:3.91|P-value:1.19E-4 ID:SGTC_2130|Compound:NSC 7|FD-Score:3.71|P-value:2.47E-4 ID:SGTC_2191|Compound:5911152|FD-Score:3.62|P-value:3.32E-4 ID:SGTC_2203|Compound:7227154|FD-Score:3.87|P-value:1.37E-4 ID:SGTC_2224|Compound:6650123|FD-Score:3.36|P-value:7.88E-4 ID:SGTC_2350|Compound:9023895|FD-Score:-4.17|P-value:4.35E-5 ID:SGTC_2403|Compound:6032726|FD-Score:5.05|P-value:1.03E-6 ID:SGTC_2415|Compound:st077333|FD-Score:-3.75|P-value:2.02E-4 ID:SGTC_2426|Compound:5582046|FD-Score:-3.46|P-value:5.57E-4 ID:SGTC_2756|Compound:carbadox|FD-Score:3.34|P-value:8.43E-4 ID:SGTC_2915|Compound:7971052|FD-Score:-3.32|P-value:8.77E-4 ID:SGTC_2988|Compound:9073640|FD-Score:5.14|P-value:6.73E-7 ID:SGTC_3004|Compound:9076122|FD-Score:-3.47|P-value:5.30E-4 ID:SGTC_3011|Compound:9081274|FD-Score:-4.46|P-value:1.32E-5 ID:SGTC_3012|Compound:9080433|FD-Score:-3.52|P-value:4.55E-4 ID:SGTC_3052|Compound:9092717|FD-Score:4.78|P-value:3.47E-6 ID:SGTC_3295|Compound:9122362|FD-Score:3.68|P-value:2.72E-4 ID:SGTC_48|Compound:0382-0018|FD-Score:3.73|P-value:2.27E-4 ID:SGTC_147|Compound:4466-0538|FD-Score:3.71|P-value:2.47E-4 ID:SGTC_162|Compound:k030-0015|FD-Score:4.25|P-value:3.24E-5 ID:SGTC_171|Compound:k064-0041|FD-Score:-3.31|P-value:9.18E-4 ID:SGTC_277|Compound:nystatin|FD-Score:-4.65|P-value:5.90E-6 ID:SGTC_333|Compound:3486-0131|FD-Score:4.02|P-value:7.85E-5 ID:SGTC_391|Compound:gliotoxin|FD-Score:3.55|P-value:4.21E-4 ID:SGTC_429|Compound:1112-0049|FD-Score:3.67|P-value:2.82E-4 ID:SGTC_479|Compound:n-linoleoylglycine|FD-Score:4.33|P-value:2.32E-5 ID:SGTC_548|Compound:1436-0017|FD-Score:-3.97|P-value:9.11E-5 ID:SGTC_870|Compound:0573-2213|FD-Score:3.34|P-value:8.36E-4 ID:SGTC_931|Compound:2812-0076|FD-Score:4.25|P-value:3.27E-5 ID:SGTC_1018|Compound:4259-0013|FD-Score:3.98|P-value:9.03E-5 ID:SGTC_1285|Compound:0929-0069|FD-Score:6.05|P-value:6.42E-9 ID:SGTC_1286|Compound:0929-0070|FD-Score:6.76|P-value:1.04E-10 ID:SGTC_1347|Compound:1493-0251|FD-Score:-3.54|P-value:4.27E-4 ID:SGTC_1363|Compound:1636-0063|FD-Score:3.86|P-value:1.43E-4 ID:SGTC_1410|Compound:3909-8106|FD-Score:-3.65|P-value:2.95E-4 ID:SGTC_1608|Compound:st001473|FD-Score:3.44|P-value:6.12E-4 ID:SGTC_1770|Compound:st043884|FD-Score:3.63|P-value:3.26E-4 ID:SGTC_1950|Compound:st077106|FD-Score:-3.87|P-value:1.31E-4 ID:SGTC_1967|Compound:st070177|FD-Score:3.88|P-value:1.30E-4 ID:SGTC_1982|Compound:st072467|FD-Score:-3.29|P-value:9.79E-4 ID:SGTC_2016|Compound:5121758|FD-Score:3.91|P-value:1.19E-4 ID:SGTC_2130|Compound:NSC 7|FD-Score:3.71|P-value:2.47E-4 ID:SGTC_2191|Compound:5911152|FD-Score:3.62|P-value:3.32E-4 ID:SGTC_2203|Compound:7227154|FD-Score:3.87|P-value:1.37E-4 ID:SGTC_2224|Compound:6650123|FD-Score:3.36|P-value:7.88E-4 ID:SGTC_2350|Compound:9023895|FD-Score:-4.17|P-value:4.35E-5 ID:SGTC_2403|Compound:6032726|FD-Score:5.05|P-value:1.03E-6 ID:SGTC_2415|Compound:st077333|FD-Score:-3.75|P-value:2.02E-4 ID:SGTC_2426|Compound:5582046|FD-Score:-3.46|P-value:5.57E-4 ID:SGTC_2756|Compound:carbadox|FD-Score:3.34|P-value:8.43E-4 ID:SGTC_2915|Compound:7971052|FD-Score:-3.32|P-value:8.77E-4 ID:SGTC_2988|Compound:9073640|FD-Score:5.14|P-value:6.73E-7 ID:SGTC_3004|Compound:9076122|FD-Score:-3.47|P-value:5.30E-4 ID:SGTC_3011|Compound:9081274|FD-Score:-4.46|P-value:1.32E-5 ID:SGTC_3012|Compound:9080433|FD-Score:-3.52|P-value:4.55E-4 ID:SGTC_3052|Compound:9092717|FD-Score:4.78|P-value:3.47E-6 ID:SGTC_3295|Compound:9122362|FD-Score:3.68|P-value:2.72E-4

Top fitness defect scores for YJL191W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature		Screen
Rank
Screen
P-value
1 SGTC_1286 0929-0070 6.76 131.0 µM 1.04E-10 2 7.08E-12
2 SGTC_1285 0929-0069 6.05 65.5 µM 6.42E-9 3 7.37E-10
3 SGTC_2988 9073640 5.14 71.4 µM 6.73E-7 11 1.38E-7
4 SGTC_2403 6032726 5.05 181.2 µM 1.03E-6 16 2.23E-7
5 SGTC_3052 9092717 4.78 49.5 µM 3.47E-6 14 8.75E-7
6 SGTC_479 n-linoleoylglycine 4.33 10.0 µM 2.32E-5 6 7.41E-6
7 SGTC_162 k030-0015 4.25 37.8 µM 3.24E-5 iron homeostasis 19 1.08E-5
8 SGTC_931 2812-0076 4.25 566.0 µM 3.27E-5 16 1.09E-5
9 SGTC_333 3486-0131 4.02 40.1 µM 7.85E-5 amide catabolism 9 2.92E-5
10 SGTC_1018 4259-0013 3.98 28.1 µM 9.03E-5 15 3.41E-5
11 SGTC_2016 5121758 3.91 140.0 µM 1.19E-4 redox potentiating 55 4.64E-5
12 SGTC_1967 st070177 3.88 51.4 µM 1.30E-4 14 5.12E-5
13 SGTC_2203 7227154 3.87 166.4 µM 1.37E-4 16 5.45E-5
14 SGTC_1363 1636-0063 3.86 10.4 µM 1.43E-4 Golgi 29 5.74E-5
15 SGTC_48 0382-0018 3.73 55.0 µM 2.27E-4 12 9.60E-5
16 SGTC_147 4466-0538 3.71 29.2 µM 2.47E-4 ergosterol biosynthesis 28 1.05E-4
17 SGTC_2130 NSC 7 3.71 2.5 µM 2.47E-4 copper-dependent oxidative stress 34 1.06E-4
18 SGTC_3295 9122362 3.68 53.6 µM 2.72E-4 19 1.18E-4
19 SGTC_429 1112-0049 3.67 25.5 µM 2.82E-4 DNA damage response 41 1.23E-4
20 SGTC_1770 st043884 3.63 66.3 µM 3.26E-4 20 1.44E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.130 4.53E-14 YLR399C BDF1 hom Protein involved in transcription initiation at TATA-containing promoters; associates with the basal transcription factor TFIID; contains two bromodomains; corresponds to the C-terminal region of mammalian TAF1; redundant with Bdf2p
0.091 1.29E-7 YLL013C PUF3 hom Protein of the mitochondrial outer surface, links the Arp2/3 complex with the mitochore during anterograde mitochondrial movement; also binds to and promotes degradation of mRNAs for select nuclear-encoded mitochondrial proteins
0.091 1.47E-7 YLL016W SDC25 hom Non-essential Ras guanine nucleotide exchange factor (GEF); localized to the membrane; expressed in poor nutrient conditions and on nonfermentable carbon sources; contains a stop codon in S288C, full-length gene includes YLL017W; SDC25 has a paralog, CDC25, that arose from the whole genome duplication
0.088 3.67E-7 YMR153C-A_d YMR153C-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NUP53
0.087 4.14E-7 YNL268W LYP1 hom Lysine permease; one of three amino acid permeases (Alp1p, Can1p, Lyp1p) responsible for uptake of cationic amino acids
0.084 9.54E-7 YOL138C RTC1 hom Subunit of the SEA (Seh1-associated) complex, a coatomer-related complex that associates dynamically with the vacuole; null mutation suppresses cdc13-1 temperature sensitivity; has N-terminal WD-40 repeats and a C-terminal RING motif
0.084 1.02E-6 YMR144W_p YMR144W_p hom Putative protein of unknown function; localized to the nucleus; YMR144W is not an essential gene
0.080 3.79E-6 YBR242W_p YBR242W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YBR242W is not an essential gene
0.079 5.10E-6 YBR204C LDH1 hom Serine hydrolase; exhibits active esterase plus weak triacylglycerol lipase activities; proposed role in lipid homeostasis, regulating phospholipid and non-polar lipid levels and required for mobilization of LD-stored lipids; localizes to the lipid droplet (LD) surface; contains a classical serine containing catalytic triad (GxSxG motif)
0.073 2.11E-5 YDL041W_d YDL041W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene SIR2/YDL042C
0.070 5.43E-5 YEL049W PAU2 hom Member of the seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme
0.069 6.29E-5 YMR236W TAF9 het Subunit (17 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification, similar to histone H3
0.069 6.99E-5 YGL152C_d YGL152C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF PEX14/YGL153W
0.069 7.15E-5 YPL028W ERG10 het Acetyl-CoA C-acetyltransferase (acetoacetyl-CoA thiolase), cytosolic enzyme that transfers an acetyl group from one acetyl-CoA molecule to another, forming acetoacetyl-CoA; involved in the first step in mevalonate biosynthesis
0.065 1.55E-4 YPR071W_p YPR071W_p hom Putative membrane protein; YPR071W is not an essential gene; YPR071W has paralog YIL029C