YJL192C / SOP4

ER-membrane protein; suppressor of pma1-7, deletion of SOP4 slows down the export of wild-type Pma1p and Pma1-7 from the ER

Zygosity: Homozygous strain
fixedexpanded
Profile for YJL192C / SOP4

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:13.20|P-value:1.74E-34 ID:SGTC_108|Compound:0509-0257|FD-Score:-3.69|P-value:1.58E-4 ID:SGTC_121|Compound:0557-0495|FD-Score:10.10|P-value:1.39E-20 ID:SGTC_133|Compound:0724-0033|FD-Score:-3.29|P-value:6.16E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:9.30|P-value:7.80E-18 ID:SGTC_304|Compound:1310-0298|FD-Score:4.45|P-value:3.24E-5 ID:SGTC_351|Compound:caspofungin|FD-Score:4.47|P-value:2.97E-5 ID:SGTC_355|Compound:1311-2252|FD-Score:3.94|P-value:2.20E-4 ID:SGTC_445|Compound:e6 berbamine|FD-Score:3.67|P-value:5.49E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:5.60|P-value:1.99E-7 ID:SGTC_639|Compound:0833-0042|FD-Score:4.84|P-value:6.48E-6 ID:SGTC_663|Compound:1486-0733|FD-Score:-3.19|P-value:8.61E-4 ID:SGTC_666|Compound:0272-0154|FD-Score:4.45|P-value:3.24E-5 ID:SGTC_704|Compound:1310-0270|FD-Score:-3.75|P-value:1.25E-4 ID:SGTC_731|Compound:3966-0296|FD-Score:4.90|P-value:5.08E-6 ID:SGTC_792|Compound:4534-1957|FD-Score:6.77|P-value:3.66E-10 ID:SGTC_951|Compound:1171-0579|FD-Score:5.79|P-value:7.74E-8 ID:SGTC_1068|Compound:loratadine|FD-Score:-3.44|P-value:3.81E-4 ID:SGTC_1105|Compound:epirubicin|FD-Score:3.62|P-value:6.31E-4 ID:SGTC_1117|Compound:retinoic acid|FD-Score:3.73|P-value:4.48E-4 ID:SGTC_1162|Compound:k048-0130|FD-Score:3.81|P-value:3.44E-4 ID:SGTC_1227|Compound:3909-8010|FD-Score:3.64|P-value:5.97E-4 ID:SGTC_1326|Compound:1431-2094|FD-Score:4.37|P-value:4.37E-5 ID:SGTC_1412|Compound:3909-8563|FD-Score:3.92|P-value:2.32E-4 ID:SGTC_1477|Compound:0139-0234|FD-Score:5.15|P-value:1.65E-6 ID:SGTC_1479|Compound:0549-0158|FD-Score:5.46|P-value:3.93E-7 ID:SGTC_1482|Compound:3346-2049|FD-Score:4.35|P-value:4.80E-5 ID:SGTC_1493|Compound:4348-0038|FD-Score:5.62|P-value:1.78E-7 ID:SGTC_1495|Compound:4469-0029|FD-Score:6.84|P-value:2.38E-10 ID:SGTC_1502|Compound:4534-4282|FD-Score:5.68|P-value:1.37E-7 ID:SGTC_1544|Compound:7-methoxy-4-methylcoumarin|FD-Score:3.54|P-value:8.22E-4 ID:SGTC_1622|Compound:st003707|FD-Score:4.02|P-value:1.66E-4 ID:SGTC_1623|Compound:st003709|FD-Score:3.79|P-value:3.63E-4 ID:SGTC_1715|Compound:st032160|FD-Score:3.70|P-value:4.98E-4 ID:SGTC_1720|Compound:st037298|FD-Score:5.05|P-value:2.58E-6 ID:SGTC_1725|Compound:st036284|FD-Score:3.78|P-value:3.80E-4 ID:SGTC_1734|Compound:st037168|FD-Score:4.46|P-value:3.06E-5 ID:SGTC_1736|Compound:st036774|FD-Score:4.82|P-value:7.10E-6 ID:SGTC_1780|Compound:st038448|FD-Score:4.19|P-value:8.77E-5 ID:SGTC_1800|Compound:st050079|FD-Score:3.57|P-value:7.54E-4 ID:SGTC_1930|Compound:st074634|FD-Score:3.52|P-value:8.92E-4 ID:SGTC_1949|Compound:st076024|FD-Score:6.02|P-value:2.37E-8 ID:SGTC_2069|Compound:5228469|FD-Score:3.61|P-value:6.61E-4 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:-3.80|P-value:1.05E-4 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:4.03|P-value:1.59E-4 ID:SGTC_2448|Compound:5185112|FD-Score:-5.23|P-value:2.33E-7 ID:SGTC_2452|Compound:5863136|FD-Score:-4.40|P-value:9.89E-6 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:4.20|P-value:8.37E-5 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:-4.59|P-value:4.37E-6 ID:SGTC_2800|Compound:7887935|FD-Score:4.27|P-value:6.48E-5 ID:SGTC_2817|Compound:7995342|FD-Score:4.78|P-value:8.48E-6 ID:SGTC_3047|Compound:9092122|FD-Score:4.06|P-value:1.43E-4 ID:SGTC_3133|Compound:9127736|FD-Score:3.64|P-value:5.94E-4 ID:SGTC_3234|Compound:9132280|FD-Score:3.95|P-value:2.11E-4 ID:SGTC_3302|Compound:9125395|FD-Score:-4.48|P-value:7.28E-6 ID:SGTC_3303|Compound:9125618|FD-Score:5.29|P-value:8.98E-7 ID:SGTC_3306|Compound:9127676|FD-Score:3.55|P-value:8.08E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:13.20|P-value:1.74E-34 ID:SGTC_108|Compound:0509-0257|FD-Score:-3.69|P-value:1.58E-4 ID:SGTC_121|Compound:0557-0495|FD-Score:10.10|P-value:1.39E-20 ID:SGTC_133|Compound:0724-0033|FD-Score:-3.29|P-value:6.16E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:9.30|P-value:7.80E-18 ID:SGTC_304|Compound:1310-0298|FD-Score:4.45|P-value:3.24E-5 ID:SGTC_351|Compound:caspofungin|FD-Score:4.47|P-value:2.97E-5 ID:SGTC_355|Compound:1311-2252|FD-Score:3.94|P-value:2.20E-4 ID:SGTC_445|Compound:e6 berbamine|FD-Score:3.67|P-value:5.49E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:5.60|P-value:1.99E-7 ID:SGTC_639|Compound:0833-0042|FD-Score:4.84|P-value:6.48E-6 ID:SGTC_663|Compound:1486-0733|FD-Score:-3.19|P-value:8.61E-4 ID:SGTC_666|Compound:0272-0154|FD-Score:4.45|P-value:3.24E-5 ID:SGTC_704|Compound:1310-0270|FD-Score:-3.75|P-value:1.25E-4 ID:SGTC_731|Compound:3966-0296|FD-Score:4.90|P-value:5.08E-6 ID:SGTC_792|Compound:4534-1957|FD-Score:6.77|P-value:3.66E-10 ID:SGTC_951|Compound:1171-0579|FD-Score:5.79|P-value:7.74E-8 ID:SGTC_1068|Compound:loratadine|FD-Score:-3.44|P-value:3.81E-4 ID:SGTC_1105|Compound:epirubicin|FD-Score:3.62|P-value:6.31E-4 ID:SGTC_1117|Compound:retinoic acid|FD-Score:3.73|P-value:4.48E-4 ID:SGTC_1162|Compound:k048-0130|FD-Score:3.81|P-value:3.44E-4 ID:SGTC_1227|Compound:3909-8010|FD-Score:3.64|P-value:5.97E-4 ID:SGTC_1326|Compound:1431-2094|FD-Score:4.37|P-value:4.37E-5 ID:SGTC_1412|Compound:3909-8563|FD-Score:3.92|P-value:2.32E-4 ID:SGTC_1477|Compound:0139-0234|FD-Score:5.15|P-value:1.65E-6 ID:SGTC_1479|Compound:0549-0158|FD-Score:5.46|P-value:3.93E-7 ID:SGTC_1482|Compound:3346-2049|FD-Score:4.35|P-value:4.80E-5 ID:SGTC_1493|Compound:4348-0038|FD-Score:5.62|P-value:1.78E-7 ID:SGTC_1495|Compound:4469-0029|FD-Score:6.84|P-value:2.38E-10 ID:SGTC_1502|Compound:4534-4282|FD-Score:5.68|P-value:1.37E-7 ID:SGTC_1544|Compound:7-methoxy-4-methylcoumarin|FD-Score:3.54|P-value:8.22E-4 ID:SGTC_1622|Compound:st003707|FD-Score:4.02|P-value:1.66E-4 ID:SGTC_1623|Compound:st003709|FD-Score:3.79|P-value:3.63E-4 ID:SGTC_1715|Compound:st032160|FD-Score:3.70|P-value:4.98E-4 ID:SGTC_1720|Compound:st037298|FD-Score:5.05|P-value:2.58E-6 ID:SGTC_1725|Compound:st036284|FD-Score:3.78|P-value:3.80E-4 ID:SGTC_1734|Compound:st037168|FD-Score:4.46|P-value:3.06E-5 ID:SGTC_1736|Compound:st036774|FD-Score:4.82|P-value:7.10E-6 ID:SGTC_1780|Compound:st038448|FD-Score:4.19|P-value:8.77E-5 ID:SGTC_1800|Compound:st050079|FD-Score:3.57|P-value:7.54E-4 ID:SGTC_1930|Compound:st074634|FD-Score:3.52|P-value:8.92E-4 ID:SGTC_1949|Compound:st076024|FD-Score:6.02|P-value:2.37E-8 ID:SGTC_2069|Compound:5228469|FD-Score:3.61|P-value:6.61E-4 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:-3.80|P-value:1.05E-4 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:4.03|P-value:1.59E-4 ID:SGTC_2448|Compound:5185112|FD-Score:-5.23|P-value:2.33E-7 ID:SGTC_2452|Compound:5863136|FD-Score:-4.40|P-value:9.89E-6 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:4.20|P-value:8.37E-5 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:-4.59|P-value:4.37E-6 ID:SGTC_2800|Compound:7887935|FD-Score:4.27|P-value:6.48E-5 ID:SGTC_2817|Compound:7995342|FD-Score:4.78|P-value:8.48E-6 ID:SGTC_3047|Compound:9092122|FD-Score:4.06|P-value:1.43E-4 ID:SGTC_3133|Compound:9127736|FD-Score:3.64|P-value:5.94E-4 ID:SGTC_3234|Compound:9132280|FD-Score:3.95|P-value:2.11E-4 ID:SGTC_3302|Compound:9125395|FD-Score:-4.48|P-value:7.28E-6 ID:SGTC_3303|Compound:9125618|FD-Score:5.29|P-value:8.98E-7 ID:SGTC_3306|Compound:9127676|FD-Score:3.55|P-value:8.08E-4

Top fitness defect scores for YJL192C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_58 0957-0393 13.20 9.0 µM 1.74E-34 cell wall 37 2.87E-40
2 SGTC_121 0557-0495 10.10 61.3 µM 1.39E-20 calcium & mitochondrial duress 6 4.30E-24
3 SGTC_138 0850-0259 9.30 40.9 µM 7.80E-18 cell wall 51 6.93E-21
4 SGTC_1495 4469-0029 6.84 237.0 µM 2.38E-10 39 3.93E-12
5 SGTC_792 4534-1957 6.77 155.0 µM 3.66E-10 5 6.48E-12
6 SGTC_1949 st076024 6.02 69.1 µM 2.37E-8 3 8.69E-10
7 SGTC_951 1171-0579 5.79 82.7 µM 7.74E-8 cell wall 36 3.49E-9
8 SGTC_1502 4534-4282 5.68 27.7 µM 1.37E-7 3 6.85E-9
9 SGTC_1493 4348-0038 5.62 111.0 µM 1.78E-7 RSC complex & mRNA processing 4 9.28E-9
10 SGTC_514 4466-0038 5.60 2.6 nM 1.99E-7 cell wall 86 1.06E-8
11 SGTC_1479 0549-0158 5.46 134.0 µM 3.93E-7 6 2.36E-8
12 SGTC_3303 9125618 5.29 40.6 µM 8.98E-7 18 6.25E-8
13 SGTC_1477 0139-0234 5.15 16.0 µM 1.65E-6 2 1.28E-7
14 SGTC_1720 st037298 5.05 9.5 µM 2.58E-6 22 2.17E-7
15 SGTC_731 3966-0296 4.90 387.0 µM 5.08E-6 4 4.83E-7
16 SGTC_639 0833-0042 4.84 114.0 µM 6.48E-6 25 6.43E-7
17 SGTC_1736 st036774 4.82 51.0 µM 7.10E-6 18 7.16E-7
18 SGTC_2817 7995342 4.78 71.4 µM 8.48E-6 13 8.83E-7
19 SGTC_351 caspofungin 4.47 25.0 nM 2.97E-5 cell wall 74 3.89E-6
20 SGTC_1734 st037168 4.46 69.4 µM 3.06E-5 13 4.03E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.341 2.96E-92 YJR054W KCH1 hom Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate
0.301 3.54E-71 YOL003C PFA4 hom Palmitoyltransferase with autoacylation activity, required for palmitoylation of amino acid permeases containing a C-terminal Phe-Trp-Cys site; required for modification of Chs3p; member of the DHHC family of putative palmitoyltransferases
0.295 1.61E-68 YCL005W LDB16 hom Protein of unknown function; null mutants have decreased net negative cell surface charge; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; native protein is detected in purified mitochondria
0.291 1.19E-66 YDL066W IDP1 hom Mitochondrial NADP-specific isocitrate dehydrogenase, catalyzes the oxidation of isocitrate to alpha-ketoglutarate; not required for mitochondrial respiration and may function to divert alpha-ketoglutarate to biosynthetic processes
0.281 4.52E-62 YJR142W_p YJR142W_p hom Putative protein of unknown function; GST fusion protein is a Dbf2p-Mob1p phosphorylation target in a proteome chip analysis; synthetic lethal with PH085 deletion; plays a role in restricting Ty1 transposition; nudix hydrolase family member
0.280 2.28E-61 YKL033W-A_p YKL033W-A_p hom Putative protein of unknown function; similar to uncharacterized proteins from other fungi
0.278 1.89E-60 YJL080C SCP160 hom Essential RNA-binding G protein effector of mating response pathway, mainly associated with nuclear envelope and ER, interacts in mRNA-dependent manner with translating ribosomes via multiple KH domains, similar to vertebrate vigilins
0.275 2.96E-59 YKL076C_d PSY1_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 69% of ORF overlaps the uncharacterized ORF YKL075C
0.273 1.98E-58 YPL269W KAR9 hom Karyogamy protein required for correct positioning of the mitotic spindle and for orienting cytoplasmic microtubules, localizes at the shmoo tip in mating cells and at the tip of the growing bud in small-budded cells through anaphase
0.263 5.17E-54 YAL015C NTG1 hom DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; involved in base excision repair; acts in both nucleus and mitochondrion; creates a double-strand break at mtDNA origins that stimulates replication in response to oxidative stress; NTG1 has a paralog, NTG2, that arose from the whole genome duplication
0.260 6.04E-53 YDL021W GPM2 hom Homolog of Gpm1p phosphoglycerate mutase, which converts 3-phosphoglycerate to 2-phosphoglycerate in glycolysis; may be non-functional derivative of a gene duplication event
0.260 7.67E-53 YDR205W MSC2 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
0.252 9.42E-50 YNL314W DAL82 hom Positive regulator of allophanate inducible genes; binds a dodecanucleotide sequence upstream of all genes that are induced by allophanate; contains an UISALL DNA-binding, a transcriptional activation, and a coiled-coil domain
0.248 4.45E-48 YMR152W YIM1 hom Protein of unknown function; null mutant displays sensitivity to DNA damaging agents; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress
0.244 7.19E-47 YLR331C_d JIP3_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene MID2