YJL197W / UBP12

Ubiquitin-specific protease; cleaves ubiquitin from ubiquitinated proteins; present in the nucleus and cytoplasm

Zygosity: Homozygous strain
fixedexpanded
Profile for YJL197W / UBP12

Click on Significant Values for Screen Details ID:SGTC_86|Compound:0417-1630|FD-Score:3.03|P-value:8.26E-4 ID:SGTC_129|Compound:0088-0017|FD-Score:-6.47|P-value:9.46E-12 ID:SGTC_136|Compound:0097-0015|FD-Score:4.25|P-value:5.03E-6 ID:SGTC_137|Compound:0438-0332|FD-Score:4.82|P-value:2.84E-7 ID:SGTC_142|Compound:0335-0849|FD-Score:5.61|P-value:2.94E-9 ID:SGTC_190|Compound:3970-0790|FD-Score:3.65|P-value:7.45E-5 ID:SGTC_255|Compound:tunicamycin|FD-Score:3.24|P-value:3.90E-4 ID:SGTC_365|Compound:0121-0052|FD-Score:3.25|P-value:3.66E-4 ID:SGTC_370|Compound:0180-0345|FD-Score:-4.64|P-value:7.42E-7 ID:SGTC_438|Compound:sphingosine|FD-Score:-3.23|P-value:4.09E-4 ID:SGTC_474|Compound:dl-dihydrosphingosine|FD-Score:3.60|P-value:9.26E-5 ID:SGTC_588|Compound:3970-1144|FD-Score:2.99|P-value:9.63E-4 ID:SGTC_635|Compound:k038-0028|FD-Score:3.72|P-value:5.51E-5 ID:SGTC_777|Compound:1315-0167|FD-Score:-3.12|P-value:5.94E-4 ID:SGTC_785|Compound:1270-0111|FD-Score:3.00|P-value:9.24E-4 ID:SGTC_786|Compound:4544-0069|FD-Score:-3.06|P-value:7.46E-4 ID:SGTC_873|Compound:0591-4978|FD-Score:3.48|P-value:1.52E-4 ID:SGTC_876|Compound:0720-0963|FD-Score:3.63|P-value:8.05E-5 ID:SGTC_939|Compound:1165-0479|FD-Score:3.36|P-value:2.44E-4 ID:SGTC_971|Compound:1315-0384|FD-Score:3.82|P-value:3.71E-5 ID:SGTC_985|Compound:1493-0307|FD-Score:3.34|P-value:2.63E-4 ID:SGTC_1002|Compound:4049-0206|FD-Score:3.06|P-value:7.47E-4 ID:SGTC_1050|Compound:3232-1156|FD-Score:6.08|P-value:1.37E-10 ID:SGTC_1057|Compound:3448-5381|FD-Score:-3.42|P-value:1.97E-4 ID:SGTC_1077|Compound:5-fluorocytosine|FD-Score:3.07|P-value:7.17E-4 ID:SGTC_1089|Compound:terbinafine|FD-Score:3.08|P-value:6.94E-4 ID:SGTC_1142|Compound:3253-1408|FD-Score:3.02|P-value:8.71E-4 ID:SGTC_1164|Compound:k060-0068|FD-Score:6.26|P-value:4.13E-11 ID:SGTC_1350|Compound:1495-0454|FD-Score:3.58|P-value:9.95E-5 ID:SGTC_1382|Compound:3002-2117|FD-Score:4.13|P-value:9.20E-6 ID:SGTC_1405|Compound:3909-7894|FD-Score:3.15|P-value:5.32E-4 ID:SGTC_1576|Compound:erythromycin ethylsuccinate|FD-Score:3.11|P-value:6.21E-4 ID:SGTC_1609|Compound:st001574|FD-Score:4.86|P-value:2.29E-7 ID:SGTC_1824|Compound:st053723|FD-Score:-3.54|P-value:1.21E-4 ID:SGTC_1840|Compound:st055363|FD-Score:3.90|P-value:2.54E-5 ID:SGTC_1855|Compound:st056195|FD-Score:3.37|P-value:2.37E-4 ID:SGTC_1913|Compound:st060213|FD-Score:3.34|P-value:2.60E-4 ID:SGTC_1995|Compound:st072814|FD-Score:3.05|P-value:7.71E-4 ID:SGTC_2019|Compound:4016004|FD-Score:3.40|P-value:2.08E-4 ID:SGTC_2039|Compound:Aminomethylbenzodioxan|FD-Score:2.98|P-value:9.80E-4 ID:SGTC_2156|Compound:5649887|FD-Score:-3.50|P-value:1.43E-4 ID:SGTC_2157|Compound:5649910|FD-Score:4.71|P-value:4.92E-7 ID:SGTC_2161|Compound:5662504|FD-Score:3.87|P-value:3.00E-5 ID:SGTC_2192|Compound:5915882|FD-Score:3.18|P-value:4.80E-4 ID:SGTC_2220|Compound:6782180|FD-Score:3.05|P-value:7.74E-4 ID:SGTC_2244|Compound:6635614|FD-Score:-3.90|P-value:2.61E-5 ID:SGTC_2318|Compound:6029776|FD-Score:3.48|P-value:1.48E-4 ID:SGTC_2327|Compound:6189656|FD-Score:3.17|P-value:4.99E-4 ID:SGTC_2430|Compound:5571206|FD-Score:3.61|P-value:8.91E-5 ID:SGTC_2605|Compound:digitonin|FD-Score:3.47|P-value:1.55E-4 ID:SGTC_2700|Compound:st077718|FD-Score:3.02|P-value:8.71E-4 ID:SGTC_2785|Compound:7756463|FD-Score:4.17|P-value:7.49E-6 ID:SGTC_2842|Compound:9000675|FD-Score:-3.41|P-value:2.02E-4 ID:SGTC_2863|Compound:9028737|FD-Score:3.40|P-value:2.09E-4 ID:SGTC_2870|Compound:9038528|FD-Score:3.65|P-value:7.64E-5 ID:SGTC_2910|Compound:7948405|FD-Score:3.41|P-value:1.99E-4 ID:SGTC_2946|Compound:9065502|FD-Score:3.18|P-value:4.73E-4 ID:SGTC_2989|Compound:9073649|FD-Score:-3.25|P-value:3.66E-4 ID:SGTC_2991|Compound:9074669|FD-Score:-2.99|P-value:9.53E-4 ID:SGTC_2994|Compound:9053520|FD-Score:3.13|P-value:5.73E-4 ID:SGTC_3006|Compound:9075424|FD-Score:3.38|P-value:2.23E-4 ID:SGTC_3048|Compound:9093155|FD-Score:3.27|P-value:3.43E-4 ID:SGTC_3057|Compound:9095946|FD-Score:-3.51|P-value:1.37E-4 ID:SGTC_3061|Compound:glucosamine|FD-Score:6.11|P-value:1.10E-10 ID:SGTC_3260|Compound:9137109|FD-Score:3.12|P-value:5.99E-4 ID:SGTC_3289|Compound:9119912|FD-Score:3.44|P-value:1.77E-4 ID:SGTC_3320|Compound:9137005|FD-Score:3.31|P-value:2.97E-4 ID:SGTC_86|Compound:0417-1630|FD-Score:3.03|P-value:8.26E-4 ID:SGTC_129|Compound:0088-0017|FD-Score:-6.47|P-value:9.46E-12 ID:SGTC_136|Compound:0097-0015|FD-Score:4.25|P-value:5.03E-6 ID:SGTC_137|Compound:0438-0332|FD-Score:4.82|P-value:2.84E-7 ID:SGTC_142|Compound:0335-0849|FD-Score:5.61|P-value:2.94E-9 ID:SGTC_190|Compound:3970-0790|FD-Score:3.65|P-value:7.45E-5 ID:SGTC_255|Compound:tunicamycin|FD-Score:3.24|P-value:3.90E-4 ID:SGTC_365|Compound:0121-0052|FD-Score:3.25|P-value:3.66E-4 ID:SGTC_370|Compound:0180-0345|FD-Score:-4.64|P-value:7.42E-7 ID:SGTC_438|Compound:sphingosine|FD-Score:-3.23|P-value:4.09E-4 ID:SGTC_474|Compound:dl-dihydrosphingosine|FD-Score:3.60|P-value:9.26E-5 ID:SGTC_588|Compound:3970-1144|FD-Score:2.99|P-value:9.63E-4 ID:SGTC_635|Compound:k038-0028|FD-Score:3.72|P-value:5.51E-5 ID:SGTC_777|Compound:1315-0167|FD-Score:-3.12|P-value:5.94E-4 ID:SGTC_785|Compound:1270-0111|FD-Score:3.00|P-value:9.24E-4 ID:SGTC_786|Compound:4544-0069|FD-Score:-3.06|P-value:7.46E-4 ID:SGTC_873|Compound:0591-4978|FD-Score:3.48|P-value:1.52E-4 ID:SGTC_876|Compound:0720-0963|FD-Score:3.63|P-value:8.05E-5 ID:SGTC_939|Compound:1165-0479|FD-Score:3.36|P-value:2.44E-4 ID:SGTC_971|Compound:1315-0384|FD-Score:3.82|P-value:3.71E-5 ID:SGTC_985|Compound:1493-0307|FD-Score:3.34|P-value:2.63E-4 ID:SGTC_1002|Compound:4049-0206|FD-Score:3.06|P-value:7.47E-4 ID:SGTC_1050|Compound:3232-1156|FD-Score:6.08|P-value:1.37E-10 ID:SGTC_1057|Compound:3448-5381|FD-Score:-3.42|P-value:1.97E-4 ID:SGTC_1077|Compound:5-fluorocytosine|FD-Score:3.07|P-value:7.17E-4 ID:SGTC_1089|Compound:terbinafine|FD-Score:3.08|P-value:6.94E-4 ID:SGTC_1142|Compound:3253-1408|FD-Score:3.02|P-value:8.71E-4 ID:SGTC_1164|Compound:k060-0068|FD-Score:6.26|P-value:4.13E-11 ID:SGTC_1350|Compound:1495-0454|FD-Score:3.58|P-value:9.95E-5 ID:SGTC_1382|Compound:3002-2117|FD-Score:4.13|P-value:9.20E-6 ID:SGTC_1405|Compound:3909-7894|FD-Score:3.15|P-value:5.32E-4 ID:SGTC_1576|Compound:erythromycin ethylsuccinate|FD-Score:3.11|P-value:6.21E-4 ID:SGTC_1609|Compound:st001574|FD-Score:4.86|P-value:2.29E-7 ID:SGTC_1824|Compound:st053723|FD-Score:-3.54|P-value:1.21E-4 ID:SGTC_1840|Compound:st055363|FD-Score:3.90|P-value:2.54E-5 ID:SGTC_1855|Compound:st056195|FD-Score:3.37|P-value:2.37E-4 ID:SGTC_1913|Compound:st060213|FD-Score:3.34|P-value:2.60E-4 ID:SGTC_1995|Compound:st072814|FD-Score:3.05|P-value:7.71E-4 ID:SGTC_2019|Compound:4016004|FD-Score:3.40|P-value:2.08E-4 ID:SGTC_2039|Compound:Aminomethylbenzodioxan|FD-Score:2.98|P-value:9.80E-4 ID:SGTC_2156|Compound:5649887|FD-Score:-3.50|P-value:1.43E-4 ID:SGTC_2157|Compound:5649910|FD-Score:4.71|P-value:4.92E-7 ID:SGTC_2161|Compound:5662504|FD-Score:3.87|P-value:3.00E-5 ID:SGTC_2192|Compound:5915882|FD-Score:3.18|P-value:4.80E-4 ID:SGTC_2220|Compound:6782180|FD-Score:3.05|P-value:7.74E-4 ID:SGTC_2244|Compound:6635614|FD-Score:-3.90|P-value:2.61E-5 ID:SGTC_2318|Compound:6029776|FD-Score:3.48|P-value:1.48E-4 ID:SGTC_2327|Compound:6189656|FD-Score:3.17|P-value:4.99E-4 ID:SGTC_2430|Compound:5571206|FD-Score:3.61|P-value:8.91E-5 ID:SGTC_2605|Compound:digitonin|FD-Score:3.47|P-value:1.55E-4 ID:SGTC_2700|Compound:st077718|FD-Score:3.02|P-value:8.71E-4 ID:SGTC_2785|Compound:7756463|FD-Score:4.17|P-value:7.49E-6 ID:SGTC_2842|Compound:9000675|FD-Score:-3.41|P-value:2.02E-4 ID:SGTC_2863|Compound:9028737|FD-Score:3.40|P-value:2.09E-4 ID:SGTC_2870|Compound:9038528|FD-Score:3.65|P-value:7.64E-5 ID:SGTC_2910|Compound:7948405|FD-Score:3.41|P-value:1.99E-4 ID:SGTC_2946|Compound:9065502|FD-Score:3.18|P-value:4.73E-4 ID:SGTC_2989|Compound:9073649|FD-Score:-3.25|P-value:3.66E-4 ID:SGTC_2991|Compound:9074669|FD-Score:-2.99|P-value:9.53E-4 ID:SGTC_2994|Compound:9053520|FD-Score:3.13|P-value:5.73E-4 ID:SGTC_3006|Compound:9075424|FD-Score:3.38|P-value:2.23E-4 ID:SGTC_3048|Compound:9093155|FD-Score:3.27|P-value:3.43E-4 ID:SGTC_3057|Compound:9095946|FD-Score:-3.51|P-value:1.37E-4 ID:SGTC_3061|Compound:glucosamine|FD-Score:6.11|P-value:1.10E-10 ID:SGTC_3260|Compound:9137109|FD-Score:3.12|P-value:5.99E-4 ID:SGTC_3289|Compound:9119912|FD-Score:3.44|P-value:1.77E-4 ID:SGTC_3320|Compound:9137005|FD-Score:3.31|P-value:2.97E-4

Top fitness defect scores for YJL197W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1164 k060-0068 6.26 93.7 µM 4.13E-11 2 1.96E-10
2 SGTC_3061 glucosamine 6.11 200.0 µM 1.10E-10 1 4.89E-10
3 SGTC_1050 3232-1156 6.08 69.3 µM 1.37E-10 RSC complex & mRNA processing 3 5.97E-10
4 SGTC_142 0335-0849 5.61 62.7 µM 2.94E-9 ubiquinone biosynthesis & proteasome 68 1.04E-8
5 SGTC_1609 st001574 4.86 46.4 µM 2.29E-7 4 5.94E-7
6 SGTC_137 0438-0332 4.82 85.4 µM 2.84E-7 ubiquinone biosynthesis & proteasome 79 7.26E-7
7 SGTC_2157 5649910 4.71 96.4 µM 4.92E-7 10 1.21E-6
8 SGTC_136 0097-0015 4.25 404.5 µM 5.03E-6 60S ribosome export 12 1.05E-5
9 SGTC_2785 7756463 4.17 72.7 µM 7.49E-6 24 1.53E-5
10 SGTC_1382 3002-2117 4.13 298.0 µM 9.20E-6 9 1.85E-5
11 SGTC_1840 st055363 3.90 71.0 µM 2.54E-5 13 4.76E-5
12 SGTC_2161 5662504 3.87 8.5 µM 3.00E-5 tubulin folding & SWR complex 25 5.55E-5
13 SGTC_971 1315-0384 3.82 26.7 µM 3.71E-5 cell wall signaling 27 6.77E-5
14 SGTC_635 k038-0028 3.72 24.7 µM 5.51E-5 ubiquinone biosynthesis & proteasome 51 9.79E-5
15 SGTC_190 3970-0790 3.65 3.7 µM 7.45E-5 11 1.30E-4
16 SGTC_2870 9038528 3.65 13.0 µM 7.64E-5 24 1.33E-4
17 SGTC_876 0720-0963 3.63 56.8 µM 8.05E-5 25 1.39E-4
18 SGTC_2430 5571206 3.61 200.0 µM 8.91E-5 68 1.53E-4
19 SGTC_474 dl-dihydrosphingosine 3.60 5.0 µM 9.26E-5 38 1.59E-4
20 SGTC_1350 1495-0454 3.58 146.0 µM 9.95E-5 46 1.70E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.159 2.56E-20 YJL193W_p YJL193W_p hom Putative protein of unknown function, predicted to encode a triose phosphate transporter subfamily member based on phylogenetic analysis; similar to YOR307C/SLY41; deletion mutant has a respiratory growth defect
0.143 7.14E-17 YML034C-A_d YML034C-A_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.128 1.25E-13 YPR148C YPR148C hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
0.126 2.19E-13 YDL183C YDL183C hom Mitochondrial inner-membrane protein thought to be involved in the formation of an active mitochondrial K+/H+ exchanger (KHE) system; non-essential gene
0.124 6.35E-13 YOR254C SEC63 het Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
0.120 2.63E-12 YER012W PRE1 het Beta 4 subunit of the 20S proteasome; localizes to the nucleus throughout the cell cycle
0.120 3.21E-12 YOR165W SEY1 hom Dynamin-like GTPase that mediates homotypic ER fusion; has a role in ER morphology; interacts physically and genetically with Yop1p and Rtn1p; functional ortholog of the human atlastin ATL1, defects in which cause a form of the human disease hereditary spastic paraplegia; homolog of Arabidopsis RHD3
0.119 4.66E-12 YDR086C SSS1 het Subunit of the Sec61p translocation complex (Sec61p-Sss1p-Sbh1p) that forms a channel for passage of secretory proteins through the endoplasmic reticulum membrane, and of the Ssh1p complex (Ssh1p-Sbh2p-Sss1p); interacts with Ost4p and Wbp1p
0.114 4.20E-11 YML034W SRC1 hom Inner nuclear membrane protein; functions in regulation of subtelomeric genes and is linked to TREX (transcription export) factors; SRC1 produces 2 splice variant proteins with different functions; alternative splicing of SRC1 pre-mRNA is promoted by Hub1p; mutant has aneuploidy tolerance
0.110 1.53E-10 YJL155C FBP26 hom Fructose-2,6-bisphosphatase, required for glucose metabolism; protein abundance increases in response to DNA replication stress
0.107 4.54E-10 YPL181W CTI6 hom Protein that relieves transcriptional repression by binding to the Cyc8p-Tup1p corepressor and recruiting the SAGA complex to the repressed promoter; contains a PHD finger domain
0.107 5.60E-10 YBR275C RIF1 hom Protein that binds to the Rap1p C-terminus and acts synergistically with Rif2p to help control telomere length and establish telomeric silencing; deletion results in telomere elongation
0.101 4.10E-9 YIL090W ICE2 hom Integral ER membrane protein with type-III transmembrane domains; required for maintenance of ER zinc homeostasis; necessary for efficient targeting of Trm1p tRNA methyltransferase to inner nuclear membrane; mutations cause defects in cortical ER morphology in both the mother and daughter cells
0.100 5.97E-9 YOL096C COQ3 hom O-methyltransferase, catalyzes two different O-methylation steps in ubiquinone (Coenzyme Q) biosynthesis; component of a mitochondrial ubiquinone-synthesizing complex; phosphoprotein
0.098 1.23E-8 YPR064W_d YPR064W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data