YJL198W / PHO90

Low-affinity phosphate transporter; deletion of pho84, pho87, pho89, pho90, and pho91 causes synthetic lethality; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth; PHO90 has a paralog, PHO87, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YJL198W / PHO90

Click on Significant Values for Screen Details ID:SGTC_64|Compound:000l-0018|FD-Score:-4.51|P-value:7.61E-6 ID:SGTC_67|Compound:0335-0847|FD-Score:-3.44|P-value:4.91E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:-4.85|P-value:1.59E-6 ID:SGTC_77|Compound:0828-0286|FD-Score:3.43|P-value:4.43E-4 ID:SGTC_127|Compound:0180-0333|FD-Score:-3.52|P-value:3.62E-4 ID:SGTC_131|Compound:0141-0277|FD-Score:-5.90|P-value:7.22E-9 ID:SGTC_146|Compound:3448-8650|FD-Score:-5.04|P-value:6.60E-7 ID:SGTC_155|Compound:k072-0202|FD-Score:-3.26|P-value:8.82E-4 ID:SGTC_227|Compound:fluconazole|FD-Score:3.74|P-value:1.46E-4 ID:SGTC_597|Compound:k018-0003|FD-Score:3.47|P-value:3.90E-4 ID:SGTC_640|Compound:3381-0960|FD-Score:3.26|P-value:8.01E-4 ID:SGTC_662|Compound:k832-1615|FD-Score:-3.83|P-value:1.21E-4 ID:SGTC_955|Compound:1216-0110|FD-Score:3.66|P-value:2.00E-4 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:3.56|P-value:2.81E-4 ID:SGTC_1244|Compound:0416-0015|FD-Score:-3.34|P-value:6.88E-4 ID:SGTC_1605|Compound:st000082|FD-Score:4.86|P-value:1.30E-6 ID:SGTC_1722|Compound:st034304|FD-Score:3.26|P-value:8.07E-4 ID:SGTC_1730|Compound:st033808|FD-Score:-3.54|P-value:3.38E-4 ID:SGTC_1767|Compound:st044992|FD-Score:3.25|P-value:8.40E-4 ID:SGTC_1798|Compound:st045719|FD-Score:-3.93|P-value:8.20E-5 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:4.69|P-value:2.94E-6 ID:SGTC_2011|Compound:4012611|FD-Score:-4.47|P-value:8.91E-6 ID:SGTC_2065|Compound:5221596|FD-Score:-3.29|P-value:8.03E-4 ID:SGTC_2069|Compound:5228469|FD-Score:-3.80|P-value:1.31E-4 ID:SGTC_2077|Compound:5212015|FD-Score:-3.26|P-value:9.00E-4 ID:SGTC_2142|Compound:5622915|FD-Score:3.82|P-value:1.09E-4 ID:SGTC_2153|Compound:5569715|FD-Score:4.56|P-value:5.21E-6 ID:SGTC_2157|Compound:5649910|FD-Score:4.20|P-value:2.44E-5 ID:SGTC_2208|Compound:7283366|FD-Score:3.21|P-value:9.52E-4 ID:SGTC_2213|Compound:7173844|FD-Score:3.34|P-value:6.16E-4 ID:SGTC_2533|Compound:agelasine|FD-Score:-3.49|P-value:4.05E-4 ID:SGTC_2606|Compound:farnesol|FD-Score:4.91|P-value:1.03E-6 ID:SGTC_2686|Compound:alizarin|FD-Score:3.63|P-value:2.25E-4 ID:SGTC_2699|Compound:st077704|FD-Score:4.51|P-value:6.38E-6 ID:SGTC_2708|Compound:st078559|FD-Score:-3.34|P-value:6.83E-4 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:-3.24|P-value:9.53E-4 ID:SGTC_2779|Compound:methotrexate|FD-Score:3.20|P-value:9.82E-4 ID:SGTC_2786|Compound:7743617|FD-Score:4.58|P-value:4.85E-6 ID:SGTC_2813|Compound:7971799|FD-Score:3.74|P-value:1.51E-4 ID:SGTC_2942|Compound:9052777|FD-Score:4.67|P-value:3.24E-6 ID:SGTC_2957|Compound:9076800|FD-Score:3.77|P-value:1.33E-4 ID:SGTC_2962|Compound:9082311|FD-Score:4.30|P-value:1.63E-5 ID:SGTC_2967|Compound:9089538|FD-Score:-3.30|P-value:7.69E-4 ID:SGTC_3135|Compound:9127742|FD-Score:3.36|P-value:5.66E-4 ID:SGTC_3246|Compound:9135460|FD-Score:-3.34|P-value:6.78E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:-4.51|P-value:7.61E-6 ID:SGTC_67|Compound:0335-0847|FD-Score:-3.44|P-value:4.91E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:-4.85|P-value:1.59E-6 ID:SGTC_77|Compound:0828-0286|FD-Score:3.43|P-value:4.43E-4 ID:SGTC_127|Compound:0180-0333|FD-Score:-3.52|P-value:3.62E-4 ID:SGTC_131|Compound:0141-0277|FD-Score:-5.90|P-value:7.22E-9 ID:SGTC_146|Compound:3448-8650|FD-Score:-5.04|P-value:6.60E-7 ID:SGTC_155|Compound:k072-0202|FD-Score:-3.26|P-value:8.82E-4 ID:SGTC_227|Compound:fluconazole|FD-Score:3.74|P-value:1.46E-4 ID:SGTC_597|Compound:k018-0003|FD-Score:3.47|P-value:3.90E-4 ID:SGTC_640|Compound:3381-0960|FD-Score:3.26|P-value:8.01E-4 ID:SGTC_662|Compound:k832-1615|FD-Score:-3.83|P-value:1.21E-4 ID:SGTC_955|Compound:1216-0110|FD-Score:3.66|P-value:2.00E-4 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:3.56|P-value:2.81E-4 ID:SGTC_1244|Compound:0416-0015|FD-Score:-3.34|P-value:6.88E-4 ID:SGTC_1605|Compound:st000082|FD-Score:4.86|P-value:1.30E-6 ID:SGTC_1722|Compound:st034304|FD-Score:3.26|P-value:8.07E-4 ID:SGTC_1730|Compound:st033808|FD-Score:-3.54|P-value:3.38E-4 ID:SGTC_1767|Compound:st044992|FD-Score:3.25|P-value:8.40E-4 ID:SGTC_1798|Compound:st045719|FD-Score:-3.93|P-value:8.20E-5 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:4.69|P-value:2.94E-6 ID:SGTC_2011|Compound:4012611|FD-Score:-4.47|P-value:8.91E-6 ID:SGTC_2065|Compound:5221596|FD-Score:-3.29|P-value:8.03E-4 ID:SGTC_2069|Compound:5228469|FD-Score:-3.80|P-value:1.31E-4 ID:SGTC_2077|Compound:5212015|FD-Score:-3.26|P-value:9.00E-4 ID:SGTC_2142|Compound:5622915|FD-Score:3.82|P-value:1.09E-4 ID:SGTC_2153|Compound:5569715|FD-Score:4.56|P-value:5.21E-6 ID:SGTC_2157|Compound:5649910|FD-Score:4.20|P-value:2.44E-5 ID:SGTC_2208|Compound:7283366|FD-Score:3.21|P-value:9.52E-4 ID:SGTC_2213|Compound:7173844|FD-Score:3.34|P-value:6.16E-4 ID:SGTC_2533|Compound:agelasine|FD-Score:-3.49|P-value:4.05E-4 ID:SGTC_2606|Compound:farnesol|FD-Score:4.91|P-value:1.03E-6 ID:SGTC_2686|Compound:alizarin|FD-Score:3.63|P-value:2.25E-4 ID:SGTC_2699|Compound:st077704|FD-Score:4.51|P-value:6.38E-6 ID:SGTC_2708|Compound:st078559|FD-Score:-3.34|P-value:6.83E-4 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:-3.24|P-value:9.53E-4 ID:SGTC_2779|Compound:methotrexate|FD-Score:3.20|P-value:9.82E-4 ID:SGTC_2786|Compound:7743617|FD-Score:4.58|P-value:4.85E-6 ID:SGTC_2813|Compound:7971799|FD-Score:3.74|P-value:1.51E-4 ID:SGTC_2942|Compound:9052777|FD-Score:4.67|P-value:3.24E-6 ID:SGTC_2957|Compound:9076800|FD-Score:3.77|P-value:1.33E-4 ID:SGTC_2962|Compound:9082311|FD-Score:4.30|P-value:1.63E-5 ID:SGTC_2967|Compound:9089538|FD-Score:-3.30|P-value:7.69E-4 ID:SGTC_3135|Compound:9127742|FD-Score:3.36|P-value:5.66E-4 ID:SGTC_3246|Compound:9135460|FD-Score:-3.34|P-value:6.78E-4

Top fitness defect scores for YJL198W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2606 farnesol 4.91 9.8 µM 1.03E-6 9 4.52E-7
2 SGTC_1605 st000082 4.86 49.1 µM 1.30E-6 60S ribosome export 3 5.77E-7
3 SGTC_1951 sophoraflavanone G 4.69 9.2 µM 2.94E-6 RNA processing & uracil transport 10 1.39E-6
4 SGTC_2942 9052777 4.67 62.2 µM 3.24E-6 15 1.54E-6
5 SGTC_2786 7743617 4.58 45.5 µM 4.85E-6 15 2.37E-6
6 SGTC_2153 5569715 4.56 200.0 µM 5.21E-6 iron homeostasis 13 2.56E-6
7 SGTC_2699 st077704 4.51 54.6 µM 6.38E-6 endomembrane recycling 39 3.18E-6
8 SGTC_2962 9082311 4.30 13.2 µM 1.63E-5 10 8.70E-6
9 SGTC_2157 5649910 4.20 96.4 µM 2.44E-5 19 1.33E-5
10 SGTC_2142 5622915 3.82 118.5 µM 1.09E-4 14 6.63E-5
11 SGTC_2957 9076800 3.77 11.5 µM 1.33E-4 24 8.21E-5
12 SGTC_227 fluconazole 3.74 33.5 µM 1.46E-4 azole & statin 98 9.07E-5
13 SGTC_2813 7971799 3.74 71.4 µM 1.51E-4 23 9.38E-5
14 SGTC_955 1216-0110 3.66 33.0 µM 2.00E-4 sphingolipid biosynthesis & PDR1 88 1.26E-4
15 SGTC_2686 alizarin 3.63 95.4 µM 2.25E-4 RPP1 & pyrimidine depletion 38 1.43E-4
16 SGTC_1110 3-hydroxy-3'-methoxyflavone 3.56 1.2 µM 2.81E-4 iron homeostasis 55 1.82E-4
17 SGTC_597 k018-0003 3.47 82.8 µM 3.90E-4 RNA pol III & RNase P/MRP 22 2.59E-4
18 SGTC_77 0828-0286 3.43 12.5 µM 4.43E-4 TSC3-RPN4 60 2.97E-4
19 SGTC_3135 9127742 3.36 49.5 µM 5.66E-4 39 3.85E-4
20 SGTC_2213 7173844 3.34 200.0 µM 6.16E-4 32 4.22E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.105 1.10E-9 YGR267C FOL2 het GTP-cyclohydrolase I, catalyzes the first step in the folic acid biosynthetic pathway
0.095 3.00E-8 YPR199C ARR1 hom Transcriptional activator of the basic leucine zipper (bZIP) family, required for transcription of genes involved in resistance to arsenic compounds
0.092 8.36E-8 YML087C AIM33 hom Putative protein of unknown function, highly conserved across species; homolog of human CYB5R4; null mutant displays reduced frequency of mitochondrial genome loss; AIM33 has a paralog, PGA3, that arose from the whole genome duplication
0.088 3.13E-7 YOL024W_p YOL024W_p hom Putative protein of unknown function; predicted to have thiol-disulfide oxidoreductase active site; YOL024W has a paralog, IGD1, that arose from the whole genome duplication
0.083 1.43E-6 YDR271C_d YDR271C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CCC2/YDR270W
0.083 1.67E-6 YOR132W VPS17 hom Subunit of the membrane-associated retromer complex essential for endosome-to-Golgi retrograde protein transport; peripheral membrane protein that assembles onto the membrane with Vps5p to promote vesicle formation; required for recruiting the retromer complex to the endosome membranes
0.081 2.33E-6 YJL158C CIS3 hom Mannose-containing glycoprotein constituent of the cell wall; member of the PIR (proteins with internal repeats) family
0.080 3.10E-6 YDR258C HSP78 hom Oligomeric mitochondrial matrix chaperone that cooperates with Ssc1p in mitochondrial thermotolerance after heat shock; able to prevent the aggregation of misfolded proteins as well as resolubilize protein aggregates
0.078 5.74E-6 YBR170C NPL4 hom Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase; assists Cdc48p in the dislocation of misfolded, polyubiquitinated ERAD substrates that are subsequently delivered to the proteasome for degradation; also involved in the regulated destruction of resident ER membrane proteins, such as HMG-CoA reductase (Hmg1/2p) and cytoplasmic proteins (Fbp1p); role in mobilizing membrane bound transcription factors by regulated ubiquitin/proteasome-dependent processing (RUP)
0.078 6.57E-6 YLL048C YBT1 hom Transporter of the ATP-binding cassette (ABC) family; involved in bile acid transport; negative regulator of vacuole fusion; regulates the release of lumenal Ca2+ stores; similar to mammalian bile transporters
0.076 1.14E-5 YJR131W MNS1 hom Alpha-1,2-mannosidase involved in ER-associated protein degradation (ERAD); catalyzes the removal of one mannose residue from a glycosylated protein, converting the modification from Man9GlcNAc to Man8GlcNAc; catalyzes the last step in glycoprotein maturation in the ER and is critical for ER protein degradation
0.074 1.68E-5 YPL056C_p LCL1_p hom Putative protein of unknown function; deletion mutant is fluconazole resistant and has long chronological lifespan
0.073 2.21E-5 YOL138C RTC1 hom Subunit of the SEA (Seh1-associated) complex, a coatomer-related complex that associates dynamically with the vacuole; null mutation suppresses cdc13-1 temperature sensitivity; has N-terminal WD-40 repeats and a C-terminal RING motif
0.073 2.31E-5 YOL126C MDH2 hom Cytoplasmic malate dehydrogenase, one of three isozymes that catalyze interconversion of malate and oxaloacetate; involved in the glyoxylate cycle and gluconeogenesis during growth on two-carbon compounds; interacts with Pck1p and Fbp1
0.073 2.43E-5 YGR203W YCH1 hom Phosphatase with sequence similarity to Cdc25p, Arr2p and Mih1p; member of the single-domain rhodanese homology superfamily; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus