HIPHOP chemogenomics database

YJL198W / PHO90

Low-affinity phosphate transporter; deletion of pho84, pho87, pho89, pho90, and pho91 causes synthetic lethality; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth; PHO90 has a paralog, PHO87, that arose from the whole genome duplication

Zygosity: Homozygous strain

fixedexpanded
Profile for YJL198W / PHO90

Click on Significant Values for Screen Details

Top fitness defect scores for YJL198W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_2606	farnesol	4.91	9.8 µM	1.03E-6		9	4.52E-7
2	SGTC_1605	st000082	4.86	49.1 µM	1.30E-6	60S ribosome export	3	5.77E-7
3	SGTC_1951	sophoraflavanone G	4.69	9.2 µM	2.94E-6	RNA processing & uracil transport	10	1.39E-6
4	SGTC_2942	9052777	4.67	62.2 µM	3.24E-6		15	1.54E-6
5	SGTC_2786	7743617	4.58	45.5 µM	4.85E-6		15	2.37E-6
6	SGTC_2153	5569715	4.56	200.0 µM	5.21E-6	iron homeostasis	13	2.56E-6
7	SGTC_2699	st077704	4.51	54.6 µM	6.38E-6	endomembrane recycling	39	3.18E-6
8	SGTC_2962	9082311	4.30	13.2 µM	1.63E-5		10	8.70E-6
9	SGTC_2157	5649910	4.20	96.4 µM	2.44E-5		19	1.33E-5
10	SGTC_2142	5622915	3.82	118.5 µM	1.09E-4		14	6.63E-5
11	SGTC_2957	9076800	3.77	11.5 µM	1.33E-4		24	8.21E-5
12	SGTC_227	fluconazole	3.74	33.5 µM	1.46E-4	azole & statin	98	9.07E-5
13	SGTC_2813	7971799	3.74	71.4 µM	1.51E-4		23	9.38E-5
14	SGTC_955	1216-0110	3.66	33.0 µM	2.00E-4	sphingolipid biosynthesis & PDR1	88	1.26E-4
15	SGTC_2686	alizarin	3.63	95.4 µM	2.25E-4	RPP1 & pyrimidine depletion	38	1.43E-4
16	SGTC_1110	3-hydroxy-3'-methoxyflavone	3.56	1.2 µM	2.81E-4	iron homeostasis	55	1.82E-4
17	SGTC_597	k018-0003	3.47	82.8 µM	3.90E-4	RNA pol III & RNase P/MRP	22	2.59E-4
18	SGTC_77	0828-0286	3.43	12.5 µM	4.43E-4	TSC3-RPN4	60	2.97E-4
19	SGTC_3135	9127742	3.36	49.5 µM	5.66E-4		39	3.85E-4
20	SGTC_2213	7173844	3.34	200.0 µM	6.16E-4		32	4.22E-4

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.105	1.10E-9	YGR267C	FOL2	het	GTP-cyclohydrolase I, catalyzes the first step in the folic acid biosynthetic pathway
0.095	3.00E-8	YPR199C	ARR1	hom	Transcriptional activator of the basic leucine zipper (bZIP) family, required for transcription of genes involved in resistance to arsenic compounds
0.092	8.36E-8	YML087C	AIM33	hom	Putative protein of unknown function, highly conserved across species; homolog of human CYB5R4; null mutant displays reduced frequency of mitochondrial genome loss; AIM33 has a paralog, PGA3, that arose from the whole genome duplication
0.088	3.13E-7	YOL024W_p	YOL024W_p	hom	Putative protein of unknown function; predicted to have thiol-disulfide oxidoreductase active site; YOL024W has a paralog, IGD1, that arose from the whole genome duplication
0.083	1.43E-6	YDR271C_d	YDR271C_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CCC2/YDR270W
0.083	1.67E-6	YOR132W	VPS17	hom	Subunit of the membrane-associated retromer complex essential for endosome-to-Golgi retrograde protein transport; peripheral membrane protein that assembles onto the membrane with Vps5p to promote vesicle formation; required for recruiting the retromer complex to the endosome membranes
0.081	2.33E-6	YJL158C	CIS3	hom	Mannose-containing glycoprotein constituent of the cell wall; member of the PIR (proteins with internal repeats) family
0.080	3.10E-6	YDR258C	HSP78	hom	Oligomeric mitochondrial matrix chaperone that cooperates with Ssc1p in mitochondrial thermotolerance after heat shock; able to prevent the aggregation of misfolded proteins as well as resolubilize protein aggregates
0.078	5.74E-6	YBR170C	NPL4	hom	Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase; assists Cdc48p in the dislocation of misfolded, polyubiquitinated ERAD substrates that are subsequently delivered to the proteasome for degradation; also involved in the regulated destruction of resident ER membrane proteins, such as HMG-CoA reductase (Hmg1/2p) and cytoplasmic proteins (Fbp1p); role in mobilizing membrane bound transcription factors by regulated ubiquitin/proteasome-dependent processing (RUP)
0.078	6.57E-6	YLL048C	YBT1	hom	Transporter of the ATP-binding cassette (ABC) family; involved in bile acid transport; negative regulator of vacuole fusion; regulates the release of lumenal Ca2+ stores; similar to mammalian bile transporters
0.076	1.14E-5	YJR131W	MNS1	hom	Alpha-1,2-mannosidase involved in ER-associated protein degradation (ERAD); catalyzes the removal of one mannose residue from a glycosylated protein, converting the modification from Man9GlcNAc to Man8GlcNAc; catalyzes the last step in glycoprotein maturation in the ER and is critical for ER protein degradation
0.074	1.68E-5	YPL056C_p	LCL1_p	hom	Putative protein of unknown function; deletion mutant is fluconazole resistant and has long chronological lifespan
0.073	2.21E-5	YOL138C	RTC1	hom	Subunit of the SEA (Seh1-associated) complex, a coatomer-related complex that associates dynamically with the vacuole; null mutation suppresses cdc13-1 temperature sensitivity; has N-terminal WD-40 repeats and a C-terminal RING motif
0.073	2.31E-5	YOL126C	MDH2	hom	Cytoplasmic malate dehydrogenase, one of three isozymes that catalyze interconversion of malate and oxaloacetate; involved in the glyoxylate cycle and gluconeogenesis during growth on two-carbon compounds; interacts with Pck1p and Fbp1
0.073	2.43E-5	YGR203W	YCH1	hom	Phosphatase with sequence similarity to Cdc25p, Arr2p and Mih1p; member of the single-domain rhodanese homology superfamily; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus