YJL199C_d / MBB1

Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; protein detected in large-scale protein-protein interaction studies

Zygosity: Homozygous strain
fixedexpanded
Profile for YJL199C / MBB1

Click on Significant Values for Screen Details ID:SGTC_139|Compound:0099-0334|FD-Score:3.21|P-value:5.21E-4 ID:SGTC_160|Compound:3453-0671|FD-Score:3.20|P-value:5.44E-4 ID:SGTC_345|Compound:1362-0200|FD-Score:3.25|P-value:4.62E-4 ID:SGTC_369|Compound:0957-0393|FD-Score:3.20|P-value:5.51E-4 ID:SGTC_538|Compound:2922-0838|FD-Score:3.37|P-value:2.96E-4 ID:SGTC_633|Compound:0437-0093|FD-Score:3.10|P-value:7.90E-4 ID:SGTC_652|Compound:0437-0092|FD-Score:3.99|P-value:2.36E-5 ID:SGTC_660|Compound:4031-1742|FD-Score:-3.17|P-value:5.86E-4 ID:SGTC_739|Compound:1486-1183|FD-Score:4.19|P-value:9.68E-6 ID:SGTC_746|Compound:1095-0025|FD-Score:4.18|P-value:1.01E-5 ID:SGTC_861|Compound:0443-0273|FD-Score:3.62|P-value:1.09E-4 ID:SGTC_887|Compound:0885-0007|FD-Score:3.64|P-value:1.02E-4 ID:SGTC_919|Compound:tnp00227|FD-Score:3.08|P-value:8.52E-4 ID:SGTC_1105|Compound:epirubicin|FD-Score:-4.31|P-value:5.05E-6 ID:SGTC_1150|Compound:3909-7983|FD-Score:-3.02|P-value:9.88E-4 ID:SGTC_1158|Compound:4092-0494|FD-Score:3.04|P-value:9.53E-4 ID:SGTC_1340|Compound:1486-1359|FD-Score:4.56|P-value:1.58E-6 ID:SGTC_1475|Compound:4092-1048|FD-Score:3.51|P-value:1.70E-4 ID:SGTC_1482|Compound:3346-2049|FD-Score:3.37|P-value:2.96E-4 ID:SGTC_1510|Compound:1123-0200|FD-Score:-3.09|P-value:7.66E-4 ID:SGTC_1551|Compound:6-bromo-3'-methylflavone|FD-Score:-3.07|P-value:8.26E-4 ID:SGTC_1699|Compound:st031318|FD-Score:-3.33|P-value:3.27E-4 ID:SGTC_1755|Compound:st041960|FD-Score:3.32|P-value:3.49E-4 ID:SGTC_1814|Compound:st052110|FD-Score:3.38|P-value:2.79E-4 ID:SGTC_1900|Compound:st060200|FD-Score:4.59|P-value:1.43E-6 ID:SGTC_1906|Compound:st060206|FD-Score:-3.93|P-value:2.90E-5 ID:SGTC_1966|Compound:st070145|FD-Score:-4.30|P-value:5.29E-6 ID:SGTC_2005|Compound:4024620|FD-Score:-3.06|P-value:8.64E-4 ID:SGTC_2031|Compound:5180455|FD-Score:-3.27|P-value:4.07E-4 ID:SGTC_2058|Compound:5236698|FD-Score:-3.94|P-value:2.71E-5 ID:SGTC_2263|Compound:7948595|FD-Score:3.46|P-value:2.07E-4 ID:SGTC_2265|Compound:7929201|FD-Score:-3.03|P-value:9.40E-4 ID:SGTC_2331|Compound:7980721|FD-Score:6.77|P-value:2.38E-12 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:3.72|P-value:7.25E-5 ID:SGTC_2481|Compound:5478948|FD-Score:-3.47|P-value:1.87E-4 ID:SGTC_2517|Compound:totarol|FD-Score:-4.25|P-value:6.81E-6 ID:SGTC_2520|Compound:obtusaquinone|FD-Score:-4.15|P-value:1.07E-5 ID:SGTC_2535|Compound:4',4'-dimethoxydalbergione|FD-Score:3.28|P-value:4.03E-4 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:4.57|P-value:1.53E-6 ID:SGTC_2628|Compound:lathosterol|FD-Score:3.24|P-value:4.69E-4 ID:SGTC_2645|Compound:abamectin|FD-Score:3.55|P-value:1.44E-4 ID:SGTC_3164|Compound:9100705|FD-Score:3.27|P-value:4.28E-4 ID:SGTC_139|Compound:0099-0334|FD-Score:3.21|P-value:5.21E-4 ID:SGTC_160|Compound:3453-0671|FD-Score:3.20|P-value:5.44E-4 ID:SGTC_345|Compound:1362-0200|FD-Score:3.25|P-value:4.62E-4 ID:SGTC_369|Compound:0957-0393|FD-Score:3.20|P-value:5.51E-4 ID:SGTC_538|Compound:2922-0838|FD-Score:3.37|P-value:2.96E-4 ID:SGTC_633|Compound:0437-0093|FD-Score:3.10|P-value:7.90E-4 ID:SGTC_652|Compound:0437-0092|FD-Score:3.99|P-value:2.36E-5 ID:SGTC_660|Compound:4031-1742|FD-Score:-3.17|P-value:5.86E-4 ID:SGTC_739|Compound:1486-1183|FD-Score:4.19|P-value:9.68E-6 ID:SGTC_746|Compound:1095-0025|FD-Score:4.18|P-value:1.01E-5 ID:SGTC_861|Compound:0443-0273|FD-Score:3.62|P-value:1.09E-4 ID:SGTC_887|Compound:0885-0007|FD-Score:3.64|P-value:1.02E-4 ID:SGTC_919|Compound:tnp00227|FD-Score:3.08|P-value:8.52E-4 ID:SGTC_1105|Compound:epirubicin|FD-Score:-4.31|P-value:5.05E-6 ID:SGTC_1150|Compound:3909-7983|FD-Score:-3.02|P-value:9.88E-4 ID:SGTC_1158|Compound:4092-0494|FD-Score:3.04|P-value:9.53E-4 ID:SGTC_1340|Compound:1486-1359|FD-Score:4.56|P-value:1.58E-6 ID:SGTC_1475|Compound:4092-1048|FD-Score:3.51|P-value:1.70E-4 ID:SGTC_1482|Compound:3346-2049|FD-Score:3.37|P-value:2.96E-4 ID:SGTC_1510|Compound:1123-0200|FD-Score:-3.09|P-value:7.66E-4 ID:SGTC_1551|Compound:6-bromo-3'-methylflavone|FD-Score:-3.07|P-value:8.26E-4 ID:SGTC_1699|Compound:st031318|FD-Score:-3.33|P-value:3.27E-4 ID:SGTC_1755|Compound:st041960|FD-Score:3.32|P-value:3.49E-4 ID:SGTC_1814|Compound:st052110|FD-Score:3.38|P-value:2.79E-4 ID:SGTC_1900|Compound:st060200|FD-Score:4.59|P-value:1.43E-6 ID:SGTC_1906|Compound:st060206|FD-Score:-3.93|P-value:2.90E-5 ID:SGTC_1966|Compound:st070145|FD-Score:-4.30|P-value:5.29E-6 ID:SGTC_2005|Compound:4024620|FD-Score:-3.06|P-value:8.64E-4 ID:SGTC_2031|Compound:5180455|FD-Score:-3.27|P-value:4.07E-4 ID:SGTC_2058|Compound:5236698|FD-Score:-3.94|P-value:2.71E-5 ID:SGTC_2263|Compound:7948595|FD-Score:3.46|P-value:2.07E-4 ID:SGTC_2265|Compound:7929201|FD-Score:-3.03|P-value:9.40E-4 ID:SGTC_2331|Compound:7980721|FD-Score:6.77|P-value:2.38E-12 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:3.72|P-value:7.25E-5 ID:SGTC_2481|Compound:5478948|FD-Score:-3.47|P-value:1.87E-4 ID:SGTC_2517|Compound:totarol|FD-Score:-4.25|P-value:6.81E-6 ID:SGTC_2520|Compound:obtusaquinone|FD-Score:-4.15|P-value:1.07E-5 ID:SGTC_2535|Compound:4',4'-dimethoxydalbergione|FD-Score:3.28|P-value:4.03E-4 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:4.57|P-value:1.53E-6 ID:SGTC_2628|Compound:lathosterol|FD-Score:3.24|P-value:4.69E-4 ID:SGTC_2645|Compound:abamectin|FD-Score:3.55|P-value:1.44E-4 ID:SGTC_3164|Compound:9100705|FD-Score:3.27|P-value:4.28E-4

Top fitness defect scores for YJL199C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2331 7980721 6.77 200.0 µM 2.38E-12 1 6.52E-12
2 SGTC_1900 st060200 4.59 72.8 µM 1.43E-6 15 2.27E-6
3 SGTC_2565 isoliquiritigenin 4.57 100.0 µM 1.53E-6 21 2.42E-6
4 SGTC_1340 1486-1359 4.56 257.0 µM 1.58E-6 8 2.50E-6
5 SGTC_739 1486-1183 4.19 203.0 µM 9.68E-6 14 1.42E-5
6 SGTC_746 1095-0025 4.18 46.6 µM 1.01E-5 RSC & ERG11 11 1.49E-5
7 SGTC_652 0437-0092 3.99 114.0 µM 2.36E-5 16 3.34E-5
8 SGTC_2422 chlorphenesin carbamate 3.72 384.2 µM 7.25E-5 34 9.83E-5
9 SGTC_887 0885-0007 3.64 9.6 µM 1.02E-4 endomembrane recycling 42 1.36E-4
10 SGTC_861 0443-0273 3.62 110.0 µM 1.09E-4 16 1.46E-4
11 SGTC_2645 abamectin 3.55 100.0 µM 1.44E-4 heme requiring 44 1.90E-4
12 SGTC_1475 4092-1048 3.51 11.7 µM 1.70E-4 plasma membrane duress 47 2.23E-4
13 SGTC_2263 7948595 3.46 193.3 µM 2.07E-4 15 2.69E-4
14 SGTC_1814 st052110 3.38 31.5 µM 2.79E-4 RNA processing & uracil transport 22 3.59E-4
15 SGTC_1482 3346-2049 3.37 8.5 µM 2.96E-4 43 3.80E-4
16 SGTC_538 2922-0838 3.37 53.3 µM 2.96E-4 Golgi 52 3.80E-4
17 SGTC_1755 st041960 3.32 45.2 µM 3.49E-4 41 4.45E-4
18 SGTC_2535 4',4'-dimethoxydalbergione 3.28 51.2 µM 4.03E-4 DNA damage response 34 5.11E-4
19 SGTC_3164 9100705 3.27 49.5 µM 4.28E-4 16 5.42E-4
20 SGTC_345 1362-0200 3.25 395.0 µM 4.62E-4 41 5.83E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.096 2.24E-8 YJR123W RPS5 het Protein component of the small (40S) ribosomal subunit; least basic of non-acidic ribosomal proteins; phosphorylated in vivo; essential for viability; homologous to mammalian ribosomal protein S5 and bacterial S7
0.089 2.46E-7 YNL261W ORC5 het Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing
0.088 3.01E-7 YGR281W YOR1 hom Plasma membrane ATP-binding cassette (ABC) transporter, multidrug transporter mediates export of many different organic anions including oligomycin; similar to human cystic fibrosis transmembrane receptor (CFTR)
0.085 8.27E-7 YER087C-B SBH1 hom Beta subunit of the Sec61p ER translocation complex (Sec61p-Sss1p-Sbh1p); involved in protein translocation into the endoplasmic reticulum; interacts with the exocyst complex and also with Rtn1p; homologous to Sbh2p
0.081 2.67E-6 YJR107W_p YJR107W_p hom Putative lipase
0.080 3.12E-6 YDL159W-A_p YDL159W-A_p hom Putative protein of unknown function; identified by sequence comparison with hemiascomycetous yeast species
0.078 5.64E-6 YER078C ICP55 hom Mitochondrial aminopeptidase; cleaves the N termini of at least 38 imported proteins after cleavage by the mitochondrial processing peptidase (MPP), thereby increasing their stability; member of the aminopeptidase P family
0.078 6.80E-6 YDR534C FIT1 hom Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall
0.077 8.24E-6 YFL051C_p YFL051C_p hom Putative protein of unknown function; YFL051C is not an essential gene
0.075 1.22E-5 YGL177W_d YGL177W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.073 2.29E-5 YPL009C TAE2 hom Protein of unknown function, involved in protein translation; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.071 3.51E-5 YEL013W VAC8 hom Phosphorylated and palmitoylated vacuolar membrane protein that interacts with Atg13p, required for the cytoplasm-to-vacuole targeting (Cvt) pathway; interacts with Nvj1p to form nucleus-vacuole junctions
0.071 3.75E-5 YHL040C ARN1 hom ARN family transporter for siderophore-iron chelates; responsible for uptake of iron bound to ferrirubin, ferrirhodin, and related siderophores; protein increases in abundance and relocalizes to the vacuole upon DNA replication stress
0.070 4.65E-5 YGR085C RPL11B hom Ribosomal 60S subunit protein L11B; expressed at half the level of Rpl11Ap; involved in ribosomal assembly; depletion causes degradation of 60S proteins and RNA; homologous to mammalian ribosomal protein L11 and bacterial L5; RPL11B has a paralog, RPL11A, that arose from the whole genome duplication
0.070 5.31E-5 YPR121W THI22 hom Protein with similarity to hydroxymethylpyrimidine phosphate kinases; member of a gene family with THI20 and THI21; not required for thiamine biosynthesis