YJL200C / ACO2

Putative mitochondrial aconitase isozyme; similarity to Aco1p, an aconitase required for the TCA cycle; expression induced during growth on glucose, by amino acid starvation via Gcn4p, and repressed on ethanol

Zygosity: Homozygous strain
fixedexpanded
Profile for YJL200C / ACO2

Click on Significant Values for Screen Details ID:SGTC_43|Compound:0570-0105|FD-Score:-3.01|P-value:6.25E-4 ID:SGTC_77|Compound:0828-0286|FD-Score:-3.65|P-value:4.21E-5 ID:SGTC_78|Compound:0336-0123|FD-Score:-3.27|P-value:2.24E-4 ID:SGTC_126|Compound:0417-1624|FD-Score:-3.53|P-value:7.12E-5 ID:SGTC_133|Compound:0724-0033|FD-Score:3.55|P-value:4.07E-5 ID:SGTC_196|Compound:k015-0023|FD-Score:-3.95|P-value:1.00E-5 ID:SGTC_208|Compound:k072-0098|FD-Score:-3.58|P-value:5.92E-5 ID:SGTC_368|Compound:fentichlor|FD-Score:2.94|P-value:5.24E-4 ID:SGTC_369|Compound:0957-0393|FD-Score:2.85|P-value:7.49E-4 ID:SGTC_392|Compound:N-ethylmaleimide|FD-Score:2.86|P-value:7.10E-4 ID:SGTC_419|Compound:nsc-638432|FD-Score:-3.02|P-value:5.89E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:2.79|P-value:9.37E-4 ID:SGTC_437|Compound:s-farnesyl-l-cysteine methyl ester|FD-Score:-2.93|P-value:8.26E-4 ID:SGTC_497|Compound:capsazepine|FD-Score:-4.08|P-value:5.51E-6 ID:SGTC_507|Compound:nimesulide|FD-Score:3.06|P-value:3.30E-4 ID:SGTC_532|Compound:1548-0774|FD-Score:2.92|P-value:5.78E-4 ID:SGTC_540|Compound:1187-0821|FD-Score:-2.97|P-value:7.07E-4 ID:SGTC_541|Compound:4513-1321|FD-Score:-3.11|P-value:4.15E-4 ID:SGTC_648|Compound:0375-0473|FD-Score:-3.27|P-value:2.20E-4 ID:SGTC_708|Compound:3448-5400|FD-Score:-2.93|P-value:8.19E-4 ID:SGTC_762|Compound:1165-0429|FD-Score:3.03|P-value:3.69E-4 ID:SGTC_792|Compound:4534-1957|FD-Score:3.73|P-value:1.74E-5 ID:SGTC_796|Compound:1234-0020|FD-Score:-2.90|P-value:9.37E-4 ID:SGTC_867|Compound:0518-0118|FD-Score:-4.99|P-value:3.32E-8 ID:SGTC_875|Compound:0709-0210|FD-Score:3.33|P-value:1.09E-4 ID:SGTC_954|Compound:1189-0853|FD-Score:-3.02|P-value:5.96E-4 ID:SGTC_1138|Compound:3761-0006|FD-Score:2.86|P-value:7.25E-4 ID:SGTC_1140|Compound:3229-1848|FD-Score:3.46|P-value:6.19E-5 ID:SGTC_1813|Compound:st051246|FD-Score:3.19|P-value:1.97E-4 ID:SGTC_1840|Compound:st055363|FD-Score:4.50|P-value:3.21E-7 ID:SGTC_1908|Compound:st060353|FD-Score:5.40|P-value:1.21E-9 ID:SGTC_2134|Compound:5324836|FD-Score:2.83|P-value:8.10E-4 ID:SGTC_2136|Compound:5328288|FD-Score:-3.39|P-value:1.31E-4 ID:SGTC_2143|Compound:5623677|FD-Score:3.34|P-value:1.02E-4 ID:SGTC_2195|Compound:6536160|FD-Score:3.40|P-value:7.92E-5 ID:SGTC_2316|Compound:5844804|FD-Score:3.67|P-value:2.30E-5 ID:SGTC_2333|Compound:9017922|FD-Score:2.90|P-value:6.29E-4 ID:SGTC_2374|Compound:9071832|FD-Score:3.26|P-value:1.45E-4 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:3.91|P-value:7.27E-6 ID:SGTC_2814|Compound:7977482|FD-Score:4.38|P-value:6.19E-7 ID:SGTC_3317|Compound:9138495|FD-Score:-3.11|P-value:4.11E-4 ID:SGTC_3323|Compound:9138564|FD-Score:2.94|P-value:5.28E-4 ID:SGTC_43|Compound:0570-0105|FD-Score:-3.01|P-value:6.25E-4 ID:SGTC_77|Compound:0828-0286|FD-Score:-3.65|P-value:4.21E-5 ID:SGTC_78|Compound:0336-0123|FD-Score:-3.27|P-value:2.24E-4 ID:SGTC_126|Compound:0417-1624|FD-Score:-3.53|P-value:7.12E-5 ID:SGTC_133|Compound:0724-0033|FD-Score:3.55|P-value:4.07E-5 ID:SGTC_196|Compound:k015-0023|FD-Score:-3.95|P-value:1.00E-5 ID:SGTC_208|Compound:k072-0098|FD-Score:-3.58|P-value:5.92E-5 ID:SGTC_368|Compound:fentichlor|FD-Score:2.94|P-value:5.24E-4 ID:SGTC_369|Compound:0957-0393|FD-Score:2.85|P-value:7.49E-4 ID:SGTC_392|Compound:N-ethylmaleimide|FD-Score:2.86|P-value:7.10E-4 ID:SGTC_419|Compound:nsc-638432|FD-Score:-3.02|P-value:5.89E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:2.79|P-value:9.37E-4 ID:SGTC_437|Compound:s-farnesyl-l-cysteine methyl ester|FD-Score:-2.93|P-value:8.26E-4 ID:SGTC_497|Compound:capsazepine|FD-Score:-4.08|P-value:5.51E-6 ID:SGTC_507|Compound:nimesulide|FD-Score:3.06|P-value:3.30E-4 ID:SGTC_532|Compound:1548-0774|FD-Score:2.92|P-value:5.78E-4 ID:SGTC_540|Compound:1187-0821|FD-Score:-2.97|P-value:7.07E-4 ID:SGTC_541|Compound:4513-1321|FD-Score:-3.11|P-value:4.15E-4 ID:SGTC_648|Compound:0375-0473|FD-Score:-3.27|P-value:2.20E-4 ID:SGTC_708|Compound:3448-5400|FD-Score:-2.93|P-value:8.19E-4 ID:SGTC_762|Compound:1165-0429|FD-Score:3.03|P-value:3.69E-4 ID:SGTC_792|Compound:4534-1957|FD-Score:3.73|P-value:1.74E-5 ID:SGTC_796|Compound:1234-0020|FD-Score:-2.90|P-value:9.37E-4 ID:SGTC_867|Compound:0518-0118|FD-Score:-4.99|P-value:3.32E-8 ID:SGTC_875|Compound:0709-0210|FD-Score:3.33|P-value:1.09E-4 ID:SGTC_954|Compound:1189-0853|FD-Score:-3.02|P-value:5.96E-4 ID:SGTC_1138|Compound:3761-0006|FD-Score:2.86|P-value:7.25E-4 ID:SGTC_1140|Compound:3229-1848|FD-Score:3.46|P-value:6.19E-5 ID:SGTC_1813|Compound:st051246|FD-Score:3.19|P-value:1.97E-4 ID:SGTC_1840|Compound:st055363|FD-Score:4.50|P-value:3.21E-7 ID:SGTC_1908|Compound:st060353|FD-Score:5.40|P-value:1.21E-9 ID:SGTC_2134|Compound:5324836|FD-Score:2.83|P-value:8.10E-4 ID:SGTC_2136|Compound:5328288|FD-Score:-3.39|P-value:1.31E-4 ID:SGTC_2143|Compound:5623677|FD-Score:3.34|P-value:1.02E-4 ID:SGTC_2195|Compound:6536160|FD-Score:3.40|P-value:7.92E-5 ID:SGTC_2316|Compound:5844804|FD-Score:3.67|P-value:2.30E-5 ID:SGTC_2333|Compound:9017922|FD-Score:2.90|P-value:6.29E-4 ID:SGTC_2374|Compound:9071832|FD-Score:3.26|P-value:1.45E-4 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:3.91|P-value:7.27E-6 ID:SGTC_2814|Compound:7977482|FD-Score:4.38|P-value:6.19E-7 ID:SGTC_3317|Compound:9138495|FD-Score:-3.11|P-value:4.11E-4 ID:SGTC_3323|Compound:9138564|FD-Score:2.94|P-value:5.28E-4

Top fitness defect scores for YJL200C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1908 st060353 5.40 56.5 µM 1.21E-9 RPP1 & pyrimidine depletion 14 3.28E-8
2 SGTC_1840 st055363 4.50 71.0 µM 3.21E-7 5 3.42E-6
3 SGTC_2814 7977482 4.38 43.0 µM 6.19E-7 39 5.91E-6
4 SGTC_2595 hexamethylquercetagetin 3.91 100.0 µM 7.27E-6 26 4.60E-5
5 SGTC_792 4534-1957 3.73 155.0 µM 1.74E-5 43 9.52E-5
6 SGTC_2316 5844804 3.67 197.4 µM 2.30E-5 40 1.20E-4
7 SGTC_133 0724-0033 3.55 378.9 µM 4.07E-5 41 1.93E-4
8 SGTC_1140 3229-1848 3.46 3.0 µM 6.19E-5 18 2.74E-4
9 SGTC_2195 6536160 3.40 144.2 µM 7.92E-5 60S ribosome export 24 3.36E-4
10 SGTC_2143 5623677 3.34 140.5 µM 1.02E-4 14 4.16E-4
11 SGTC_875 0709-0210 3.33 25.7 µM 1.09E-4 fatty acid desaturase (OLE1) 55 4.38E-4
12 SGTC_2374 9071832 3.26 200.0 µM 1.45E-4 endomembrane recycling 22 5.58E-4
13 SGTC_1813 st051246 3.19 8.6 µM 1.97E-4 TSC3-RPN4 24 7.19E-4
14 SGTC_507 nimesulide 3.06 162.0 µM 3.30E-4 50 0.00110
15 SGTC_762 1165-0429 3.03 115.0 µM 3.69E-4 TSC3-RPN4 60 0.00121
16 SGTC_368 fentichlor 2.94 4.6 µM 5.24E-4 71 0.00163
17 SGTC_3323 9138564 2.94 53.9 µM 5.28E-4 71 0.00164
18 SGTC_532 1548-0774 2.92 215.0 µM 5.78E-4 59 0.00176
19 SGTC_2333 9017922 2.90 200.0 µM 6.29E-4 78 0.00189
20 SGTC_392 N-ethylmaleimide 2.86 8.3 µM 7.10E-4 RNA pol III & RNase P/MRP 58 0.00209

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.155 1.63E-19 YLR097C HRT3 hom Putative SCF-ubiquitin ligase F-box protein, based on both genetic and physical interactions and sequence similarity; identified in association with Cdc53p, Skp1p and Ubi4 in large and small-scale studies
0.114 3.06E-11 YPL096W PNG1 hom Conserved peptide N-glycanase required for deglycosylation of misfolded glycoproteins during proteasome-dependent degradation; localizes to the cytoplasm and nucleus; activity is enhanced by interaction with Rad23p
0.110 1.69E-10 YJR080C AIM24 hom Protein of unknown function; the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant displays reduced respiratory growth and elevated frequency of mitochondrial genome loss
0.108 3.79E-10 YHR131C_p YHR131C_p hom Putative protein of unknown function; GFP-fusion protein localizes to the cytoplasm; overexpression causes cell cycle delay or arrest; contains a PH domain and binds phosphatidylinositols and other lipids in a large-scale study
0.107 4.71E-10 YBR052C RFS1 hom Protein of unknown function; member of a flavodoxin-like fold protein family that includes Pst2p and Ycp4p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; RFS1 has a paralog, PST2, that arose from the whole genome duplication
0.106 8.44E-10 YKR015C_p YKR015C_p hom Putative protein of unknown function
0.104 1.37E-9 YNL038W GPI15 het Protein involved in the synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; homologous to the human PIG-H protein
0.103 2.18E-9 YPR195C_d YPR195C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.103 2.52E-9 YJR058C APS2 hom Small subunit of the clathrin-associated adaptor complex AP-2, which is involved in protein sorting at the plasma membrane; related to the sigma subunit of the mammalian plasma membrane clathrin-associated protein (AP-2) complex
0.099 8.49E-9 YDR020C_p DAS2_p hom Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; weak similarity with uridine kinases and with phosphoribokinases
0.095 3.47E-8 YMR253C_p YMR253C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; YMR253C is not an essential gene
0.093 6.88E-8 YML104C MDM1 hom Intermediate filament protein, required for nuclear and mitochondrial transmission to daughter buds; contains a Phox homology (PX) domain and specifically binds phosphatidylinositol 3-phosphate (PtdIns-3-P)
0.092 8.63E-8 YPL027W SMA1 hom Protein of unknown function involved in the assembly of the prospore membrane during sporulation; interacts with Spo14p
0.092 1.02E-7 YLL020C_d YLL020C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene KNS1
0.091 1.40E-7 YBL081W_p YBL081W_p hom Non-essential protein of unknown function; null mutation results in a decrease in plasma membrane electron transport