YJL201W / ECM25

Non-essential protein of unknown function; promoter contains a consensus binding sequence for factor Abf1p

Zygosity: Homozygous strain
fixedexpanded
Profile for YJL201W / ECM25

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:3.64|P-value:6.04E-5 ID:SGTC_151|Compound:3013-0144|FD-Score:3.47|P-value:1.26E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:-3.27|P-value:1.41E-4 ID:SGTC_422|Compound:cantharidin|FD-Score:-2.81|P-value:8.54E-4 ID:SGTC_433|Compound:pimozide|FD-Score:2.97|P-value:9.09E-4 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:4.02|P-value:1.03E-5 ID:SGTC_497|Compound:capsazepine|FD-Score:3.14|P-value:4.70E-4 ID:SGTC_554|Compound:4483-2211|FD-Score:3.49|P-value:1.13E-4 ID:SGTC_635|Compound:k038-0028|FD-Score:3.03|P-value:7.09E-4 ID:SGTC_675|Compound:1309-0189|FD-Score:5.21|P-value:1.40E-8 ID:SGTC_811|Compound:0416-0114|FD-Score:3.90|P-value:1.83E-5 ID:SGTC_870|Compound:0573-2213|FD-Score:3.45|P-value:1.36E-4 ID:SGTC_874|Compound:0599-0792|FD-Score:3.80|P-value:2.90E-5 ID:SGTC_876|Compound:0720-0963|FD-Score:4.01|P-value:1.07E-5 ID:SGTC_973|Compound:1325-0077|FD-Score:4.37|P-value:1.72E-6 ID:SGTC_977|Compound:1348-1378|FD-Score:2.95|P-value:9.63E-4 ID:SGTC_985|Compound:1493-0307|FD-Score:5.48|P-value:2.58E-9 ID:SGTC_987|Compound:1497-1013|FD-Score:3.34|P-value:2.14E-4 ID:SGTC_1022|Compound:4477-0945|FD-Score:4.76|P-value:2.03E-7 ID:SGTC_1064|Compound:honokiol|FD-Score:3.56|P-value:8.51E-5 ID:SGTC_1103|Compound:duloxetine|FD-Score:3.34|P-value:2.15E-4 ID:SGTC_1206|Compound:3978-0017|FD-Score:-3.18|P-value:1.99E-4 ID:SGTC_1229|Compound:0139-0193|FD-Score:3.67|P-value:5.28E-5 ID:SGTC_1233|Compound:0325-0408|FD-Score:3.39|P-value:1.75E-4 ID:SGTC_1304|Compound:1165-0502|FD-Score:3.79|P-value:3.05E-5 ID:SGTC_1342|Compound:1486-1464|FD-Score:3.22|P-value:3.39E-4 ID:SGTC_1469|Compound:k284-2957|FD-Score:2.95|P-value:9.52E-4 ID:SGTC_1477|Compound:0139-0234|FD-Score:6.14|P-value:2.87E-11 ID:SGTC_1479|Compound:0549-0158|FD-Score:5.64|P-value:8.84E-10 ID:SGTC_1490|Compound:4089-0339|FD-Score:3.51|P-value:1.06E-4 ID:SGTC_1578|Compound:josamycin|FD-Score:-4.55|P-value:2.67E-7 ID:SGTC_1582|Compound:3',3',6'-trihydroxyflavone|FD-Score:-3.07|P-value:3.20E-4 ID:SGTC_1583|Compound:clindamycin|FD-Score:-3.43|P-value:6.96E-5 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:-4.37|P-value:6.89E-7 ID:SGTC_1598|Compound:3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin|FD-Score:-5.51|P-value:7.05E-10 ID:SGTC_1723|Compound:st034307|FD-Score:3.66|P-value:5.51E-5 ID:SGTC_1730|Compound:st033808|FD-Score:-3.23|P-value:1.65E-4 ID:SGTC_1733|Compound:st037357|FD-Score:3.16|P-value:4.36E-4 ID:SGTC_1780|Compound:st038448|FD-Score:3.41|P-value:1.62E-4 ID:SGTC_1781|Compound:st038725|FD-Score:-3.18|P-value:2.01E-4 ID:SGTC_1782|Compound:st039423|FD-Score:-2.87|P-value:6.90E-4 ID:SGTC_1801|Compound:st050089|FD-Score:3.05|P-value:6.76E-4 ID:SGTC_1807|Compound:st050092|FD-Score:3.74|P-value:3.72E-5 ID:SGTC_1934|Compound:st074720|FD-Score:-5.06|P-value:1.23E-8 ID:SGTC_1937|Compound:st074714|FD-Score:-3.43|P-value:7.21E-5 ID:SGTC_1967|Compound:st070177|FD-Score:3.14|P-value:4.67E-4 ID:SGTC_1973|Compound:st070275|FD-Score:3.31|P-value:2.40E-4 ID:SGTC_1974|Compound:st069448|FD-Score:3.34|P-value:2.11E-4 ID:SGTC_2036|Compound:5160441|FD-Score:3.54|P-value:9.09E-5 ID:SGTC_2200|Compound:6600604|FD-Score:3.20|P-value:3.67E-4 ID:SGTC_2206|Compound:7254556|FD-Score:3.01|P-value:7.69E-4 ID:SGTC_2315|Compound:7733312|FD-Score:-2.89|P-value:6.33E-4 ID:SGTC_2356|Compound:9061756|FD-Score:3.60|P-value:7.20E-5 ID:SGTC_2438|Compound:5259590|FD-Score:3.79|P-value:2.99E-5 ID:SGTC_2452|Compound:5863136|FD-Score:-2.92|P-value:5.62E-4 ID:SGTC_2516|Compound:gossypol|FD-Score:4.03|P-value:9.96E-6 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:5.55|P-value:1.63E-9 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:-2.95|P-value:5.17E-4 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:-3.02|P-value:3.92E-4 ID:SGTC_2630|Compound:antimycin a|FD-Score:-2.98|P-value:4.58E-4 ID:SGTC_2754|Compound:granisetron|FD-Score:5.25|P-value:1.09E-8 ID:SGTC_2756|Compound:carbadox|FD-Score:7.25|P-value:4.51E-15 ID:SGTC_2759|Compound:disulfiram|FD-Score:-3.93|P-value:7.03E-6 ID:SGTC_2794|Compound:7785382|FD-Score:3.64|P-value:5.91E-5 ID:SGTC_2820|Compound:7989630|FD-Score:3.03|P-value:7.17E-4 ID:SGTC_2831|Compound:7999036|FD-Score:3.31|P-value:2.43E-4 ID:SGTC_2889|Compound:9059656|FD-Score:3.27|P-value:2.78E-4 ID:SGTC_2929|Compound:9013348|FD-Score:-3.28|P-value:1.32E-4 ID:SGTC_2938|Compound:9059746|FD-Score:7.43|P-value:8.92E-16 ID:SGTC_2973|Compound:9094665|FD-Score:-2.85|P-value:7.44E-4 ID:SGTC_3037|Compound:9091026|FD-Score:3.42|P-value:1.53E-4 ID:SGTC_3138|Compound:9097216|FD-Score:-4.06|P-value:3.56E-6 ID:SGTC_3143|Compound:9086658|FD-Score:4.88|P-value:1.04E-7 ID:SGTC_3144|Compound:9087057|FD-Score:3.04|P-value:7.02E-4 ID:SGTC_3263|Compound:9137018|FD-Score:3.20|P-value:3.70E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:3.64|P-value:6.04E-5 ID:SGTC_151|Compound:3013-0144|FD-Score:3.47|P-value:1.26E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:-3.27|P-value:1.41E-4 ID:SGTC_422|Compound:cantharidin|FD-Score:-2.81|P-value:8.54E-4 ID:SGTC_433|Compound:pimozide|FD-Score:2.97|P-value:9.09E-4 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:4.02|P-value:1.03E-5 ID:SGTC_497|Compound:capsazepine|FD-Score:3.14|P-value:4.70E-4 ID:SGTC_554|Compound:4483-2211|FD-Score:3.49|P-value:1.13E-4 ID:SGTC_635|Compound:k038-0028|FD-Score:3.03|P-value:7.09E-4 ID:SGTC_675|Compound:1309-0189|FD-Score:5.21|P-value:1.40E-8 ID:SGTC_811|Compound:0416-0114|FD-Score:3.90|P-value:1.83E-5 ID:SGTC_870|Compound:0573-2213|FD-Score:3.45|P-value:1.36E-4 ID:SGTC_874|Compound:0599-0792|FD-Score:3.80|P-value:2.90E-5 ID:SGTC_876|Compound:0720-0963|FD-Score:4.01|P-value:1.07E-5 ID:SGTC_973|Compound:1325-0077|FD-Score:4.37|P-value:1.72E-6 ID:SGTC_977|Compound:1348-1378|FD-Score:2.95|P-value:9.63E-4 ID:SGTC_985|Compound:1493-0307|FD-Score:5.48|P-value:2.58E-9 ID:SGTC_987|Compound:1497-1013|FD-Score:3.34|P-value:2.14E-4 ID:SGTC_1022|Compound:4477-0945|FD-Score:4.76|P-value:2.03E-7 ID:SGTC_1064|Compound:honokiol|FD-Score:3.56|P-value:8.51E-5 ID:SGTC_1103|Compound:duloxetine|FD-Score:3.34|P-value:2.15E-4 ID:SGTC_1206|Compound:3978-0017|FD-Score:-3.18|P-value:1.99E-4 ID:SGTC_1229|Compound:0139-0193|FD-Score:3.67|P-value:5.28E-5 ID:SGTC_1233|Compound:0325-0408|FD-Score:3.39|P-value:1.75E-4 ID:SGTC_1304|Compound:1165-0502|FD-Score:3.79|P-value:3.05E-5 ID:SGTC_1342|Compound:1486-1464|FD-Score:3.22|P-value:3.39E-4 ID:SGTC_1469|Compound:k284-2957|FD-Score:2.95|P-value:9.52E-4 ID:SGTC_1477|Compound:0139-0234|FD-Score:6.14|P-value:2.87E-11 ID:SGTC_1479|Compound:0549-0158|FD-Score:5.64|P-value:8.84E-10 ID:SGTC_1490|Compound:4089-0339|FD-Score:3.51|P-value:1.06E-4 ID:SGTC_1578|Compound:josamycin|FD-Score:-4.55|P-value:2.67E-7 ID:SGTC_1582|Compound:3',3',6'-trihydroxyflavone|FD-Score:-3.07|P-value:3.20E-4 ID:SGTC_1583|Compound:clindamycin|FD-Score:-3.43|P-value:6.96E-5 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:-4.37|P-value:6.89E-7 ID:SGTC_1598|Compound:3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin|FD-Score:-5.51|P-value:7.05E-10 ID:SGTC_1723|Compound:st034307|FD-Score:3.66|P-value:5.51E-5 ID:SGTC_1730|Compound:st033808|FD-Score:-3.23|P-value:1.65E-4 ID:SGTC_1733|Compound:st037357|FD-Score:3.16|P-value:4.36E-4 ID:SGTC_1780|Compound:st038448|FD-Score:3.41|P-value:1.62E-4 ID:SGTC_1781|Compound:st038725|FD-Score:-3.18|P-value:2.01E-4 ID:SGTC_1782|Compound:st039423|FD-Score:-2.87|P-value:6.90E-4 ID:SGTC_1801|Compound:st050089|FD-Score:3.05|P-value:6.76E-4 ID:SGTC_1807|Compound:st050092|FD-Score:3.74|P-value:3.72E-5 ID:SGTC_1934|Compound:st074720|FD-Score:-5.06|P-value:1.23E-8 ID:SGTC_1937|Compound:st074714|FD-Score:-3.43|P-value:7.21E-5 ID:SGTC_1967|Compound:st070177|FD-Score:3.14|P-value:4.67E-4 ID:SGTC_1973|Compound:st070275|FD-Score:3.31|P-value:2.40E-4 ID:SGTC_1974|Compound:st069448|FD-Score:3.34|P-value:2.11E-4 ID:SGTC_2036|Compound:5160441|FD-Score:3.54|P-value:9.09E-5 ID:SGTC_2200|Compound:6600604|FD-Score:3.20|P-value:3.67E-4 ID:SGTC_2206|Compound:7254556|FD-Score:3.01|P-value:7.69E-4 ID:SGTC_2315|Compound:7733312|FD-Score:-2.89|P-value:6.33E-4 ID:SGTC_2356|Compound:9061756|FD-Score:3.60|P-value:7.20E-5 ID:SGTC_2438|Compound:5259590|FD-Score:3.79|P-value:2.99E-5 ID:SGTC_2452|Compound:5863136|FD-Score:-2.92|P-value:5.62E-4 ID:SGTC_2516|Compound:gossypol|FD-Score:4.03|P-value:9.96E-6 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:5.55|P-value:1.63E-9 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:-2.95|P-value:5.17E-4 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:-3.02|P-value:3.92E-4 ID:SGTC_2630|Compound:antimycin a|FD-Score:-2.98|P-value:4.58E-4 ID:SGTC_2754|Compound:granisetron|FD-Score:5.25|P-value:1.09E-8 ID:SGTC_2756|Compound:carbadox|FD-Score:7.25|P-value:4.51E-15 ID:SGTC_2759|Compound:disulfiram|FD-Score:-3.93|P-value:7.03E-6 ID:SGTC_2794|Compound:7785382|FD-Score:3.64|P-value:5.91E-5 ID:SGTC_2820|Compound:7989630|FD-Score:3.03|P-value:7.17E-4 ID:SGTC_2831|Compound:7999036|FD-Score:3.31|P-value:2.43E-4 ID:SGTC_2889|Compound:9059656|FD-Score:3.27|P-value:2.78E-4 ID:SGTC_2929|Compound:9013348|FD-Score:-3.28|P-value:1.32E-4 ID:SGTC_2938|Compound:9059746|FD-Score:7.43|P-value:8.92E-16 ID:SGTC_2973|Compound:9094665|FD-Score:-2.85|P-value:7.44E-4 ID:SGTC_3037|Compound:9091026|FD-Score:3.42|P-value:1.53E-4 ID:SGTC_3138|Compound:9097216|FD-Score:-4.06|P-value:3.56E-6 ID:SGTC_3143|Compound:9086658|FD-Score:4.88|P-value:1.04E-7 ID:SGTC_3144|Compound:9087057|FD-Score:3.04|P-value:7.02E-4 ID:SGTC_3263|Compound:9137018|FD-Score:3.20|P-value:3.70E-4

Top fitness defect scores for YJL201W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2938 9059746 7.43 27.3 µM 8.92E-16 fatty acid desaturase (OLE1) 7 5.29E-14
2 SGTC_2756 carbadox 7.25 75.1 µM 4.51E-15 10 2.15E-13
3 SGTC_1477 0139-0234 6.14 16.0 µM 2.87E-11 1 4.24E-10
4 SGTC_1479 0549-0158 5.64 134.0 µM 8.84E-10 3 8.33E-9
5 SGTC_2567 aureobasidin a 5.55 60.0 nM 1.63E-9 50 1.41E-8
6 SGTC_985 1493-0307 5.48 8.7 µM 2.58E-9 TSC3-RPN4 8 2.11E-8
7 SGTC_2754 granisetron 5.25 64.0 µM 1.09E-8 16 7.40E-8
8 SGTC_675 1309-0189 5.21 238.0 µM 1.40E-8 4 9.21E-8
9 SGTC_3143 9086658 4.88 49.5 µM 1.04E-7 18 5.28E-7
10 SGTC_1022 4477-0945 4.76 21.3 µM 2.03E-7 8 9.46E-7
11 SGTC_973 1325-0077 4.37 65.9 µM 1.72E-6 3 6.10E-6
12 SGTC_2516 gossypol 4.03 71.5 µM 9.96E-6 12 2.84E-5
13 SGTC_436 n,n-dimethylsphingosine 4.02 3.3 µM 1.03E-5 25 2.94E-5
14 SGTC_876 0720-0963 4.01 56.8 µM 1.07E-5 14 3.04E-5
15 SGTC_811 0416-0114 3.90 265.0 µM 1.83E-5 22 4.84E-5
16 SGTC_874 0599-0792 3.80 117.0 µM 2.90E-5 31 7.27E-5
17 SGTC_2438 5259590 3.79 200.0 µM 2.99E-5 21 7.46E-5
18 SGTC_1304 1165-0502 3.79 251.0 µM 3.05E-5 64 7.58E-5
19 SGTC_1807 st050092 3.74 58.9 µM 3.72E-5 60S ribosome export 16 9.03E-5
20 SGTC_1229 0139-0193 3.67 12.2 µM 5.28E-5 RSC complex & mRNA processing 19 1.23E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.177 6.09E-25 YKL004W AUR1 het Phosphatidylinositol:ceramide phosphoinositol transferase (IPC synthase), required for sphingolipid synthesis; can mutate to confer aureobasidin A resistance
0.130 3.89E-14 YPL116W HOS3 hom Trichostatin A-insensitive homodimeric histone deacetylase (HDAC) with specificity in vitro for histones H3, H4, H2A, and H2B; similar to Hda1p, Rpd3p, Hos1p, and Hos2p; deletion results in increased histone acetylation at rDNA repeats
0.118 5.92E-12 YDR367W KEI1 het Component of inositol phosphorylceramide (IPC) synthase; forms a complex with Aur1p and regulates its activity; required for IPC synthase complex localization to the Golgi; post-translationally processed by Kex2p; KEI1 is an essential gene
0.118 8.25E-12 YOL137W BSC6 hom Protein of unknown function containing 8 putative transmembrane seqments; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression
0.110 1.70E-10 YGL210W YPT32 hom Rab family GTPase involved in the exocytic pathway; mediates intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi; protein abundance increases in response to DNA replication stress; YPT32 has a paralog, YPT31, that arose from the whole genome duplication
0.108 4.08E-10 YJL192C SOP4 hom ER-membrane protein; suppressor of pma1-7, deletion of SOP4 slows down the export of wild-type Pma1p and Pma1-7 from the ER
0.104 1.30E-9 YBR110W ALG1 het Mannosyltransferase, involved in asparagine-linked glycosylation in the endoplasmic reticulum (ER); essential for viability, mutation is functionally complemented by human ortholog
0.104 1.38E-9 YPL220W RPL1A hom Ribosomal 60S subunit protein L1A; N-terminally acetylated; homologous to mammalian ribosomal protein L10A and bacterial L1; RPL1A has a paralog, RPL1B, that arose from the whole genome duplication; rpl1a rpl1b double null mutation is lethal
0.103 1.96E-9 YGR201C_p YGR201C_p hom Putative protein of unknown function
0.098 1.18E-8 YBR244W GPX2 hom Phospholipid hydroperoxide glutathione peroxidase; protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress; induced by glucose starvation; protein abundance increases in response to DNA replication stress
0.097 2.03E-8 YDR239C YDR239C hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments
0.094 5.72E-8 YOL014W_p YOL014W_p hom Putative protein of unknown function
0.093 6.04E-8 YMR182W-A_p YMR182W-A_p hom Putative protein of unknown function
0.087 4.92E-7 YDR132C YDR132C hom Protein of unknown function; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress; YDR132C has a paralog, YLR108C, that arose from the whole genome duplication
0.086 5.73E-7 YCL005W LDB16 hom Protein of unknown function; null mutants have decreased net negative cell surface charge; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; native protein is detected in purified mitochondria