YJL202C_d

Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 3' end of essential PRP21 gene encoding a subunit of the SF3a splicing factor complex

Zygosity: Heterozygous strain
fixedexpanded
Profile for YJL202C / YJL202C

Click on Significant Values for Screen Details ID:SGTC_20|Compound:0481-0013|FD-Score:4.47|P-value:8.70E-6 ID:SGTC_133|Compound:0724-0033|FD-Score:3.35|P-value:6.39E-4 ID:SGTC_150|Compound:3970-0969|FD-Score:3.26|P-value:8.72E-4 ID:SGTC_159|Compound:3970-0959|FD-Score:5.23|P-value:2.38E-7 ID:SGTC_164|Compound:4100-3994|FD-Score:-3.48|P-value:3.84E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:7.20|P-value:2.13E-12 ID:SGTC_207|Compound:4185-0010|FD-Score:-3.46|P-value:4.05E-4 ID:SGTC_208|Compound:k072-0098|FD-Score:-3.64|P-value:2.14E-4 ID:SGTC_377|Compound:3970-0964|FD-Score:4.19|P-value:2.84E-5 ID:SGTC_422|Compound:cantharidin|FD-Score:3.62|P-value:2.54E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:4.82|P-value:1.81E-6 ID:SGTC_724|Compound:3910-0327|FD-Score:3.55|P-value:3.23E-4 ID:SGTC_734|Compound:2023-0417|FD-Score:3.52|P-value:3.56E-4 ID:SGTC_786|Compound:4544-0069|FD-Score:3.28|P-value:7.99E-4 ID:SGTC_790|Compound:1575-0012|FD-Score:-3.70|P-value:1.74E-4 ID:SGTC_969|Compound:1313-0238|FD-Score:5.72|P-value:1.85E-8 ID:SGTC_982|Compound:1491-0518|FD-Score:3.27|P-value:8.42E-4 ID:SGTC_983|Compound:1491-0821|FD-Score:3.73|P-value:1.70E-4 ID:SGTC_984|Compound:1492-0255|FD-Score:4.15|P-value:3.31E-5 ID:SGTC_1049|Compound:3226-0134|FD-Score:5.53|P-value:5.21E-8 ID:SGTC_1067|Compound:clotrimazole|FD-Score:3.89|P-value:9.19E-5 ID:SGTC_1234|Compound:0326-0494|FD-Score:3.43|P-value:4.84E-4 ID:SGTC_1335|Compound:1486-0900|FD-Score:3.58|P-value:2.89E-4 ID:SGTC_1337|Compound:1486-1011|FD-Score:3.87|P-value:9.91E-5 ID:SGTC_1524|Compound:corynanthine|FD-Score:-6.27|P-value:7.07E-10 ID:SGTC_1613|Compound:st002381|FD-Score:3.28|P-value:7.98E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:3.66|P-value:2.14E-4 ID:SGTC_1797|Compound:st048695|FD-Score:-3.36|P-value:5.84E-4 ID:SGTC_1885|Compound:st057546|FD-Score:3.99|P-value:6.28E-5 ID:SGTC_2139|Compound:5578692|FD-Score:-3.24|P-value:8.78E-4 ID:SGTC_2150|Compound:5556613|FD-Score:4.45|P-value:9.30E-6 ID:SGTC_2233|Compound:sulbentine|FD-Score:4.10|P-value:4.05E-5 ID:SGTC_2248|Compound:tofa|FD-Score:3.76|P-value:1.53E-4 ID:SGTC_2270|Compound:7924575|FD-Score:3.45|P-value:4.60E-4 ID:SGTC_2390|Compound:9097792|FD-Score:-4.13|P-value:3.31E-5 ID:SGTC_2418|Compound:pentamidine|FD-Score:-3.70|P-value:1.78E-4 ID:SGTC_2515|Compound:chrysin|FD-Score:-3.48|P-value:3.86E-4 ID:SGTC_2521|Compound:angolensin|FD-Score:-3.71|P-value:1.71E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:3.95|P-value:7.38E-5 ID:SGTC_2601|Compound:securinine|FD-Score:-3.24|P-value:8.57E-4 ID:SGTC_2624|Compound:nerol|FD-Score:3.56|P-value:3.09E-4 ID:SGTC_2682|Compound:pyrogallin|FD-Score:4.03|P-value:5.25E-5 ID:SGTC_2769|Compound:toremifene|FD-Score:3.32|P-value:7.16E-4 ID:SGTC_2773|Compound:thioridazine|FD-Score:3.63|P-value:2.45E-4 ID:SGTC_2881|Compound:9058953|FD-Score:4.15|P-value:3.23E-5 ID:SGTC_2978|Compound:9011784|FD-Score:4.69|P-value:3.29E-6 ID:SGTC_2996|Compound:9066192|FD-Score:3.94|P-value:7.57E-5 ID:SGTC_3050|Compound:9093513|FD-Score:-3.99|P-value:5.87E-5 ID:SGTC_3274|Compound:9138298|FD-Score:5.47|P-value:7.27E-8 ID:SGTC_3312|Compound:9133330|FD-Score:4.23|P-value:2.36E-5 ID:SGTC_20|Compound:0481-0013|FD-Score:4.47|P-value:8.70E-6 ID:SGTC_133|Compound:0724-0033|FD-Score:3.35|P-value:6.39E-4 ID:SGTC_150|Compound:3970-0969|FD-Score:3.26|P-value:8.72E-4 ID:SGTC_159|Compound:3970-0959|FD-Score:5.23|P-value:2.38E-7 ID:SGTC_164|Compound:4100-3994|FD-Score:-3.48|P-value:3.84E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:7.20|P-value:2.13E-12 ID:SGTC_207|Compound:4185-0010|FD-Score:-3.46|P-value:4.05E-4 ID:SGTC_208|Compound:k072-0098|FD-Score:-3.64|P-value:2.14E-4 ID:SGTC_377|Compound:3970-0964|FD-Score:4.19|P-value:2.84E-5 ID:SGTC_422|Compound:cantharidin|FD-Score:3.62|P-value:2.54E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:4.82|P-value:1.81E-6 ID:SGTC_724|Compound:3910-0327|FD-Score:3.55|P-value:3.23E-4 ID:SGTC_734|Compound:2023-0417|FD-Score:3.52|P-value:3.56E-4 ID:SGTC_786|Compound:4544-0069|FD-Score:3.28|P-value:7.99E-4 ID:SGTC_790|Compound:1575-0012|FD-Score:-3.70|P-value:1.74E-4 ID:SGTC_969|Compound:1313-0238|FD-Score:5.72|P-value:1.85E-8 ID:SGTC_982|Compound:1491-0518|FD-Score:3.27|P-value:8.42E-4 ID:SGTC_983|Compound:1491-0821|FD-Score:3.73|P-value:1.70E-4 ID:SGTC_984|Compound:1492-0255|FD-Score:4.15|P-value:3.31E-5 ID:SGTC_1049|Compound:3226-0134|FD-Score:5.53|P-value:5.21E-8 ID:SGTC_1067|Compound:clotrimazole|FD-Score:3.89|P-value:9.19E-5 ID:SGTC_1234|Compound:0326-0494|FD-Score:3.43|P-value:4.84E-4 ID:SGTC_1335|Compound:1486-0900|FD-Score:3.58|P-value:2.89E-4 ID:SGTC_1337|Compound:1486-1011|FD-Score:3.87|P-value:9.91E-5 ID:SGTC_1524|Compound:corynanthine|FD-Score:-6.27|P-value:7.07E-10 ID:SGTC_1613|Compound:st002381|FD-Score:3.28|P-value:7.98E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:3.66|P-value:2.14E-4 ID:SGTC_1797|Compound:st048695|FD-Score:-3.36|P-value:5.84E-4 ID:SGTC_1885|Compound:st057546|FD-Score:3.99|P-value:6.28E-5 ID:SGTC_2139|Compound:5578692|FD-Score:-3.24|P-value:8.78E-4 ID:SGTC_2150|Compound:5556613|FD-Score:4.45|P-value:9.30E-6 ID:SGTC_2233|Compound:sulbentine|FD-Score:4.10|P-value:4.05E-5 ID:SGTC_2248|Compound:tofa|FD-Score:3.76|P-value:1.53E-4 ID:SGTC_2270|Compound:7924575|FD-Score:3.45|P-value:4.60E-4 ID:SGTC_2390|Compound:9097792|FD-Score:-4.13|P-value:3.31E-5 ID:SGTC_2418|Compound:pentamidine|FD-Score:-3.70|P-value:1.78E-4 ID:SGTC_2515|Compound:chrysin|FD-Score:-3.48|P-value:3.86E-4 ID:SGTC_2521|Compound:angolensin|FD-Score:-3.71|P-value:1.71E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:3.95|P-value:7.38E-5 ID:SGTC_2601|Compound:securinine|FD-Score:-3.24|P-value:8.57E-4 ID:SGTC_2624|Compound:nerol|FD-Score:3.56|P-value:3.09E-4 ID:SGTC_2682|Compound:pyrogallin|FD-Score:4.03|P-value:5.25E-5 ID:SGTC_2769|Compound:toremifene|FD-Score:3.32|P-value:7.16E-4 ID:SGTC_2773|Compound:thioridazine|FD-Score:3.63|P-value:2.45E-4 ID:SGTC_2881|Compound:9058953|FD-Score:4.15|P-value:3.23E-5 ID:SGTC_2978|Compound:9011784|FD-Score:4.69|P-value:3.29E-6 ID:SGTC_2996|Compound:9066192|FD-Score:3.94|P-value:7.57E-5 ID:SGTC_3050|Compound:9093513|FD-Score:-3.99|P-value:5.87E-5 ID:SGTC_3274|Compound:9138298|FD-Score:5.47|P-value:7.27E-8 ID:SGTC_3312|Compound:9133330|FD-Score:4.23|P-value:2.36E-5

Top fitness defect scores for YJL202C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_168 3970-0862 7.20 530.5 µM 2.13E-12 13 3.06E-13 0.33
2 SGTC_969 1313-0238 5.72 134.0 µM 1.85E-8 mitochondrial processes 6 5.28E-9 0.07
3 SGTC_1049 3226-0134 5.53 66.0 µM 5.21E-8 5 1.61E-8 1.21
4 SGTC_3274 9138298 5.47 49.5 µM 7.27E-8 2 2.31E-8 0.59
5 SGTC_159 3970-0959 5.23 50.0 µM 2.38E-7 11 8.29E-8 0.62
6 SGTC_513 4245-1575 4.82 41.7 µM 1.81E-6 unfolded protein response 19 7.34E-7 0.02
7 SGTC_2978 9011784 4.69 43.0 µM 3.29E-6 3 1.39E-6 0.54
8 SGTC_20 0481-0013 4.47 4.9 µM 8.70E-6 4 3.97E-6 0.43
9 SGTC_2150 5556613 4.45 200.0 µM 9.30E-6 2 4.26E-6 0.45
10 SGTC_3312 9133330 4.23 71.4 µM 2.36E-5 3 1.16E-5 0.31
11 SGTC_377 3970-0964 4.19 33.1 µM 2.84E-5 5 1.41E-5 9.71E-4
12 SGTC_2881 9058953 4.15 52.0 µM 3.23E-5 4 1.63E-5 0.14
13 SGTC_984 1492-0255 4.15 2.9 µM 3.31E-5 SWF1 & branched chain AA biosynthesis 7 1.67E-5 1.12
14 SGTC_2233 sulbentine 4.10 40.4 µM 4.05E-5 35 2.07E-5 0.01
15 SGTC_2682 pyrogallin 4.03 40.0 µM 5.25E-5 copper-dependent oxidative stress 3 2.74E-5 0.27
16 SGTC_1885 st057546 3.99 99.9 µM 6.28E-5 2 3.32E-5 0.45
17 SGTC_2584 androsterone 3.95 48.7 µM 7.38E-5 cell wall 27 3.96E-5 0.04
18 SGTC_2996 9066192 3.94 71.4 µM 7.57E-5 8 4.06E-5 0.13
19 SGTC_1067 clotrimazole 3.89 1.4 µM 9.19E-5 azole & statin 21 5.00E-5 0.28
20 SGTC_1337 1486-1011 3.87 40.3 µM 9.91E-5 4 5.42E-5 0.54

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.178 2.99E-25 YDR005C MAF1 hom Highly conserved negative regulator of RNA polymerase III; binds to the N-terminal domain of the Rpc160p subunit of Pol III to prevent closed-complex formation; localization and activity are regulated by phosphorylation, mediated by TORC1, protein kinase A, and Sch9p; localizes to cytoplasm during vegetative growth and translocates to the nucleus and nucleolus under stress conditions
0.173 7.69E-24 YJL101C GSH1 hom Gamma glutamylcysteine synthetase; catalyzes the first step in glutathione (GSH) biosynthesis; expression induced by oxidants, cadmium, and mercury; protein abundance increases in response to DNA replication stress
0.156 9.54E-20 YOL049W GSH2 hom Glutathione synthetase, catalyzes the ATP-dependent synthesis of glutathione (GSH) from gamma-glutamylcysteine and glycine; induced by oxidative stress and heat shock
0.151 1.75E-18 YDR069C DOA4 hom Ubiquitin isopeptidase, required for recycling ubiquitin from proteasome-bound ubiquitinated intermediates, acts at the late endosome/prevacuolar compartment to recover ubiquitin from ubiquitinated membrane proteins en route to the vacuole
0.136 2.25E-15 YFR002W NIC96 het Linker nucleoporin component of the nuclear pore complex (NPC); also part of the NPC nuclear basket; contributes to nucleocytoplasmic transport and NPC biogenesis; forms stable associations with three FG-nucleoporins (Nsp1p, Nup57p, and Nup49p)
0.125 3.57E-13 YOL034W SMC5 het Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; binds single-stranded DNA and has ATPase activity; S. pombe homolog forms a heterodimer with S. pombe Rad18p that is involved in DNA repair
0.120 2.76E-12 YFL033C RIM15 hom Glucose-repressible protein kinase involved in signal transduction during cell proliferation in response to nutrients, specifically the establishment of stationary phase; identified as a regulator of IME2; substrate of Pho80p-Pho85p kinase
0.118 6.53E-12 YHR177W_p YHR177W_p hom Putative protein of unknown function; overexpression causes a cell cycle delay or arrest
0.109 2.30E-10 YDR049W VMS1 hom Component of a Cdc48p-complex involved in protein quality control; exhibits cytosolic and ER-membrane localization, with Cdc48p, during normal growth, and contributes to ER-associated degradation (ERAD) of specific substrates at a step after their ubiquitination; forms a mitochondrially-associated complex with Cdc48p and Npl4p under oxidative stress that is required for ubiquitin-mediated mitochondria-associated protein degradation (MAD); conserved in C. elegans and humans
0.103 2.62E-9 YDR032C PST2 hom Protein with similarity to a family of flavodoxin-like proteins; induced by oxidative stress in a Yap1p dependent manner; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress; PST2 has a paralog, RFS1, that arose from the whole genome duplication
0.102 3.04E-9 YJL054W TIM54 het Component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane
0.099 1.05E-8 YHR205W SCH9 hom AGC family protein kinase; functional ortholog of mammalian S6 kinase; phosphorylated by Tor1p and required for TORC1-mediated regulation of ribosome biogenesis, translation initiation, and entry into G0 phase; involved in transactivation of osmostress-responsive genes; regulates G1 progression, cAPK activity and nitrogen activation of the FGM pathway; integrates nutrient signals and stress signals from sphingolipids to regulate lifespan
0.098 1.31E-8 YDR001C NTH1 hom Neutral trehalase, degrades trehalose; required for thermotolerance and may mediate resistance to other cellular stresses; may be phosphorylated by Cdc28p; NTH1 has a paralog, NTH2, that arose from the whole genome duplication
0.097 1.63E-8 YBR198C TAF5 het Subunit (90 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification
0.097 1.60E-8 YOR091W TMA46 hom Protein of unknown function that associates with translating ribosomes; interacts with GTPase Rbg1p