YJL203W / PRP21

Subunit of the SF3a splicing factor complex, required for spliceosome assembly

Zygosity: Heterozygous strain
fixedexpanded
Profile for YJL203W / PRP21

Click on Significant Values for Screen Details ID:SGTC_144|Compound:4161-2749|FD-Score:-3.15|P-value:2.17E-4 ID:SGTC_150|Compound:3970-0969|FD-Score:3.06|P-value:3.93E-4 ID:SGTC_154|Compound:3389-1638|FD-Score:3.31|P-value:1.36E-4 ID:SGTC_317|Compound:4495-0002|FD-Score:-2.93|P-value:5.42E-4 ID:SGTC_330|Compound:1488-0319|FD-Score:3.00|P-value:4.94E-4 ID:SGTC_337|Compound:1315-0038|FD-Score:3.66|P-value:2.83E-5 ID:SGTC_392|Compound:N-ethylmaleimide|FD-Score:-3.48|P-value:5.30E-5 ID:SGTC_500|Compound:h-89|FD-Score:2.93|P-value:6.54E-4 ID:SGTC_716|Compound:1683-5115|FD-Score:2.92|P-value:6.78E-4 ID:SGTC_728|Compound:3030-5151|FD-Score:3.59|P-value:3.95E-5 ID:SGTC_892|Compound:0929-0076|FD-Score:3.38|P-value:1.03E-4 ID:SGTC_953|Compound:1188-0045|FD-Score:3.24|P-value:1.88E-4 ID:SGTC_956|Compound:1185-0240|FD-Score:3.35|P-value:1.16E-4 ID:SGTC_968|Compound:1309-0633|FD-Score:3.67|P-value:2.64E-5 ID:SGTC_1132|Compound:3456-3614|FD-Score:2.97|P-value:5.46E-4 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:2.86|P-value:8.30E-4 ID:SGTC_1136|Compound:pergolide|FD-Score:4.43|P-value:5.32E-7 ID:SGTC_1588|Compound:farnesol|FD-Score:-2.78|P-value:9.66E-4 ID:SGTC_1623|Compound:st003709|FD-Score:-3.15|P-value:2.23E-4 ID:SGTC_2004|Compound:4023728|FD-Score:3.41|P-value:8.96E-5 ID:SGTC_2005|Compound:4024620|FD-Score:-3.96|P-value:5.18E-6 ID:SGTC_2032|Compound:5185112|FD-Score:2.88|P-value:7.90E-4 ID:SGTC_2329|Compound:6138490|FD-Score:4.46|P-value:4.57E-7 ID:SGTC_2341|Compound:7987486|FD-Score:2.85|P-value:8.88E-4 ID:SGTC_2352|Compound:9027995|FD-Score:-2.96|P-value:4.83E-4 ID:SGTC_2431|Compound:5490079|FD-Score:2.98|P-value:5.37E-4 ID:SGTC_2852|Compound:9023854|FD-Score:3.25|P-value:1.79E-4 ID:SGTC_2899|Compound:9053889|FD-Score:3.26|P-value:1.68E-4 ID:SGTC_144|Compound:4161-2749|FD-Score:-3.15|P-value:2.17E-4 ID:SGTC_150|Compound:3970-0969|FD-Score:3.06|P-value:3.93E-4 ID:SGTC_154|Compound:3389-1638|FD-Score:3.31|P-value:1.36E-4 ID:SGTC_317|Compound:4495-0002|FD-Score:-2.93|P-value:5.42E-4 ID:SGTC_330|Compound:1488-0319|FD-Score:3.00|P-value:4.94E-4 ID:SGTC_337|Compound:1315-0038|FD-Score:3.66|P-value:2.83E-5 ID:SGTC_392|Compound:N-ethylmaleimide|FD-Score:-3.48|P-value:5.30E-5 ID:SGTC_500|Compound:h-89|FD-Score:2.93|P-value:6.54E-4 ID:SGTC_716|Compound:1683-5115|FD-Score:2.92|P-value:6.78E-4 ID:SGTC_728|Compound:3030-5151|FD-Score:3.59|P-value:3.95E-5 ID:SGTC_892|Compound:0929-0076|FD-Score:3.38|P-value:1.03E-4 ID:SGTC_953|Compound:1188-0045|FD-Score:3.24|P-value:1.88E-4 ID:SGTC_956|Compound:1185-0240|FD-Score:3.35|P-value:1.16E-4 ID:SGTC_968|Compound:1309-0633|FD-Score:3.67|P-value:2.64E-5 ID:SGTC_1132|Compound:3456-3614|FD-Score:2.97|P-value:5.46E-4 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:2.86|P-value:8.30E-4 ID:SGTC_1136|Compound:pergolide|FD-Score:4.43|P-value:5.32E-7 ID:SGTC_1588|Compound:farnesol|FD-Score:-2.78|P-value:9.66E-4 ID:SGTC_1623|Compound:st003709|FD-Score:-3.15|P-value:2.23E-4 ID:SGTC_2004|Compound:4023728|FD-Score:3.41|P-value:8.96E-5 ID:SGTC_2005|Compound:4024620|FD-Score:-3.96|P-value:5.18E-6 ID:SGTC_2032|Compound:5185112|FD-Score:2.88|P-value:7.90E-4 ID:SGTC_2329|Compound:6138490|FD-Score:4.46|P-value:4.57E-7 ID:SGTC_2341|Compound:7987486|FD-Score:2.85|P-value:8.88E-4 ID:SGTC_2352|Compound:9027995|FD-Score:-2.96|P-value:4.83E-4 ID:SGTC_2431|Compound:5490079|FD-Score:2.98|P-value:5.37E-4 ID:SGTC_2852|Compound:9023854|FD-Score:3.25|P-value:1.79E-4 ID:SGTC_2899|Compound:9053889|FD-Score:3.26|P-value:1.68E-4

Top fitness defect scores for YJL203W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2329 6138490 4.46 200.0 µM 4.57E-7 7 4.14E-6 0.02
2 SGTC_1136 pergolide 4.43 1.1 µM 5.32E-7 10 4.70E-6 0.27
3 SGTC_968 1309-0633 3.67 340.0 µM 2.64E-5 6 1.19E-4 0.07
4 SGTC_337 1315-0038 3.66 354.0 µM 2.83E-5 amide catabolism 7 1.26E-4 0.62
5 SGTC_728 3030-5151 3.59 22.5 µM 3.95E-5 4 1.66E-4 0.44
6 SGTC_2004 4023728 3.41 41.9 µM 8.96E-5 34 3.28E-4 0.08
7 SGTC_892 0929-0076 3.38 29.0 µM 1.03E-4 TRP & mitochondrial translation 6 3.67E-4 0.03
8 SGTC_956 1185-0240 3.35 191.0 µM 1.16E-4 7 4.06E-4 0.06
9 SGTC_154 3389-1638 3.31 511.1 µM 1.36E-4 11 4.62E-4 0.04
10 SGTC_2899 9053889 3.26 58.4 µM 1.68E-4 5 5.54E-4 0.22
11 SGTC_2852 9023854 3.25 52.0 µM 1.79E-4 14 5.83E-4 0.03
12 SGTC_953 1188-0045 3.24 9.7 µM 1.88E-4 60S ribosome export 16 6.07E-4 0.02
13 SGTC_150 3970-0969 3.06 77.2 µM 3.93E-4 44 0.00112 0.05
14 SGTC_330 1488-0319 3.00 80.1 µM 4.94E-4 RPP1 & pyrimidine depletion 20 0.00135 0.07
15 SGTC_2431 5490079 2.98 200.0 µM 5.37E-4 18 0.00145 0.02
16 SGTC_1132 3456-3614 2.97 2.5 µM 5.46E-4 tubulin folding & SWR complex 16 0.00147 0.04
17 SGTC_500 h-89 2.93 112.0 µM 6.54E-4 cell wall signaling 22 0.00171 0.09
18 SGTC_716 1683-5115 2.92 658.0 µM 6.78E-4 13 0.00176 4.91E-4
19 SGTC_2032 5185112 2.88 26.0 µM 7.90E-4 3 0.00201 0.12
20 SGTC_1135 dihydrocapsaicin 2.86 536.7 nM 8.30E-4 17 0.00209 0.04

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.145 3.54E-17 YMR281W GPI12 het ER membrane protein involved in the second step of glycosylphosphatidylinositol (GPI) anchor assembly, the de-N-acetylation of the N-acetylglucosaminylphosphatidylinositol intermediate; functional homolog of human PIG-Lp
0.141 1.98E-16 YMR158W-B_d YMR158W-B_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene ATG16/YMR159C
0.141 2.68E-16 YPR160W GPH1 hom Non-essential glycogen phosphorylase required for the mobilization of glycogen, activity is regulated by cyclic AMP-mediated phosphorylation, expression is regulated by stress-response elements and by the HOG MAP kinase pathway
0.138 1.00E-15 YLR327C TMA10 hom Protein of unknown function that associates with ribosomes; putative homolog of the F1F0-ATPase synthase regulator Stf2p; protein abundance increases in response to DNA replication stress
0.133 1.25E-14 YDL160C-A MHF2 hom Component of the heterotetrameric MHF histone-fold complex; in humans the MMF complex interacts with both DNA and Mph1p ortholog FANCM to stabilize and remodel blocked replication forks and repair damaged DNA; mhf2 srs2 double mutants are MMS hypersensitive; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-X, also known as MHF2
0.129 6.00E-14 YMR175W-A_p YMR175W-A_p hom Putative protein of unknown function
0.126 2.71E-13 YLR223C IFH1 het Coactivator that regulates transcription of ribosomal protein (RP) genes; recruited to RP gene promoters during optimal growth conditions via Fhl1p; subunit of CURI, a complex that coordinates RP production and pre-rRNA processing
0.123 1.03E-12 YLL035W GRC3 het Polynucleotide kinase present on rDNA that is required for efficient transcription termination by RNA polymerase I; required for cell growth; mRNA is cell-cycle regulated
0.120 3.20E-12 YIL120W QDR1 hom Multidrug transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; required for resistance to quinidine, ketoconazole, fluconazole, and barban; QDR1 has a paralog, AQR1, that arose from the whole genome duplication
0.119 4.17E-12 YAL027W SAW1 hom 5'- and 3'-flap DNA binding protein; stimulates the endonuclease activity of Rad1/Rad10p; involved in Rad1p/Rad10p-dependent removal of 3'-nonhomologous tails during double-strand break repair via single-strand annealing; green fluorescent protein (GFP)-fusion protein localizes to the nucleus
0.114 3.32E-11 YDR527W RBA50 het Protein involved in transcription; interacts with RNA polymerase II subunits Rpb2p, Rpb3, and Rpb11p; has similarity to human RPAP1
0.108 4.16E-10 YDR531W CAB1 het Pantothenate kinase (ATP:D-pantothenate 4'-phosphotransferase, EC 2.7.1.33); catalyzes the first committed step in the universal biosynthetic pathway for synthesis of coenzyme A (CoA); transcriptionally regulated by Upc2p via a sterol response element
0.107 5.49E-10 YER023W PRO3 het Delta 1-pyrroline-5-carboxylate reductase, catalyzes the last step in proline biosynthesis
0.106 7.67E-10 YGR213C RTA1 hom Protein involved in 7-aminocholesterol resistance; has seven potential membrane-spanning regions; expression is induced under both low-heme and low-oxygen conditions; member of the fungal lipid-translocating exporter (LTE) family of protein
0.106 8.28E-10 YPR154W PIN3 hom Protein that induces appearance of [PIN+] prion when overproduced