YJL206C_p

Putative protein of unknown function; similar to transcriptional regulators from the Zn[2]-Cys[6] binuclear cluster protein family; mRNA is weakly cell cycle regulated, peaking in S phase; induced rapidly upon MMS treatment

Zygosity: Homozygous strain
fixedexpanded
Profile for YJL206C / YJL206C

Click on Significant Values for Screen Details ID:SGTC_23|Compound:0213-0011|FD-Score:3.11|P-value:6.32E-4 ID:SGTC_47|Compound:0149-0135|FD-Score:3.32|P-value:2.92E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:4.63|P-value:8.01E-7 ID:SGTC_103|Compound:0844-0104|FD-Score:4.24|P-value:5.56E-6 ID:SGTC_270|Compound:tamoxifen|FD-Score:-4.15|P-value:8.42E-6 ID:SGTC_316|Compound:k060-0003|FD-Score:-3.24|P-value:3.90E-4 ID:SGTC_329|Compound:k048-0121|FD-Score:4.77|P-value:3.70E-7 ID:SGTC_497|Compound:capsazepine|FD-Score:3.34|P-value:2.64E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:3.58|P-value:1.02E-4 ID:SGTC_588|Compound:3970-1144|FD-Score:3.83|P-value:3.62E-5 ID:SGTC_682|Compound:0kpi-0099|FD-Score:4.06|P-value:1.27E-5 ID:SGTC_758|Compound:0868-0029|FD-Score:3.40|P-value:2.14E-4 ID:SGTC_833|Compound:3852-0053|FD-Score:3.45|P-value:1.77E-4 ID:SGTC_927|Compound:2425-1185|FD-Score:4.66|P-value:6.84E-7 ID:SGTC_950|Compound:1165-0508|FD-Score:3.68|P-value:6.89E-5 ID:SGTC_951|Compound:1171-0579|FD-Score:4.37|P-value:2.94E-6 ID:SGTC_1093|Compound:fluphenazine|FD-Score:3.25|P-value:3.74E-4 ID:SGTC_1134|Compound:3477-0009|FD-Score:4.87|P-value:2.25E-7 ID:SGTC_1137|Compound:ixabepilone|FD-Score:-3.25|P-value:3.75E-4 ID:SGTC_1163|Compound:k060-0048|FD-Score:3.16|P-value:5.25E-4 ID:SGTC_1303|Compound:1160-0052|FD-Score:3.86|P-value:3.10E-5 ID:SGTC_1605|Compound:st000082|FD-Score:-3.10|P-value:6.63E-4 ID:SGTC_1656|Compound:st012921|FD-Score:3.10|P-value:6.57E-4 ID:SGTC_1752|Compound:st044819|FD-Score:3.09|P-value:6.88E-4 ID:SGTC_1822|Compound:st052468|FD-Score:4.61|P-value:8.67E-7 ID:SGTC_1882|Compound:5615643|FD-Score:3.12|P-value:6.00E-4 ID:SGTC_1884|Compound:5633444|FD-Score:3.64|P-value:8.19E-5 ID:SGTC_1910|Compound:st062352|FD-Score:4.33|P-value:3.64E-6 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:-3.20|P-value:4.60E-4 ID:SGTC_2054|Compound:5233173|FD-Score:5.06|P-value:7.73E-8 ID:SGTC_2083|Compound:5306046|FD-Score:-3.57|P-value:1.08E-4 ID:SGTC_2094|Compound:5332512|FD-Score:-3.92|P-value:2.40E-5 ID:SGTC_2307|Compound:7538926|FD-Score:-4.89|P-value:1.97E-7 ID:SGTC_2309|Compound:7664088|FD-Score:-3.21|P-value:4.31E-4 ID:SGTC_2313|Compound:7726885|FD-Score:3.21|P-value:4.44E-4 ID:SGTC_2318|Compound:6029776|FD-Score:3.05|P-value:7.87E-4 ID:SGTC_2358|Compound:9037157|FD-Score:-3.80|P-value:4.15E-5 ID:SGTC_2360|Compound:9040895|FD-Score:4.26|P-value:4.96E-6 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:-3.38|P-value:2.27E-4 ID:SGTC_2416|Compound:tofa|FD-Score:3.97|P-value:1.97E-5 ID:SGTC_2507|Compound:purpurin|FD-Score:3.25|P-value:3.73E-4 ID:SGTC_2623|Compound:humulene|FD-Score:4.15|P-value:8.26E-6 ID:SGTC_2737|Compound:bleomycin|FD-Score:3.77|P-value:4.60E-5 ID:SGTC_3004|Compound:9076122|FD-Score:-3.26|P-value:3.67E-4 ID:SGTC_3154|Compound:9100113|FD-Score:-3.27|P-value:3.55E-4 ID:SGTC_3170|Compound:9103054|FD-Score:-3.19|P-value:4.76E-4 ID:SGTC_3173|Compound:9105693|FD-Score:3.01|P-value:9.02E-4 ID:SGTC_3187|Compound:9109394|FD-Score:3.82|P-value:3.67E-5 ID:SGTC_3266|Compound:9136860|FD-Score:3.29|P-value:3.21E-4 ID:SGTC_3281|Compound:9140613|FD-Score:-3.06|P-value:7.57E-4 ID:SGTC_3325|Compound:9138760|FD-Score:3.23|P-value:4.08E-4 ID:SGTC_23|Compound:0213-0011|FD-Score:3.11|P-value:6.32E-4 ID:SGTC_47|Compound:0149-0135|FD-Score:3.32|P-value:2.92E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:4.63|P-value:8.01E-7 ID:SGTC_103|Compound:0844-0104|FD-Score:4.24|P-value:5.56E-6 ID:SGTC_270|Compound:tamoxifen|FD-Score:-4.15|P-value:8.42E-6 ID:SGTC_316|Compound:k060-0003|FD-Score:-3.24|P-value:3.90E-4 ID:SGTC_329|Compound:k048-0121|FD-Score:4.77|P-value:3.70E-7 ID:SGTC_497|Compound:capsazepine|FD-Score:3.34|P-value:2.64E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:3.58|P-value:1.02E-4 ID:SGTC_588|Compound:3970-1144|FD-Score:3.83|P-value:3.62E-5 ID:SGTC_682|Compound:0kpi-0099|FD-Score:4.06|P-value:1.27E-5 ID:SGTC_758|Compound:0868-0029|FD-Score:3.40|P-value:2.14E-4 ID:SGTC_833|Compound:3852-0053|FD-Score:3.45|P-value:1.77E-4 ID:SGTC_927|Compound:2425-1185|FD-Score:4.66|P-value:6.84E-7 ID:SGTC_950|Compound:1165-0508|FD-Score:3.68|P-value:6.89E-5 ID:SGTC_951|Compound:1171-0579|FD-Score:4.37|P-value:2.94E-6 ID:SGTC_1093|Compound:fluphenazine|FD-Score:3.25|P-value:3.74E-4 ID:SGTC_1134|Compound:3477-0009|FD-Score:4.87|P-value:2.25E-7 ID:SGTC_1137|Compound:ixabepilone|FD-Score:-3.25|P-value:3.75E-4 ID:SGTC_1163|Compound:k060-0048|FD-Score:3.16|P-value:5.25E-4 ID:SGTC_1303|Compound:1160-0052|FD-Score:3.86|P-value:3.10E-5 ID:SGTC_1605|Compound:st000082|FD-Score:-3.10|P-value:6.63E-4 ID:SGTC_1656|Compound:st012921|FD-Score:3.10|P-value:6.57E-4 ID:SGTC_1752|Compound:st044819|FD-Score:3.09|P-value:6.88E-4 ID:SGTC_1822|Compound:st052468|FD-Score:4.61|P-value:8.67E-7 ID:SGTC_1882|Compound:5615643|FD-Score:3.12|P-value:6.00E-4 ID:SGTC_1884|Compound:5633444|FD-Score:3.64|P-value:8.19E-5 ID:SGTC_1910|Compound:st062352|FD-Score:4.33|P-value:3.64E-6 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:-3.20|P-value:4.60E-4 ID:SGTC_2054|Compound:5233173|FD-Score:5.06|P-value:7.73E-8 ID:SGTC_2083|Compound:5306046|FD-Score:-3.57|P-value:1.08E-4 ID:SGTC_2094|Compound:5332512|FD-Score:-3.92|P-value:2.40E-5 ID:SGTC_2307|Compound:7538926|FD-Score:-4.89|P-value:1.97E-7 ID:SGTC_2309|Compound:7664088|FD-Score:-3.21|P-value:4.31E-4 ID:SGTC_2313|Compound:7726885|FD-Score:3.21|P-value:4.44E-4 ID:SGTC_2318|Compound:6029776|FD-Score:3.05|P-value:7.87E-4 ID:SGTC_2358|Compound:9037157|FD-Score:-3.80|P-value:4.15E-5 ID:SGTC_2360|Compound:9040895|FD-Score:4.26|P-value:4.96E-6 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:-3.38|P-value:2.27E-4 ID:SGTC_2416|Compound:tofa|FD-Score:3.97|P-value:1.97E-5 ID:SGTC_2507|Compound:purpurin|FD-Score:3.25|P-value:3.73E-4 ID:SGTC_2623|Compound:humulene|FD-Score:4.15|P-value:8.26E-6 ID:SGTC_2737|Compound:bleomycin|FD-Score:3.77|P-value:4.60E-5 ID:SGTC_3004|Compound:9076122|FD-Score:-3.26|P-value:3.67E-4 ID:SGTC_3154|Compound:9100113|FD-Score:-3.27|P-value:3.55E-4 ID:SGTC_3170|Compound:9103054|FD-Score:-3.19|P-value:4.76E-4 ID:SGTC_3173|Compound:9105693|FD-Score:3.01|P-value:9.02E-4 ID:SGTC_3187|Compound:9109394|FD-Score:3.82|P-value:3.67E-5 ID:SGTC_3266|Compound:9136860|FD-Score:3.29|P-value:3.21E-4 ID:SGTC_3281|Compound:9140613|FD-Score:-3.06|P-value:7.57E-4 ID:SGTC_3325|Compound:9138760|FD-Score:3.23|P-value:4.08E-4

Top fitness defect scores for YJL206C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2054 5233173 5.06 129.0 µM 7.73E-8 mitochondrial response to ROS 24 2.09E-7
2 SGTC_1134 3477-0009 4.87 42.5 µM 2.25E-7 22 5.67E-7
3 SGTC_329 k048-0121 4.77 21.3 µM 3.70E-7 RSC & ERG11 6 9.00E-7
4 SGTC_927 2425-1185 4.66 123.0 µM 6.84E-7 15 1.60E-6
5 SGTC_58 0957-0393 4.63 9.0 µM 8.01E-7 cell wall 320 1.85E-6
6 SGTC_1822 st052468 4.61 42.0 µM 8.67E-7 4 1.99E-6
7 SGTC_951 1171-0579 4.37 82.7 µM 2.94E-6 cell wall 59 6.22E-6
8 SGTC_1910 st062352 4.33 60.4 µM 3.64E-6 23 7.60E-6
9 SGTC_2360 9040895 4.26 200.0 µM 4.96E-6 RPP1 & pyrimidine depletion 13 1.01E-5
10 SGTC_103 0844-0104 4.24 51.8 µM 5.56E-6 ERAD & cell cycle 131 1.13E-5
11 SGTC_2623 humulene 4.15 100.0 µM 8.26E-6 14 1.63E-5
12 SGTC_682 0kpi-0099 4.06 17.0 µM 1.27E-5 67 2.45E-5
13 SGTC_2416 tofa 3.97 880.0 nM 1.97E-5 sphingolipid biosynthesis & PDR1 51 3.67E-5
14 SGTC_1303 1160-0052 3.86 261.0 µM 3.10E-5 8 5.61E-5
15 SGTC_588 3970-1144 3.83 52.9 µM 3.62E-5 31 6.48E-5
16 SGTC_3187 9109394 3.82 49.5 µM 3.67E-5 Golgi 25 6.57E-5
17 SGTC_2737 bleomycin 3.77 30.5 nM 4.60E-5 Golgi 95 8.10E-5
18 SGTC_950 1165-0508 3.68 94.1 µM 6.89E-5 39 1.18E-4
19 SGTC_1884 5633444 3.64 25.0 µM 8.19E-5 redox potentiating 67 1.39E-4
20 SGTC_513 4245-1575 3.58 41.7 µM 1.02E-4 unfolded protein response 133 1.71E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.153 4.87E-19 YKR028W SAP190 hom Protein that forms a complex with the Sit4p protein phosphatase; required for Sit4p function; member of a family of similar proteins including Sap4p, Sap155p, and Sap185p; SAP190 has a paralog, SAP185, that arose from the whole genome duplication
0.150 2.24E-18 YPL269W KAR9 hom Karyogamy protein required for correct positioning of the mitotic spindle and for orienting cytoplasmic microtubules, localizes at the shmoo tip in mating cells and at the tip of the growing bud in small-budded cells through anaphase
0.143 8.63E-17 YOR231W MKK1 hom MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication
0.140 4.76E-16 YNL179C_d YNL179C_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; deletion in cyr1 mutant results in loss of stress resistance
0.135 4.60E-15 YCL005W LDB16 hom Protein of unknown function; null mutants have decreased net negative cell surface charge; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; native protein is detected in purified mitochondria
0.135 4.61E-15 YGR037C ACB1 hom Acyl-CoA-binding protein, transports newly synthesized acyl-CoA esters from fatty acid synthetase (Fas1p-Fas2p) to acyl-CoA-consuming processes; subject to starvation-induced, Grh1p-mediated unconventional secretion; protein abundance increases in response to DNA replication stress
0.131 2.80E-14 YGR058W PEF1 hom Penta-EF-hand protein required for polar bud growth and cell wall abscission; binds calcium and zinc with different affinity; localizes to bud site in G1, bud neck in G2; binds to Sec31p and modulates COPII coat assembly
0.118 8.09E-12 YKL033W-A_p YKL033W-A_p hom Putative protein of unknown function; similar to uncharacterized proteins from other fungi
0.117 1.22E-11 YJR054W KCH1 hom Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate
0.115 2.05E-11 YLR412W BER1 hom Protein involved in microtubule-related processes, N-acetylation; GFP-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YLR412W is not an essential gene; similar to Arabidopsis SRR1 gene
0.114 2.98E-11 YDL066W IDP1 hom Mitochondrial NADP-specific isocitrate dehydrogenase, catalyzes the oxidation of isocitrate to alpha-ketoglutarate; not required for mitochondrial respiration and may function to divert alpha-ketoglutarate to biosynthetic processes
0.114 3.97E-11 YKL115C_d YKL115C_d hom Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene PRR1
0.113 4.95E-11 YNL314W DAL82 hom Positive regulator of allophanate inducible genes; binds a dodecanucleotide sequence upstream of all genes that are induced by allophanate; contains an UISALL DNA-binding, a transcriptional activation, and a coiled-coil domain
0.111 1.21E-10 YML126C ERG13 het 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase, catalyzes the formation of HMG-CoA from acetyl-CoA and acetoacetyl-CoA; involved in the second step in mevalonate biosynthesis
0.110 1.71E-10 YJR117W STE24 hom Highly conserved zinc metalloprotease that functions in two steps of a-factor maturation, C-terminal CAAX proteolysis and the first step of N-terminal proteolytic processing; contains multiple transmembrane spans