YJL210W / PEX2

RING-finger peroxin and E3 ubiquitin ligase, peroxisomal membrane protein with a C-terminal zinc-binding RING domain, forms translocation subcomplex with Pex10p and Pex12p which functions in peroxisomal matrix protein import

Zygosity: Homozygous strain
fixedexpanded
Profile for YJL210W / PEX2

Click on Significant Values for Screen Details ID:SGTC_358|Compound:0075-0058|FD-Score:3.52|P-value:1.26E-4 ID:SGTC_505|Compound:gw-5074|FD-Score:-4.07|P-value:1.22E-5 ID:SGTC_767|Compound:0929-0023|FD-Score:3.33|P-value:2.63E-4 ID:SGTC_1012|Compound:4112-3522|FD-Score:4.21|P-value:6.18E-6 ID:SGTC_1127|Compound:asiatic acid|FD-Score:3.39|P-value:2.12E-4 ID:SGTC_1269|Compound:0831-0796|FD-Score:4.46|P-value:1.79E-6 ID:SGTC_1280|Compound:0880-0253|FD-Score:3.07|P-value:7.05E-4 ID:SGTC_1373|Compound:2887-0003|FD-Score:-3.25|P-value:3.80E-4 ID:SGTC_1686|Compound:st019653|FD-Score:3.38|P-value:2.24E-4 ID:SGTC_1713|Compound:st033146|FD-Score:3.81|P-value:3.66E-5 ID:SGTC_1722|Compound:st034304|FD-Score:-3.04|P-value:8.09E-4 ID:SGTC_1767|Compound:st044992|FD-Score:3.52|P-value:1.24E-4 ID:SGTC_1779|Compound:st039427|FD-Score:-3.20|P-value:4.46E-4 ID:SGTC_1782|Compound:st039423|FD-Score:-3.37|P-value:2.38E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:4.69|P-value:5.57E-7 ID:SGTC_2258|Compound:7960471|FD-Score:-3.71|P-value:6.02E-5 ID:SGTC_2405|Compound:ticlatone|FD-Score:3.64|P-value:7.59E-5 ID:SGTC_2411|Compound:st077133|FD-Score:3.20|P-value:4.39E-4 ID:SGTC_2585|Compound:alliin|FD-Score:3.74|P-value:5.02E-5 ID:SGTC_2608|Compound:thymoquinone|FD-Score:-3.00|P-value:9.27E-4 ID:SGTC_2612|Compound:dictamnine|FD-Score:-3.39|P-value:2.22E-4 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:3.66|P-value:7.08E-5 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:4.56|P-value:1.06E-6 ID:SGTC_2951|Compound:9072950|FD-Score:-3.71|P-value:5.99E-5 ID:SGTC_2962|Compound:9082311|FD-Score:-5.50|P-value:5.72E-9 ID:SGTC_2965|Compound:9082772|FD-Score:4.12|P-value:9.13E-6 ID:SGTC_3101|Compound:9120531|FD-Score:3.71|P-value:5.86E-5 ID:SGTC_3103|Compound:9120822|FD-Score:4.19|P-value:6.70E-6 ID:SGTC_3131|Compound:9127911|FD-Score:5.08|P-value:6.62E-8 ID:SGTC_3195|Compound:9113082|FD-Score:3.30|P-value:3.05E-4 ID:SGTC_3216|Compound:9129716|FD-Score:3.17|P-value:4.98E-4 ID:SGTC_3276|Compound:9139060|FD-Score:3.71|P-value:5.70E-5 ID:SGTC_358|Compound:0075-0058|FD-Score:3.52|P-value:1.26E-4 ID:SGTC_505|Compound:gw-5074|FD-Score:-4.07|P-value:1.22E-5 ID:SGTC_767|Compound:0929-0023|FD-Score:3.33|P-value:2.63E-4 ID:SGTC_1012|Compound:4112-3522|FD-Score:4.21|P-value:6.18E-6 ID:SGTC_1127|Compound:asiatic acid|FD-Score:3.39|P-value:2.12E-4 ID:SGTC_1269|Compound:0831-0796|FD-Score:4.46|P-value:1.79E-6 ID:SGTC_1280|Compound:0880-0253|FD-Score:3.07|P-value:7.05E-4 ID:SGTC_1373|Compound:2887-0003|FD-Score:-3.25|P-value:3.80E-4 ID:SGTC_1686|Compound:st019653|FD-Score:3.38|P-value:2.24E-4 ID:SGTC_1713|Compound:st033146|FD-Score:3.81|P-value:3.66E-5 ID:SGTC_1722|Compound:st034304|FD-Score:-3.04|P-value:8.09E-4 ID:SGTC_1767|Compound:st044992|FD-Score:3.52|P-value:1.24E-4 ID:SGTC_1779|Compound:st039427|FD-Score:-3.20|P-value:4.46E-4 ID:SGTC_1782|Compound:st039423|FD-Score:-3.37|P-value:2.38E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:4.69|P-value:5.57E-7 ID:SGTC_2258|Compound:7960471|FD-Score:-3.71|P-value:6.02E-5 ID:SGTC_2405|Compound:ticlatone|FD-Score:3.64|P-value:7.59E-5 ID:SGTC_2411|Compound:st077133|FD-Score:3.20|P-value:4.39E-4 ID:SGTC_2585|Compound:alliin|FD-Score:3.74|P-value:5.02E-5 ID:SGTC_2608|Compound:thymoquinone|FD-Score:-3.00|P-value:9.27E-4 ID:SGTC_2612|Compound:dictamnine|FD-Score:-3.39|P-value:2.22E-4 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:3.66|P-value:7.08E-5 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:4.56|P-value:1.06E-6 ID:SGTC_2951|Compound:9072950|FD-Score:-3.71|P-value:5.99E-5 ID:SGTC_2962|Compound:9082311|FD-Score:-5.50|P-value:5.72E-9 ID:SGTC_2965|Compound:9082772|FD-Score:4.12|P-value:9.13E-6 ID:SGTC_3101|Compound:9120531|FD-Score:3.71|P-value:5.86E-5 ID:SGTC_3103|Compound:9120822|FD-Score:4.19|P-value:6.70E-6 ID:SGTC_3131|Compound:9127911|FD-Score:5.08|P-value:6.62E-8 ID:SGTC_3195|Compound:9113082|FD-Score:3.30|P-value:3.05E-4 ID:SGTC_3216|Compound:9129716|FD-Score:3.17|P-value:4.98E-4 ID:SGTC_3276|Compound:9139060|FD-Score:3.71|P-value:5.70E-5

Top fitness defect scores for YJL210W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3131 9127911 5.08 49.5 µM 6.62E-8 6 1.93E-7
2 SGTC_1787 fluconazole 4.69 80.0 µM 5.57E-7 iron homeostasis 13 1.39E-6
3 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 4.56 100.0 µM 1.06E-6 15 2.53E-6
4 SGTC_1269 0831-0796 4.46 3.0 µM 1.79E-6 60S ribosome export 8 4.12E-6
5 SGTC_1012 4112-3522 4.21 18.0 µM 6.18E-6 20 1.30E-5
6 SGTC_3103 9120822 4.19 49.5 µM 6.70E-6 10 1.41E-5
7 SGTC_2965 9082772 4.12 38.6 µM 9.13E-6 mitochondrial response to ROS 36 1.88E-5
8 SGTC_1713 st033146 3.81 12.8 µM 3.66E-5 30 6.81E-5
9 SGTC_2585 alliin 3.74 100.0 µM 5.02E-5 31 9.15E-5
10 SGTC_3276 9139060 3.71 49.5 µM 5.70E-5 60S ribosome export 6 1.03E-4
11 SGTC_3101 9120531 3.71 49.5 µM 5.86E-5 40 1.06E-4
12 SGTC_2613 3',4'-dimethoxydalbergione 3.66 24.6 µM 7.08E-5 35 1.26E-4
13 SGTC_2405 ticlatone 3.64 3.5 µM 7.59E-5 77 1.34E-4
14 SGTC_1767 st044992 3.52 70.3 µM 1.24E-4 33 2.13E-4
15 SGTC_358 0075-0058 3.52 9.4 µM 1.26E-4 85 2.16E-4
16 SGTC_1127 asiatic acid 3.39 681.4 nM 2.12E-4 40 3.50E-4
17 SGTC_1686 st019653 3.38 115.5 µM 2.24E-4 mitochondrial processes 23 3.68E-4
18 SGTC_767 0929-0023 3.33 86.0 µM 2.63E-4 TRP & mitochondrial translation 125 4.27E-4
19 SGTC_3195 9113082 3.30 49.5 µM 3.05E-4 34 4.91E-4
20 SGTC_2411 st077133 3.20 39.9 µM 4.39E-4 RNA pol III & RNase P/MRP 81 6.88E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.150 3.40E-18 YOR282W_d YOR282W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps essential, verified gene PLP2/YOR281C
0.119 4.48E-12 YML009C MRPL39 hom Mitochondrial ribosomal protein of the large subunit
0.101 4.16E-9 YER074W RPS24A hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S24, no bacterial homolog; RPS24A has a paralog, RPS24B, that arose from the whole genome duplication
0.100 7.13E-9 YDR420W HKR1 hom Mucin family member that functions as an osmosensor in the Sho1p-mediated HOG pathway with Msb2p; proposed to be a negative regulator of filamentous growth; mutant displays defects in beta-1,3 glucan synthesis and bud site selection
0.096 2.16E-8 YJL212C OPT1 hom Proton-coupled oligopeptide transporter of the plasma membrane; also transports glutathione and phytochelatin; member of the OPT family
0.096 2.83E-8 YOR139C_d YOR139C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SFL1/YOR140W
0.092 9.89E-8 YJL060W BNA3 hom Kynurenine aminotransferase, catalyzes formation of kynurenic acid from kynurenine; potential Cdc28p substrate
0.091 1.12E-7 YAL043C PTA1 het Subunit of holo-CPF, a multiprotein complex and functional homolog of mammalian CPSF, required for the cleavage and polyadenylation of mRNA and snoRNA 3' ends; involved in pre-tRNA processing; binds to the phosphorylated CTD of RNAPII
0.090 1.74E-7 YBR184W_p YBR184W_p hom Putative protein of unknown function; YBR184W is not an essential gene
0.088 3.57E-7 YJR115W_p YJR115W_p hom Putative protein of unknown function; YJR115W has a paralog, ECM13, that arose from the whole genome duplication
0.086 7.02E-7 YPL091W GLR1 hom Cytosolic and mitochondrial glutathione oxidoreductase; converts oxidized glutathione to reduced glutathione; mitochondrial but not cytosolic form has a role in resistance to hyperoxia; protein abundance increases in response to DNA replication stress
0.085 7.13E-7 YMR213W CEF1 het Essential splicing factor; associated with Prp19p and the spliceosome, contains an N-terminal c-Myb DNA binding motif necessary for cell viability but not for Prp19p association, evolutionarily conserved and homologous to S. pombe Cdc5p
0.085 7.51E-7 YHR148W IMP3 het Component of the SSU processome, which is required for pre-18S rRNA processing, essential protein that interacts with Mpp10p and mediates interactions of Imp4p and Mpp10p with U3 snoRNA
0.080 3.46E-6 YKL162C_p YKL162C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion
0.080 3.98E-6 YHL042W_p YHL042W_p hom Putative protein of unknown function; member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins