YJL214W / HXT8

Protein of unknown function with similarity to hexose transporter family members, expression is induced by low levels of glucose and repressed by high levels of glucose

Zygosity: Homozygous strain
fixedexpanded
Profile for YJL214W / HXT8

Click on Significant Values for Screen Details ID:SGTC_17|Compound:0960-0276|FD-Score:3.78|P-value:8.07E-5 ID:SGTC_35|Compound:0133-0054|FD-Score:4.42|P-value:5.22E-6 ID:SGTC_74|Compound:000s-0487|FD-Score:4.29|P-value:9.03E-6 ID:SGTC_128|Compound:0906-2981|FD-Score:-4.22|P-value:1.45E-5 ID:SGTC_131|Compound:0141-0277|FD-Score:-4.38|P-value:7.05E-6 ID:SGTC_133|Compound:0724-0033|FD-Score:-3.97|P-value:4.25E-5 ID:SGTC_250|Compound:brefeldin a|FD-Score:3.10|P-value:9.86E-4 ID:SGTC_286|Compound:k060-0067|FD-Score:5.08|P-value:2.02E-7 ID:SGTC_358|Compound:0075-0058|FD-Score:-3.91|P-value:5.28E-5 ID:SGTC_366|Compound:0181-0206|FD-Score:3.83|P-value:6.51E-5 ID:SGTC_503|Compound:tyrphostin 8|FD-Score:-3.35|P-value:4.52E-4 ID:SGTC_745|Compound:0469-0705|FD-Score:3.30|P-value:4.88E-4 ID:SGTC_815|Compound:1582-0027|FD-Score:3.78|P-value:8.12E-5 ID:SGTC_820|Compound:1582-0060|FD-Score:4.59|P-value:2.36E-6 ID:SGTC_914|Compound:3820-6779|FD-Score:-3.86|P-value:6.47E-5 ID:SGTC_1016|Compound:4226-1401|FD-Score:3.26|P-value:5.63E-4 ID:SGTC_1226|Compound:3909-7979|FD-Score:4.43|P-value:4.94E-6 ID:SGTC_1321|Compound:1326-2144|FD-Score:3.64|P-value:1.38E-4 ID:SGTC_1343|Compound:1487-0095|FD-Score:3.76|P-value:8.62E-5 ID:SGTC_1356|Compound:1502-0781|FD-Score:-3.35|P-value:4.56E-4 ID:SGTC_1378|Compound:2093-0007|FD-Score:-3.13|P-value:9.87E-4 ID:SGTC_1401|Compound:3807-4679|FD-Score:4.68|P-value:1.47E-6 ID:SGTC_1403|Compound:3909-7815|FD-Score:3.23|P-value:6.30E-4 ID:SGTC_1727|Compound:st034309|FD-Score:3.64|P-value:1.39E-4 ID:SGTC_1769|Compound:st044406|FD-Score:4.60|P-value:2.18E-6 ID:SGTC_1841|Compound:st054148|FD-Score:4.13|P-value:1.83E-5 ID:SGTC_1860|Compound:st056228|FD-Score:-3.14|P-value:9.55E-4 ID:SGTC_1971|Compound:st069429|FD-Score:3.93|P-value:4.40E-5 ID:SGTC_2003|Compound:4023581|FD-Score:3.63|P-value:1.44E-4 ID:SGTC_2011|Compound:4012611|FD-Score:-3.58|P-value:1.97E-4 ID:SGTC_2045|Compound:5106652|FD-Score:3.09|P-value:9.97E-4 ID:SGTC_2064|Compound:5220758|FD-Score:5.28|P-value:6.85E-8 ID:SGTC_2260|Compound:7964312|FD-Score:3.29|P-value:5.07E-4 ID:SGTC_2364|Compound:9055074|FD-Score:-3.16|P-value:8.74E-4 ID:SGTC_2397|Compound:5161689|FD-Score:-3.29|P-value:5.58E-4 ID:SGTC_2402|Compound:5553605|FD-Score:-4.20|P-value:1.57E-5 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:4.07|P-value:2.37E-5 ID:SGTC_2750|Compound:bromebric acid|FD-Score:4.98|P-value:3.45E-7 ID:SGTC_2778|Compound:tioconazole|FD-Score:4.14|P-value:1.76E-5 ID:SGTC_2862|Compound:9027634|FD-Score:3.25|P-value:5.82E-4 ID:SGTC_3119|Compound:9125183|FD-Score:3.33|P-value:4.44E-4 ID:SGTC_3332|Compound:9141069|FD-Score:-3.26|P-value:6.23E-4 ID:SGTC_17|Compound:0960-0276|FD-Score:3.78|P-value:8.07E-5 ID:SGTC_35|Compound:0133-0054|FD-Score:4.42|P-value:5.22E-6 ID:SGTC_74|Compound:000s-0487|FD-Score:4.29|P-value:9.03E-6 ID:SGTC_128|Compound:0906-2981|FD-Score:-4.22|P-value:1.45E-5 ID:SGTC_131|Compound:0141-0277|FD-Score:-4.38|P-value:7.05E-6 ID:SGTC_133|Compound:0724-0033|FD-Score:-3.97|P-value:4.25E-5 ID:SGTC_250|Compound:brefeldin a|FD-Score:3.10|P-value:9.86E-4 ID:SGTC_286|Compound:k060-0067|FD-Score:5.08|P-value:2.02E-7 ID:SGTC_358|Compound:0075-0058|FD-Score:-3.91|P-value:5.28E-5 ID:SGTC_366|Compound:0181-0206|FD-Score:3.83|P-value:6.51E-5 ID:SGTC_503|Compound:tyrphostin 8|FD-Score:-3.35|P-value:4.52E-4 ID:SGTC_745|Compound:0469-0705|FD-Score:3.30|P-value:4.88E-4 ID:SGTC_815|Compound:1582-0027|FD-Score:3.78|P-value:8.12E-5 ID:SGTC_820|Compound:1582-0060|FD-Score:4.59|P-value:2.36E-6 ID:SGTC_914|Compound:3820-6779|FD-Score:-3.86|P-value:6.47E-5 ID:SGTC_1016|Compound:4226-1401|FD-Score:3.26|P-value:5.63E-4 ID:SGTC_1226|Compound:3909-7979|FD-Score:4.43|P-value:4.94E-6 ID:SGTC_1321|Compound:1326-2144|FD-Score:3.64|P-value:1.38E-4 ID:SGTC_1343|Compound:1487-0095|FD-Score:3.76|P-value:8.62E-5 ID:SGTC_1356|Compound:1502-0781|FD-Score:-3.35|P-value:4.56E-4 ID:SGTC_1378|Compound:2093-0007|FD-Score:-3.13|P-value:9.87E-4 ID:SGTC_1401|Compound:3807-4679|FD-Score:4.68|P-value:1.47E-6 ID:SGTC_1403|Compound:3909-7815|FD-Score:3.23|P-value:6.30E-4 ID:SGTC_1727|Compound:st034309|FD-Score:3.64|P-value:1.39E-4 ID:SGTC_1769|Compound:st044406|FD-Score:4.60|P-value:2.18E-6 ID:SGTC_1841|Compound:st054148|FD-Score:4.13|P-value:1.83E-5 ID:SGTC_1860|Compound:st056228|FD-Score:-3.14|P-value:9.55E-4 ID:SGTC_1971|Compound:st069429|FD-Score:3.93|P-value:4.40E-5 ID:SGTC_2003|Compound:4023581|FD-Score:3.63|P-value:1.44E-4 ID:SGTC_2011|Compound:4012611|FD-Score:-3.58|P-value:1.97E-4 ID:SGTC_2045|Compound:5106652|FD-Score:3.09|P-value:9.97E-4 ID:SGTC_2064|Compound:5220758|FD-Score:5.28|P-value:6.85E-8 ID:SGTC_2260|Compound:7964312|FD-Score:3.29|P-value:5.07E-4 ID:SGTC_2364|Compound:9055074|FD-Score:-3.16|P-value:8.74E-4 ID:SGTC_2397|Compound:5161689|FD-Score:-3.29|P-value:5.58E-4 ID:SGTC_2402|Compound:5553605|FD-Score:-4.20|P-value:1.57E-5 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:4.07|P-value:2.37E-5 ID:SGTC_2750|Compound:bromebric acid|FD-Score:4.98|P-value:3.45E-7 ID:SGTC_2778|Compound:tioconazole|FD-Score:4.14|P-value:1.76E-5 ID:SGTC_2862|Compound:9027634|FD-Score:3.25|P-value:5.82E-4 ID:SGTC_3119|Compound:9125183|FD-Score:3.33|P-value:4.44E-4 ID:SGTC_3332|Compound:9141069|FD-Score:-3.26|P-value:6.23E-4

Top fitness defect scores for YJL214W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2064 5220758 5.28 200.0 µM 6.85E-8 13 6.40E-8
2 SGTC_286 k060-0067 5.08 22.9 µM 2.02E-7 tubulin folding & SWR complex 13 1.91E-7
3 SGTC_2750 bromebric acid 4.98 70.2 µM 3.45E-7 13 3.26E-7
4 SGTC_1401 3807-4679 4.68 7.6 µM 1.47E-6 tubulin folding & SWR complex 10 1.41E-6
5 SGTC_1769 st044406 4.60 64.4 µM 2.18E-6 2 2.09E-6
6 SGTC_820 1582-0060 4.59 59.9 µM 2.36E-6 19 2.27E-6
7 SGTC_1226 3909-7979 4.43 35.4 µM 4.94E-6 30 4.76E-6
8 SGTC_35 0133-0054 4.42 64.1 µM 5.22E-6 21 5.03E-6
9 SGTC_74 000s-0487 4.29 160.3 µM 9.03E-6 18 8.74E-6
10 SGTC_2778 tioconazole 4.14 65.1 nM 1.76E-5 ergosterol depletion effects on membrane 56 1.71E-5
11 SGTC_1841 st054148 4.13 70.0 µM 1.83E-5 9 1.78E-5
12 SGTC_2626 ethyl orsellinate 4.07 100.0 µM 2.37E-5 31 2.31E-5
13 SGTC_1971 st069429 3.93 63.5 µM 4.40E-5 60S ribosome export 14 4.30E-5
14 SGTC_366 0181-0206 3.83 4.3 µM 6.51E-5 Golgi 46 6.38E-5
15 SGTC_17 0960-0276 3.78 49.8 µM 8.07E-5 43 7.93E-5
16 SGTC_815 1582-0027 3.78 36.9 µM 8.12E-5 35 7.98E-5
17 SGTC_1343 1487-0095 3.76 224.0 µM 8.62E-5 10 8.47E-5
18 SGTC_1321 1326-2144 3.64 215.0 µM 1.38E-4 16 1.36E-4
19 SGTC_1727 st034309 3.64 9.9 µM 1.39E-4 56 1.37E-4
20 SGTC_2003 4023581 3.63 200.0 µM 1.44E-4 cell wall signaling 39 1.42E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.113 6.42E-11 YDL080C THI3 hom Probable alpha-ketoisocaproate decarboxylase, may have a role in catabolism of amino acids to long-chain and complex alcohols; required for expression of enzymes involved in thiamine biosynthesis
0.100 6.19E-9 YGR071C ENV11 hom Protein proposed to be involved in vacuolar functions; mutant shows defect in CPY processing and fragmented vacuoles; deletion mutant has increased glycogen accumulation and displays elongated buds; green fluorescent protein (GFP)-fusion protein localizes to the nucleus
0.098 1.46E-8 YMR160W YMR160W hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the membrane of the vacuole; mutant has enhanced sensitivity to overexpression of mutant huntingtin; YMR160W is not an essential gene; relative distribution within the vacuolar membrane changes upon DNA replication stress
0.090 1.53E-7 YER051W JHD1 hom JmjC domain family histone demethylase specific for H3-K36, similar to proteins found in human, mouse, drosophila, X. laevis, C. elegans, and S. pombe
0.085 8.48E-7 YGR284C ERV29 hom Protein localized to COPII-coated vesicles; involved in vesicle formation and incorporation of specific secretory cargo; protein abundance increases in response to DNA replication stress
0.081 2.36E-6 YBR213W MET8 hom Bifunctional dehydrogenase and ferrochelatase, involved in the biosynthesis of siroheme, a prosthetic group used by sulfite reductase; required for sulfate assimilation and methionine biosynthesis
0.080 3.49E-6 YEL020C_p YEL020C_p hom Protein of unknown function with low sequence identity to Pdc1p; mRNA identified as translated by ribosome profiling data
0.078 6.64E-6 YGR012W YGR012W hom Putative cysteine synthase, localized to the mitochondrial outer membrane
0.074 1.80E-5 YOR225W_d YOR225W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.074 1.94E-5 YJR010C-A SPC1 hom Subunit of the signal peptidase complex (SPC); SPC cleaves the signal sequence from proteins targeted to the endoplasmic reticulum (ER); homolog of the SPC12 subunit of mammalian signal peptidase complex; protein abundance increases in response to DNA replication stress
0.071 3.89E-5 YFR011C AIM13 hom Mitochondrial protein peripheral to the inner membrane; component of the mitochondrial inner membrane organizing system (MINOS, MitOS, or MICOS), a scaffold-like structure on the intermembrane space side of the inner membrane which has a role in the maintenance of crista junctions and inner membrane architecture
0.071 4.24E-5 YDR412W RRP17 het Component of the pre-60S pre-ribosomal particle; required for cell viability under standard (aerobic) conditions but not under anaerobic conditions; exonuclease required for 5′ end processing of pre-60S ribosomal RNA
0.069 6.59E-5 YPR055W SEC8 het Essential 121 kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane prior to SNARE-mediated fusion; involved in ER and Golgi inheritance in small buds; relocalizes away from bud neck upon DNA replication stress
0.069 7.02E-5 YIR017C MET28 hom Basic leucine zipper (bZIP) transcriptional activator in the Cbf1p-Met4p-Met28p complex, participates in the regulation of sulfur metabolism
0.067 9.90E-5 YNL116W DMA2 hom Ubiquitin-protein ligase (E3); controls septin dynamics and the spindle position checkpoint (SPOC) along with functionally redundant ligase Dma1p by regulating the recruitment of Elm1p to the bud neck; regulates levels of the translation initiation factor eIF2 subunit Gcd11p, as well as abundance, localization, and ubiquitination of Cdk inhibitory kinase Swe1p; ortholog of human RNF8 protein, with sequence similarity to human Chfr; contains FHA and RING finger domains