YJL215C_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YJL215C / YJL215C

Click on Significant Values for Screen Details ID:SGTC_147|Compound:4466-0538|FD-Score:-5.16|P-value:1.05E-6 ID:SGTC_421|Compound:streptovitacin|FD-Score:4.95|P-value:2.27E-6 ID:SGTC_540|Compound:1187-0821|FD-Score:4.09|P-value:7.52E-5 ID:SGTC_619|Compound:1652-1634|FD-Score:3.57|P-value:4.70E-4 ID:SGTC_640|Compound:3381-0960|FD-Score:-3.64|P-value:4.15E-4 ID:SGTC_665|Compound:3914-0008|FD-Score:3.55|P-value:5.04E-4 ID:SGTC_692|Compound:k241-0027|FD-Score:3.83|P-value:1.91E-4 ID:SGTC_864|Compound:0469-0573|FD-Score:3.98|P-value:1.11E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:4.85|P-value:3.50E-6 ID:SGTC_1405|Compound:3909-7894|FD-Score:4.75|P-value:5.42E-6 ID:SGTC_1573|Compound:oleylamine|FD-Score:3.40|P-value:8.12E-4 ID:SGTC_2287|Compound:7945887|FD-Score:-3.38|P-value:9.61E-4 ID:SGTC_2391|Compound:6285546|FD-Score:4.08|P-value:7.78E-5 ID:SGTC_2477|Compound:5967686|FD-Score:6.33|P-value:2.35E-9 ID:SGTC_2557|Compound:derrustone|FD-Score:4.00|P-value:1.05E-4 ID:SGTC_2581|Compound:avocatin a|FD-Score:3.51|P-value:5.69E-4 ID:SGTC_2629|Compound:bisabolol|FD-Score:5.09|P-value:1.21E-6 ID:SGTC_2791|Compound:5663188|FD-Score:4.68|P-value:7.19E-6 ID:SGTC_2904|Compound:7225135|FD-Score:5.44|P-value:2.41E-7 ID:SGTC_2908|Compound:7930301|FD-Score:-3.42|P-value:8.35E-4 ID:SGTC_2916|Compound:7875993|FD-Score:-6.25|P-value:4.38E-9 ID:SGTC_2920|Compound:7982904|FD-Score:4.18|P-value:5.41E-5 ID:SGTC_2974|Compound:9094440|FD-Score:-3.76|P-value:2.81E-4 ID:SGTC_3026|Compound:9090633|FD-Score:4.47|P-value:1.72E-5 ID:SGTC_3108|Compound:9121785|FD-Score:-4.27|P-value:4.39E-5 ID:SGTC_3149|Compound:9097855|FD-Score:3.37|P-value:8.91E-4 ID:SGTC_3179|Compound:9107801|FD-Score:4.13|P-value:6.46E-5 ID:SGTC_3225|Compound:9130819|FD-Score:-3.38|P-value:9.61E-4 ID:SGTC_3319|Compound:9138450|FD-Score:3.69|P-value:3.14E-4 ID:SGTC_3340|Compound:9146634|FD-Score:4.60|P-value:1.01E-5 ID:SGTC_147|Compound:4466-0538|FD-Score:-5.16|P-value:1.05E-6 ID:SGTC_421|Compound:streptovitacin|FD-Score:4.95|P-value:2.27E-6 ID:SGTC_540|Compound:1187-0821|FD-Score:4.09|P-value:7.52E-5 ID:SGTC_619|Compound:1652-1634|FD-Score:3.57|P-value:4.70E-4 ID:SGTC_640|Compound:3381-0960|FD-Score:-3.64|P-value:4.15E-4 ID:SGTC_665|Compound:3914-0008|FD-Score:3.55|P-value:5.04E-4 ID:SGTC_692|Compound:k241-0027|FD-Score:3.83|P-value:1.91E-4 ID:SGTC_864|Compound:0469-0573|FD-Score:3.98|P-value:1.11E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:4.85|P-value:3.50E-6 ID:SGTC_1405|Compound:3909-7894|FD-Score:4.75|P-value:5.42E-6 ID:SGTC_1573|Compound:oleylamine|FD-Score:3.40|P-value:8.12E-4 ID:SGTC_2287|Compound:7945887|FD-Score:-3.38|P-value:9.61E-4 ID:SGTC_2391|Compound:6285546|FD-Score:4.08|P-value:7.78E-5 ID:SGTC_2477|Compound:5967686|FD-Score:6.33|P-value:2.35E-9 ID:SGTC_2557|Compound:derrustone|FD-Score:4.00|P-value:1.05E-4 ID:SGTC_2581|Compound:avocatin a|FD-Score:3.51|P-value:5.69E-4 ID:SGTC_2629|Compound:bisabolol|FD-Score:5.09|P-value:1.21E-6 ID:SGTC_2791|Compound:5663188|FD-Score:4.68|P-value:7.19E-6 ID:SGTC_2904|Compound:7225135|FD-Score:5.44|P-value:2.41E-7 ID:SGTC_2908|Compound:7930301|FD-Score:-3.42|P-value:8.35E-4 ID:SGTC_2916|Compound:7875993|FD-Score:-6.25|P-value:4.38E-9 ID:SGTC_2920|Compound:7982904|FD-Score:4.18|P-value:5.41E-5 ID:SGTC_2974|Compound:9094440|FD-Score:-3.76|P-value:2.81E-4 ID:SGTC_3026|Compound:9090633|FD-Score:4.47|P-value:1.72E-5 ID:SGTC_3108|Compound:9121785|FD-Score:-4.27|P-value:4.39E-5 ID:SGTC_3149|Compound:9097855|FD-Score:3.37|P-value:8.91E-4 ID:SGTC_3179|Compound:9107801|FD-Score:4.13|P-value:6.46E-5 ID:SGTC_3225|Compound:9130819|FD-Score:-3.38|P-value:9.61E-4 ID:SGTC_3319|Compound:9138450|FD-Score:3.69|P-value:3.14E-4 ID:SGTC_3340|Compound:9146634|FD-Score:4.60|P-value:1.01E-5

Top fitness defect scores for YJL215C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2477 5967686 6.33 25.2 µM 2.35E-9 5 1.22E-10
2 SGTC_2904 7225135 5.44 42.0 µM 2.41E-7 2 2.70E-8
3 SGTC_2629 bisabolol 5.09 100.0 µM 1.21E-6 7 1.77E-7
4 SGTC_421 streptovitacin 4.95 30.0 mM 2.27E-6 7 3.68E-7
5 SGTC_1082 camptothecin 4.85 424.9 nM 3.50E-6 DNA damage response 32 6.08E-7
6 SGTC_1405 3909-7894 4.75 12.0 µM 5.42E-6 60S ribosome export 2 1.01E-6
7 SGTC_2791 5663188 4.68 71.4 µM 7.19E-6 RPP1 & pyrimidine depletion 9 1.41E-6
8 SGTC_3340 9146634 4.60 11.1 µM 1.01E-5 7 2.08E-6
9 SGTC_3026 9090633 4.47 49.5 µM 1.72E-5 10 3.88E-6
10 SGTC_2920 7982904 4.18 15.8 µM 5.41E-5 18 1.47E-5
11 SGTC_3179 9107801 4.13 49.5 µM 6.46E-5 6 1.80E-5
12 SGTC_540 1187-0821 4.09 17.3 µM 7.52E-5 14 2.15E-5
13 SGTC_2391 6285546 4.08 200.0 µM 7.78E-5 15 2.24E-5
14 SGTC_2557 derrustone 4.00 83.8 µM 1.05E-4 32 3.18E-5
15 SGTC_864 0469-0573 3.98 172.0 µM 1.11E-4 19 3.39E-5
16 SGTC_692 k241-0027 3.83 77.8 µM 1.91E-4 10 6.36E-5
17 SGTC_3319 9138450 3.69 16.8 µM 3.14E-4 27 1.13E-4
18 SGTC_619 1652-1634 3.57 108.0 µM 4.70E-4 PDR1 27 1.80E-4
19 SGTC_665 3914-0008 3.55 307.0 µM 5.04E-4 29 1.95E-4
20 SGTC_2581 avocatin a 3.51 64.0 µM 5.69E-4 sphingolipid biosynthesis & PDR1 68 2.24E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.085 7.28E-7 YBR099C_d YBR099C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene MMS4
0.082 1.81E-6 YDL071C_d YDL071C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF BDF2/YDL070W
0.080 3.64E-6 YBR074W_p YBR074W_p hom Putative metalloprotease
0.077 7.93E-6 YNL181W_p YNL181W_p het Putative oxidoreductase; required for cell viability
0.075 1.20E-5 YJL075C_d APQ13_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 85% of ORF overlaps the verified gene NET1; null mutant is sensitive to sorbate
0.075 1.21E-5 YOR058C ASE1 hom Mitotic spindle midzone localized protein; microtubule-associated protein (MAP) family member; required for spindle elongation and stabilization; undergoes cell cycle-regulated degradation by anaphase promoting complex; potential Cdc28p substrate; relative distribution to microtubules decreases upon DNA replication stress
0.075 1.25E-5 YMR172W HOT1 hom Transcription factor required for the transient induction of glycerol biosynthetic genes GPD1 and GPP2 in response to high osmolarity; targets Hog1p to osmostress responsive promoters; has similarity to Msn1p and Gcr1p
0.073 2.23E-5 YIL095W PRK1 hom Protein serine/threonine kinase; regulates the organization and function of the actin cytoskeleton and reduces endocytic ability of cell through the phosphorylation of the Pan1p-Sla1p-End3p protein complex; PRK1 has a paralog, ARK1, that arose from the whole genome duplication
0.072 2.71E-5 YPL130W SPO19 hom Meiosis-specific prospore protein; required to produce bending force necessary for proper assembly of the prospore membrane during sporulation; identified as a weak high-copy suppressor of the spo1-1 ts mutation
0.072 3.13E-5 YBL098W BNA4 hom Kynurenine 3-mono oxygenase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p; putative therapeutic target for Huntington disease
0.072 3.24E-5 YDR006C SOK1 hom Protein whose overexpression suppresses the growth defect of mutants lacking protein kinase A activity; involved in cAMP-mediated signaling; localized to the nucleus; similar to the mouse testis-specific protein PBS13
0.072 3.30E-5 YBR058C UBP14 hom Ubiquitin-specific protease that specifically disassembles unanchored ubiquitin chains; involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; similar to human isopeptidase T
0.070 4.49E-5 YPL154C PEP4 hom Vacuolar aspartyl protease (proteinase A), required for the posttranslational precursor maturation of vacuolar proteinases; important for protein turnover after oxidative damage; synthesized as a zymogen, self-activates
0.069 6.41E-5 YOR028C CIN5 hom Basic leucine zipper (bZIP) transcription factor of the yAP-1 family; physically interacts with the Tup1-Cyc8 complex and recruits Tup1p to its targets; mediates pleiotropic drug resistance and salt tolerance; nuclearly localized under oxidative stress and sequestered in the cytoplasm by Lot6p under reducing conditions; CIN5 has a paralog, YAP6, that arose from the whole genome duplication
0.069 7.06E-5 YIL101C XBP1 hom Transcriptional repressor; binds to promoter sequences of the cyclin genes, CYS3, and SMF2; expression is induced by stress or starvation during mitosis, and late in meiosis; member of the Swi4p/Mbp1p family; potential Cdc28p substrate; relative distribution to the nucleus increases upon DNA replication stress