YJL218W_p

Putative acetyltransferase; similar to bacterial galactoside O-acetyltransferases; induced by oleate in an OAF1/PIP2-dependent manner; promoter contains an oleate response element consensus sequence; non-essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YJL218W / YJL218W

Click on Significant Values for Screen Details ID:SGTC_456|Compound:gingerol|FD-Score:3.22|P-value:6.37E-4 ID:SGTC_651|Compound:3253-0966|FD-Score:-3.70|P-value:1.00E-4 ID:SGTC_666|Compound:0272-0154|FD-Score:-4.96|P-value:3.30E-7 ID:SGTC_757|Compound:1066-0008|FD-Score:5.97|P-value:1.17E-9 ID:SGTC_775|Compound:4577-0580|FD-Score:4.65|P-value:1.66E-6 ID:SGTC_785|Compound:1270-0111|FD-Score:4.85|P-value:6.23E-7 ID:SGTC_789|Compound:1309-1135|FD-Score:10.60|P-value:1.02E-26 ID:SGTC_844|Compound:0330-0132|FD-Score:4.48|P-value:3.69E-6 ID:SGTC_913|Compound:3487-1245|FD-Score:3.30|P-value:4.93E-4 ID:SGTC_971|Compound:1315-0384|FD-Score:3.19|P-value:7.09E-4 ID:SGTC_1051|Compound:3253-3903|FD-Score:-3.22|P-value:6.10E-4 ID:SGTC_1053|Compound:3366-3204|FD-Score:5.29|P-value:6.13E-8 ID:SGTC_1054|Compound:3429-0080|FD-Score:4.88|P-value:5.26E-7 ID:SGTC_1055|Compound:3448-0672|FD-Score:-3.43|P-value:2.86E-4 ID:SGTC_1124|Compound:fisetin|FD-Score:3.49|P-value:2.44E-4 ID:SGTC_1248|Compound:0469-0687|FD-Score:-3.33|P-value:4.14E-4 ID:SGTC_1271|Compound:0832-2808|FD-Score:-3.25|P-value:5.55E-4 ID:SGTC_1740|Compound:st038286|FD-Score:3.30|P-value:4.83E-4 ID:SGTC_1747|Compound:st037496|FD-Score:3.54|P-value:2.04E-4 ID:SGTC_1811|Compound:st050069|FD-Score:3.98|P-value:3.41E-5 ID:SGTC_1819|Compound:st053448|FD-Score:4.63|P-value:1.84E-6 ID:SGTC_1821|Compound:st053465|FD-Score:3.57|P-value:1.79E-4 ID:SGTC_2165|Compound:5727197|FD-Score:3.63|P-value:1.44E-4 ID:SGTC_2273|Compound:7815444|FD-Score:3.09|P-value:9.93E-4 ID:SGTC_2313|Compound:7726885|FD-Score:3.44|P-value:2.96E-4 ID:SGTC_2413|Compound:inermin|FD-Score:3.82|P-value:6.66E-5 ID:SGTC_2416|Compound:tofa|FD-Score:4.98|P-value:3.20E-7 ID:SGTC_2563|Compound:tomatine|FD-Score:3.73|P-value:9.65E-5 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:-3.55|P-value:1.83E-4 ID:SGTC_2640|Compound:pentamidine|FD-Score:-3.64|P-value:1.28E-4 ID:SGTC_2830|Compound:7992007|FD-Score:5.51|P-value:1.79E-8 ID:SGTC_2992|Compound:9074591|FD-Score:3.10|P-value:9.72E-4 ID:SGTC_456|Compound:gingerol|FD-Score:3.22|P-value:6.37E-4 ID:SGTC_651|Compound:3253-0966|FD-Score:-3.70|P-value:1.00E-4 ID:SGTC_666|Compound:0272-0154|FD-Score:-4.96|P-value:3.30E-7 ID:SGTC_757|Compound:1066-0008|FD-Score:5.97|P-value:1.17E-9 ID:SGTC_775|Compound:4577-0580|FD-Score:4.65|P-value:1.66E-6 ID:SGTC_785|Compound:1270-0111|FD-Score:4.85|P-value:6.23E-7 ID:SGTC_789|Compound:1309-1135|FD-Score:10.60|P-value:1.02E-26 ID:SGTC_844|Compound:0330-0132|FD-Score:4.48|P-value:3.69E-6 ID:SGTC_913|Compound:3487-1245|FD-Score:3.30|P-value:4.93E-4 ID:SGTC_971|Compound:1315-0384|FD-Score:3.19|P-value:7.09E-4 ID:SGTC_1051|Compound:3253-3903|FD-Score:-3.22|P-value:6.10E-4 ID:SGTC_1053|Compound:3366-3204|FD-Score:5.29|P-value:6.13E-8 ID:SGTC_1054|Compound:3429-0080|FD-Score:4.88|P-value:5.26E-7 ID:SGTC_1055|Compound:3448-0672|FD-Score:-3.43|P-value:2.86E-4 ID:SGTC_1124|Compound:fisetin|FD-Score:3.49|P-value:2.44E-4 ID:SGTC_1248|Compound:0469-0687|FD-Score:-3.33|P-value:4.14E-4 ID:SGTC_1271|Compound:0832-2808|FD-Score:-3.25|P-value:5.55E-4 ID:SGTC_1740|Compound:st038286|FD-Score:3.30|P-value:4.83E-4 ID:SGTC_1747|Compound:st037496|FD-Score:3.54|P-value:2.04E-4 ID:SGTC_1811|Compound:st050069|FD-Score:3.98|P-value:3.41E-5 ID:SGTC_1819|Compound:st053448|FD-Score:4.63|P-value:1.84E-6 ID:SGTC_1821|Compound:st053465|FD-Score:3.57|P-value:1.79E-4 ID:SGTC_2165|Compound:5727197|FD-Score:3.63|P-value:1.44E-4 ID:SGTC_2273|Compound:7815444|FD-Score:3.09|P-value:9.93E-4 ID:SGTC_2313|Compound:7726885|FD-Score:3.44|P-value:2.96E-4 ID:SGTC_2413|Compound:inermin|FD-Score:3.82|P-value:6.66E-5 ID:SGTC_2416|Compound:tofa|FD-Score:4.98|P-value:3.20E-7 ID:SGTC_2563|Compound:tomatine|FD-Score:3.73|P-value:9.65E-5 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:-3.55|P-value:1.83E-4 ID:SGTC_2640|Compound:pentamidine|FD-Score:-3.64|P-value:1.28E-4 ID:SGTC_2830|Compound:7992007|FD-Score:5.51|P-value:1.79E-8 ID:SGTC_2992|Compound:9074591|FD-Score:3.10|P-value:9.72E-4

Top fitness defect scores for YJL218W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_789 1309-1135 10.60 70.6 µM 1.02E-26 ERG2 2 1.19E-26
2 SGTC_757 1066-0008 5.97 322.0 µM 1.17E-9 Golgi 4 1.20E-9
3 SGTC_2830 7992007 5.51 71.4 µM 1.79E-8 4 1.82E-8
4 SGTC_1053 3366-3204 5.29 134.0 µM 6.13E-8 cell wall 13 6.24E-8
5 SGTC_2416 tofa 4.98 880.0 nM 3.20E-7 sphingolipid biosynthesis & PDR1 27 3.24E-7
6 SGTC_1054 3429-0080 4.88 167.0 µM 5.26E-7 17 5.33E-7
7 SGTC_785 1270-0111 4.85 65.3 µM 6.23E-7 10 6.31E-7
8 SGTC_775 4577-0580 4.65 57.3 µM 1.66E-6 4 1.68E-6
9 SGTC_1819 st053448 4.63 58.6 µM 1.84E-6 amide catabolism 8 1.86E-6
10 SGTC_844 0330-0132 4.48 15.3 µM 3.69E-6 10 3.72E-6
11 SGTC_1811 st050069 3.98 61.5 µM 3.41E-5 4 3.42E-5
12 SGTC_2413 inermin 3.82 26.1 µM 6.66E-5 60 6.67E-5
13 SGTC_2563 tomatine 3.73 8.5 µM 9.65E-5 59 9.66E-5
14 SGTC_2165 5727197 3.63 32.1 µM 1.44E-4 46 1.44E-4
15 SGTC_1821 st053465 3.57 65.6 µM 1.79E-4 13 1.78E-4
16 SGTC_1747 st037496 3.54 66.6 µM 2.04E-4 28 2.04E-4
17 SGTC_1124 fisetin 3.49 1.2 µM 2.44E-4 52 2.43E-4
18 SGTC_2313 7726885 3.44 200.0 µM 2.96E-4 RPP1 & pyrimidine depletion 52 2.96E-4
19 SGTC_1740 st038286 3.30 13.2 µM 4.83E-4 57 4.82E-4
20 SGTC_913 3487-1245 3.30 167.0 µM 4.93E-4 64 4.92E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.159 2.27E-20 YKR028W SAP190 hom Protein that forms a complex with the Sit4p protein phosphatase; required for Sit4p function; member of a family of similar proteins including Sap4p, Sap155p, and Sap185p; SAP190 has a paralog, SAP185, that arose from the whole genome duplication
0.135 3.44E-15 YIR032C DAL3 hom Ureidoglycolate hydrolase, converts ureidoglycolate to glyoxylate and urea in the third step of allantoin degradation; expression sensitive to nitrogen catabolite repression
0.116 1.81E-11 YJR023C_d YJR023C_d het Putative protein of unknown function; open reading frame overlaps LSM8/YJR022W encoding an essential snRNP protein required for RNA processing and splicing
0.115 2.85E-11 YFL038C YPT1 het Rab family GTPase, involved in the ER-to-Golgi step of the secretory pathway; complex formation with the Rab escort protein Mrs6p is required for prenylation of Ypt1p by protein geranylgeranyltransferase type II (Bet2p-Bet4p)
0.103 2.48E-9 YBR236C ABD1 het Methyltransferase, catalyzes the transfer of a methyl group from S-adenosylmethionine to the GpppN terminus of capped mRNA
0.100 6.49E-9 YNR066C_p YNR066C_p hom Putative membrane-localized protein of unknown function
0.100 7.26E-9 YAL044W-A_p YAL044W-A_p hom Putative protein of unknown function; similar to S. pombe uvi31 which is a putative DNA repair protein
0.099 8.02E-9 YNR032C-A HUB1 hom Ubiquitin-like protein modifier; promotes alternative splicing of SRC1 pre-mRNA; binds non-covalently to the HIND domain of Snu66, may function in modification of Sph1p and Hbt1p, functionally complemented by the human or S. pombe ortholog; mechanism of Hub1p adduct formation not yet clear
0.097 1.77E-8 YFL046W_p FMP32_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.096 2.45E-8 YIL140W AXL2 hom Integral plasma membrane protein required for axial budding in haploid cells, localizes to the incipient bud site and bud neck; glycosylated by Pmt4p; potential Cdc28p substrate
0.095 3.02E-8 YKR013W PRY2 hom Sterol binding protein involved in the export of acetylated sterols; secreted glycoprotein and member of the CAP protein superfamily (cysteine-rich secretory proteins (CRISP), antigen 5, and pathogenesis related 1 proteins); sterol export function is redundant with that of PRY1; may be involved in detoxification of hydrophobic compounds; PRY2 has a paralog, PRY1, that arose from the whole genome duplication
0.094 4.41E-8 YEL062W NPR2 hom Subunit of SEA (Seh1-associated), Npr2/3, and Iml1p complexes; Npr2/3 complex mediates downregulation of TORC1 activity upon amino acid limitation; SEA complex is a coatomer-related complex that associates dynamically with the vacuole; Iml1p complex (Iml1p-Npr2p-Npr3p) is required for non-nitrogen-starvation (NNS)-induced autophagy; Iml1p interacts primarily with phosphorylated Npr2p; homolog of human NPRL2; target of Grr1p; required for growth on urea and proline
0.092 9.95E-8 YLR348C DIC1 hom Mitochondrial dicarboxylate carrier, integral membrane protein, catalyzes a dicarboxylate-phosphate exchange across the inner mitochondrial membrane, transports cytoplasmic dicarboxylates into the mitochondrial matrix
0.090 1.81E-7 YLR341W SPO77 hom Meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensable for both nuclear divisions during meiosis
0.088 3.00E-7 YGR203W YCH1 hom Phosphatase with sequence similarity to Cdc25p, Arr2p and Mih1p; member of the single-domain rhodanese homology superfamily; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus