YJR004C / SAG1

Alpha-agglutinin of alpha-cells, binds to Aga1p during agglutination, N-terminal half is homologous to the immunoglobulin superfamily and contains binding site for a-agglutinin, C-terminal half is highly glycosylated and contains GPI anchor

Zygosity: Homozygous strain
fixedexpanded
Profile for YJR004C / SAG1

Click on Significant Values for Screen Details ID:SGTC_135|Compound:0933-0004|FD-Score:3.41|P-value:3.02E-4 ID:SGTC_283|Compound:0987-0079|FD-Score:3.87|P-value:4.93E-5 ID:SGTC_375|Compound:3970-0961|FD-Score:-3.74|P-value:7.63E-5 ID:SGTC_382|Compound:3229-0966|FD-Score:4.15|P-value:1.48E-5 ID:SGTC_564|Compound:3555-0129|FD-Score:3.24|P-value:5.46E-4 ID:SGTC_1044|Compound:1222-0021|FD-Score:3.19|P-value:6.54E-4 ID:SGTC_1493|Compound:4348-0038|FD-Score:4.43|P-value:3.94E-6 ID:SGTC_1592|Compound:4',5'-dihydroxyflavone|FD-Score:3.07|P-value:9.92E-4 ID:SGTC_1598|Compound:3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin|FD-Score:3.36|P-value:3.53E-4 ID:SGTC_1732|Compound:st034308|FD-Score:3.23|P-value:5.81E-4 ID:SGTC_2004|Compound:4023728|FD-Score:3.50|P-value:2.13E-4 ID:SGTC_2008|Compound:4012253|FD-Score:4.81|P-value:6.36E-7 ID:SGTC_2022|Compound:5136654|FD-Score:3.23|P-value:5.72E-4 ID:SGTC_2027|Compound:5150920|FD-Score:3.40|P-value:3.08E-4 ID:SGTC_2304|Compound:7443016|FD-Score:-3.31|P-value:4.12E-4 ID:SGTC_2341|Compound:7987486|FD-Score:3.63|P-value:1.28E-4 ID:SGTC_2570|Compound:licareol|FD-Score:3.26|P-value:5.06E-4 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:-3.12|P-value:8.04E-4 ID:SGTC_2639|Compound:lactacystin|FD-Score:7.13|P-value:3.19E-13 ID:SGTC_2647|Compound:atorvastatin|FD-Score:4.22|P-value:1.07E-5 ID:SGTC_2884|Compound:9058502|FD-Score:3.96|P-value:3.36E-5 ID:SGTC_2907|Compound:7721985|FD-Score:-3.26|P-value:4.80E-4 ID:SGTC_2915|Compound:7971052|FD-Score:3.77|P-value:7.29E-5 ID:SGTC_2960|Compound:9079389|FD-Score:3.59|P-value:1.49E-4 ID:SGTC_3216|Compound:9129716|FD-Score:3.10|P-value:9.03E-4 ID:SGTC_3218|Compound:9131285|FD-Score:6.69|P-value:7.63E-12 ID:SGTC_3219|Compound:9131112|FD-Score:3.42|P-value:2.86E-4 ID:SGTC_3319|Compound:9138450|FD-Score:3.50|P-value:2.15E-4 ID:SGTC_135|Compound:0933-0004|FD-Score:3.41|P-value:3.02E-4 ID:SGTC_283|Compound:0987-0079|FD-Score:3.87|P-value:4.93E-5 ID:SGTC_375|Compound:3970-0961|FD-Score:-3.74|P-value:7.63E-5 ID:SGTC_382|Compound:3229-0966|FD-Score:4.15|P-value:1.48E-5 ID:SGTC_564|Compound:3555-0129|FD-Score:3.24|P-value:5.46E-4 ID:SGTC_1044|Compound:1222-0021|FD-Score:3.19|P-value:6.54E-4 ID:SGTC_1493|Compound:4348-0038|FD-Score:4.43|P-value:3.94E-6 ID:SGTC_1592|Compound:4',5'-dihydroxyflavone|FD-Score:3.07|P-value:9.92E-4 ID:SGTC_1598|Compound:3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin|FD-Score:3.36|P-value:3.53E-4 ID:SGTC_1732|Compound:st034308|FD-Score:3.23|P-value:5.81E-4 ID:SGTC_2004|Compound:4023728|FD-Score:3.50|P-value:2.13E-4 ID:SGTC_2008|Compound:4012253|FD-Score:4.81|P-value:6.36E-7 ID:SGTC_2022|Compound:5136654|FD-Score:3.23|P-value:5.72E-4 ID:SGTC_2027|Compound:5150920|FD-Score:3.40|P-value:3.08E-4 ID:SGTC_2304|Compound:7443016|FD-Score:-3.31|P-value:4.12E-4 ID:SGTC_2341|Compound:7987486|FD-Score:3.63|P-value:1.28E-4 ID:SGTC_2570|Compound:licareol|FD-Score:3.26|P-value:5.06E-4 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:-3.12|P-value:8.04E-4 ID:SGTC_2639|Compound:lactacystin|FD-Score:7.13|P-value:3.19E-13 ID:SGTC_2647|Compound:atorvastatin|FD-Score:4.22|P-value:1.07E-5 ID:SGTC_2884|Compound:9058502|FD-Score:3.96|P-value:3.36E-5 ID:SGTC_2907|Compound:7721985|FD-Score:-3.26|P-value:4.80E-4 ID:SGTC_2915|Compound:7971052|FD-Score:3.77|P-value:7.29E-5 ID:SGTC_2960|Compound:9079389|FD-Score:3.59|P-value:1.49E-4 ID:SGTC_3216|Compound:9129716|FD-Score:3.10|P-value:9.03E-4 ID:SGTC_3218|Compound:9131285|FD-Score:6.69|P-value:7.63E-12 ID:SGTC_3219|Compound:9131112|FD-Score:3.42|P-value:2.86E-4 ID:SGTC_3319|Compound:9138450|FD-Score:3.50|P-value:2.15E-4

Top fitness defect scores for YJR004C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2639 lactacystin 7.13 53.0 µM 3.19E-13 2 4.89E-13
2 SGTC_3218 9131285 6.69 49.5 µM 7.63E-12 endomembrane recycling 10 1.11E-11
3 SGTC_2008 4012253 4.81 172.0 µM 6.36E-7 8 7.66E-7
4 SGTC_1493 4348-0038 4.43 111.0 µM 3.94E-6 RSC complex & mRNA processing 15 4.61E-6
5 SGTC_2647 atorvastatin 4.22 60.2 µM 1.07E-5 azole & statin 13 1.23E-5
6 SGTC_382 3229-0966 4.15 23.2 µM 1.48E-5 14 1.70E-5
7 SGTC_2884 9058502 3.96 52.0 µM 3.36E-5 30 3.80E-5
8 SGTC_283 0987-0079 3.87 11.7 µM 4.93E-5 28 5.54E-5
9 SGTC_2915 7971052 3.77 15.2 µM 7.29E-5 9 8.14E-5
10 SGTC_2341 7987486 3.63 176.7 µM 1.28E-4 25 1.42E-4
11 SGTC_2960 9079389 3.59 6.0 µM 1.49E-4 43 1.64E-4
12 SGTC_2004 4023728 3.50 41.9 µM 2.13E-4 40 2.33E-4
13 SGTC_3319 9138450 3.50 16.8 µM 2.15E-4 32 2.36E-4
14 SGTC_3219 9131112 3.42 49.5 µM 2.86E-4 Golgi 54 3.13E-4
15 SGTC_135 0933-0004 3.41 26.4 µM 3.02E-4 60S ribosome export 42 3.30E-4
16 SGTC_2027 5150920 3.40 200.0 µM 3.08E-4 26 3.36E-4
17 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 3.36 19.1 µM 3.53E-4 47 3.84E-4
18 SGTC_2570 licareol 3.26 100.0 µM 5.06E-4 59 5.48E-4
19 SGTC_564 3555-0129 3.24 330.0 µM 5.46E-4 20 5.90E-4
20 SGTC_2022 5136654 3.23 200.0 µM 5.72E-4 45 6.19E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.138 1.23E-15 YJL064W_d YJL064W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene YJL065C/DLS1
0.128 1.01E-13 YLR080W EMP46 hom Integral membrane component of endoplasmic reticulum-derived COPII-coated vesicles, which function in ER to Golgi transport
0.113 5.51E-11 YOR288C MPD1 hom Member of the protein disulfide isomerase (PDI) family; interacts with and inhibits the chaperone activity of Cne1p; MPD1 overexpression in a pdi1 null mutant suppresses defects in Pdi1p functions such as carboxypeptidase Y maturation
0.112 8.01E-11 YBR273C UBX7 hom UBX (ubiquitin regulatory X) domain-containing protein; interacts with Cdc48p; UBX7 has a paralog, UBX6, that arose from the whole genome duplication
0.111 1.30E-10 YKR031C SPO14 hom Phospholipase D; catalyzes the hydrolysis of phosphatidylcholine, producing choline and phosphatidic acid; involved in Sec14p-independent secretion; required for meiosis and spore formation; differently regulated in secretion and meiosis; participates in transcription initiation and/or early elongation of specific genes; interacts with foot domain of RNA polymerase II; deletion results in abnormal CTD-Ser5 phosphorylation of RNA polymerase II at specific promoter regions
0.100 7.14E-9 YHR095W_d YHR095W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.097 1.94E-8 YOR380W RDR1 hom Transcriptional repressor involved in the control of multidrug resistance; negatively regulates expression of the PDR5 gene; member of the Gal4p family of zinc cluster proteins
0.096 2.87E-8 YDR021W FAL1 het Nucleolar protein required for maturation of 18S rRNA, member of the eIF4A subfamily of DEAD-box ATP-dependent RNA helicases
0.091 1.21E-7 YBL013W FMT1 hom Methionyl-tRNA formyltransferase, catalyzes the formylation of initiator Met-tRNA in mitochondria; potential Cdc28p substrate
0.090 1.64E-7 YOR344C TYE7 hom Serine-rich protein that contains a basic-helix-loop-helix (bHLH) DNA binding motif; binds E-boxes of glycolytic genes and contributes to their activation; may function as a transcriptional activator in Ty1-mediated gene expression
0.084 1.09E-6 YOR348C PUT4 hom Proline permease, required for high-affinity transport of proline; also transports the toxic proline analog azetidine-2-carboxylate (AzC); PUT4 transcription is repressed in ammonia-grown cells
0.083 1.47E-6 YJL107C_p YJL107C_p hom Putative protein of unknown function; expression is induced by activation of the HOG1 mitogen-activated signaling pathway and this induction is Hog1p/Pbs2p dependent; YJL107C and adjacent ORF, YJL108C are merged in related fungi
0.081 2.60E-6 YCR015C_p YCR015C_p hom Putative protein of unknown function; YCR015C is not an essential gene
0.081 2.99E-6 YGR115C_d YGR115C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified and essential ORF SPT6/YGR115C
0.080 3.35E-6 YGL073W HSF1 het Trimeric heat shock transcription factor, activates multiple genes in response to stresses that include hyperthermia; recognizes variable heat shock elements (HSEs) consisting of inverted NGAAN repeats; posttranslationally regulated