YJR005C-A_p

Putative protein of unknown function; originally identified as a syntenic homolog of an Ashbya gossypii gene; YJR005C-A has a paralog, YGR169C-A, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YJR005C-A / YJR005C-A

Click on Significant Values for Screen Details ID:SGTC_159|Compound:3970-0959|FD-Score:-4.39|P-value:2.07E-6 ID:SGTC_162|Compound:k030-0015|FD-Score:5.42|P-value:6.32E-9 ID:SGTC_179|Compound:1273-0063|FD-Score:-3.56|P-value:9.49E-5 ID:SGTC_236|Compound:1509-0011|FD-Score:5.56|P-value:2.65E-9 ID:SGTC_319|Compound:1348-1596|FD-Score:3.21|P-value:3.77E-4 ID:SGTC_345|Compound:1362-0200|FD-Score:3.43|P-value:1.54E-4 ID:SGTC_746|Compound:1095-0025|FD-Score:3.22|P-value:3.61E-4 ID:SGTC_797|Compound:k781-0471|FD-Score:-2.97|P-value:9.11E-4 ID:SGTC_811|Compound:0416-0114|FD-Score:4.42|P-value:1.70E-6 ID:SGTC_922|Compound:1866-0035|FD-Score:3.47|P-value:1.34E-4 ID:SGTC_1269|Compound:0831-0796|FD-Score:5.31|P-value:1.20E-8 ID:SGTC_1283|Compound:0922-0125|FD-Score:3.54|P-value:9.76E-5 ID:SGTC_1384|Compound:3089-0840|FD-Score:3.28|P-value:2.80E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.60|P-value:7.92E-5 ID:SGTC_1520|Compound:flindersine|FD-Score:3.96|P-value:1.58E-5 ID:SGTC_1522|Compound:st012842|FD-Score:6.67|P-value:1.24E-12 ID:SGTC_1617|Compound:st002906|FD-Score:3.65|P-value:6.38E-5 ID:SGTC_1635|Compound:st007035|FD-Score:3.14|P-value:4.78E-4 ID:SGTC_1714|Compound:st033236|FD-Score:4.18|P-value:5.49E-6 ID:SGTC_1717|Compound:st033143|FD-Score:5.57|P-value:2.49E-9 ID:SGTC_1725|Compound:st036284|FD-Score:3.60|P-value:7.76E-5 ID:SGTC_1820|Compound:st053765|FD-Score:-3.30|P-value:2.72E-4 ID:SGTC_1908|Compound:st060353|FD-Score:3.18|P-value:4.20E-4 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:3.08|P-value:6.11E-4 ID:SGTC_1919|Compound:st067113|FD-Score:3.42|P-value:1.63E-4 ID:SGTC_1924|Compound:st058459|FD-Score:2.95|P-value:9.58E-4 ID:SGTC_1932|Compound:st074806|FD-Score:6.04|P-value:1.07E-10 ID:SGTC_1984|Compound:st072354|FD-Score:2.94|P-value:9.94E-4 ID:SGTC_2014|Compound:4013930|FD-Score:3.61|P-value:7.40E-5 ID:SGTC_2112|Compound:5488546|FD-Score:-3.67|P-value:5.98E-5 ID:SGTC_2116|Compound:5511452|FD-Score:3.92|P-value:1.91E-5 ID:SGTC_2119|Compound:5528445|FD-Score:3.26|P-value:3.10E-4 ID:SGTC_2215|Compound:7188065|FD-Score:3.38|P-value:1.88E-4 ID:SGTC_2270|Compound:7924575|FD-Score:3.53|P-value:1.04E-4 ID:SGTC_2423|Compound:st077119|FD-Score:-3.36|P-value:2.15E-4 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:3.12|P-value:5.21E-4 ID:SGTC_2605|Compound:digitonin|FD-Score:3.17|P-value:4.37E-4 ID:SGTC_2754|Compound:granisetron|FD-Score:3.70|P-value:5.04E-5 ID:SGTC_2784|Compound:7567673|FD-Score:-3.27|P-value:2.96E-4 ID:SGTC_2817|Compound:7995342|FD-Score:-4.85|P-value:1.80E-7 ID:SGTC_2827|Compound:7993847|FD-Score:3.00|P-value:7.96E-4 ID:SGTC_2848|Compound:9016370|FD-Score:4.49|P-value:1.18E-6 ID:SGTC_2852|Compound:9023854|FD-Score:3.30|P-value:2.62E-4 ID:SGTC_2858|Compound:9025781|FD-Score:5.59|P-value:2.18E-9 ID:SGTC_2917|Compound:7979103|FD-Score:3.30|P-value:2.63E-4 ID:SGTC_2922|Compound:7999257|FD-Score:-4.01|P-value:1.27E-5 ID:SGTC_2943|Compound:9068529|FD-Score:-3.11|P-value:5.46E-4 ID:SGTC_2950|Compound:9072895|FD-Score:-3.44|P-value:1.53E-4 ID:SGTC_2969|Compound:9091408|FD-Score:-2.95|P-value:9.77E-4 ID:SGTC_2973|Compound:9094665|FD-Score:-3.20|P-value:3.89E-4 ID:SGTC_3077|Compound:9117319|FD-Score:-3.73|P-value:4.55E-5 ID:SGTC_3332|Compound:9141069|FD-Score:-2.98|P-value:8.90E-4 ID:SGTC_159|Compound:3970-0959|FD-Score:-4.39|P-value:2.07E-6 ID:SGTC_162|Compound:k030-0015|FD-Score:5.42|P-value:6.32E-9 ID:SGTC_179|Compound:1273-0063|FD-Score:-3.56|P-value:9.49E-5 ID:SGTC_236|Compound:1509-0011|FD-Score:5.56|P-value:2.65E-9 ID:SGTC_319|Compound:1348-1596|FD-Score:3.21|P-value:3.77E-4 ID:SGTC_345|Compound:1362-0200|FD-Score:3.43|P-value:1.54E-4 ID:SGTC_746|Compound:1095-0025|FD-Score:3.22|P-value:3.61E-4 ID:SGTC_797|Compound:k781-0471|FD-Score:-2.97|P-value:9.11E-4 ID:SGTC_811|Compound:0416-0114|FD-Score:4.42|P-value:1.70E-6 ID:SGTC_922|Compound:1866-0035|FD-Score:3.47|P-value:1.34E-4 ID:SGTC_1269|Compound:0831-0796|FD-Score:5.31|P-value:1.20E-8 ID:SGTC_1283|Compound:0922-0125|FD-Score:3.54|P-value:9.76E-5 ID:SGTC_1384|Compound:3089-0840|FD-Score:3.28|P-value:2.80E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.60|P-value:7.92E-5 ID:SGTC_1520|Compound:flindersine|FD-Score:3.96|P-value:1.58E-5 ID:SGTC_1522|Compound:st012842|FD-Score:6.67|P-value:1.24E-12 ID:SGTC_1617|Compound:st002906|FD-Score:3.65|P-value:6.38E-5 ID:SGTC_1635|Compound:st007035|FD-Score:3.14|P-value:4.78E-4 ID:SGTC_1714|Compound:st033236|FD-Score:4.18|P-value:5.49E-6 ID:SGTC_1717|Compound:st033143|FD-Score:5.57|P-value:2.49E-9 ID:SGTC_1725|Compound:st036284|FD-Score:3.60|P-value:7.76E-5 ID:SGTC_1820|Compound:st053765|FD-Score:-3.30|P-value:2.72E-4 ID:SGTC_1908|Compound:st060353|FD-Score:3.18|P-value:4.20E-4 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:3.08|P-value:6.11E-4 ID:SGTC_1919|Compound:st067113|FD-Score:3.42|P-value:1.63E-4 ID:SGTC_1924|Compound:st058459|FD-Score:2.95|P-value:9.58E-4 ID:SGTC_1932|Compound:st074806|FD-Score:6.04|P-value:1.07E-10 ID:SGTC_1984|Compound:st072354|FD-Score:2.94|P-value:9.94E-4 ID:SGTC_2014|Compound:4013930|FD-Score:3.61|P-value:7.40E-5 ID:SGTC_2112|Compound:5488546|FD-Score:-3.67|P-value:5.98E-5 ID:SGTC_2116|Compound:5511452|FD-Score:3.92|P-value:1.91E-5 ID:SGTC_2119|Compound:5528445|FD-Score:3.26|P-value:3.10E-4 ID:SGTC_2215|Compound:7188065|FD-Score:3.38|P-value:1.88E-4 ID:SGTC_2270|Compound:7924575|FD-Score:3.53|P-value:1.04E-4 ID:SGTC_2423|Compound:st077119|FD-Score:-3.36|P-value:2.15E-4 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:3.12|P-value:5.21E-4 ID:SGTC_2605|Compound:digitonin|FD-Score:3.17|P-value:4.37E-4 ID:SGTC_2754|Compound:granisetron|FD-Score:3.70|P-value:5.04E-5 ID:SGTC_2784|Compound:7567673|FD-Score:-3.27|P-value:2.96E-4 ID:SGTC_2817|Compound:7995342|FD-Score:-4.85|P-value:1.80E-7 ID:SGTC_2827|Compound:7993847|FD-Score:3.00|P-value:7.96E-4 ID:SGTC_2848|Compound:9016370|FD-Score:4.49|P-value:1.18E-6 ID:SGTC_2852|Compound:9023854|FD-Score:3.30|P-value:2.62E-4 ID:SGTC_2858|Compound:9025781|FD-Score:5.59|P-value:2.18E-9 ID:SGTC_2917|Compound:7979103|FD-Score:3.30|P-value:2.63E-4 ID:SGTC_2922|Compound:7999257|FD-Score:-4.01|P-value:1.27E-5 ID:SGTC_2943|Compound:9068529|FD-Score:-3.11|P-value:5.46E-4 ID:SGTC_2950|Compound:9072895|FD-Score:-3.44|P-value:1.53E-4 ID:SGTC_2969|Compound:9091408|FD-Score:-2.95|P-value:9.77E-4 ID:SGTC_2973|Compound:9094665|FD-Score:-3.20|P-value:3.89E-4 ID:SGTC_3077|Compound:9117319|FD-Score:-3.73|P-value:4.55E-5 ID:SGTC_3332|Compound:9141069|FD-Score:-2.98|P-value:8.90E-4

Top fitness defect scores for YJR005C-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1522 st012842 6.67 45.6 µM 1.24E-12 RNA pol III & RNase P/MRP 4 1.30E-11
2 SGTC_1932 st074806 6.04 40.9 µM 1.07E-10 1 7.50E-10
3 SGTC_2858 9025781 5.59 9.0 µM 2.18E-9 sphingolipid biosynthesis & PDR1 54 1.15E-8
4 SGTC_1717 st033143 5.57 58.0 µM 2.49E-9 16 1.30E-8
5 SGTC_236 1509-0011 5.56 5.3 µM 2.65E-9 302 1.38E-8
6 SGTC_162 k030-0015 5.42 37.8 µM 6.32E-9 iron homeostasis 5 3.04E-8
7 SGTC_1269 0831-0796 5.31 3.0 µM 1.20E-8 60S ribosome export 3 5.43E-8
8 SGTC_2848 9016370 4.49 26.0 µM 1.18E-6 14 3.52E-6
9 SGTC_811 0416-0114 4.42 265.0 µM 1.70E-6 11 4.92E-6
10 SGTC_1714 st033236 4.18 13.6 µM 5.49E-6 17 1.43E-5
11 SGTC_1520 flindersine 3.96 88.0 µM 1.58E-5 32 3.74E-5
12 SGTC_2116 5511452 3.92 16.9 µM 1.91E-5 14 4.46E-5
13 SGTC_2754 granisetron 3.70 64.0 µM 5.04E-5 40 1.08E-4
14 SGTC_1617 st002906 3.65 78.0 µM 6.38E-5 33 1.34E-4
15 SGTC_2014 4013930 3.61 200.0 µM 7.40E-5 53 1.53E-4
16 SGTC_1725 st036284 3.60 20.6 µM 7.76E-5 41 1.60E-4
17 SGTC_1283 0922-0125 3.54 16.4 µM 9.76E-5 37 1.97E-4
18 SGTC_2270 7924575 3.53 90.9 µM 1.04E-4 RPP1 & pyrimidine depletion 25 2.08E-4
19 SGTC_922 1866-0035 3.47 480.0 µM 1.34E-4 excess fatty acid 82 2.62E-4
20 SGTC_345 1362-0200 3.43 395.0 µM 1.54E-4 33 2.98E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.212 2.47E-35 YHR050W-A_p YHR050W-A_p hom Protein of unknown function; identified by expression profiling and mass spectrometry
0.199 3.03E-31 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.195 4.21E-30 YDR230W_d YDR230W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.193 1.36E-29 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.191 5.24E-29 YER058W PET117 hom Protein required for assembly of cytochrome c oxidase
0.185 2.55E-27 YOR065W CYT1 hom Cytochrome c1, component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex
0.185 3.01E-27 YGL237C HAP2 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding
0.184 5.10E-27 YGR183C QCR9 hom Subunit 9 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; required for electron transfer at the ubiquinol oxidase site of the complex
0.184 8.71E-27 YJR120W YJR120W hom Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p
0.178 2.77E-25 YMR151W_d YIM2_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1
0.174 3.25E-24 YPL215W CBP3 hom Mitochondrial protein required for assembly of cytochrome bc1 complex; forms a complex with Cbp6p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.173 5.59E-24 YMR035W IMP2 hom Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
0.171 1.71E-23 YBL064C PRX1 hom Mitochondrial peroxiredoxin with thioredoxin peroxidase activity; has a role in reduction of hydroperoxides; reactivation requires Trr2p and glutathione; induced during respiratory growth and oxidative stress; phosphorylated; protein abundance increases in response to DNA replication stress
0.170 3.25E-23 YPL013C MRPS16 hom Mitochondrial ribosomal protein of the small subunit
0.167 2.15E-22 YJL127C-B_p YJL127C-B_p hom Putative protein of unknown function; identified based on homology to the filamentous fungus, Ashbya gossypii