YJR006W / POL31

Subunit of DNA polymerase delta (polymerase III); essential for cell viability; involved in DNA replication and DNA repair

Zygosity: Heterozygous strain
fixedexpanded
Profile for YJR006W / POL31

Click on Significant Values for Screen Details ID:SGTC_163|Compound:1327-0036|FD-Score:3.48|P-value:9.81E-5 ID:SGTC_619|Compound:1652-1634|FD-Score:3.65|P-value:4.79E-5 ID:SGTC_682|Compound:0kpi-0099|FD-Score:5.10|P-value:2.59E-8 ID:SGTC_742|Compound:0kpi-0133|FD-Score:-3.18|P-value:3.65E-4 ID:SGTC_1112|Compound:tnp00069|FD-Score:3.38|P-value:1.53E-4 ID:SGTC_1390|Compound:3413-2614|FD-Score:3.57|P-value:6.67E-5 ID:SGTC_1441|Compound:4106-0040|FD-Score:-2.93|P-value:9.36E-4 ID:SGTC_1447|Compound:4239-0816|FD-Score:-3.08|P-value:5.24E-4 ID:SGTC_1652|Compound:st011932|FD-Score:3.43|P-value:1.21E-4 ID:SGTC_1715|Compound:st032160|FD-Score:3.02|P-value:6.16E-4 ID:SGTC_1724|Compound:st037281|FD-Score:-2.91|P-value:9.99E-4 ID:SGTC_1735|Compound:st034310|FD-Score:4.06|P-value:7.02E-6 ID:SGTC_1739|Compound:st037196|FD-Score:3.66|P-value:4.59E-5 ID:SGTC_1888|Compound:azatryptophan|FD-Score:6.76|P-value:2.75E-13 ID:SGTC_1900|Compound:st060200|FD-Score:4.54|P-value:6.13E-7 ID:SGTC_1907|Compound:st060210|FD-Score:5.92|P-value:1.33E-10 ID:SGTC_1919|Compound:st067113|FD-Score:3.95|P-value:1.25E-5 ID:SGTC_1928|Compound:4'-methoxychalcone|FD-Score:-3.62|P-value:6.00E-5 ID:SGTC_2014|Compound:4013930|FD-Score:3.31|P-value:2.04E-4 ID:SGTC_2153|Compound:5569715|FD-Score:-3.02|P-value:6.62E-4 ID:SGTC_2167|Compound:5876490|FD-Score:3.10|P-value:4.65E-4 ID:SGTC_2296|Compound:7971656|FD-Score:2.98|P-value:7.09E-4 ID:SGTC_2308|Compound:7584454|FD-Score:3.18|P-value:3.42E-4 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:-3.86|P-value:1.99E-5 ID:SGTC_2713|Compound:st079149|FD-Score:3.05|P-value:5.47E-4 ID:SGTC_2716|Compound:st080858|FD-Score:3.21|P-value:2.99E-4 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:3.37|P-value:1.60E-4 ID:SGTC_2765|Compound:myclobutanil|FD-Score:3.89|P-value:1.59E-5 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:4.24|P-value:2.89E-6 ID:SGTC_2774|Compound:tamoxifen|FD-Score:-2.99|P-value:7.41E-4 ID:SGTC_2920|Compound:7982904|FD-Score:3.26|P-value:2.45E-4 ID:SGTC_2932|Compound:9016711|FD-Score:4.13|P-value:5.16E-6 ID:SGTC_3074|Compound:9116018|FD-Score:-3.70|P-value:4.09E-5 ID:SGTC_3093|Compound:9117344|FD-Score:3.01|P-value:6.33E-4 ID:SGTC_3110|Compound:9122132|FD-Score:3.23|P-value:2.72E-4 ID:SGTC_3154|Compound:9100113|FD-Score:-3.40|P-value:1.47E-4 ID:SGTC_3197|Compound:9113331|FD-Score:4.40|P-value:1.33E-6 ID:SGTC_3291|Compound:9121177|FD-Score:3.12|P-value:4.29E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:3.48|P-value:9.81E-5 ID:SGTC_619|Compound:1652-1634|FD-Score:3.65|P-value:4.79E-5 ID:SGTC_682|Compound:0kpi-0099|FD-Score:5.10|P-value:2.59E-8 ID:SGTC_742|Compound:0kpi-0133|FD-Score:-3.18|P-value:3.65E-4 ID:SGTC_1112|Compound:tnp00069|FD-Score:3.38|P-value:1.53E-4 ID:SGTC_1390|Compound:3413-2614|FD-Score:3.57|P-value:6.67E-5 ID:SGTC_1441|Compound:4106-0040|FD-Score:-2.93|P-value:9.36E-4 ID:SGTC_1447|Compound:4239-0816|FD-Score:-3.08|P-value:5.24E-4 ID:SGTC_1652|Compound:st011932|FD-Score:3.43|P-value:1.21E-4 ID:SGTC_1715|Compound:st032160|FD-Score:3.02|P-value:6.16E-4 ID:SGTC_1724|Compound:st037281|FD-Score:-2.91|P-value:9.99E-4 ID:SGTC_1735|Compound:st034310|FD-Score:4.06|P-value:7.02E-6 ID:SGTC_1739|Compound:st037196|FD-Score:3.66|P-value:4.59E-5 ID:SGTC_1888|Compound:azatryptophan|FD-Score:6.76|P-value:2.75E-13 ID:SGTC_1900|Compound:st060200|FD-Score:4.54|P-value:6.13E-7 ID:SGTC_1907|Compound:st060210|FD-Score:5.92|P-value:1.33E-10 ID:SGTC_1919|Compound:st067113|FD-Score:3.95|P-value:1.25E-5 ID:SGTC_1928|Compound:4'-methoxychalcone|FD-Score:-3.62|P-value:6.00E-5 ID:SGTC_2014|Compound:4013930|FD-Score:3.31|P-value:2.04E-4 ID:SGTC_2153|Compound:5569715|FD-Score:-3.02|P-value:6.62E-4 ID:SGTC_2167|Compound:5876490|FD-Score:3.10|P-value:4.65E-4 ID:SGTC_2296|Compound:7971656|FD-Score:2.98|P-value:7.09E-4 ID:SGTC_2308|Compound:7584454|FD-Score:3.18|P-value:3.42E-4 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:-3.86|P-value:1.99E-5 ID:SGTC_2713|Compound:st079149|FD-Score:3.05|P-value:5.47E-4 ID:SGTC_2716|Compound:st080858|FD-Score:3.21|P-value:2.99E-4 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:3.37|P-value:1.60E-4 ID:SGTC_2765|Compound:myclobutanil|FD-Score:3.89|P-value:1.59E-5 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:4.24|P-value:2.89E-6 ID:SGTC_2774|Compound:tamoxifen|FD-Score:-2.99|P-value:7.41E-4 ID:SGTC_2920|Compound:7982904|FD-Score:3.26|P-value:2.45E-4 ID:SGTC_2932|Compound:9016711|FD-Score:4.13|P-value:5.16E-6 ID:SGTC_3074|Compound:9116018|FD-Score:-3.70|P-value:4.09E-5 ID:SGTC_3093|Compound:9117344|FD-Score:3.01|P-value:6.33E-4 ID:SGTC_3110|Compound:9122132|FD-Score:3.23|P-value:2.72E-4 ID:SGTC_3154|Compound:9100113|FD-Score:-3.40|P-value:1.47E-4 ID:SGTC_3197|Compound:9113331|FD-Score:4.40|P-value:1.33E-6 ID:SGTC_3291|Compound:9121177|FD-Score:3.12|P-value:4.29E-4

Top fitness defect scores for YJR006W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1888 azatryptophan 6.76 97.5 µM 2.75E-13 1 7.11E-12 1.49
2 SGTC_1907 st060210 5.92 83.7 µM 1.33E-10 3 1.65E-9 0.90
3 SGTC_682 0kpi-0099 5.10 17.0 µM 2.59E-8 18 1.72E-7 0.17
4 SGTC_1900 st060200 4.54 72.8 µM 6.13E-7 3 2.79E-6 0.51
5 SGTC_3197 9113331 4.40 49.5 µM 1.33E-6 7 5.53E-6 0.31
6 SGTC_2768 sulfasalazine 4.24 50.2 µM 2.89E-6 6 1.10E-5 0.22
7 SGTC_2932 9016711 4.13 44.5 µM 5.16E-6 8 1.83E-5 0.20
8 SGTC_1735 st034310 4.06 56.8 µM 7.02E-6 Golgi 9 2.40E-5 0.14
9 SGTC_1919 st067113 3.95 52.3 µM 1.25E-5 TSC3-RPN4 11 3.99E-5 0.00
10 SGTC_2765 myclobutanil 3.89 7.7 µM 1.59E-5 azole & statin 9 4.96E-5 0.07
11 SGTC_1739 st037196 3.66 92.5 µM 4.59E-5 4 1.26E-4 0.29
12 SGTC_619 1652-1634 3.65 108.0 µM 4.79E-5 PDR1 8 1.31E-4 0.01
13 SGTC_1390 3413-2614 3.57 145.0 µM 6.67E-5 fatty acid desaturase (OLE1) 14 1.76E-4 0.14
14 SGTC_163 1327-0036 3.48 7.5 µM 9.81E-5 54 2.47E-4 0.05
15 SGTC_1652 st011932 3.43 78.0 µM 1.21E-4 RSC complex & mRNA processing 38 2.98E-4 0.11
16 SGTC_1112 tnp00069 3.38 1.2 µM 1.53E-4 6 3.67E-4 0.17
17 SGTC_2751 anetholtrithion 3.37 17.2 µM 1.60E-4 11 3.81E-4 0.12
18 SGTC_2014 4013930 3.31 200.0 µM 2.04E-4 9 4.71E-4 0.02
19 SGTC_2920 7982904 3.26 15.8 µM 2.45E-4 22 5.55E-4 0.17
20 SGTC_3110 9122132 3.23 49.5 µM 2.72E-4 redox potentiating 18 6.08E-4 0.07

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.178 3.37E-25 YML126C ERG13 het 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase, catalyzes the formation of HMG-CoA from acetyl-CoA and acetoacetyl-CoA; involved in the second step in mevalonate biosynthesis
0.118 6.13E-12 YLR070C XYL2 hom Xylitol dehydrogenase, converts xylitol to D-xylulose; expression induced by xylose, even though this pentose sugar is not well utilized by S. cerevisiae; null mutant has cell wall defect
0.115 2.25E-11 YIR020C_p YIR020C_p hom Protein of unknown function; mRNA identified as translated by ribosome profiling data
0.095 4.12E-8 YER089C PTC2 hom Type 2C protein phosphatase (PP2C); dephosphorylates Hog1p to limit maximal osmostress induced kinase activity; dephosphorylates Ire1p to downregulate the unfolded protein response; dephosphorylates Cdc28p; inactivates the DNA damage checkpoint; PTC2 has a paralog, PTC3, that arose from the whole genome duplication
0.094 4.30E-8 YGR164W_d YGR164W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.094 4.32E-8 YHL011C PRS3 hom 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes
0.092 9.90E-8 YDR392W SPT3 hom Subunit of the SAGA and SAGA-like transcriptional regulatory complexes, interacts with Spt15p to activate transcription of some RNA polymerase II-dependent genes, also functions to inhibit transcription at some promoters
0.091 1.39E-7 YGR193C PDX1 hom Dihydrolipoamide dehydrogenase (E3)-binding protein (E3BP) of the mitochondrial pyruvate dehydrogenase (PDH) complex, plays a structural role in the complex by binding and positioning E3 to the dihydrolipoamide acetyltransferase (E2) core
0.090 1.78E-7 YJL055W_p YJL055W_p hom Putative protein of unknown function, proposed to be involved in the metabolism of purine and pyrimidine base analogues; deletion mutants are sensitive to HAP and AHA; overexpression confers resistance to 5-FOA and 5-FU
0.085 7.08E-7 YPL209C IPL1 het Aurora kinase subunit of the conserved chromosomal passenger complex (CPC; Ipl1p-Sli15p-Bir1p-Nbl1p), involved in regulating kinetochore-microtubule attachments; helps maintain condensed chromosomes during anaphase and early telophase; required for SPB cohesion and prevention of multipolar spindle formation; localizes to nuclear foci that become diffuse upon DNA replication stress; required for inhibition of karyopherin/importin Pse1p (aka Kap121p) upon SAC arrest
0.082 1.72E-6 YOR244W ESA1 het Catalytic subunit of the histone acetyltransferase complex (NuA4); acetylates four conserved internal lysines of histone H4 N-terminal tail and can acetylate histone H2A; required for cell cycle progression and transcriptional silencing at the rDNA locus and regulation of autophagy
0.082 1.76E-6 YIR008C PRI1 het Subunit of DNA primase, which is required for DNA synthesis and double-strand break repair
0.082 1.82E-6 YDR454C GUK1 het Guanylate kinase, converts GMP to GDP; required for growth and mannose outer chain elongation of cell wall N-linked glycoproteins
0.082 2.09E-6 YER052C HOM3 hom Aspartate kinase (L-aspartate 4-P-transferase); cytoplasmic enzyme that catalyzes the first step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis
0.081 2.83E-6 YOR336W KRE5 het Protein required for beta-1,6 glucan biosynthesis; mutations result in aberrant morphology and severe growth defects