YJR009C / TDH2

Glyceraldehyde-3-phosphate dehydrogenase, isozyme 2; involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell wall; protein abundance increases in response to DNA replication stress; TDH2 has a paralog, TDH3, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YJR009C / TDH2

Click on Significant Values for Screen Details ID:SGTC_44|Compound:0929-0055|FD-Score:-2.85|P-value:8.58E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:4.23|P-value:1.34E-6 ID:SGTC_145|Compound:3737-0113|FD-Score:-2.83|P-value:9.36E-4 ID:SGTC_146|Compound:3448-8650|FD-Score:-3.04|P-value:4.17E-4 ID:SGTC_306|Compound:1672-3436|FD-Score:2.81|P-value:8.89E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:3.16|P-value:2.19E-4 ID:SGTC_590|Compound:k048-0076|FD-Score:2.78|P-value:9.81E-4 ID:SGTC_619|Compound:1652-1634|FD-Score:-5.17|P-value:6.04E-9 ID:SGTC_623|Compound:k072-0108|FD-Score:-6.17|P-value:5.07E-12 ID:SGTC_624|Compound:k048-0052|FD-Score:-2.95|P-value:5.83E-4 ID:SGTC_633|Compound:0437-0093|FD-Score:-3.40|P-value:9.18E-5 ID:SGTC_831|Compound:k061-1017|FD-Score:2.85|P-value:7.69E-4 ID:SGTC_939|Compound:1165-0479|FD-Score:3.66|P-value:2.44E-5 ID:SGTC_1013|Compound:4112-3890|FD-Score:-3.56|P-value:4.46E-5 ID:SGTC_1049|Compound:3226-0134|FD-Score:-3.18|P-value:2.32E-4 ID:SGTC_1232|Compound:0279-0259|FD-Score:4.06|P-value:3.33E-6 ID:SGTC_1305|Compound:1181-0477|FD-Score:3.15|P-value:2.32E-4 ID:SGTC_1519|Compound:esterone|FD-Score:-4.39|P-value:6.40E-7 ID:SGTC_1601|Compound:4'-hydroxyflavanone|FD-Score:4.34|P-value:7.12E-7 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:3.12|P-value:2.59E-4 ID:SGTC_1707|Compound:st032323|FD-Score:3.04|P-value:3.60E-4 ID:SGTC_1713|Compound:st033146|FD-Score:2.89|P-value:6.58E-4 ID:SGTC_1738|Compound:st035555|FD-Score:3.25|P-value:1.50E-4 ID:SGTC_1741|Compound:st038134|FD-Score:3.28|P-value:1.34E-4 ID:SGTC_1783|Compound:st039459|FD-Score:3.01|P-value:4.04E-4 ID:SGTC_1962|Compound:st076595|FD-Score:3.40|P-value:7.99E-5 ID:SGTC_2005|Compound:4024620|FD-Score:-3.06|P-value:3.81E-4 ID:SGTC_2240|Compound:6690706|FD-Score:3.18|P-value:2.05E-4 ID:SGTC_2253|Compound:7938677|FD-Score:4.33|P-value:7.66E-7 ID:SGTC_2256|Compound:7954252|FD-Score:5.05|P-value:1.04E-8 ID:SGTC_2259|Compound:7964009|FD-Score:3.03|P-value:3.74E-4 ID:SGTC_2265|Compound:7929201|FD-Score:2.89|P-value:6.57E-4 ID:SGTC_2294|Compound:7971431|FD-Score:-3.16|P-value:2.56E-4 ID:SGTC_2304|Compound:7443016|FD-Score:3.57|P-value:3.71E-5 ID:SGTC_2308|Compound:7584454|FD-Score:-3.26|P-value:1.67E-4 ID:SGTC_2312|Compound:7706453|FD-Score:-3.11|P-value:3.15E-4 ID:SGTC_2315|Compound:7733312|FD-Score:-5.74|P-value:1.17E-10 ID:SGTC_2359|Compound:9039622|FD-Score:3.24|P-value:1.57E-4 ID:SGTC_2480|Compound:5767542|FD-Score:3.50|P-value:5.18E-5 ID:SGTC_2481|Compound:5478948|FD-Score:2.86|P-value:7.49E-4 ID:SGTC_2493|Compound:resveratrol|FD-Score:-3.28|P-value:1.50E-4 ID:SGTC_2497|Compound:7-hydroxyflavone|FD-Score:8.72|P-value:2.30E-22 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:-6.16|P-value:5.48E-12 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:8.08|P-value:1.67E-19 ID:SGTC_2503|Compound:beta-caryophyllene alcohol|FD-Score:9.61|P-value:8.81E-27 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:-3.57|P-value:4.25E-5 ID:SGTC_2526|Compound:patulin|FD-Score:-4.81|P-value:5.55E-8 ID:SGTC_2612|Compound:dictamnine|FD-Score:2.85|P-value:7.57E-4 ID:SGTC_2668|Compound:2',4'-dihydroxychalcone|FD-Score:-3.47|P-value:6.66E-5 ID:SGTC_2687|Compound:chenodiol|FD-Score:3.16|P-value:2.20E-4 ID:SGTC_2757|Compound:clomiphene|FD-Score:2.84|P-value:7.82E-4 ID:SGTC_2761|Compound:levamisole|FD-Score:-3.35|P-value:1.12E-4 ID:SGTC_2767|Compound:sibutramine|FD-Score:-3.26|P-value:1.64E-4 ID:SGTC_2770|Compound:toltrazuril|FD-Score:3.60|P-value:3.24E-5 ID:SGTC_2773|Compound:thioridazine|FD-Score:-3.15|P-value:2.59E-4 ID:SGTC_2909|Compound:7941780|FD-Score:3.64|P-value:2.60E-5 ID:SGTC_3290|Compound:9121031|FD-Score:-2.87|P-value:7.94E-4 ID:SGTC_3292|Compound:9120825|FD-Score:3.09|P-value:2.99E-4 ID:SGTC_3320|Compound:9137005|FD-Score:3.30|P-value:1.25E-4 ID:SGTC_44|Compound:0929-0055|FD-Score:-2.85|P-value:8.58E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:4.23|P-value:1.34E-6 ID:SGTC_145|Compound:3737-0113|FD-Score:-2.83|P-value:9.36E-4 ID:SGTC_146|Compound:3448-8650|FD-Score:-3.04|P-value:4.17E-4 ID:SGTC_306|Compound:1672-3436|FD-Score:2.81|P-value:8.89E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:3.16|P-value:2.19E-4 ID:SGTC_590|Compound:k048-0076|FD-Score:2.78|P-value:9.81E-4 ID:SGTC_619|Compound:1652-1634|FD-Score:-5.17|P-value:6.04E-9 ID:SGTC_623|Compound:k072-0108|FD-Score:-6.17|P-value:5.07E-12 ID:SGTC_624|Compound:k048-0052|FD-Score:-2.95|P-value:5.83E-4 ID:SGTC_633|Compound:0437-0093|FD-Score:-3.40|P-value:9.18E-5 ID:SGTC_831|Compound:k061-1017|FD-Score:2.85|P-value:7.69E-4 ID:SGTC_939|Compound:1165-0479|FD-Score:3.66|P-value:2.44E-5 ID:SGTC_1013|Compound:4112-3890|FD-Score:-3.56|P-value:4.46E-5 ID:SGTC_1049|Compound:3226-0134|FD-Score:-3.18|P-value:2.32E-4 ID:SGTC_1232|Compound:0279-0259|FD-Score:4.06|P-value:3.33E-6 ID:SGTC_1305|Compound:1181-0477|FD-Score:3.15|P-value:2.32E-4 ID:SGTC_1519|Compound:esterone|FD-Score:-4.39|P-value:6.40E-7 ID:SGTC_1601|Compound:4'-hydroxyflavanone|FD-Score:4.34|P-value:7.12E-7 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:3.12|P-value:2.59E-4 ID:SGTC_1707|Compound:st032323|FD-Score:3.04|P-value:3.60E-4 ID:SGTC_1713|Compound:st033146|FD-Score:2.89|P-value:6.58E-4 ID:SGTC_1738|Compound:st035555|FD-Score:3.25|P-value:1.50E-4 ID:SGTC_1741|Compound:st038134|FD-Score:3.28|P-value:1.34E-4 ID:SGTC_1783|Compound:st039459|FD-Score:3.01|P-value:4.04E-4 ID:SGTC_1962|Compound:st076595|FD-Score:3.40|P-value:7.99E-5 ID:SGTC_2005|Compound:4024620|FD-Score:-3.06|P-value:3.81E-4 ID:SGTC_2240|Compound:6690706|FD-Score:3.18|P-value:2.05E-4 ID:SGTC_2253|Compound:7938677|FD-Score:4.33|P-value:7.66E-7 ID:SGTC_2256|Compound:7954252|FD-Score:5.05|P-value:1.04E-8 ID:SGTC_2259|Compound:7964009|FD-Score:3.03|P-value:3.74E-4 ID:SGTC_2265|Compound:7929201|FD-Score:2.89|P-value:6.57E-4 ID:SGTC_2294|Compound:7971431|FD-Score:-3.16|P-value:2.56E-4 ID:SGTC_2304|Compound:7443016|FD-Score:3.57|P-value:3.71E-5 ID:SGTC_2308|Compound:7584454|FD-Score:-3.26|P-value:1.67E-4 ID:SGTC_2312|Compound:7706453|FD-Score:-3.11|P-value:3.15E-4 ID:SGTC_2315|Compound:7733312|FD-Score:-5.74|P-value:1.17E-10 ID:SGTC_2359|Compound:9039622|FD-Score:3.24|P-value:1.57E-4 ID:SGTC_2480|Compound:5767542|FD-Score:3.50|P-value:5.18E-5 ID:SGTC_2481|Compound:5478948|FD-Score:2.86|P-value:7.49E-4 ID:SGTC_2493|Compound:resveratrol|FD-Score:-3.28|P-value:1.50E-4 ID:SGTC_2497|Compound:7-hydroxyflavone|FD-Score:8.72|P-value:2.30E-22 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:-6.16|P-value:5.48E-12 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:8.08|P-value:1.67E-19 ID:SGTC_2503|Compound:beta-caryophyllene alcohol|FD-Score:9.61|P-value:8.81E-27 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:-3.57|P-value:4.25E-5 ID:SGTC_2526|Compound:patulin|FD-Score:-4.81|P-value:5.55E-8 ID:SGTC_2612|Compound:dictamnine|FD-Score:2.85|P-value:7.57E-4 ID:SGTC_2668|Compound:2',4'-dihydroxychalcone|FD-Score:-3.47|P-value:6.66E-5 ID:SGTC_2687|Compound:chenodiol|FD-Score:3.16|P-value:2.20E-4 ID:SGTC_2757|Compound:clomiphene|FD-Score:2.84|P-value:7.82E-4 ID:SGTC_2761|Compound:levamisole|FD-Score:-3.35|P-value:1.12E-4 ID:SGTC_2767|Compound:sibutramine|FD-Score:-3.26|P-value:1.64E-4 ID:SGTC_2770|Compound:toltrazuril|FD-Score:3.60|P-value:3.24E-5 ID:SGTC_2773|Compound:thioridazine|FD-Score:-3.15|P-value:2.59E-4 ID:SGTC_2909|Compound:7941780|FD-Score:3.64|P-value:2.60E-5 ID:SGTC_3290|Compound:9121031|FD-Score:-2.87|P-value:7.94E-4 ID:SGTC_3292|Compound:9120825|FD-Score:3.09|P-value:2.99E-4 ID:SGTC_3320|Compound:9137005|FD-Score:3.30|P-value:1.25E-4

Top fitness defect scores for YJR009C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2503 beta-caryophyllene alcohol 9.61 24.7 µM 8.81E-27 1 3.50E-22
2 SGTC_2497 7-hydroxyflavone 8.72 100.0 µM 2.30E-22 1 1.43E-18
3 SGTC_2501 sodium tetradecyl sulfate 8.08 13.4 µM 1.67E-19 4 3.14E-16
4 SGTC_2256 7954252 5.05 200.0 µM 1.04E-8 mitochondrial processes 3 2.16E-7
5 SGTC_1601 4'-hydroxyflavanone 4.34 55.5 µM 7.12E-7 RPP1 & pyrimidine depletion 21 6.97E-6
6 SGTC_2253 7938677 4.33 135.8 µM 7.66E-7 7 7.40E-6
7 SGTC_137 0438-0332 4.23 85.4 µM 1.34E-6 ubiquinone biosynthesis & proteasome 109 1.17E-5
8 SGTC_1232 0279-0259 4.06 161.0 µM 3.33E-6 15 2.48E-5
9 SGTC_939 1165-0479 3.66 45.3 µM 2.44E-5 43 1.27E-4
10 SGTC_2909 7941780 3.64 10.5 µM 2.60E-5 27 1.34E-4
11 SGTC_2770 toltrazuril 3.60 17.5 µM 3.24E-5 36 1.61E-4
12 SGTC_2304 7443016 3.57 91.4 µM 3.71E-5 27 1.80E-4
13 SGTC_2480 5767542 3.50 37.2 µM 5.18E-5 22 2.37E-4
14 SGTC_1962 st076595 3.40 64.5 µM 7.99E-5 redox potentiating 51 3.38E-4
15 SGTC_3320 9137005 3.30 35.1 µM 1.25E-4 endomembrane recycling 30 4.91E-4
16 SGTC_1741 st038134 3.28 10.2 µM 1.34E-4 58 5.18E-4
17 SGTC_1738 st035555 3.25 74.0 µM 1.50E-4 TSC3-RPN4 62 5.67E-4
18 SGTC_2359 9039622 3.24 200.0 µM 1.57E-4 endomembrane recycling 48 5.90E-4
19 SGTC_2240 6690706 3.18 185.9 µM 2.05E-4 38 7.36E-4
20 SGTC_513 4245-1575 3.16 41.7 µM 2.19E-4 unfolded protein response 172 7.77E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.136 2.68E-15 YPL158C AIM44 hom Protein of unknown function; GFP-fusion protein localizes to the bud neck; transcription is regulated by Swi5p; null mutant displays elevated frequency of mitochondrial genome loss; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.107 5.46E-10 YMR297W PRC1 hom Vacuolar carboxypeptidase Y (proteinase C; CPY), broad-specificity C-terminal exopeptidase involved in non-specific protein degradation in the vacuole; member of the serine carboxypeptidase family
0.088 2.88E-7 YBR183W YPC1 hom Alkaline ceramidase; also has reverse (CoA-independent) ceramide synthase activity; catalyzes both breakdown and synthesis of phytoceramide; overexpression confers fumonisin B1 resistance; YPC1 has a paralog, YDC1, that arose from the whole genome duplication
0.088 3.73E-7 YOR124C UBP2 hom Ubiquitin-specific protease that removes ubiquitin from ubiquitinated proteins; interacts with Rsp5p and is required for MVB sorting of membrane proteins; can cleave polyubiquitin and has isopeptidase activity
0.086 6.76E-7 YPR147C_p YPR147C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS
0.080 3.45E-6 YDL135C RDI1 hom Rho GDP dissociation inhibitor; involved in the localization and regulation of Cdc42p and Rho1p; protein abundance increases in response to DNA replication stress
0.077 7.16E-6 YCR002C CDC10 hom Component of the septin ring, required for cytokinesis; septins are GTP-binding proteins that assemble into rod-like hetero-oligomers that can associate to form filaments; septin rings at the mother-bud neck act as scaffolds for recruiting cell division factors and as barriers to prevent diffusion of specific proteins between mother and daughter cells; N-terminus interacts with phosphatidylinositol-4,5-bisphosphate; protein abundance increases under DNA damage stress
0.077 7.26E-6 YLR288C MEC3 hom DNA damage and meiotic pachytene checkpoint protein; subunit of a heterotrimeric complex (Rad17p-Mec3p-Ddc1p) that forms a sliding clamp, loaded onto partial duplex DNA by a clamp loader complex; homolog of human and S. pombe Hus1
0.077 8.72E-6 YOR033C EXO1 hom 5'-3' exonuclease and flap-endonuclease; involved in recombination, double-strand break repair and DNA mismatch repair; member of the Rad2p nuclease family, with conserved N and I nuclease domains; relative distribution to the nucleus increases upon DNA replication stress
0.074 1.97E-5 YGL136C MRM2 hom Mitochondrial 2' O-ribose methyltransferase, required for methylation of U(2791) in 21S rRNA; MRM2 deletion confers thermosensitive respiration and loss of mitochondrial DNA; has similarity to Spb1p and Trm7p, and to E. coli FtsJ/RrmJ
0.074 2.00E-5 YPR089W_p YPR089W_p hom Protein of unknown function; exhibits genetic interaction with ERG11 and protein-protein interaction with Hsp82p
0.073 2.30E-5 YBR199W KTR4 hom Putative mannosyltransferase involved in protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family
0.073 2.53E-5 YER012W PRE1 het Beta 4 subunit of the 20S proteasome; localizes to the nucleus throughout the cell cycle
0.072 2.83E-5 YIL113W SDP1 hom Stress-inducible dual-specificity MAP kinase phosphatase, negatively regulates Slt2p MAP kinase by direct dephosphorylation, diffuse localization under normal conditions shifts to punctate localization after heat shock
0.072 3.00E-5 YIL094C LYS12 hom Homo-isocitrate dehydrogenase, an NAD-linked mitochondrial enzyme required for the fourth step in the biosynthesis of lysine, in which homo-isocitrate is oxidatively decarboxylated to alpha-ketoadipate