YJR010C-A / SPC1

Subunit of the signal peptidase complex (SPC); SPC cleaves the signal sequence from proteins targeted to the endoplasmic reticulum (ER); homolog of the SPC12 subunit of mammalian signal peptidase complex; protein abundance increases in response to DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YJR010C-A / SPC1

Click on Significant Values for Screen Details ID:SGTC_17|Compound:0960-0276|FD-Score:4.93|P-value:4.59E-7 ID:SGTC_77|Compound:0828-0286|FD-Score:3.12|P-value:9.77E-4 ID:SGTC_127|Compound:0180-0333|FD-Score:-3.59|P-value:1.66E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:3.40|P-value:3.68E-4 ID:SGTC_182|Compound:3448-4371|FD-Score:-4.96|P-value:3.73E-7 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:4.07|P-value:2.62E-5 ID:SGTC_229|Compound:benomyl|FD-Score:3.77|P-value:9.04E-5 ID:SGTC_264|Compound:promethazine|FD-Score:4.82|P-value:8.09E-7 ID:SGTC_335|Compound:4077-0256|FD-Score:-3.94|P-value:4.25E-5 ID:SGTC_365|Compound:0121-0052|FD-Score:3.89|P-value:5.39E-5 ID:SGTC_603|Compound:3794-0023|FD-Score:-3.17|P-value:7.62E-4 ID:SGTC_611|Compound:3453-1652|FD-Score:3.78|P-value:8.69E-5 ID:SGTC_650|Compound:1328-0195|FD-Score:-3.58|P-value:1.77E-4 ID:SGTC_658|Compound:3253-0951|FD-Score:3.18|P-value:7.80E-4 ID:SGTC_680|Compound:0417-1641|FD-Score:3.88|P-value:5.64E-5 ID:SGTC_757|Compound:1066-0008|FD-Score:5.49|P-value:2.33E-8 ID:SGTC_847|Compound:0342-0274|FD-Score:4.93|P-value:4.78E-7 ID:SGTC_1054|Compound:3429-0080|FD-Score:-3.84|P-value:6.40E-5 ID:SGTC_1061|Compound:3448-9325|FD-Score:-3.22|P-value:6.58E-4 ID:SGTC_1203|Compound:3992-3522|FD-Score:-4.85|P-value:6.40E-7 ID:SGTC_1256|Compound:0570-0116|FD-Score:3.20|P-value:7.22E-4 ID:SGTC_1277|Compound:0873-0036|FD-Score:3.36|P-value:4.15E-4 ID:SGTC_1519|Compound:esterone|FD-Score:3.64|P-value:1.45E-4 ID:SGTC_1638|Compound:st008370|FD-Score:3.23|P-value:6.68E-4 ID:SGTC_1738|Compound:st035555|FD-Score:3.65|P-value:1.45E-4 ID:SGTC_1746|Compound:st038117|FD-Score:3.33|P-value:4.69E-4 ID:SGTC_1780|Compound:st038448|FD-Score:-3.44|P-value:2.97E-4 ID:SGTC_1893|Compound:st059353|FD-Score:7.10|P-value:7.71E-13 ID:SGTC_1900|Compound:st060200|FD-Score:5.41|P-value:3.73E-8 ID:SGTC_1916|Compound:st067606|FD-Score:4.35|P-value:7.50E-6 ID:SGTC_1960|Compound:st011366|FD-Score:3.76|P-value:9.11E-5 ID:SGTC_1994|Compound:st072947|FD-Score:3.40|P-value:3.63E-4 ID:SGTC_2034|Compound:5197015|FD-Score:3.71|P-value:1.12E-4 ID:SGTC_2064|Compound:5220758|FD-Score:4.10|P-value:2.26E-5 ID:SGTC_2125|Compound:5246583|FD-Score:-3.61|P-value:1.58E-4 ID:SGTC_2134|Compound:5324836|FD-Score:4.70|P-value:1.50E-6 ID:SGTC_2173|Compound:5763948|FD-Score:3.19|P-value:7.51E-4 ID:SGTC_2184|Compound:6075246|FD-Score:3.50|P-value:2.48E-4 ID:SGTC_2444|Compound:5485484|FD-Score:3.60|P-value:1.73E-4 ID:SGTC_2445|Compound:5742597|FD-Score:-3.11|P-value:9.60E-4 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:4.20|P-value:1.49E-5 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:-4.60|P-value:2.17E-6 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:3.13|P-value:9.44E-4 ID:SGTC_2750|Compound:bromebric acid|FD-Score:3.44|P-value:3.14E-4 ID:SGTC_2819|Compound:7996655|FD-Score:3.50|P-value:2.49E-4 ID:SGTC_2821|Compound:7996764|FD-Score:3.17|P-value:8.05E-4 ID:SGTC_2883|Compound:9059145|FD-Score:3.44|P-value:3.11E-4 ID:SGTC_2944|Compound:9067346|FD-Score:3.24|P-value:6.43E-4 ID:SGTC_2998|Compound:9066762|FD-Score:5.10|P-value:1.96E-7 ID:SGTC_3106|Compound:9121286|FD-Score:-3.39|P-value:3.50E-4 ID:SGTC_3192|Compound:9110362|FD-Score:4.26|P-value:1.13E-5 ID:SGTC_3196|Compound:9111891|FD-Score:7.18|P-value:4.41E-13 ID:SGTC_3294|Compound:9122953|FD-Score:3.64|P-value:1.49E-4 ID:SGTC_17|Compound:0960-0276|FD-Score:4.93|P-value:4.59E-7 ID:SGTC_77|Compound:0828-0286|FD-Score:3.12|P-value:9.77E-4 ID:SGTC_127|Compound:0180-0333|FD-Score:-3.59|P-value:1.66E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:3.40|P-value:3.68E-4 ID:SGTC_182|Compound:3448-4371|FD-Score:-4.96|P-value:3.73E-7 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:4.07|P-value:2.62E-5 ID:SGTC_229|Compound:benomyl|FD-Score:3.77|P-value:9.04E-5 ID:SGTC_264|Compound:promethazine|FD-Score:4.82|P-value:8.09E-7 ID:SGTC_335|Compound:4077-0256|FD-Score:-3.94|P-value:4.25E-5 ID:SGTC_365|Compound:0121-0052|FD-Score:3.89|P-value:5.39E-5 ID:SGTC_603|Compound:3794-0023|FD-Score:-3.17|P-value:7.62E-4 ID:SGTC_611|Compound:3453-1652|FD-Score:3.78|P-value:8.69E-5 ID:SGTC_650|Compound:1328-0195|FD-Score:-3.58|P-value:1.77E-4 ID:SGTC_658|Compound:3253-0951|FD-Score:3.18|P-value:7.80E-4 ID:SGTC_680|Compound:0417-1641|FD-Score:3.88|P-value:5.64E-5 ID:SGTC_757|Compound:1066-0008|FD-Score:5.49|P-value:2.33E-8 ID:SGTC_847|Compound:0342-0274|FD-Score:4.93|P-value:4.78E-7 ID:SGTC_1054|Compound:3429-0080|FD-Score:-3.84|P-value:6.40E-5 ID:SGTC_1061|Compound:3448-9325|FD-Score:-3.22|P-value:6.58E-4 ID:SGTC_1203|Compound:3992-3522|FD-Score:-4.85|P-value:6.40E-7 ID:SGTC_1256|Compound:0570-0116|FD-Score:3.20|P-value:7.22E-4 ID:SGTC_1277|Compound:0873-0036|FD-Score:3.36|P-value:4.15E-4 ID:SGTC_1519|Compound:esterone|FD-Score:3.64|P-value:1.45E-4 ID:SGTC_1638|Compound:st008370|FD-Score:3.23|P-value:6.68E-4 ID:SGTC_1738|Compound:st035555|FD-Score:3.65|P-value:1.45E-4 ID:SGTC_1746|Compound:st038117|FD-Score:3.33|P-value:4.69E-4 ID:SGTC_1780|Compound:st038448|FD-Score:-3.44|P-value:2.97E-4 ID:SGTC_1893|Compound:st059353|FD-Score:7.10|P-value:7.71E-13 ID:SGTC_1900|Compound:st060200|FD-Score:5.41|P-value:3.73E-8 ID:SGTC_1916|Compound:st067606|FD-Score:4.35|P-value:7.50E-6 ID:SGTC_1960|Compound:st011366|FD-Score:3.76|P-value:9.11E-5 ID:SGTC_1994|Compound:st072947|FD-Score:3.40|P-value:3.63E-4 ID:SGTC_2034|Compound:5197015|FD-Score:3.71|P-value:1.12E-4 ID:SGTC_2064|Compound:5220758|FD-Score:4.10|P-value:2.26E-5 ID:SGTC_2125|Compound:5246583|FD-Score:-3.61|P-value:1.58E-4 ID:SGTC_2134|Compound:5324836|FD-Score:4.70|P-value:1.50E-6 ID:SGTC_2173|Compound:5763948|FD-Score:3.19|P-value:7.51E-4 ID:SGTC_2184|Compound:6075246|FD-Score:3.50|P-value:2.48E-4 ID:SGTC_2444|Compound:5485484|FD-Score:3.60|P-value:1.73E-4 ID:SGTC_2445|Compound:5742597|FD-Score:-3.11|P-value:9.60E-4 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:4.20|P-value:1.49E-5 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:-4.60|P-value:2.17E-6 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:3.13|P-value:9.44E-4 ID:SGTC_2750|Compound:bromebric acid|FD-Score:3.44|P-value:3.14E-4 ID:SGTC_2819|Compound:7996655|FD-Score:3.50|P-value:2.49E-4 ID:SGTC_2821|Compound:7996764|FD-Score:3.17|P-value:8.05E-4 ID:SGTC_2883|Compound:9059145|FD-Score:3.44|P-value:3.11E-4 ID:SGTC_2944|Compound:9067346|FD-Score:3.24|P-value:6.43E-4 ID:SGTC_2998|Compound:9066762|FD-Score:5.10|P-value:1.96E-7 ID:SGTC_3106|Compound:9121286|FD-Score:-3.39|P-value:3.50E-4 ID:SGTC_3192|Compound:9110362|FD-Score:4.26|P-value:1.13E-5 ID:SGTC_3196|Compound:9111891|FD-Score:7.18|P-value:4.41E-13 ID:SGTC_3294|Compound:9122953|FD-Score:3.64|P-value:1.49E-4

Top fitness defect scores for YJR010C-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3196 9111891 7.18 49.5 µM 4.41E-13 mitochondrial processes 1 3.46E-13
2 SGTC_1893 st059353 7.10 36.1 µM 7.71E-13 2 6.08E-13
3 SGTC_757 1066-0008 5.49 322.0 µM 2.33E-8 Golgi 6 2.00E-8
4 SGTC_1900 st060200 5.41 72.8 µM 3.73E-8 5 3.21E-8
5 SGTC_2998 9066762 5.10 71.4 µM 1.96E-7 RPP1 & pyrimidine depletion 6 1.71E-7
6 SGTC_17 0960-0276 4.93 49.8 µM 4.59E-7 14 4.03E-7
7 SGTC_847 0342-0274 4.93 5.5 µM 4.78E-7 11 4.20E-7
8 SGTC_264 promethazine 4.82 12.5 mM 8.09E-7 DNA intercalators 34 7.14E-7
9 SGTC_2134 5324836 4.70 1.5 µM 1.50E-6 8 1.33E-6
10 SGTC_1916 st067606 4.35 49.2 µM 7.50E-6 24 6.75E-6
11 SGTC_3192 9110362 4.26 49.5 µM 1.13E-5 mitochondrial processes 9 1.02E-5
12 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 4.20 92.6 µM 1.49E-5 24 1.35E-5
13 SGTC_2064 5220758 4.10 200.0 µM 2.26E-5 31 2.05E-5
14 SGTC_219 mitoxanthrone 4.07 164.4 µM 2.62E-5 DNA intercalators 50 2.38E-5
15 SGTC_365 0121-0052 3.89 13.6 µM 5.39E-5 mitochondrial response to ROS 59 4.93E-5
16 SGTC_680 0417-1641 3.88 114.0 µM 5.64E-5 RPP1 & pyrimidine depletion 17 5.17E-5
17 SGTC_611 3453-1652 3.78 23.7 µM 8.69E-5 29 7.99E-5
18 SGTC_229 benomyl 3.77 22.9 µM 9.04E-5 tubulin folding & SWR complex 35 8.31E-5
19 SGTC_1960 st011366 3.76 51.8 µM 9.11E-5 13 8.38E-5
20 SGTC_2034 5197015 3.71 53.1 µM 1.12E-4 SWF1 & branched chain AA biosynthesis 28 1.03E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.200 1.05E-31 YMR166C_p YMR166C_p hom Predicted transporter of the mitochondrial inner membrane; has similarity to human mitochondrial ATP-Mg/Pi carriers; YMR166C is not an essential gene
0.195 4.47E-30 YMR168C CEP3 het Essential kinetochore protein, component of the CBF3 complex that binds the CDEIII region of the centromere; contains an N-terminal Zn2Cys6 type zinc finger domain, a C-terminal acidic domain, and a putative coiled coil dimerization domain
0.174 3.86E-24 YHL039W EFM1 hom Lysine methyltransferase involved in the monomethylation of eEF1A (Tef1p/Tef2p); SET-domain family member; predicted involvement in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.161 5.39E-21 YPL157W TGS1 hom Trimethyl guanosine synthase, conserved nucleolar methyl transferase that converts the m(7)G cap structure of snRNAs, snoRNAs, and telomerase TLC1 RNA to m(2,2,7)G; also required for nucleolar assembly and splicing of meiotic pre-mRNAs
0.157 7.23E-20 YMR289W ABZ2 hom Aminodeoxychorismate lyase (4-amino-4-deoxychorismate lyase), catalyzes the third step in para-aminobenzoic acid biosynthesis; involved in folic acid biosynthesis
0.140 3.08E-16 YOR133W EFT1 hom Elongation factor 2 (EF-2), also encoded by EFT2; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin; EFT1 has a paralog, EFT2, that arose from the whole genome duplication
0.133 1.03E-14 YGL118C_d YGL118C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.126 3.00E-13 YGL041C_d YGL041C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.118 6.49E-12 YGL200C EMP24 hom Component of the p24 complex; binds to GPI anchor proteins and mediates their efficient transport from the ER to the Golgi; integral membrane protein that associates with endoplasmic reticulum-derived COPII-coated vesicles
0.114 4.02E-11 YDL223C HBT1 hom Substrate of the Hub1p ubiquitin-like protein that localizes to the shmoo tip (mating projection); mutants are defective for mating projection formation, thereby implicating Hbt1p in polarized cell morphogenesis
0.113 4.84E-11 YGR065C VHT1 het High-affinity plasma membrane H+-biotin (vitamin H) symporter; mutation results in fatty acid auxotrophy; 12 transmembrane domain containing major facilitator subfamily member; mRNA levels negatively regulated by iron deprivation and biotin
0.112 8.61E-11 YMR262W_p YMR262W_p hom Protein of unknown function; interacts weakly with Knr4p; YMR262W is not an essential gene
0.110 1.65E-10 YBR196C-B_p YBR196C-B_p hom Putative protein of unknown function; identified by expression profiling and mass spectrometry
0.108 3.30E-10 YBR170C NPL4 hom Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase; assists Cdc48p in the dislocation of misfolded, polyubiquitinated ERAD substrates that are subsequently delivered to the proteasome for degradation; also involved in the regulated destruction of resident ER membrane proteins, such as HMG-CoA reductase (Hmg1/2p) and cytoplasmic proteins (Fbp1p); role in mobilizing membrane bound transcription factors by regulated ubiquitin/proteasome-dependent processing (RUP)
0.105 1.16E-9 YML057W CMP2 hom Calcineurin A; one isoform (the other is CNA1) of the catalytic subunit of calcineurin, a Ca++/calmodulin-regulated protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is CNB1