YJR011C_p

Putative protein of unknown function; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS

Zygosity: Homozygous strain
fixedexpanded
Profile for YJR011C / YJR011C

Click on Significant Values for Screen Details ID:SGTC_38|Compound:0929-0051|FD-Score:2.94|P-value:8.65E-4 ID:SGTC_39|Compound:0986-0283|FD-Score:5.64|P-value:9.15E-10 ID:SGTC_41|Compound:0478-0632|FD-Score:4.27|P-value:2.74E-6 ID:SGTC_64|Compound:000l-0018|FD-Score:4.98|P-value:5.40E-8 ID:SGTC_73|Compound:0327-0325|FD-Score:3.31|P-value:2.08E-4 ID:SGTC_158|Compound:k038-0087|FD-Score:3.86|P-value:2.00E-5 ID:SGTC_360|Compound:0957-0399|FD-Score:3.52|P-value:8.74E-5 ID:SGTC_448|Compound:monastrol|FD-Score:-3.12|P-value:4.33E-4 ID:SGTC_660|Compound:4031-1742|FD-Score:-2.96|P-value:7.80E-4 ID:SGTC_777|Compound:1315-0167|FD-Score:3.32|P-value:2.03E-4 ID:SGTC_783|Compound:0848-0141|FD-Score:-3.14|P-value:3.97E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:3.35|P-value:1.81E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:-5.38|P-value:4.56E-9 ID:SGTC_909|Compound:3448-9333|FD-Score:-5.22|P-value:1.21E-8 ID:SGTC_912|Compound:3474-0017|FD-Score:2.97|P-value:7.83E-4 ID:SGTC_913|Compound:3487-1245|FD-Score:-4.40|P-value:1.30E-6 ID:SGTC_916|Compound:4466-0038|FD-Score:3.73|P-value:3.60E-5 ID:SGTC_1036|Compound:k216-0215|FD-Score:-3.51|P-value:8.86E-5 ID:SGTC_1043|Compound:0916-0009|FD-Score:5.44|P-value:3.33E-9 ID:SGTC_1218|Compound:1348-1416|FD-Score:-3.74|P-value:3.27E-5 ID:SGTC_1250|Compound:0485-0349|FD-Score:-4.14|P-value:4.79E-6 ID:SGTC_1276|Compound:0871-0068|FD-Score:3.26|P-value:2.60E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:-2.91|P-value:9.28E-4 ID:SGTC_1467|Compound:k284-1082|FD-Score:2.93|P-value:9.11E-4 ID:SGTC_1489|Compound:4065-0444|FD-Score:3.40|P-value:1.46E-4 ID:SGTC_1494|Compound:4358-1428|FD-Score:-2.93|P-value:8.61E-4 ID:SGTC_1560|Compound:lithocholic acid|FD-Score:3.44|P-value:1.24E-4 ID:SGTC_1599|Compound:8-chlro-1-tetrahydronorharmanone|FD-Score:3.14|P-value:4.15E-4 ID:SGTC_1630|Compound:st005209|FD-Score:3.38|P-value:1.58E-4 ID:SGTC_1923|Compound:st058458|FD-Score:3.74|P-value:3.35E-5 ID:SGTC_1930|Compound:st074634|FD-Score:-2.96|P-value:7.62E-4 ID:SGTC_2006|Compound:4011487|FD-Score:-3.13|P-value:4.17E-4 ID:SGTC_2051|Compound:5263410|FD-Score:-3.17|P-value:3.45E-4 ID:SGTC_2054|Compound:5233173|FD-Score:-3.39|P-value:1.43E-4 ID:SGTC_2061|Compound:5245884|FD-Score:3.09|P-value:4.90E-4 ID:SGTC_2071|Compound:5230951|FD-Score:-3.43|P-value:1.23E-4 ID:SGTC_2293|Compound:7624732|FD-Score:-3.24|P-value:2.63E-4 ID:SGTC_2299|Compound:7976368|FD-Score:-3.18|P-value:3.40E-4 ID:SGTC_2332|Compound:7982454|FD-Score:-4.27|P-value:2.58E-6 ID:SGTC_2335|Compound:9018011|FD-Score:2.90|P-value:9.97E-4 ID:SGTC_2336|Compound:9001819|FD-Score:3.64|P-value:5.22E-5 ID:SGTC_2382|Compound:9035899|FD-Score:2.93|P-value:9.17E-4 ID:SGTC_2383|Compound:9036125|FD-Score:-3.14|P-value:4.02E-4 ID:SGTC_2485|Compound:5633444|FD-Score:-3.49|P-value:9.76E-5 ID:SGTC_2796|Compound:7949634|FD-Score:3.24|P-value:2.84E-4 ID:SGTC_2830|Compound:7992007|FD-Score:-3.00|P-value:6.74E-4 ID:SGTC_3202|Compound:9113761|FD-Score:4.08|P-value:6.96E-6 ID:SGTC_3206|Compound:9114350|FD-Score:-6.12|P-value:3.08E-11 ID:SGTC_3222|Compound:9128301|FD-Score:-4.20|P-value:3.59E-6 ID:SGTC_3290|Compound:9121031|FD-Score:-3.08|P-value:5.02E-4 ID:SGTC_3348|Compound:9149464|FD-Score:-3.00|P-value:6.64E-4 ID:SGTC_38|Compound:0929-0051|FD-Score:2.94|P-value:8.65E-4 ID:SGTC_39|Compound:0986-0283|FD-Score:5.64|P-value:9.15E-10 ID:SGTC_41|Compound:0478-0632|FD-Score:4.27|P-value:2.74E-6 ID:SGTC_64|Compound:000l-0018|FD-Score:4.98|P-value:5.40E-8 ID:SGTC_73|Compound:0327-0325|FD-Score:3.31|P-value:2.08E-4 ID:SGTC_158|Compound:k038-0087|FD-Score:3.86|P-value:2.00E-5 ID:SGTC_360|Compound:0957-0399|FD-Score:3.52|P-value:8.74E-5 ID:SGTC_448|Compound:monastrol|FD-Score:-3.12|P-value:4.33E-4 ID:SGTC_660|Compound:4031-1742|FD-Score:-2.96|P-value:7.80E-4 ID:SGTC_777|Compound:1315-0167|FD-Score:3.32|P-value:2.03E-4 ID:SGTC_783|Compound:0848-0141|FD-Score:-3.14|P-value:3.97E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:3.35|P-value:1.81E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:-5.38|P-value:4.56E-9 ID:SGTC_909|Compound:3448-9333|FD-Score:-5.22|P-value:1.21E-8 ID:SGTC_912|Compound:3474-0017|FD-Score:2.97|P-value:7.83E-4 ID:SGTC_913|Compound:3487-1245|FD-Score:-4.40|P-value:1.30E-6 ID:SGTC_916|Compound:4466-0038|FD-Score:3.73|P-value:3.60E-5 ID:SGTC_1036|Compound:k216-0215|FD-Score:-3.51|P-value:8.86E-5 ID:SGTC_1043|Compound:0916-0009|FD-Score:5.44|P-value:3.33E-9 ID:SGTC_1218|Compound:1348-1416|FD-Score:-3.74|P-value:3.27E-5 ID:SGTC_1250|Compound:0485-0349|FD-Score:-4.14|P-value:4.79E-6 ID:SGTC_1276|Compound:0871-0068|FD-Score:3.26|P-value:2.60E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:-2.91|P-value:9.28E-4 ID:SGTC_1467|Compound:k284-1082|FD-Score:2.93|P-value:9.11E-4 ID:SGTC_1489|Compound:4065-0444|FD-Score:3.40|P-value:1.46E-4 ID:SGTC_1494|Compound:4358-1428|FD-Score:-2.93|P-value:8.61E-4 ID:SGTC_1560|Compound:lithocholic acid|FD-Score:3.44|P-value:1.24E-4 ID:SGTC_1599|Compound:8-chlro-1-tetrahydronorharmanone|FD-Score:3.14|P-value:4.15E-4 ID:SGTC_1630|Compound:st005209|FD-Score:3.38|P-value:1.58E-4 ID:SGTC_1923|Compound:st058458|FD-Score:3.74|P-value:3.35E-5 ID:SGTC_1930|Compound:st074634|FD-Score:-2.96|P-value:7.62E-4 ID:SGTC_2006|Compound:4011487|FD-Score:-3.13|P-value:4.17E-4 ID:SGTC_2051|Compound:5263410|FD-Score:-3.17|P-value:3.45E-4 ID:SGTC_2054|Compound:5233173|FD-Score:-3.39|P-value:1.43E-4 ID:SGTC_2061|Compound:5245884|FD-Score:3.09|P-value:4.90E-4 ID:SGTC_2071|Compound:5230951|FD-Score:-3.43|P-value:1.23E-4 ID:SGTC_2293|Compound:7624732|FD-Score:-3.24|P-value:2.63E-4 ID:SGTC_2299|Compound:7976368|FD-Score:-3.18|P-value:3.40E-4 ID:SGTC_2332|Compound:7982454|FD-Score:-4.27|P-value:2.58E-6 ID:SGTC_2335|Compound:9018011|FD-Score:2.90|P-value:9.97E-4 ID:SGTC_2336|Compound:9001819|FD-Score:3.64|P-value:5.22E-5 ID:SGTC_2382|Compound:9035899|FD-Score:2.93|P-value:9.17E-4 ID:SGTC_2383|Compound:9036125|FD-Score:-3.14|P-value:4.02E-4 ID:SGTC_2485|Compound:5633444|FD-Score:-3.49|P-value:9.76E-5 ID:SGTC_2796|Compound:7949634|FD-Score:3.24|P-value:2.84E-4 ID:SGTC_2830|Compound:7992007|FD-Score:-3.00|P-value:6.74E-4 ID:SGTC_3202|Compound:9113761|FD-Score:4.08|P-value:6.96E-6 ID:SGTC_3206|Compound:9114350|FD-Score:-6.12|P-value:3.08E-11 ID:SGTC_3222|Compound:9128301|FD-Score:-4.20|P-value:3.59E-6 ID:SGTC_3290|Compound:9121031|FD-Score:-3.08|P-value:5.02E-4 ID:SGTC_3348|Compound:9149464|FD-Score:-3.00|P-value:6.64E-4

Top fitness defect scores for YJR011C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_39 0986-0283 5.64 58.4 µM 9.15E-10 calcium & mitochondrial duress 8 8.49E-9
2 SGTC_1043 0916-0009 5.44 19.3 µM 3.33E-9 4 2.65E-8
3 SGTC_64 000l-0018 4.98 272.1 µM 5.40E-8 ubiquinone biosynthesis & proteasome 109 3.10E-7
4 SGTC_41 0478-0632 4.27 82.6 µM 2.74E-6 22 9.96E-6
5 SGTC_3202 9113761 4.08 49.5 µM 6.96E-6 45 2.27E-5
6 SGTC_158 k038-0087 3.86 26.4 µM 2.00E-5 ubiquinone biosynthesis & proteasome 149 5.78E-5
7 SGTC_1923 st058458 3.74 19.1 µM 3.35E-5 37 9.13E-5
8 SGTC_916 4466-0038 3.73 42.0 nM 3.60E-5 cell wall 79 9.73E-5
9 SGTC_2336 9001819 3.64 198.7 µM 5.22E-5 heme biosynthesis & mitochondrial translocase 66 1.35E-4
10 SGTC_360 0957-0399 3.52 1.0 µM 8.74E-5 cell wall 61 2.13E-4
11 SGTC_1560 lithocholic acid 3.44 53.1 µM 1.24E-4 8 2.91E-4
12 SGTC_1489 4065-0444 3.40 182.0 µM 1.46E-4 33 3.36E-4
13 SGTC_1630 st005209 3.38 31.3 µM 1.58E-4 46 3.60E-4
14 SGTC_893 0958-0369 3.35 48.9 µM 1.81E-4 46 4.06E-4
15 SGTC_777 1315-0167 3.32 517.0 µM 2.03E-4 Golgi 48 4.50E-4
16 SGTC_73 0327-0325 3.31 16.2 µM 2.08E-4 DNA damage response 77 4.60E-4
17 SGTC_1276 0871-0068 3.26 94.2 µM 2.60E-4 42 5.60E-4
18 SGTC_2796 7949634 3.24 45.5 µM 2.84E-4 50 6.07E-4
19 SGTC_1599 8-chlro-1-tetrahydronorharmanone 3.14 90.6 µM 4.15E-4 71 8.50E-4
20 SGTC_2061 5245884 3.09 81.0 µM 4.90E-4 tubulin folding & SWR complex 58 9.84E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.228 1.31E-40 YJL109C UTP10 het Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA; mutant has increased aneuploidy tolerance
0.215 1.49E-36 YLR199C PBA1 hom Protein involved in 20S proteasome assembly; forms a heterodimer with Add66p that binds to proteasome precursors; similar to human PAC1 constituent of the PAC1-PAC2 complex involved in proteasome assembly
0.156 9.32E-20 YLR023C IZH3 hom Membrane protein involved in zinc ion homeostasis, member of the four-protein IZH family, expression induced by zinc deficiency; deletion reduces sensitivity to elevated zinc and shortens lag phase, overexpression reduces Zap1p activity
0.151 1.69E-18 YKL100C_p YKL100C_p hom Putative protein of unknown function with similarity to a human minor histocompatibility antigen and signal peptide peptidases; YKL100C is not an essential gene
0.137 1.28E-15 YBR115C LYS2 hom Alpha aminoadipate reductase, catalyzes the reduction of alpha-aminoadipate to alpha-aminoadipate 6-semialdehyde, which is the fifth step in biosynthesis of lysine; activation requires posttranslational phosphopantetheinylation by Lys5p
0.132 1.60E-14 YLR276C DBP9 het DEAD-box protein required for 27S rRNA processing; exhibits DNA, RNA and DNA/RNA helicase activities; ATPase activity shows preference for DNA over RNA; DNA helicase activity abolished by mutation in RNA-binding domain
0.130 5.15E-14 YLR189C ATG26 hom UDP-glucose:sterol glucosyltransferase, conserved enzyme involved in synthesis of sterol glucoside membrane lipids; in contrast to ATG26 from P. pastoris, S. cerevisiae ATG26 is not involved in autophagy
0.129 6.87E-14 YLR201C COQ9 hom Protein required for ubiquinone (coenzyme Q) biosynthesis and respiratory growth; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes
0.129 6.99E-14 YBL015W ACH1 hom Protein with CoA transferase activity, particularly for CoASH transfer from succinyl-CoA to acetate; has minor acetyl-CoA-hydrolase activity; phosphorylated; required for acetate utilization and for diploid pseudohyphal growth
0.129 7.86E-14 YMR314W PRE5 het Alpha 6 subunit of the 20S proteasome; protein abundance increases in response to DNA replication stress
0.127 1.60E-13 YGL119W COQ8 hom Protein required for ubiquinone biosynthesis and respiratory growth; exhibits genetic interaction with COQ9, suggesting a common function; similar to prokaryotic proteins involved in early steps of ubiquinone biosynthesis; COQ8 has a paralog, YBR230W-A, that arose from the whole genome duplication
0.127 1.67E-13 YER019C-A SBH2 hom Ssh1p-Sss1p-Sbh2p complex component, involved in protein translocation into the endoplasmic reticulum; homologous to Sbh1p
0.125 3.36E-13 YML116W ATR1 hom Multidrug efflux pump of the major facilitator superfamily; required for resistance to aminotriazole and 4-nitroquinoline-N-oxide; ATR1 has a paralog, YMR279C, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.120 3.68E-12 YFL063W_d YFL063W_d hom Dubious open reading frame, based on available experimental and comparative sequence data
0.120 3.68E-12 YGR255C COQ6 hom Putative flavin-dependent monooxygenase; involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes; human COX6 can rescue a yeast cox6 mutant and is implicated in steroid-resistant nephrotic syndrome (SRNS)