HIPHOP chemogenomics database

YJR011C_p

Putative protein of unknown function; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS

Zygosity: Homozygous strain

fixedexpanded
Profile for YJR011C / YJR011C

Click on Significant Values for Screen Details

Top fitness defect scores for YJR011C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_39	0986-0283	5.64	58.4 µM	9.15E-10	calcium & mitochondrial duress	8	8.49E-9
2	SGTC_1043	0916-0009	5.44	19.3 µM	3.33E-9		4	2.65E-8
3	SGTC_64	000l-0018	4.98	272.1 µM	5.40E-8	ubiquinone biosynthesis & proteasome	109	3.10E-7
4	SGTC_41	0478-0632	4.27	82.6 µM	2.74E-6		22	9.96E-6
5	SGTC_3202	9113761	4.08	49.5 µM	6.96E-6		45	2.27E-5
6	SGTC_158	k038-0087	3.86	26.4 µM	2.00E-5	ubiquinone biosynthesis & proteasome	149	5.78E-5
7	SGTC_1923	st058458	3.74	19.1 µM	3.35E-5		37	9.13E-5
8	SGTC_916	4466-0038	3.73	42.0 nM	3.60E-5	cell wall	79	9.73E-5
9	SGTC_2336	9001819	3.64	198.7 µM	5.22E-5	heme biosynthesis & mitochondrial translocase	66	1.35E-4
10	SGTC_360	0957-0399	3.52	1.0 µM	8.74E-5	cell wall	61	2.13E-4
11	SGTC_1560	lithocholic acid	3.44	53.1 µM	1.24E-4		8	2.91E-4
12	SGTC_1489	4065-0444	3.40	182.0 µM	1.46E-4		33	3.36E-4
13	SGTC_1630	st005209	3.38	31.3 µM	1.58E-4		46	3.60E-4
14	SGTC_893	0958-0369	3.35	48.9 µM	1.81E-4		46	4.06E-4
15	SGTC_777	1315-0167	3.32	517.0 µM	2.03E-4	Golgi	48	4.50E-4
16	SGTC_73	0327-0325	3.31	16.2 µM	2.08E-4	DNA damage response	77	4.60E-4
17	SGTC_1276	0871-0068	3.26	94.2 µM	2.60E-4		42	5.60E-4
18	SGTC_2796	7949634	3.24	45.5 µM	2.84E-4		50	6.07E-4
19	SGTC_1599	8-chlro-1-tetrahydronorharmanone	3.14	90.6 µM	4.15E-4		71	8.50E-4
20	SGTC_2061	5245884	3.09	81.0 µM	4.90E-4	tubulin folding & SWR complex	58	9.84E-4

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.228	1.31E-40	YJL109C	UTP10	het	Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA; mutant has increased aneuploidy tolerance
0.215	1.49E-36	YLR199C	PBA1	hom	Protein involved in 20S proteasome assembly; forms a heterodimer with Add66p that binds to proteasome precursors; similar to human PAC1 constituent of the PAC1-PAC2 complex involved in proteasome assembly
0.156	9.32E-20	YLR023C	IZH3	hom	Membrane protein involved in zinc ion homeostasis, member of the four-protein IZH family, expression induced by zinc deficiency; deletion reduces sensitivity to elevated zinc and shortens lag phase, overexpression reduces Zap1p activity
0.151	1.69E-18	YKL100C_p	YKL100C_p	hom	Putative protein of unknown function with similarity to a human minor histocompatibility antigen and signal peptide peptidases; YKL100C is not an essential gene
0.137	1.28E-15	YBR115C	LYS2	hom	Alpha aminoadipate reductase, catalyzes the reduction of alpha-aminoadipate to alpha-aminoadipate 6-semialdehyde, which is the fifth step in biosynthesis of lysine; activation requires posttranslational phosphopantetheinylation by Lys5p
0.132	1.60E-14	YLR276C	DBP9	het	DEAD-box protein required for 27S rRNA processing; exhibits DNA, RNA and DNA/RNA helicase activities; ATPase activity shows preference for DNA over RNA; DNA helicase activity abolished by mutation in RNA-binding domain
0.130	5.15E-14	YLR189C	ATG26	hom	UDP-glucose:sterol glucosyltransferase, conserved enzyme involved in synthesis of sterol glucoside membrane lipids; in contrast to ATG26 from P. pastoris, S. cerevisiae ATG26 is not involved in autophagy
0.129	6.87E-14	YLR201C	COQ9	hom	Protein required for ubiquinone (coenzyme Q) biosynthesis and respiratory growth; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes
0.129	6.99E-14	YBL015W	ACH1	hom	Protein with CoA transferase activity, particularly for CoASH transfer from succinyl-CoA to acetate; has minor acetyl-CoA-hydrolase activity; phosphorylated; required for acetate utilization and for diploid pseudohyphal growth
0.129	7.86E-14	YMR314W	PRE5	het	Alpha 6 subunit of the 20S proteasome; protein abundance increases in response to DNA replication stress
0.127	1.60E-13	YGL119W	COQ8	hom	Protein required for ubiquinone biosynthesis and respiratory growth; exhibits genetic interaction with COQ9, suggesting a common function; similar to prokaryotic proteins involved in early steps of ubiquinone biosynthesis; COQ8 has a paralog, YBR230W-A, that arose from the whole genome duplication
0.127	1.67E-13	YER019C-A	SBH2	hom	Ssh1p-Sss1p-Sbh2p complex component, involved in protein translocation into the endoplasmic reticulum; homologous to Sbh1p
0.125	3.36E-13	YML116W	ATR1	hom	Multidrug efflux pump of the major facilitator superfamily; required for resistance to aminotriazole and 4-nitroquinoline-N-oxide; ATR1 has a paralog, YMR279C, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.120	3.68E-12	YFL063W_d	YFL063W_d	hom	Dubious open reading frame, based on available experimental and comparative sequence data
0.120	3.68E-12	YGR255C	COQ6	hom	Putative flavin-dependent monooxygenase; involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes; human COX6 can rescue a yeast cox6 mutant and is implicated in steroid-resistant nephrotic syndrome (SRNS)