YJR012C_p

Essential protein of unknown function; proposed involvement in transport based on mass spectrometry analysis of copurifying proteins; partially overlaps neighboring ORF, GPI14/YJR013W

Zygosity: Heterozygous strain
fixedexpanded
Profile for YJR012C / YJR012C

Click on Significant Values for Screen Details ID:SGTC_67|Compound:0335-0847|FD-Score:3.23|P-value:1.08E-4 ID:SGTC_165|Compound:k038-0023|FD-Score:3.40|P-value:4.92E-5 ID:SGTC_183|Compound:3914-0051|FD-Score:4.37|P-value:2.73E-7 ID:SGTC_234|Compound:nsc-17383|FD-Score:2.83|P-value:5.85E-4 ID:SGTC_325|Compound:2810-4341|FD-Score:3.48|P-value:3.36E-5 ID:SGTC_351|Compound:caspofungin|FD-Score:2.88|P-value:4.85E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:3.39|P-value:4.98E-5 ID:SGTC_365|Compound:0121-0052|FD-Score:3.13|P-value:1.64E-4 ID:SGTC_433|Compound:pimozide|FD-Score:-2.86|P-value:5.30E-4 ID:SGTC_494|Compound:Boc-Gly-Val-Val-CHO|FD-Score:3.87|P-value:4.67E-6 ID:SGTC_509|Compound:pifithrin|FD-Score:-2.95|P-value:3.59E-4 ID:SGTC_566|Compound:0958-0068|FD-Score:3.15|P-value:1.55E-4 ID:SGTC_579|Compound:4491-1009|FD-Score:-2.78|P-value:7.23E-4 ID:SGTC_645|Compound:0845-0943|FD-Score:4.58|P-value:7.41E-8 ID:SGTC_827|Compound:3253-0474|FD-Score:4.53|P-value:1.06E-7 ID:SGTC_829|Compound:1635-0120|FD-Score:3.30|P-value:7.86E-5 ID:SGTC_833|Compound:3852-0053|FD-Score:3.42|P-value:4.39E-5 ID:SGTC_845|Compound:0330-0138|FD-Score:3.05|P-value:2.34E-4 ID:SGTC_935|Compound:2996-0153|FD-Score:2.81|P-value:6.33E-4 ID:SGTC_1094|Compound:duloxetine|FD-Score:-2.79|P-value:7.05E-4 ID:SGTC_1097|Compound:itavastatin|FD-Score:-2.73|P-value:8.65E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:4.18|P-value:8.19E-7 ID:SGTC_1213|Compound:1315-0166|FD-Score:3.06|P-value:2.28E-4 ID:SGTC_1461|Compound:k072-0203|FD-Score:-2.84|P-value:5.73E-4 ID:SGTC_1501|Compound:4491-0275|FD-Score:2.80|P-value:6.74E-4 ID:SGTC_1727|Compound:st034309|FD-Score:3.21|P-value:1.17E-4 ID:SGTC_1860|Compound:st056228|FD-Score:3.09|P-value:1.96E-4 ID:SGTC_1875|Compound:nocodazole|FD-Score:2.78|P-value:7.23E-4 ID:SGTC_2020|Compound:4017018|FD-Score:3.30|P-value:7.80E-5 ID:SGTC_2073|Compound:5212005|FD-Score:-2.93|P-value:3.85E-4 ID:SGTC_2139|Compound:5578692|FD-Score:3.01|P-value:2.83E-4 ID:SGTC_2162|Compound:5663267|FD-Score:3.14|P-value:1.62E-4 ID:SGTC_2170|Compound:morpholine|FD-Score:3.29|P-value:8.30E-5 ID:SGTC_2174|Compound:5790901|FD-Score:3.05|P-value:2.34E-4 ID:SGTC_2284|Compound:7945075|FD-Score:-2.73|P-value:8.64E-4 ID:SGTC_2302|Compound:7771753|FD-Score:3.65|P-value:1.40E-5 ID:SGTC_2330|Compound:7979373|FD-Score:-3.24|P-value:1.00E-4 ID:SGTC_2398|Compound:5228213|FD-Score:3.28|P-value:8.44E-5 ID:SGTC_2414|Compound:st077232|FD-Score:-2.75|P-value:7.98E-4 ID:SGTC_2483|Compound:5729050|FD-Score:2.78|P-value:7.16E-4 ID:SGTC_2488|Compound:5268135|FD-Score:2.80|P-value:6.75E-4 ID:SGTC_2605|Compound:digitonin|FD-Score:-4.63|P-value:5.59E-8 ID:SGTC_2620|Compound:irigenin|FD-Score:4.30|P-value:4.23E-7 ID:SGTC_2630|Compound:antimycin a|FD-Score:2.77|P-value:7.56E-4 ID:SGTC_2832|Compound:7992762|FD-Score:-3.60|P-value:1.86E-5 ID:SGTC_2833|Compound:9001315|FD-Score:-6.18|P-value:6.86E-13 ID:SGTC_2870|Compound:9038528|FD-Score:3.39|P-value:5.02E-5 ID:SGTC_3099|Compound:9120367|FD-Score:-2.89|P-value:4.55E-4 ID:SGTC_3162|Compound:9099653|FD-Score:3.52|P-value:2.70E-5 ID:SGTC_3211|Compound:9128781|FD-Score:-4.08|P-value:1.42E-6 ID:SGTC_3295|Compound:9122362|FD-Score:3.09|P-value:1.95E-4 ID:SGTC_67|Compound:0335-0847|FD-Score:3.23|P-value:1.08E-4 ID:SGTC_165|Compound:k038-0023|FD-Score:3.40|P-value:4.92E-5 ID:SGTC_183|Compound:3914-0051|FD-Score:4.37|P-value:2.73E-7 ID:SGTC_234|Compound:nsc-17383|FD-Score:2.83|P-value:5.85E-4 ID:SGTC_325|Compound:2810-4341|FD-Score:3.48|P-value:3.36E-5 ID:SGTC_351|Compound:caspofungin|FD-Score:2.88|P-value:4.85E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:3.39|P-value:4.98E-5 ID:SGTC_365|Compound:0121-0052|FD-Score:3.13|P-value:1.64E-4 ID:SGTC_433|Compound:pimozide|FD-Score:-2.86|P-value:5.30E-4 ID:SGTC_494|Compound:Boc-Gly-Val-Val-CHO|FD-Score:3.87|P-value:4.67E-6 ID:SGTC_509|Compound:pifithrin|FD-Score:-2.95|P-value:3.59E-4 ID:SGTC_566|Compound:0958-0068|FD-Score:3.15|P-value:1.55E-4 ID:SGTC_579|Compound:4491-1009|FD-Score:-2.78|P-value:7.23E-4 ID:SGTC_645|Compound:0845-0943|FD-Score:4.58|P-value:7.41E-8 ID:SGTC_827|Compound:3253-0474|FD-Score:4.53|P-value:1.06E-7 ID:SGTC_829|Compound:1635-0120|FD-Score:3.30|P-value:7.86E-5 ID:SGTC_833|Compound:3852-0053|FD-Score:3.42|P-value:4.39E-5 ID:SGTC_845|Compound:0330-0138|FD-Score:3.05|P-value:2.34E-4 ID:SGTC_935|Compound:2996-0153|FD-Score:2.81|P-value:6.33E-4 ID:SGTC_1094|Compound:duloxetine|FD-Score:-2.79|P-value:7.05E-4 ID:SGTC_1097|Compound:itavastatin|FD-Score:-2.73|P-value:8.65E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:4.18|P-value:8.19E-7 ID:SGTC_1213|Compound:1315-0166|FD-Score:3.06|P-value:2.28E-4 ID:SGTC_1461|Compound:k072-0203|FD-Score:-2.84|P-value:5.73E-4 ID:SGTC_1501|Compound:4491-0275|FD-Score:2.80|P-value:6.74E-4 ID:SGTC_1727|Compound:st034309|FD-Score:3.21|P-value:1.17E-4 ID:SGTC_1860|Compound:st056228|FD-Score:3.09|P-value:1.96E-4 ID:SGTC_1875|Compound:nocodazole|FD-Score:2.78|P-value:7.23E-4 ID:SGTC_2020|Compound:4017018|FD-Score:3.30|P-value:7.80E-5 ID:SGTC_2073|Compound:5212005|FD-Score:-2.93|P-value:3.85E-4 ID:SGTC_2139|Compound:5578692|FD-Score:3.01|P-value:2.83E-4 ID:SGTC_2162|Compound:5663267|FD-Score:3.14|P-value:1.62E-4 ID:SGTC_2170|Compound:morpholine|FD-Score:3.29|P-value:8.30E-5 ID:SGTC_2174|Compound:5790901|FD-Score:3.05|P-value:2.34E-4 ID:SGTC_2284|Compound:7945075|FD-Score:-2.73|P-value:8.64E-4 ID:SGTC_2302|Compound:7771753|FD-Score:3.65|P-value:1.40E-5 ID:SGTC_2330|Compound:7979373|FD-Score:-3.24|P-value:1.00E-4 ID:SGTC_2398|Compound:5228213|FD-Score:3.28|P-value:8.44E-5 ID:SGTC_2414|Compound:st077232|FD-Score:-2.75|P-value:7.98E-4 ID:SGTC_2483|Compound:5729050|FD-Score:2.78|P-value:7.16E-4 ID:SGTC_2488|Compound:5268135|FD-Score:2.80|P-value:6.75E-4 ID:SGTC_2605|Compound:digitonin|FD-Score:-4.63|P-value:5.59E-8 ID:SGTC_2620|Compound:irigenin|FD-Score:4.30|P-value:4.23E-7 ID:SGTC_2630|Compound:antimycin a|FD-Score:2.77|P-value:7.56E-4 ID:SGTC_2832|Compound:7992762|FD-Score:-3.60|P-value:1.86E-5 ID:SGTC_2833|Compound:9001315|FD-Score:-6.18|P-value:6.86E-13 ID:SGTC_2870|Compound:9038528|FD-Score:3.39|P-value:5.02E-5 ID:SGTC_3099|Compound:9120367|FD-Score:-2.89|P-value:4.55E-4 ID:SGTC_3162|Compound:9099653|FD-Score:3.52|P-value:2.70E-5 ID:SGTC_3211|Compound:9128781|FD-Score:-4.08|P-value:1.42E-6 ID:SGTC_3295|Compound:9122362|FD-Score:3.09|P-value:1.95E-4

Top fitness defect scores for YJR012C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_645 0845-0943 4.58 5.4 µM 7.41E-8 60S ribosome export 3 2.28E-6 0.03
2 SGTC_827 3253-0474 4.53 693.0 µM 1.06E-7 3 2.99E-6 0.28
3 SGTC_183 3914-0051 4.37 30.6 µM 2.73E-7 60S ribosome export 3 6.22E-6 0.81
4 SGTC_2620 irigenin 4.30 100.0 µM 4.23E-7 11 8.69E-6 0.05
5 SGTC_1133 3473-0247 4.18 50.0 µM 8.19E-7 RSC complex & mRNA processing 41 1.45E-5 0.09
6 SGTC_494 Boc-Gly-Val-Val-CHO 3.87 140.0 µM 4.67E-6 2 5.53E-5 0.04
7 SGTC_2302 7771753 3.65 200.0 µM 1.40E-5 8 1.29E-4 0.01
8 SGTC_3162 9099653 3.52 49.5 µM 2.70E-5 1 2.14E-4 0.24
9 SGTC_325 2810-4341 3.48 181.0 µM 3.36E-5 amide catabolism 11 2.54E-4 0.22
10 SGTC_833 3852-0053 3.42 558.0 µM 4.39E-5 11 3.11E-4 0.21
11 SGTC_165 k038-0023 3.40 64.4 µM 4.92E-5 ubiquinone biosynthesis & proteasome 26 3.40E-4 0.03
12 SGTC_358 0075-0058 3.39 9.4 µM 4.98E-5 12 3.43E-4 0.02
13 SGTC_2870 9038528 3.39 13.0 µM 5.02E-5 8 3.46E-4 0.01
14 SGTC_2020 4017018 3.30 200.0 µM 7.80E-5 13 4.86E-4 0.05
15 SGTC_829 1635-0120 3.30 117.0 µM 7.86E-5 DNA damage response 61 4.89E-4 0.08
16 SGTC_2170 morpholine 3.29 200.0 µM 8.30E-5 7 5.09E-4 0.16
17 SGTC_2398 5228213 3.28 48.8 µM 8.44E-5 iron homeostasis 22 5.16E-4 0.03
18 SGTC_67 0335-0847 3.23 266.0 µM 1.08E-4 ubiquinone biosynthesis & proteasome 34 6.27E-4 0.02
19 SGTC_1727 st034309 3.21 9.9 µM 1.17E-4 27 6.65E-4 0.00
20 SGTC_566 0958-0068 3.15 16.5 µM 1.55E-4 RSC & ERG11 29 8.28E-4 0.03

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.127 1.76E-13 YLR066W SPC3 het Subunit of signal peptidase complex (Spc1p, Spc2p, Spc3p, Sec11p), which catalyzes cleavage of N-terminal signal sequences of proteins targeted to the secretory pathway; homologous to mammalian SPC22/23
0.124 4.97E-13 YJR115W_p YJR115W_p hom Putative protein of unknown function; YJR115W has a paralog, ECM13, that arose from the whole genome duplication
0.112 9.13E-11 YLL050C COF1 het Cofilin, involved in pH-dependent actin filament depolarization; binds both actin monomers and filaments and severs filaments; involved in the selective sorting, export of the secretory cargo from the late golgi; genetically interacts with pmr1; thought to be regulated by phosphorylation at SER4; ubiquitous and essential in eukaryotes
0.106 7.69E-10 YOL071W EMI5 hom Subunit of succinate dehydrogenase, which couples succinate oxidation to ubiquinone reduction; required for FAD cofactor attachment to Sdh1p; mutations in human ortholog PGL2 are associated with neuroendocrine tumors (paraganglioma)
0.106 7.81E-10 YKL131W_d YKL131W_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.104 1.66E-9 YBR003W COQ1 hom Hexaprenyl pyrophosphate synthetase, catalyzes the first step in ubiquinone (coenzyme Q) biosynthesis
0.102 3.91E-9 YDR124W_p YDR124W_p hom Putative protein of unknown function; non-essential gene; expression is strongly induced by alpha factor
0.101 4.24E-9 YKL085W MDH1 hom Mitochondrial malate dehydrogenase, catalyzes interconversion of malate and oxaloacetate; involved in the tricarboxylic acid (TCA) cycle; phosphorylated
0.097 1.55E-8 YBR169C SSE2 hom Member of the heat shock protein 70 (HSP70) family; may be involved in protein folding; localized to the cytoplasm; SSE2 has a paralog, SSE1, that arose from the whole genome duplication
0.097 1.81E-8 YOR023C AHC1 hom Subunit of the Ada histone acetyltransferase complex, required for structural integrity of the complex
0.097 2.00E-8 YMR140W SIP5 hom Protein of unknown function; interacts with both the Reg1p/Glc7p phosphatase and the Snf1p kinase; forms cytoplasmic foci upon DNA replication stress
0.095 3.79E-8 YOL080C REX4 hom Putative RNA exonuclease possibly involved in pre-rRNA processing and ribosome assembly
0.094 4.45E-8 YPR014C_d YPR014C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YPR014C is not an essential gene
0.094 5.16E-8 YOR254C SEC63 het Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
0.092 8.07E-8 YPL242C IQG1 het Essential protein required for determination of budding pattern; promotes localization of axial markers Bud4p and Cdc12p and functionally interacts with Sec3p, localizes to the contractile ring during anaphase, member of the IQGAP family; relocalizes from bud neck to cytoplasm upon DNA replication stress