HIPHOP chemogenomics database
YJR012C_p 
Essential protein of unknown function; proposed involvement in transport based on mass spectrometry analysis of copurifying proteins; partially overlaps neighboring ORF, GPI14/YJR013W
Zygosity: Heterozygous strain
fixedexpanded
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Top fitness defect scores for YJR012C deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.127 | 1.76E-13 | YLR066W | SPC3 | het | Subunit of signal peptidase complex (Spc1p, Spc2p, Spc3p, Sec11p), which catalyzes cleavage of N-terminal signal sequences of proteins targeted to the secretory pathway; homologous to mammalian SPC22/23 |
| 0.124 | 4.97E-13 | YJR115W_p | YJR115W_p | hom | Putative protein of unknown function; YJR115W has a paralog, ECM13, that arose from the whole genome duplication |
| 0.112 | 9.13E-11 | YLL050C | COF1 | het | Cofilin, involved in pH-dependent actin filament depolarization; binds both actin monomers and filaments and severs filaments; involved in the selective sorting, export of the secretory cargo from the late golgi; genetically interacts with pmr1; thought to be regulated by phosphorylation at SER4; ubiquitous and essential in eukaryotes |
| 0.106 | 7.69E-10 | YOL071W | EMI5 | hom | Subunit of succinate dehydrogenase, which couples succinate oxidation to ubiquinone reduction; required for FAD cofactor attachment to Sdh1p; mutations in human ortholog PGL2 are associated with neuroendocrine tumors (paraganglioma) |
| 0.106 | 7.81E-10 | YKL131W_d | YKL131W_d | hom | Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data |
| 0.104 | 1.66E-9 | YBR003W | COQ1 | hom | Hexaprenyl pyrophosphate synthetase, catalyzes the first step in ubiquinone (coenzyme Q) biosynthesis |
| 0.102 | 3.91E-9 | YDR124W_p | YDR124W_p | hom | Putative protein of unknown function; non-essential gene; expression is strongly induced by alpha factor |
| 0.101 | 4.24E-9 | YKL085W | MDH1 | hom | Mitochondrial malate dehydrogenase, catalyzes interconversion of malate and oxaloacetate; involved in the tricarboxylic acid (TCA) cycle; phosphorylated |
| 0.097 | 1.55E-8 | YBR169C | SSE2 | hom | Member of the heat shock protein 70 (HSP70) family; may be involved in protein folding; localized to the cytoplasm; SSE2 has a paralog, SSE1, that arose from the whole genome duplication |
| 0.097 | 1.81E-8 | YOR023C | AHC1 | hom | Subunit of the Ada histone acetyltransferase complex, required for structural integrity of the complex |
| 0.097 | 2.00E-8 | YMR140W | SIP5 | hom | Protein of unknown function; interacts with both the Reg1p/Glc7p phosphatase and the Snf1p kinase; forms cytoplasmic foci upon DNA replication stress |
| 0.095 | 3.79E-8 | YOL080C | REX4 | hom | Putative RNA exonuclease possibly involved in pre-rRNA processing and ribosome assembly |
| 0.094 | 4.45E-8 | YPR014C_d | YPR014C_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YPR014C is not an essential gene |
| 0.094 | 5.16E-8 | YOR254C | SEC63 | het | Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER |
| 0.092 | 8.07E-8 | YPL242C | IQG1 | het | Essential protein required for determination of budding pattern; promotes localization of axial markers Bud4p and Cdc12p and functionally interacts with Sec3p, localizes to the contractile ring during anaphase, member of the IQGAP family; relocalizes from bud neck to cytoplasm upon DNA replication stress |