YJR015W_p

Putative protein of unknown function; localizes to the endoplasmic reticulum and cytoplasm; predicted to encode a membrane transporter based on phylogenetic analysis; YJR015W is a non-essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YJR015W / YJR015W

Click on Significant Values for Screen Details ID:SGTC_25|Compound:0118-0223|FD-Score:3.30|P-value:2.26E-4 ID:SGTC_39|Compound:0986-0283|FD-Score:3.74|P-value:3.57E-5 ID:SGTC_266|Compound:formosanin C|FD-Score:3.05|P-value:6.09E-4 ID:SGTC_337|Compound:1315-0038|FD-Score:-3.08|P-value:5.84E-4 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:-3.32|P-value:2.32E-4 ID:SGTC_428|Compound:3448-4153|FD-Score:3.84|P-value:2.30E-5 ID:SGTC_493|Compound:zm226600|FD-Score:2.92|P-value:9.56E-4 ID:SGTC_509|Compound:pifithrin|FD-Score:-3.43|P-value:1.48E-4 ID:SGTC_542|Compound:3381-0244|FD-Score:4.26|P-value:3.18E-6 ID:SGTC_611|Compound:3453-1652|FD-Score:3.14|P-value:4.27E-4 ID:SGTC_890|Compound:0929-0006|FD-Score:4.19|P-value:4.44E-6 ID:SGTC_918|Compound:glabranin|FD-Score:3.16|P-value:3.91E-4 ID:SGTC_1249|Compound:0481-0015|FD-Score:-3.16|P-value:4.36E-4 ID:SGTC_1484|Compound:3473-2379|FD-Score:-3.11|P-value:5.13E-4 ID:SGTC_1499|Compound:4480-0877|FD-Score:3.78|P-value:3.03E-5 ID:SGTC_1500|Compound:4488-1866|FD-Score:3.99|P-value:1.15E-5 ID:SGTC_1518|Compound:st038567|FD-Score:-3.62|P-value:6.59E-5 ID:SGTC_1534|Compound:6-azauridine|FD-Score:-3.41|P-value:1.64E-4 ID:SGTC_1570|Compound:verbenone|FD-Score:3.59|P-value:6.99E-5 ID:SGTC_1578|Compound:josamycin|FD-Score:-3.09|P-value:5.70E-4 ID:SGTC_1698|Compound:5-fluorocytosine|FD-Score:3.46|P-value:1.22E-4 ID:SGTC_1749|Compound:st037932|FD-Score:3.22|P-value:3.12E-4 ID:SGTC_1767|Compound:st044992|FD-Score:3.47|P-value:1.16E-4 ID:SGTC_1904|Compound:st060225|FD-Score:-3.24|P-value:3.21E-4 ID:SGTC_2110|Compound:5483698|FD-Score:-3.14|P-value:4.68E-4 ID:SGTC_2116|Compound:5511452|FD-Score:4.40|P-value:1.52E-6 ID:SGTC_2123|Compound:5259487|FD-Score:3.10|P-value:5.05E-4 ID:SGTC_2126|Compound:5251174|FD-Score:4.24|P-value:3.35E-6 ID:SGTC_2592|Compound:piperlongumine|FD-Score:-4.15|P-value:6.00E-6 ID:SGTC_2780|Compound:5215298|FD-Score:2.92|P-value:9.74E-4 ID:SGTC_2783|Compound:7738165|FD-Score:-3.56|P-value:8.48E-5 ID:SGTC_2848|Compound:9016370|FD-Score:3.17|P-value:3.81E-4 ID:SGTC_2965|Compound:9082772|FD-Score:3.19|P-value:3.50E-4 ID:SGTC_2966|Compound:9084041|FD-Score:-3.43|P-value:1.48E-4 ID:SGTC_2971|Compound:9092186|FD-Score:-2.99|P-value:8.19E-4 ID:SGTC_25|Compound:0118-0223|FD-Score:3.30|P-value:2.26E-4 ID:SGTC_39|Compound:0986-0283|FD-Score:3.74|P-value:3.57E-5 ID:SGTC_266|Compound:formosanin C|FD-Score:3.05|P-value:6.09E-4 ID:SGTC_337|Compound:1315-0038|FD-Score:-3.08|P-value:5.84E-4 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:-3.32|P-value:2.32E-4 ID:SGTC_428|Compound:3448-4153|FD-Score:3.84|P-value:2.30E-5 ID:SGTC_493|Compound:zm226600|FD-Score:2.92|P-value:9.56E-4 ID:SGTC_509|Compound:pifithrin|FD-Score:-3.43|P-value:1.48E-4 ID:SGTC_542|Compound:3381-0244|FD-Score:4.26|P-value:3.18E-6 ID:SGTC_611|Compound:3453-1652|FD-Score:3.14|P-value:4.27E-4 ID:SGTC_890|Compound:0929-0006|FD-Score:4.19|P-value:4.44E-6 ID:SGTC_918|Compound:glabranin|FD-Score:3.16|P-value:3.91E-4 ID:SGTC_1249|Compound:0481-0015|FD-Score:-3.16|P-value:4.36E-4 ID:SGTC_1484|Compound:3473-2379|FD-Score:-3.11|P-value:5.13E-4 ID:SGTC_1499|Compound:4480-0877|FD-Score:3.78|P-value:3.03E-5 ID:SGTC_1500|Compound:4488-1866|FD-Score:3.99|P-value:1.15E-5 ID:SGTC_1518|Compound:st038567|FD-Score:-3.62|P-value:6.59E-5 ID:SGTC_1534|Compound:6-azauridine|FD-Score:-3.41|P-value:1.64E-4 ID:SGTC_1570|Compound:verbenone|FD-Score:3.59|P-value:6.99E-5 ID:SGTC_1578|Compound:josamycin|FD-Score:-3.09|P-value:5.70E-4 ID:SGTC_1698|Compound:5-fluorocytosine|FD-Score:3.46|P-value:1.22E-4 ID:SGTC_1749|Compound:st037932|FD-Score:3.22|P-value:3.12E-4 ID:SGTC_1767|Compound:st044992|FD-Score:3.47|P-value:1.16E-4 ID:SGTC_1904|Compound:st060225|FD-Score:-3.24|P-value:3.21E-4 ID:SGTC_2110|Compound:5483698|FD-Score:-3.14|P-value:4.68E-4 ID:SGTC_2116|Compound:5511452|FD-Score:4.40|P-value:1.52E-6 ID:SGTC_2123|Compound:5259487|FD-Score:3.10|P-value:5.05E-4 ID:SGTC_2126|Compound:5251174|FD-Score:4.24|P-value:3.35E-6 ID:SGTC_2592|Compound:piperlongumine|FD-Score:-4.15|P-value:6.00E-6 ID:SGTC_2780|Compound:5215298|FD-Score:2.92|P-value:9.74E-4 ID:SGTC_2783|Compound:7738165|FD-Score:-3.56|P-value:8.48E-5 ID:SGTC_2848|Compound:9016370|FD-Score:3.17|P-value:3.81E-4 ID:SGTC_2965|Compound:9082772|FD-Score:3.19|P-value:3.50E-4 ID:SGTC_2966|Compound:9084041|FD-Score:-3.43|P-value:1.48E-4 ID:SGTC_2971|Compound:9092186|FD-Score:-2.99|P-value:8.19E-4

Top fitness defect scores for YJR015W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2116 5511452 4.40 16.9 µM 1.52E-6 9 5.40E-6
2 SGTC_542 3381-0244 4.26 89.3 µM 3.18E-6 32 1.04E-5
3 SGTC_2126 5251174 4.24 33.9 µM 3.35E-6 21 1.10E-5
4 SGTC_890 0929-0006 4.19 47.2 µM 4.44E-6 15 1.41E-5
5 SGTC_1500 4488-1866 3.99 171.0 µM 1.15E-5 RPP1 & pyrimidine depletion 17 3.30E-5
6 SGTC_428 3448-4153 3.84 16.5 µM 2.30E-5 TSC3-RPN4 36 6.14E-5
7 SGTC_1499 4480-0877 3.78 67.3 µM 3.03E-5 9 7.87E-5
8 SGTC_39 0986-0283 3.74 58.4 µM 3.57E-5 calcium & mitochondrial duress 45 9.10E-5
9 SGTC_1570 verbenone 3.59 133.0 µM 6.99E-5 25 1.66E-4
10 SGTC_1767 st044992 3.47 70.3 µM 1.16E-4 37 2.62E-4
11 SGTC_1698 5-fluorocytosine 3.46 1.1 µM 1.22E-4 exosome 16 2.74E-4
12 SGTC_25 0118-0223 3.30 35.7 µM 2.26E-4 39 4.76E-4
13 SGTC_1749 st037932 3.22 54.2 µM 3.12E-4 51 6.36E-4
14 SGTC_2965 9082772 3.19 38.6 µM 3.50E-4 mitochondrial response to ROS 71 7.06E-4
15 SGTC_2848 9016370 3.17 26.0 µM 3.81E-4 63 7.62E-4
16 SGTC_918 glabranin 3.16 770.7 nM 3.91E-4 68 7.78E-4
17 SGTC_611 3453-1652 3.14 23.7 µM 4.27E-4 61 8.44E-4
18 SGTC_2123 5259487 3.10 200.0 µM 5.05E-4 49 9.80E-4
19 SGTC_266 formosanin C 3.05 406.0 nM 6.09E-4 sphingolipid biosynthesis & PDR1 109 0.00116
20 SGTC_493 zm226600 2.92 134.0 µM 9.56E-4 mitochondrial processes 61 0.00174

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.120 2.63E-12 YLR276C DBP9 het DEAD-box protein required for 27S rRNA processing; exhibits DNA, RNA and DNA/RNA helicase activities; ATPase activity shows preference for DNA over RNA; DNA helicase activity abolished by mutation in RNA-binding domain
0.113 5.42E-11 YML101C CUE4 hom Protein of unknown function; has a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination; CUE4 has a paralog, CUE1, that arose from the whole genome duplication
0.110 1.76E-10 YLR243W GPN3 het Putative GTPase with a role in biogenesis of RNA pol II and polIII; may be involved in assembly of RNA polymerases II and III and in their transport into the nucleus; contains a Gly-Pro-Asn motif in the G domain; similar to Npa3p and Gpn2p
0.092 1.10E-7 YGR137W_d YGR137W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.089 2.73E-7 YIL072W HOP1 hom Meiosis-specific protein required for chromosome synapsis; displays Red1p dependent localization to the unsynapsed axial-lateral elements of the synaptonemal complex; required for chiasma formation; in vitro, displays the ability to promote intra- and intermolecular synapsis between double-stranded DNA molecules and to fold DNA into rigid protein?DNA filaments
0.086 5.52E-7 YAL028W FRT2 hom Tail-anchored ER membrane protein of unknown function; interacts with homolog Frt1p; promotes growth in conditions of high Na+, alkaline pH, or cell wall stress, possibly via a role in posttranslational translocation; potential Cdc28p substrate; FRT2 has a paralog, FRT1, that arose from the whole genome duplication
0.086 5.77E-7 YML117W NAB6 hom Putative RNA-binding protein that associates with mRNAs encoding cell wall proteins in high-throughput studies; deletion mutants display increased sensitivity to some cell wall disrupting agents; expression negatively regulated by cAMP
0.081 2.68E-6 YKR106W GEX2 hom Proton:glutathione antiporter localized to the vacuolar and plasma membranes; expressed at a very low level; almost identical to paralog Gex1p; potential role in resistance to oxidative stress and modulation of the PKA pathway
0.080 3.06E-6 YJR062C NTA1 hom Amidase, removes the amide group from N-terminal asparagine and glutamine residues to generate proteins with N-terminal aspartate and glutamate residues that are targets of ubiquitin-mediated degradation
0.077 8.78E-6 YEL052W AFG1 hom Conserved protein that may act as a chaperone in the degradation of misfolded or unassembled cytochrome c oxidase subunits; localized to matrix face of the mitochondrial inner membrane; member of the AAA family but lacks a protease domain
0.076 1.08E-5 YGR151C_d YGR151C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF RSR1/BUD1/YGR152C; relative distribution to the nucleus increases upon DNA replication stress
0.074 1.69E-5 YMR234W RNH1 hom Ribonuclease H1; able to bind double-stranded RNAs and RNA-DNA hybrids; associates with RNAse polymerase I; the homolog of mammalian RNAse HII (the S. cerevisiae homolog of mammalian RNAse HI is RNH201)
0.074 1.71E-5 YGR005C TFG2 het TFIIF (Transcription Factor II) middle subunit; involved in both transcription initiation and elongation of RNA polymerase II; homologous to human RAP30
0.073 2.48E-5 YGR176W_d YGR176W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.072 2.91E-5 YGL096W TOS8 hom Homeodomain-containing protein and putative transcription factor; found associated with chromatin; target of SBF transcription factor; induced during meiosis and under cell-damaging conditions; TOS8 has a paralog, CUP9, that arose from the whole genome duplication