HIPHOP chemogenomics database
YJR017C / ESS1 
Peptidylprolyl-cis/trans-isomerase (PPIase); specific for phosphorylated serine and threonine residues N-terminal to proline; regulates phosphorylation of the RNAP II large subunit (Rpo21p) C-terminal domain (CTD); associates with phospho-Ser5 form of RNAP II in vivo; regulates phosphorylation of Ser7 within CTD; present along entire coding length of genes; represses initiation of CUTs; required for efficient termination of mRNA transcription and trimethylation of histone H3
Zygosity: Heterozygous strain
fixedexpanded
  Click on Significant Values for Screen Details |
Top fitness defect scores for YJR017C deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.162 | 2.94E-21 | YBR139W | YBR139W | hom | Putative serine type carboxypeptidase with a role in phytochelatin synthesis; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; expression induced by nitrogen limitation in a GLN3, GAT1-independent manner |
| 0.148 | 5.46E-18 | YOR004W | UTP23 | het | Component of the small subunit processome, involved in 40S ribosomal subunit biogenesis; interacts with snR30 and is required for dissociation of snR30 from large pre-ribosomal particles; has homology to PINc domain protein Fcf1p, although the PINc domain of Utp23p is not required for function; essential protein |
| 0.143 | 9.44E-17 | YJL136W-A_p | YJL136W-A_p | hom | Putative protein of unknown function; identified by SAGE |
| 0.133 | 8.53E-15 | YAL014C | SYN8 | hom | Endosomal SNARE related to mammalian syntaxin 8 |
| 0.133 | 1.19E-14 | YHL032C | GUT1 | hom | Glycerol kinase, converts glycerol to glycerol-3-phosphate; glucose repression of expression is mediated by Adr1p and Ino2p-Ino4p; derepression of expression on non-fermentable carbon sources is mediated by Opi1p and Rsf1p |
| 0.124 | 5.25E-13 | YJL082W | IML2 | hom | Protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress; IML2 has a paralog, YKR018C, that arose from the whole genome duplication |
| 0.123 | 9.92E-13 | YML120C | NDI1 | hom | NADH:ubiquinone oxidoreductase; transfers electrons from NADH to ubiquinone in the respiratory chain but does not pump protons, in contrast to the higher eukaryotic multisubunit respiratory complex I; phosphorylated; involved in Mn and H2O2 induced apoptosis; upon apoptotic stress, Ndip is activated in the mitochondria by N-terminal cleavage, and the truncated protein translocates to the cytoplasm to induce apoptosis; homolog of human AMID |
| 0.119 | 4.43E-12 | YGR077C | PEX8 | hom | Intraperoxisomal organizer of the peroxisomal import machinery; organizes the formation of the importomer complex, bridging the docking complex with the RING finger complex; tightly associated with the lumenal face of the peroxisomal membrane; essential for peroxisome biogenesis; binds PTS1-signal receptor Pex5p, and PTS2-signal receptor Pex7p |
| 0.113 | 4.85E-11 | YML116W | ATR1 | hom | Multidrug efflux pump of the major facilitator superfamily; required for resistance to aminotriazole and 4-nitroquinoline-N-oxide; ATR1 has a paralog, YMR279C, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress |
| 0.111 | 9.59E-11 | YPL210C | SRP72 | het | Core component of the signal recognition particle (SRP) ribonucleoprotein (RNP) complex that functions in targeting nascent secretory proteins to the endoplasmic reticulum (ER) membrane |
| 0.111 | 1.17E-10 | YJL136C | RPS21B | hom | Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S21, no bacterial homolog; RPS21B has a paralog, RPS21A, that arose from the whole genome duplication |
| 0.111 | 1.19E-10 | YIL010W | DOT5 | hom | Nuclear thiol peroxidase which functions as an alkyl-hydroperoxide reductase during post-diauxic growth |
| 0.109 | 2.39E-10 | YGR136W | LSB1 | hom | Protein containing an N-terminal SH3 domain; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; protein increases in abundance and forms nuclear foci in response to DNA replication stress |
| 0.109 | 2.53E-10 | YOR329C | SCD5 | het | Protein required for normal actin organization and endocytosis; targeting subunit for protein phosphatase type 1; undergoes Crm1p-dependent nuclear-cytoplasmic shuttling; multicopy suppressor of clathrin deficiency |
| 0.107 | 6.18E-10 | YOR291W | YPK9 | hom | Vacuolar protein with a possible role in sequestering heavy metals; has similarity to the type V P-type ATPase Spf1p; homolog of human ATP13A2 (PARK9), mutations in which are associated with Parkinson disease and Kufor-Rakeb syndrome |