YJR021C / REC107

Protein involved in early stages of meiotic recombination; involved in coordination between the initiation of recombination and the first division of meiosis; part of a complex (Rec107p-Mei4p-Rec114p) required for ds break formation

Zygosity: Homozygous strain
fixedexpanded
Profile for YJR021C / REC107

Click on Significant Values for Screen Details ID:SGTC_121|Compound:0557-0495|FD-Score:3.38|P-value:3.63E-4 ID:SGTC_610|Compound:4215-0184|FD-Score:4.66|P-value:1.64E-6 ID:SGTC_617|Compound:3770-0098|FD-Score:3.91|P-value:4.73E-5 ID:SGTC_770|Compound:0389-1121|FD-Score:3.63|P-value:1.40E-4 ID:SGTC_816|Compound:0325-0417|FD-Score:3.34|P-value:4.11E-4 ID:SGTC_824|Compound:1304-0008|FD-Score:5.13|P-value:1.53E-7 ID:SGTC_973|Compound:1325-0077|FD-Score:3.78|P-value:7.94E-5 ID:SGTC_978|Compound:1416-0512|FD-Score:5.19|P-value:1.15E-7 ID:SGTC_982|Compound:1491-0518|FD-Score:-3.39|P-value:4.45E-4 ID:SGTC_1017|Compound:4239-0030|FD-Score:4.70|P-value:1.35E-6 ID:SGTC_1132|Compound:3456-3614|FD-Score:3.94|P-value:4.21E-5 ID:SGTC_1245|Compound:0418-0076|FD-Score:3.30|P-value:4.83E-4 ID:SGTC_1250|Compound:0485-0349|FD-Score:-4.43|P-value:6.91E-6 ID:SGTC_1391|Compound:3442-0225|FD-Score:-3.22|P-value:8.18E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.19|P-value:8.99E-4 ID:SGTC_1676|Compound:st018489|FD-Score:4.33|P-value:7.77E-6 ID:SGTC_1728|Compound:st035614|FD-Score:4.27|P-value:9.98E-6 ID:SGTC_1734|Compound:st037168|FD-Score:-3.43|P-value:3.93E-4 ID:SGTC_1788|Compound:fluconazole|FD-Score:-4.22|P-value:1.73E-5 ID:SGTC_1809|Compound:st050081|FD-Score:-4.30|P-value:1.21E-5 ID:SGTC_1958|Compound:st076513|FD-Score:3.27|P-value:5.35E-4 ID:SGTC_1996|Compound:st072960|FD-Score:3.55|P-value:1.89E-4 ID:SGTC_2004|Compound:4023728|FD-Score:4.14|P-value:1.78E-5 ID:SGTC_2010|Compound:4012422|FD-Score:3.50|P-value:2.29E-4 ID:SGTC_2047|Compound:4141938|FD-Score:3.96|P-value:3.85E-5 ID:SGTC_2093|Compound:5331342|FD-Score:-3.19|P-value:8.90E-4 ID:SGTC_2308|Compound:7584454|FD-Score:-5.16|P-value:1.97E-7 ID:SGTC_2607|Compound:solasodine|FD-Score:-3.23|P-value:7.81E-4 ID:SGTC_2691|Compound:st077356|FD-Score:3.33|P-value:4.22E-4 ID:SGTC_2781|Compound:5567276|FD-Score:-5.71|P-value:9.79E-9 ID:SGTC_2785|Compound:7756463|FD-Score:3.44|P-value:2.88E-4 ID:SGTC_2791|Compound:5663188|FD-Score:3.09|P-value:9.88E-4 ID:SGTC_2845|Compound:9003024|FD-Score:3.74|P-value:9.32E-5 ID:SGTC_2974|Compound:9094440|FD-Score:-3.37|P-value:4.82E-4 ID:SGTC_3007|Compound:9078383|FD-Score:3.73|P-value:9.59E-5 ID:SGTC_3043|Compound:9092303|FD-Score:3.32|P-value:4.45E-4 ID:SGTC_3204|Compound:9114183|FD-Score:4.16|P-value:1.64E-5 ID:SGTC_3240|Compound:9133527|FD-Score:3.13|P-value:8.72E-4 ID:SGTC_3245|Compound:9134821|FD-Score:-3.37|P-value:4.80E-4 ID:SGTC_3290|Compound:9121031|FD-Score:-3.33|P-value:5.61E-4 ID:SGTC_3294|Compound:9122953|FD-Score:-4.61|P-value:3.02E-6 ID:SGTC_3306|Compound:9127676|FD-Score:-3.25|P-value:7.27E-4 ID:SGTC_121|Compound:0557-0495|FD-Score:3.38|P-value:3.63E-4 ID:SGTC_610|Compound:4215-0184|FD-Score:4.66|P-value:1.64E-6 ID:SGTC_617|Compound:3770-0098|FD-Score:3.91|P-value:4.73E-5 ID:SGTC_770|Compound:0389-1121|FD-Score:3.63|P-value:1.40E-4 ID:SGTC_816|Compound:0325-0417|FD-Score:3.34|P-value:4.11E-4 ID:SGTC_824|Compound:1304-0008|FD-Score:5.13|P-value:1.53E-7 ID:SGTC_973|Compound:1325-0077|FD-Score:3.78|P-value:7.94E-5 ID:SGTC_978|Compound:1416-0512|FD-Score:5.19|P-value:1.15E-7 ID:SGTC_982|Compound:1491-0518|FD-Score:-3.39|P-value:4.45E-4 ID:SGTC_1017|Compound:4239-0030|FD-Score:4.70|P-value:1.35E-6 ID:SGTC_1132|Compound:3456-3614|FD-Score:3.94|P-value:4.21E-5 ID:SGTC_1245|Compound:0418-0076|FD-Score:3.30|P-value:4.83E-4 ID:SGTC_1250|Compound:0485-0349|FD-Score:-4.43|P-value:6.91E-6 ID:SGTC_1391|Compound:3442-0225|FD-Score:-3.22|P-value:8.18E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.19|P-value:8.99E-4 ID:SGTC_1676|Compound:st018489|FD-Score:4.33|P-value:7.77E-6 ID:SGTC_1728|Compound:st035614|FD-Score:4.27|P-value:9.98E-6 ID:SGTC_1734|Compound:st037168|FD-Score:-3.43|P-value:3.93E-4 ID:SGTC_1788|Compound:fluconazole|FD-Score:-4.22|P-value:1.73E-5 ID:SGTC_1809|Compound:st050081|FD-Score:-4.30|P-value:1.21E-5 ID:SGTC_1958|Compound:st076513|FD-Score:3.27|P-value:5.35E-4 ID:SGTC_1996|Compound:st072960|FD-Score:3.55|P-value:1.89E-4 ID:SGTC_2004|Compound:4023728|FD-Score:4.14|P-value:1.78E-5 ID:SGTC_2010|Compound:4012422|FD-Score:3.50|P-value:2.29E-4 ID:SGTC_2047|Compound:4141938|FD-Score:3.96|P-value:3.85E-5 ID:SGTC_2093|Compound:5331342|FD-Score:-3.19|P-value:8.90E-4 ID:SGTC_2308|Compound:7584454|FD-Score:-5.16|P-value:1.97E-7 ID:SGTC_2607|Compound:solasodine|FD-Score:-3.23|P-value:7.81E-4 ID:SGTC_2691|Compound:st077356|FD-Score:3.33|P-value:4.22E-4 ID:SGTC_2781|Compound:5567276|FD-Score:-5.71|P-value:9.79E-9 ID:SGTC_2785|Compound:7756463|FD-Score:3.44|P-value:2.88E-4 ID:SGTC_2791|Compound:5663188|FD-Score:3.09|P-value:9.88E-4 ID:SGTC_2845|Compound:9003024|FD-Score:3.74|P-value:9.32E-5 ID:SGTC_2974|Compound:9094440|FD-Score:-3.37|P-value:4.82E-4 ID:SGTC_3007|Compound:9078383|FD-Score:3.73|P-value:9.59E-5 ID:SGTC_3043|Compound:9092303|FD-Score:3.32|P-value:4.45E-4 ID:SGTC_3204|Compound:9114183|FD-Score:4.16|P-value:1.64E-5 ID:SGTC_3240|Compound:9133527|FD-Score:3.13|P-value:8.72E-4 ID:SGTC_3245|Compound:9134821|FD-Score:-3.37|P-value:4.80E-4 ID:SGTC_3290|Compound:9121031|FD-Score:-3.33|P-value:5.61E-4 ID:SGTC_3294|Compound:9122953|FD-Score:-4.61|P-value:3.02E-6 ID:SGTC_3306|Compound:9127676|FD-Score:-3.25|P-value:7.27E-4

Top fitness defect scores for YJR021C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_978 1416-0512 5.19 87.4 µM 1.15E-7 redox potentiating 10 1.06E-7
2 SGTC_824 1304-0008 5.13 100.0 µM 1.53E-7 DNA damage response 20 1.42E-7
3 SGTC_1017 4239-0030 4.70 168.0 µM 1.35E-6 12 1.28E-6
4 SGTC_610 4215-0184 4.66 155.0 µM 1.64E-6 exosome 4 1.56E-6
5 SGTC_1676 st018489 4.33 23.4 µM 7.77E-6 60S ribosome export 24 7.53E-6
6 SGTC_1728 st035614 4.27 33.8 µM 9.98E-6 36 9.71E-6
7 SGTC_3204 9114183 4.16 49.5 µM 1.64E-5 26 1.60E-5
8 SGTC_2004 4023728 4.14 41.9 µM 1.78E-5 23 1.75E-5
9 SGTC_2047 4141938 3.96 200.0 µM 3.85E-5 10 3.80E-5
10 SGTC_1132 3456-3614 3.94 2.5 µM 4.21E-5 tubulin folding & SWR complex 46 4.16E-5
11 SGTC_617 3770-0098 3.91 35.0 µM 4.73E-5 exosome 15 4.68E-5
12 SGTC_973 1325-0077 3.78 65.9 µM 7.94E-5 11 7.90E-5
13 SGTC_2845 9003024 3.74 43.0 µM 9.32E-5 amide catabolism 53 9.29E-5
14 SGTC_3007 9078383 3.73 71.4 µM 9.59E-5 22 9.56E-5
15 SGTC_770 0389-1121 3.63 67.2 µM 1.40E-4 RPP1 & pyrimidine depletion 35 1.40E-4
16 SGTC_1996 st072960 3.55 66.8 µM 1.89E-4 28 1.89E-4
17 SGTC_2010 4012422 3.50 159.0 µM 2.29E-4 37 2.31E-4
18 SGTC_2785 7756463 3.44 72.7 µM 2.88E-4 46 2.90E-4
19 SGTC_121 0557-0495 3.38 61.3 µM 3.63E-4 calcium & mitochondrial duress 92 3.66E-4
20 SGTC_816 0325-0417 3.34 81.3 µM 4.11E-4 28 4.16E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.116 1.74E-11 YNL224C SQS1 hom Protein that stimulates the ATPase and helicase activities of Prp43p; acts with Prp43p to stimulate 18s rRNA maturation by Nob1p; overexpression antagonizes the suppression of splicing defects by spp382 mutants; component of pre-ribosomal particles; relocalizes from nucleus to nucleolus upon DNA replication stress
0.111 1.02E-10 YKR094C RPL40B hom Ubiquitin-ribosomal 60S subunit protein L40B fusion protein; cleaved to yield ubiquitin and ribosomal protein L40B; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes; homologous to mammalian ribosomal protein L40, no bacterial homolog; RPL40B has a paralog, RPL40A, that arose from the whole genome duplication
0.107 5.96E-10 YGR195W SKI6 het Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp41p (EXOSC4)
0.098 1.13E-8 YGR095C RRP46 het Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp46p (EXOSC5)
0.098 1.45E-8 YNL232W CSL4 het Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; predicted to contain an S1 RNA binding domain; has similarity to human hCsl4p (EXOSC1)
0.096 2.60E-8 YHR042W NCP1 het NADP-cytochrome P450 reductase; involved in ergosterol biosynthesis; associated and coordinately regulated with Erg11p
0.094 4.33E-8 YBR296C-A_p YBR296C-A_p hom Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.094 5.02E-8 YMR101C SRT1 hom Cis-prenyltransferase involved in synthesis of long-chain dolichols (19-22 isoprene units; as opposed to Rer2p which synthesizes shorter-chain dolichols); localizes to lipid bodies; transcription is induced during stationary phase
0.091 1.13E-7 YML058W SML1 hom Ribonucleotide reductase inhibitor involved in regulating dNTP production; regulated by Mec1p and Rad53p during DNA damage and S phase
0.085 7.91E-7 YDL222C FMP45 hom Integral membrane protein localized to mitochondria (untagged protein); required for sporulation and maintaining sphingolipid content; has sequence similarity to SUR7 and YNL194C
0.084 1.08E-6 YPL137C GIP3 hom Cytoplasmic protein that regulates protein phosphatase 1 Glc7p; overexpression relocalizes Glc7p from the nucleus and prevents chromosome segregation; may interact with ribosomes, based on co-purification experiments; GIP3 has a paralog, HER1, that arose from the whole genome duplication
0.083 1.63E-6 YGR158C MTR3 het Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hMtr3p (EXOSC6)
0.081 2.64E-6 YGL108C YGL108C hom Protein of unknown function, predicted to be palmitoylated; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery; protein abundance increases in response to DNA replication stress
0.081 2.96E-6 YNL137C NAM9 het Mitochondrial ribosomal component of the small subunit
0.080 3.03E-6 YMR137C PSO2 hom Nuclease required for DNA single- and double-strand break repair; acts at a post-incision step in repair of breaks that result from interstrand cross-links produced by a variety of mono- and bi-functional psoralen derivatives; induced by UV-irradiation; forms nuclear foci upon DNA replication stress