YJR022W / LSM8

Lsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) that is part of spliceosomal U6 snRNP and is also implicated in processing of pre-tRNA, pre-snoRNA, and pre-rRNA

Zygosity: Heterozygous strain
fixedexpanded
Profile for YJR022W / LSM8

Click on Significant Values for Screen Details ID:SGTC_62|Compound:0180-0423|FD-Score:-3.01|P-value:1.97E-4 ID:SGTC_424|Compound:splitomicin|FD-Score:2.67|P-value:6.74E-4 ID:SGTC_622|Compound:1348-1566|FD-Score:2.90|P-value:2.59E-4 ID:SGTC_875|Compound:0709-0210|FD-Score:2.72|P-value:5.63E-4 ID:SGTC_886|Compound:0866-0150|FD-Score:2.85|P-value:3.18E-4 ID:SGTC_1129|Compound:3453-1384|FD-Score:4.03|P-value:7.21E-7 ID:SGTC_1142|Compound:3253-1408|FD-Score:2.64|P-value:7.78E-4 ID:SGTC_1156|Compound:4092-0367|FD-Score:2.67|P-value:6.85E-4 ID:SGTC_1401|Compound:3807-4679|FD-Score:-3.23|P-value:7.28E-5 ID:SGTC_1596|Compound:piperlongumine|FD-Score:-2.76|P-value:5.91E-4 ID:SGTC_1677|Compound:st019204|FD-Score:-2.94|P-value:2.79E-4 ID:SGTC_1962|Compound:st076595|FD-Score:-8.80|P-value:1.04E-25 ID:SGTC_1970|Compound:st070122|FD-Score:6.26|P-value:4.01E-14 ID:SGTC_1971|Compound:st069429|FD-Score:3.41|P-value:2.21E-5 ID:SGTC_1990|Compound:st072050|FD-Score:2.58|P-value:9.87E-4 ID:SGTC_1999|Compound:st074831|FD-Score:3.04|P-value:1.38E-4 ID:SGTC_2035|Compound:5154463|FD-Score:2.86|P-value:2.97E-4 ID:SGTC_2064|Compound:5220758|FD-Score:-3.03|P-value:1.85E-4 ID:SGTC_2071|Compound:5230951|FD-Score:-3.05|P-value:1.67E-4 ID:SGTC_2255|Compound:7941087|FD-Score:2.77|P-value:4.50E-4 ID:SGTC_2402|Compound:5553605|FD-Score:3.57|P-value:9.45E-6 ID:SGTC_2427|Compound:5545055|FD-Score:-3.97|P-value:1.41E-6 ID:SGTC_2429|Compound:5902844|FD-Score:-3.81|P-value:3.55E-6 ID:SGTC_2432|Compound:5630864|FD-Score:-3.01|P-value:1.99E-4 ID:SGTC_2482|Compound:5981709|FD-Score:-3.60|P-value:1.11E-5 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:2.97|P-value:1.83E-4 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:3.07|P-value:1.20E-4 ID:SGTC_2787|Compound:5284540|FD-Score:4.91|P-value:2.23E-9 ID:SGTC_2975|Compound:9084847|FD-Score:-3.44|P-value:2.61E-5 ID:SGTC_2978|Compound:9011784|FD-Score:-2.94|P-value:2.76E-4 ID:SGTC_2986|Compound:9022445|FD-Score:3.05|P-value:1.30E-4 ID:SGTC_2998|Compound:9066762|FD-Score:3.33|P-value:3.43E-5 ID:SGTC_3153|Compound:9100258|FD-Score:2.93|P-value:2.24E-4 ID:SGTC_3329|Compound:9141233|FD-Score:4.16|P-value:3.26E-7 ID:SGTC_3330|Compound:9141424|FD-Score:2.86|P-value:3.01E-4 ID:SGTC_62|Compound:0180-0423|FD-Score:-3.01|P-value:1.97E-4 ID:SGTC_424|Compound:splitomicin|FD-Score:2.67|P-value:6.74E-4 ID:SGTC_622|Compound:1348-1566|FD-Score:2.90|P-value:2.59E-4 ID:SGTC_875|Compound:0709-0210|FD-Score:2.72|P-value:5.63E-4 ID:SGTC_886|Compound:0866-0150|FD-Score:2.85|P-value:3.18E-4 ID:SGTC_1129|Compound:3453-1384|FD-Score:4.03|P-value:7.21E-7 ID:SGTC_1142|Compound:3253-1408|FD-Score:2.64|P-value:7.78E-4 ID:SGTC_1156|Compound:4092-0367|FD-Score:2.67|P-value:6.85E-4 ID:SGTC_1401|Compound:3807-4679|FD-Score:-3.23|P-value:7.28E-5 ID:SGTC_1596|Compound:piperlongumine|FD-Score:-2.76|P-value:5.91E-4 ID:SGTC_1677|Compound:st019204|FD-Score:-2.94|P-value:2.79E-4 ID:SGTC_1962|Compound:st076595|FD-Score:-8.80|P-value:1.04E-25 ID:SGTC_1970|Compound:st070122|FD-Score:6.26|P-value:4.01E-14 ID:SGTC_1971|Compound:st069429|FD-Score:3.41|P-value:2.21E-5 ID:SGTC_1990|Compound:st072050|FD-Score:2.58|P-value:9.87E-4 ID:SGTC_1999|Compound:st074831|FD-Score:3.04|P-value:1.38E-4 ID:SGTC_2035|Compound:5154463|FD-Score:2.86|P-value:2.97E-4 ID:SGTC_2064|Compound:5220758|FD-Score:-3.03|P-value:1.85E-4 ID:SGTC_2071|Compound:5230951|FD-Score:-3.05|P-value:1.67E-4 ID:SGTC_2255|Compound:7941087|FD-Score:2.77|P-value:4.50E-4 ID:SGTC_2402|Compound:5553605|FD-Score:3.57|P-value:9.45E-6 ID:SGTC_2427|Compound:5545055|FD-Score:-3.97|P-value:1.41E-6 ID:SGTC_2429|Compound:5902844|FD-Score:-3.81|P-value:3.55E-6 ID:SGTC_2432|Compound:5630864|FD-Score:-3.01|P-value:1.99E-4 ID:SGTC_2482|Compound:5981709|FD-Score:-3.60|P-value:1.11E-5 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:2.97|P-value:1.83E-4 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:3.07|P-value:1.20E-4 ID:SGTC_2787|Compound:5284540|FD-Score:4.91|P-value:2.23E-9 ID:SGTC_2975|Compound:9084847|FD-Score:-3.44|P-value:2.61E-5 ID:SGTC_2978|Compound:9011784|FD-Score:-2.94|P-value:2.76E-4 ID:SGTC_2986|Compound:9022445|FD-Score:3.05|P-value:1.30E-4 ID:SGTC_2998|Compound:9066762|FD-Score:3.33|P-value:3.43E-5 ID:SGTC_3153|Compound:9100258|FD-Score:2.93|P-value:2.24E-4 ID:SGTC_3329|Compound:9141233|FD-Score:4.16|P-value:3.26E-7 ID:SGTC_3330|Compound:9141424|FD-Score:2.86|P-value:3.01E-4

Top fitness defect scores for YJR022W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature		Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1970 st070122 6.26 35.8 µM 4.01E-14 TSC3-RPN4 3 1.88E-10 0.47
2 SGTC_2787 5284540 4.91 71.4 µM 2.23E-9 6 4.48E-7 0.90
3 SGTC_3329 9141233 4.16 27.6 µM 3.26E-7 2 1.57E-5 0.19
4 SGTC_1129 3453-1384 4.03 223.0 µM 7.21E-7 15 2.77E-5 0.01
5 SGTC_2402 5553605 3.57 200.0 µM 9.45E-6 10 1.75E-4 0.09
6 SGTC_1971 st069429 3.41 63.5 µM 2.21E-5 60S ribosome export 4 3.23E-4 0.11
7 SGTC_2998 9066762 3.33 71.4 µM 3.43E-5 RPP1 & pyrimidine depletion 16 4.42E-4 0.01
8 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 3.07 100.0 µM 1.20E-4 18 0.00109 0.01
9 SGTC_2986 9022445 3.05 71.4 µM 1.30E-4 13 0.00115 0.07
10 SGTC_1999 st074831 3.04 12.5 µM 1.38E-4 plasma membrane duress 21 0.00120 0.01
11 SGTC_2615 purpurogallin-4-carboxylic acid 2.97 100.0 µM 1.83E-4 redox potentiating 23 0.00147 0.03
12 SGTC_3153 9100258 2.93 49.5 µM 2.24E-4 11 0.00170 0.18
13 SGTC_622 1348-1566 2.90 26.3 µM 2.59E-4 19 0.00189 0.01
14 SGTC_2035 5154463 2.86 94.6 µM 2.97E-4 28 0.00209 0.08
15 SGTC_3330 9141424 2.86 71.4 µM 3.01E-4 amide catabolism 9 0.00211 0.01
16 SGTC_886 0866-0150 2.85 153.0 µM 3.18E-4 16 0.00219 0.00
17 SGTC_2255 7941087 2.77 197.4 µM 4.50E-4 18 0.00282 0.01
18 SGTC_875 0709-0210 2.72 25.7 µM 5.63E-4 fatty acid desaturase (OLE1) 30 0.00331 0.09
19 SGTC_424 splitomicin 2.67 100.0 mM 6.74E-4 22 0.00377 0.01
20 SGTC_1156 4092-0367 2.67 4.9 µM 6.85E-4 23 0.00381 0.06

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.121 1.70E-12 YNL261W ORC5 het Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing
0.119 4.04E-12 YHL032C GUT1 hom Glycerol kinase, converts glycerol to glycerol-3-phosphate; glucose repression of expression is mediated by Adr1p and Ino2p-Ino4p; derepression of expression on non-fermentable carbon sources is mediated by Opi1p and Rsf1p
0.112 7.59E-11 YOR095C RKI1 het Ribose-5-phosphate ketol-isomerase, catalyzes the interconversion of ribose 5-phosphate and ribulose 5-phosphate in the pentose phosphate pathway; participates in pyridoxine biosynthesis
0.112 7.84E-11 YPL190C NAB3 het RNA-binding protein, subunit of Nrd1 complex (Nrd1p-Nab3p-Sen1p); complex interacts with the exosome to mediate 3′ end formation of some mRNAs, snRNAs, snoRNAs, and CUTs; required for termination of non-poly(A) transcripts and efficient splicing
0.111 1.32E-10 YPL147W PXA1 hom Subunit of a heterodimeric peroxisomal ATP-binding cassette transporter complex (Pxa1p-Pxa2p), required for import of long-chain fatty acids into peroxisomes; similarity to human adrenoleukodystrophy transporter ABCD1 and ABCD2 and ALD-related proteins; mutations in ABCD1 cause X-linked adrenoleukodystrophy (X-ALD), a peroxisomal disorder
0.110 2.05E-10 YPR059C_d YPR059C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YMC1/YPR058W
0.109 2.59E-10 YJL147C_p YJL147C_p hom Mitochondrial protein of unknown function; homozygous diploid deletion strain has a sporulation defect characterized by elevated dityrosine in the soluble fraction; expression induced by calcium shortage; YJL147W is a non-essential gene
0.105 9.72E-10 YLR012C_p YLR012C_p hom Putative protein of unknown function; YLR012C is not an essential gene
0.102 2.71E-9 YHR110W ERP5 hom Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport
0.098 1.47E-8 YER158C_p YER158C_p hom Protein of unknown function; potentially phosphorylated by Cdc28p; YER158C has a paralog, AFR1, that arose from the whole genome duplication
0.095 3.46E-8 YKR010C TOF2 hom Protein required for rDNA silencing and mitotic rDNA condensation; stimulates Cdc14p phosphatase activity and biphasic release to promote rDNA repeat segregation; required for condensin recruitment to the replication fork barrier site; TOF2 has a paralog, NET1, that arose from the whole genome duplication
0.090 1.81E-7 YBR150C TBS1 hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; TBS1 has a paralog, HAL9, that arose from the whole genome duplication
0.090 1.79E-7 YNL270C ALP1 hom Arginine transporter; expression is normally very low and it is unclear what conditions would induce significant expression; ALP1 has a paralog, CAN1, that arose from the whole genome duplication
0.088 3.38E-7 YHR135C YCK1 hom Palmitoylated plasma membrane-bound casein kinase I isoform; shares redundant functions with Yck2p in morphogenesis, proper septin assembly, endocytic trafficking; YCK1 has a paralog, YCK2, that arose from the whole genome duplication
0.082 1.94E-6 YBR206W_d YBR206W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene KTR3