YJR023C_d

Putative protein of unknown function; open reading frame overlaps LSM8/YJR022W encoding an essential snRNP protein required for RNA processing and splicing

Zygosity: Heterozygous strain
fixedexpanded
Profile for YJR023C / YJR023C

Click on Significant Values for Screen Details ID:SGTC_323|Compound:4013-0906|FD-Score:3.00|P-value:5.97E-4 ID:SGTC_632|Compound:0781-2353|FD-Score:4.87|P-value:8.36E-8 ID:SGTC_757|Compound:1066-0008|FD-Score:3.62|P-value:4.70E-5 ID:SGTC_778|Compound:3456-2434|FD-Score:-5.68|P-value:7.80E-10 ID:SGTC_781|Compound:4335-2806|FD-Score:2.94|P-value:7.54E-4 ID:SGTC_827|Compound:3253-0474|FD-Score:2.96|P-value:7.02E-4 ID:SGTC_857|Compound:0438-0306|FD-Score:3.56|P-value:6.22E-5 ID:SGTC_914|Compound:3820-6779|FD-Score:-3.91|P-value:1.69E-5 ID:SGTC_941|Compound:3237-0776|FD-Score:4.99|P-value:3.94E-8 ID:SGTC_943|Compound:3253-1379|FD-Score:-3.11|P-value:4.96E-4 ID:SGTC_951|Compound:1171-0579|FD-Score:-3.28|P-value:2.62E-4 ID:SGTC_1027|Compound:k015-0025|FD-Score:-3.67|P-value:4.98E-5 ID:SGTC_1030|Compound:k029-0042|FD-Score:-3.34|P-value:2.09E-4 ID:SGTC_1033|Compound:k072-0102|FD-Score:3.62|P-value:4.78E-5 ID:SGTC_1047|Compound:2043-3044|FD-Score:4.14|P-value:4.18E-6 ID:SGTC_1057|Compound:3448-5381|FD-Score:3.37|P-value:1.42E-4 ID:SGTC_1058|Compound:3448-5425|FD-Score:4.47|P-value:7.63E-7 ID:SGTC_1118|Compound:chelidonine|FD-Score:3.38|P-value:1.31E-4 ID:SGTC_1269|Compound:0831-0796|FD-Score:3.96|P-value:9.81E-6 ID:SGTC_1277|Compound:0873-0036|FD-Score:3.97|P-value:9.34E-6 ID:SGTC_1359|Compound:1582-0056|FD-Score:-4.11|P-value:6.66E-6 ID:SGTC_1365|Compound:1672-3266|FD-Score:3.30|P-value:1.82E-4 ID:SGTC_1405|Compound:3909-7894|FD-Score:3.32|P-value:1.68E-4 ID:SGTC_1406|Compound:3909-7906|FD-Score:4.13|P-value:4.26E-6 ID:SGTC_1407|Compound:3909-7909|FD-Score:3.31|P-value:1.75E-4 ID:SGTC_1409|Compound:3909-8004|FD-Score:-3.17|P-value:3.98E-4 ID:SGTC_1425|Compound:4048-4433|FD-Score:-3.35|P-value:1.94E-4 ID:SGTC_1429|Compound:4049-0205|FD-Score:-3.10|P-value:5.28E-4 ID:SGTC_1469|Compound:k284-2957|FD-Score:-2.93|P-value:9.83E-4 ID:SGTC_1540|Compound:guanosine|FD-Score:2.86|P-value:9.88E-4 ID:SGTC_1693|Compound:xanthone|FD-Score:3.61|P-value:4.88E-5 ID:SGTC_1719|Compound:st032227|FD-Score:2.99|P-value:6.18E-4 ID:SGTC_1736|Compound:st036774|FD-Score:2.94|P-value:7.60E-4 ID:SGTC_1746|Compound:st038117|FD-Score:2.96|P-value:6.89E-4 ID:SGTC_1767|Compound:st044992|FD-Score:-3.47|P-value:1.19E-4 ID:SGTC_1827|Compound:berberine|FD-Score:3.97|P-value:9.40E-6 ID:SGTC_1835|Compound:st008666|FD-Score:-3.82|P-value:2.56E-5 ID:SGTC_1865|Compound:st057639|FD-Score:3.17|P-value:3.13E-4 ID:SGTC_1866|Compound:st057638|FD-Score:-4.35|P-value:1.95E-6 ID:SGTC_1875|Compound:nocodazole|FD-Score:2.98|P-value:6.39E-4 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:3.12|P-value:3.81E-4 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:2.95|P-value:7.08E-4 ID:SGTC_1959|Compound:st077091|FD-Score:3.08|P-value:4.37E-4 ID:SGTC_1970|Compound:st070122|FD-Score:2.87|P-value:9.59E-4 ID:SGTC_1973|Compound:st070275|FD-Score:3.54|P-value:6.80E-5 ID:SGTC_2050|Compound:5263056|FD-Score:3.06|P-value:4.75E-4 ID:SGTC_2058|Compound:5236698|FD-Score:3.05|P-value:4.90E-4 ID:SGTC_2116|Compound:5511452|FD-Score:2.99|P-value:6.26E-4 ID:SGTC_2399|Compound:5884133|FD-Score:3.15|P-value:3.34E-4 ID:SGTC_2413|Compound:inermin|FD-Score:3.85|P-value:1.66E-5 ID:SGTC_2416|Compound:tofa|FD-Score:3.77|P-value:2.47E-5 ID:SGTC_2513|Compound:baicalein|FD-Score:-2.98|P-value:8.08E-4 ID:SGTC_2554|Compound:13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one|FD-Score:-3.00|P-value:7.72E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:6.53|P-value:1.14E-12 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:8.99|P-value:2.61E-22 ID:SGTC_2600|Compound:tangeritin|FD-Score:3.72|P-value:3.05E-5 ID:SGTC_2936|Compound:9038235|FD-Score:2.91|P-value:8.31E-4 ID:SGTC_2942|Compound:9052777|FD-Score:5.03|P-value:3.19E-8 ID:SGTC_2949|Compound:9072542|FD-Score:6.17|P-value:1.66E-11 ID:SGTC_2951|Compound:9072950|FD-Score:-2.95|P-value:9.02E-4 ID:SGTC_3165|Compound:9101544|FD-Score:3.28|P-value:2.04E-4 ID:SGTC_3178|Compound:9107506|FD-Score:-3.31|P-value:2.29E-4 ID:SGTC_3212|Compound:9128307|FD-Score:-2.93|P-value:9.67E-4 ID:SGTC_3293|Compound:9120939|FD-Score:3.03|P-value:5.29E-4 ID:SGTC_3301|Compound:9125354|FD-Score:-3.00|P-value:7.73E-4 ID:SGTC_323|Compound:4013-0906|FD-Score:3.00|P-value:5.97E-4 ID:SGTC_632|Compound:0781-2353|FD-Score:4.87|P-value:8.36E-8 ID:SGTC_757|Compound:1066-0008|FD-Score:3.62|P-value:4.70E-5 ID:SGTC_778|Compound:3456-2434|FD-Score:-5.68|P-value:7.80E-10 ID:SGTC_781|Compound:4335-2806|FD-Score:2.94|P-value:7.54E-4 ID:SGTC_827|Compound:3253-0474|FD-Score:2.96|P-value:7.02E-4 ID:SGTC_857|Compound:0438-0306|FD-Score:3.56|P-value:6.22E-5 ID:SGTC_914|Compound:3820-6779|FD-Score:-3.91|P-value:1.69E-5 ID:SGTC_941|Compound:3237-0776|FD-Score:4.99|P-value:3.94E-8 ID:SGTC_943|Compound:3253-1379|FD-Score:-3.11|P-value:4.96E-4 ID:SGTC_951|Compound:1171-0579|FD-Score:-3.28|P-value:2.62E-4 ID:SGTC_1027|Compound:k015-0025|FD-Score:-3.67|P-value:4.98E-5 ID:SGTC_1030|Compound:k029-0042|FD-Score:-3.34|P-value:2.09E-4 ID:SGTC_1033|Compound:k072-0102|FD-Score:3.62|P-value:4.78E-5 ID:SGTC_1047|Compound:2043-3044|FD-Score:4.14|P-value:4.18E-6 ID:SGTC_1057|Compound:3448-5381|FD-Score:3.37|P-value:1.42E-4 ID:SGTC_1058|Compound:3448-5425|FD-Score:4.47|P-value:7.63E-7 ID:SGTC_1118|Compound:chelidonine|FD-Score:3.38|P-value:1.31E-4 ID:SGTC_1269|Compound:0831-0796|FD-Score:3.96|P-value:9.81E-6 ID:SGTC_1277|Compound:0873-0036|FD-Score:3.97|P-value:9.34E-6 ID:SGTC_1359|Compound:1582-0056|FD-Score:-4.11|P-value:6.66E-6 ID:SGTC_1365|Compound:1672-3266|FD-Score:3.30|P-value:1.82E-4 ID:SGTC_1405|Compound:3909-7894|FD-Score:3.32|P-value:1.68E-4 ID:SGTC_1406|Compound:3909-7906|FD-Score:4.13|P-value:4.26E-6 ID:SGTC_1407|Compound:3909-7909|FD-Score:3.31|P-value:1.75E-4 ID:SGTC_1409|Compound:3909-8004|FD-Score:-3.17|P-value:3.98E-4 ID:SGTC_1425|Compound:4048-4433|FD-Score:-3.35|P-value:1.94E-4 ID:SGTC_1429|Compound:4049-0205|FD-Score:-3.10|P-value:5.28E-4 ID:SGTC_1469|Compound:k284-2957|FD-Score:-2.93|P-value:9.83E-4 ID:SGTC_1540|Compound:guanosine|FD-Score:2.86|P-value:9.88E-4 ID:SGTC_1693|Compound:xanthone|FD-Score:3.61|P-value:4.88E-5 ID:SGTC_1719|Compound:st032227|FD-Score:2.99|P-value:6.18E-4 ID:SGTC_1736|Compound:st036774|FD-Score:2.94|P-value:7.60E-4 ID:SGTC_1746|Compound:st038117|FD-Score:2.96|P-value:6.89E-4 ID:SGTC_1767|Compound:st044992|FD-Score:-3.47|P-value:1.19E-4 ID:SGTC_1827|Compound:berberine|FD-Score:3.97|P-value:9.40E-6 ID:SGTC_1835|Compound:st008666|FD-Score:-3.82|P-value:2.56E-5 ID:SGTC_1865|Compound:st057639|FD-Score:3.17|P-value:3.13E-4 ID:SGTC_1866|Compound:st057638|FD-Score:-4.35|P-value:1.95E-6 ID:SGTC_1875|Compound:nocodazole|FD-Score:2.98|P-value:6.39E-4 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:3.12|P-value:3.81E-4 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:2.95|P-value:7.08E-4 ID:SGTC_1959|Compound:st077091|FD-Score:3.08|P-value:4.37E-4 ID:SGTC_1970|Compound:st070122|FD-Score:2.87|P-value:9.59E-4 ID:SGTC_1973|Compound:st070275|FD-Score:3.54|P-value:6.80E-5 ID:SGTC_2050|Compound:5263056|FD-Score:3.06|P-value:4.75E-4 ID:SGTC_2058|Compound:5236698|FD-Score:3.05|P-value:4.90E-4 ID:SGTC_2116|Compound:5511452|FD-Score:2.99|P-value:6.26E-4 ID:SGTC_2399|Compound:5884133|FD-Score:3.15|P-value:3.34E-4 ID:SGTC_2413|Compound:inermin|FD-Score:3.85|P-value:1.66E-5 ID:SGTC_2416|Compound:tofa|FD-Score:3.77|P-value:2.47E-5 ID:SGTC_2513|Compound:baicalein|FD-Score:-2.98|P-value:8.08E-4 ID:SGTC_2554|Compound:13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one|FD-Score:-3.00|P-value:7.72E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:6.53|P-value:1.14E-12 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:8.99|P-value:2.61E-22 ID:SGTC_2600|Compound:tangeritin|FD-Score:3.72|P-value:3.05E-5 ID:SGTC_2936|Compound:9038235|FD-Score:2.91|P-value:8.31E-4 ID:SGTC_2942|Compound:9052777|FD-Score:5.03|P-value:3.19E-8 ID:SGTC_2949|Compound:9072542|FD-Score:6.17|P-value:1.66E-11 ID:SGTC_2951|Compound:9072950|FD-Score:-2.95|P-value:9.02E-4 ID:SGTC_3165|Compound:9101544|FD-Score:3.28|P-value:2.04E-4 ID:SGTC_3178|Compound:9107506|FD-Score:-3.31|P-value:2.29E-4 ID:SGTC_3212|Compound:9128307|FD-Score:-2.93|P-value:9.67E-4 ID:SGTC_3293|Compound:9120939|FD-Score:3.03|P-value:5.29E-4 ID:SGTC_3301|Compound:9125354|FD-Score:-3.00|P-value:7.73E-4

Top fitness defect scores for YJR023C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2566 crystal violet carbinol 8.99 226.0 nM 2.61E-22 3 1.19E-19 1.52
2 SGTC_2563 tomatine 6.53 8.5 µM 1.14E-12 3 3.18E-11 0.52
3 SGTC_2949 9072542 6.17 2.2 µM 1.66E-11 TSC3-RPN4 2 3.31E-10 0.52
4 SGTC_2942 9052777 5.03 62.2 µM 3.19E-8 3 2.46E-7 0.19
5 SGTC_941 3237-0776 4.99 460.0 µM 3.94E-8 3 2.96E-7 0.93
6 SGTC_632 0781-2353 4.87 4.7 µM 8.36E-8 Golgi 8 5.72E-7 0.00
7 SGTC_1058 3448-5425 4.47 97.3 µM 7.63E-7 7 3.96E-6 0.34
8 SGTC_1047 2043-3044 4.14 82.0 µM 4.18E-6 4 1.75E-5 0.00
9 SGTC_1406 3909-7906 4.13 11.9 µM 4.26E-6 60S ribosome export 2 1.78E-5 0.17
10 SGTC_1277 0873-0036 3.97 22.0 µM 9.34E-6 PDR1 3 3.54E-5 0.04
11 SGTC_1827 berberine 3.97 7.2 µM 9.40E-6 60S ribosome export 11 3.56E-5 0.07
12 SGTC_1269 0831-0796 3.96 3.0 µM 9.81E-6 60S ribosome export 5 3.69E-5 0.05
13 SGTC_2413 inermin 3.85 26.1 µM 1.66E-5 20 5.84E-5 0.09
14 SGTC_2416 tofa 3.77 880.0 nM 2.47E-5 sphingolipid biosynthesis & PDR1 7 8.29E-5 0.26
15 SGTC_2600 tangeritin 3.72 88.0 µM 3.05E-5 7 9.96E-5 0.44
16 SGTC_757 1066-0008 3.62 322.0 µM 4.70E-5 Golgi 6 1.46E-4 0.15
17 SGTC_1033 k072-0102 3.62 21.3 µM 4.78E-5 60S ribosome export 8 1.48E-4 0.27
18 SGTC_1693 xanthone 3.61 101.9 µM 4.88E-5 DNA damage response 11 1.50E-4 0.12
19 SGTC_857 0438-0306 3.56 1.4 µM 6.22E-5 copper-dependent oxidative stress 5 1.86E-4 0.33
20 SGTC_1973 st070275 3.54 50.2 µM 6.80E-5 2 2.01E-4 0.19

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.150 2.67E-18 YNR032C-A HUB1 hom Ubiquitin-like protein modifier; promotes alternative splicing of SRC1 pre-mRNA; binds non-covalently to the HIND domain of Snu66, may function in modification of Sph1p and Hbt1p, functionally complemented by the human or S. pombe ortholog; mechanism of Hub1p adduct formation not yet clear
0.139 4.94E-16 YCR054C CTR86 het Essential protein of unknown function; with orthologs in Ashbya gossypii and Candida albicans; similar to human ATXN10, mutations in which cause spinocerebellar ataxia type 10; codon usage corresponds to that observed for yeast genes expressed at low levels; relative distribution to the nucleus increases upon DNA replication stress
0.136 2.67E-15 YER053C-A YER053C-A hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; protein abundance increases in response to DNA replication stress
0.121 2.13E-12 YBR047W_p FMP23_p hom Putative protein of unknown function; proposed to be involved in iron or copper homeostasis; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.121 2.41E-12 YMR011W HXT2 hom High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose
0.117 1.13E-11 YOR279C RFM1 hom DNA-binding protein required for vegetative repression of middle sporulation genes; specificity factor that directs the Hst1p histone deacetylase to some of the promoters regulated by Sum1p; involved in telomere maintenance
0.116 1.81E-11 YJL218W_p YJL218W_p hom Putative acetyltransferase; similar to bacterial galactoside O-acetyltransferases; induced by oleate in an OAF1/PIP2-dependent manner; promoter contains an oleate response element consensus sequence; non-essential gene
0.114 3.82E-11 YFL038C YPT1 het Rab family GTPase, involved in the ER-to-Golgi step of the secretory pathway; complex formation with the Rab escort protein Mrs6p is required for prenylation of Ypt1p by protein geranylgeranyltransferase type II (Bet2p-Bet4p)
0.110 1.93E-10 YKR028W SAP190 hom Protein that forms a complex with the Sit4p protein phosphatase; required for Sit4p function; member of a family of similar proteins including Sap4p, Sap155p, and Sap185p; SAP190 has a paralog, SAP185, that arose from the whole genome duplication
0.109 2.14E-10 YNL212W VID27 hom Cytoplasmic protein of unknown function; possibly involved in vacuolar protein degradation; not essential for proteasome-dependent degradation of fructose-1,6-bisphosphatase (FBPase); null mutants exhibit normal growth
0.107 5.05E-10 YGR244C LSC2 hom Beta subunit of succinyl-CoA ligase, which is a mitochondrial enzyme of the TCA cycle that catalyzes the nucleotide-dependent conversion of succinyl-CoA to succinate
0.107 5.86E-10 YJR045C SSC1 het Hsp70 family ATPase; constituent of the import motor component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); involved in protein translocation and folding; subunit of SceI endonuclease; SSC1 has a paralog, ECM10, that arose from the whole genome duplication
0.100 7.64E-9 YER175C TMT1 hom Trans-aconitate methyltransferase, cytosolic enzyme that catalyzes the methyl esterification of 3-isopropylmalate, an intermediate of the leucine biosynthetic pathway, and trans-aconitate, which inhibits the citric acid cycle
0.096 2.58E-8 YAR050W FLO1 hom Lectin-like protein involved in flocculation, cell wall protein that binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin sensitive and heat resistant; similar to Flo5p
0.094 4.36E-8 YDL017W CDC7 het DDK (Dbf4-dependent kinase) catalytic subunit required for origin firing and replication fork progression in mitotic S phase through phosphorylation of Mcm2-7p complexes and Cdc45p; kinase activity correlates with cyclical DBF4 expression; required for pre-meiotic DNA replication, meiotic DSB formation, recruitment of the monopolin complex to kinetochores during meiosis I and as a gene-specific regulator of the meiosis-specific transcription factor Ndt80p