YJR024C / MDE1

5'-methylthioribulose-1-phosphate dehydratase; acts in the methionine salvage pathway; potential Smt3p sumoylation substrate; expression downregulated by caspofungin and deletion mutant is caspofungin resistant

Zygosity: Homozygous strain
fixedexpanded
Profile for YJR024C / MDE1

Click on Significant Values for Screen Details ID:SGTC_517|Compound:1365-0151|FD-Score:3.50|P-value:1.16E-4 ID:SGTC_659|Compound:k018-0002|FD-Score:-3.06|P-value:6.96E-4 ID:SGTC_945|Compound:3381-0768|FD-Score:3.76|P-value:3.80E-5 ID:SGTC_966|Compound:1300-0360|FD-Score:-5.97|P-value:1.99E-10 ID:SGTC_1293|Compound:1000-1278|FD-Score:3.54|P-value:9.79E-5 ID:SGTC_1325|Compound:1431-0015|FD-Score:-5.93|P-value:2.55E-10 ID:SGTC_1326|Compound:1431-2094|FD-Score:-5.16|P-value:3.27E-8 ID:SGTC_1337|Compound:1486-1011|FD-Score:-3.22|P-value:3.83E-4 ID:SGTC_1339|Compound:1486-1321|FD-Score:3.65|P-value:6.04E-5 ID:SGTC_1342|Compound:1486-1464|FD-Score:-4.45|P-value:1.60E-6 ID:SGTC_1374|Compound:2889-5571|FD-Score:4.67|P-value:4.42E-7 ID:SGTC_1445|Compound:4239-0156|FD-Score:3.59|P-value:7.85E-5 ID:SGTC_1480|Compound:1070-0044|FD-Score:3.93|P-value:1.81E-5 ID:SGTC_1733|Compound:st037357|FD-Score:3.18|P-value:4.07E-4 ID:SGTC_1780|Compound:st038448|FD-Score:3.22|P-value:3.49E-4 ID:SGTC_1813|Compound:st051246|FD-Score:-2.97|P-value:9.45E-4 ID:SGTC_1820|Compound:st053765|FD-Score:4.61|P-value:6.14E-7 ID:SGTC_2399|Compound:5884133|FD-Score:3.63|P-value:6.58E-5 ID:SGTC_2419|Compound:paclitaxel|FD-Score:-4.05|P-value:1.12E-5 ID:SGTC_2505|Compound:galangin|FD-Score:3.78|P-value:3.46E-5 ID:SGTC_2556|Compound:citropten|FD-Score:-3.57|P-value:9.47E-5 ID:SGTC_2557|Compound:derrustone|FD-Score:3.17|P-value:4.19E-4 ID:SGTC_2561|Compound:acetosyringone|FD-Score:3.91|P-value:1.99E-5 ID:SGTC_2610|Compound:ononetin|FD-Score:4.54|P-value:8.93E-7 ID:SGTC_2682|Compound:pyrogallin|FD-Score:4.05|P-value:1.02E-5 ID:SGTC_2749|Compound:bexarotene|FD-Score:3.22|P-value:3.49E-4 ID:SGTC_2789|Compound:5281112|FD-Score:3.48|P-value:1.24E-4 ID:SGTC_2792|Compound:7535235|FD-Score:3.68|P-value:5.30E-5 ID:SGTC_2960|Compound:9079389|FD-Score:3.71|P-value:4.82E-5 ID:SGTC_3032|Compound:9089427|FD-Score:-3.16|P-value:4.65E-4 ID:SGTC_3067|Compound:9117431|FD-Score:3.49|P-value:1.19E-4 ID:SGTC_3071|Compound:9117417|FD-Score:3.08|P-value:5.83E-4 ID:SGTC_3214|Compound:9129694|FD-Score:4.33|P-value:2.57E-6 ID:SGTC_3236|Compound:9132701|FD-Score:-5.09|P-value:4.75E-8 ID:SGTC_517|Compound:1365-0151|FD-Score:3.50|P-value:1.16E-4 ID:SGTC_659|Compound:k018-0002|FD-Score:-3.06|P-value:6.96E-4 ID:SGTC_945|Compound:3381-0768|FD-Score:3.76|P-value:3.80E-5 ID:SGTC_966|Compound:1300-0360|FD-Score:-5.97|P-value:1.99E-10 ID:SGTC_1293|Compound:1000-1278|FD-Score:3.54|P-value:9.79E-5 ID:SGTC_1325|Compound:1431-0015|FD-Score:-5.93|P-value:2.55E-10 ID:SGTC_1326|Compound:1431-2094|FD-Score:-5.16|P-value:3.27E-8 ID:SGTC_1337|Compound:1486-1011|FD-Score:-3.22|P-value:3.83E-4 ID:SGTC_1339|Compound:1486-1321|FD-Score:3.65|P-value:6.04E-5 ID:SGTC_1342|Compound:1486-1464|FD-Score:-4.45|P-value:1.60E-6 ID:SGTC_1374|Compound:2889-5571|FD-Score:4.67|P-value:4.42E-7 ID:SGTC_1445|Compound:4239-0156|FD-Score:3.59|P-value:7.85E-5 ID:SGTC_1480|Compound:1070-0044|FD-Score:3.93|P-value:1.81E-5 ID:SGTC_1733|Compound:st037357|FD-Score:3.18|P-value:4.07E-4 ID:SGTC_1780|Compound:st038448|FD-Score:3.22|P-value:3.49E-4 ID:SGTC_1813|Compound:st051246|FD-Score:-2.97|P-value:9.45E-4 ID:SGTC_1820|Compound:st053765|FD-Score:4.61|P-value:6.14E-7 ID:SGTC_2399|Compound:5884133|FD-Score:3.63|P-value:6.58E-5 ID:SGTC_2419|Compound:paclitaxel|FD-Score:-4.05|P-value:1.12E-5 ID:SGTC_2505|Compound:galangin|FD-Score:3.78|P-value:3.46E-5 ID:SGTC_2556|Compound:citropten|FD-Score:-3.57|P-value:9.47E-5 ID:SGTC_2557|Compound:derrustone|FD-Score:3.17|P-value:4.19E-4 ID:SGTC_2561|Compound:acetosyringone|FD-Score:3.91|P-value:1.99E-5 ID:SGTC_2610|Compound:ononetin|FD-Score:4.54|P-value:8.93E-7 ID:SGTC_2682|Compound:pyrogallin|FD-Score:4.05|P-value:1.02E-5 ID:SGTC_2749|Compound:bexarotene|FD-Score:3.22|P-value:3.49E-4 ID:SGTC_2789|Compound:5281112|FD-Score:3.48|P-value:1.24E-4 ID:SGTC_2792|Compound:7535235|FD-Score:3.68|P-value:5.30E-5 ID:SGTC_2960|Compound:9079389|FD-Score:3.71|P-value:4.82E-5 ID:SGTC_3032|Compound:9089427|FD-Score:-3.16|P-value:4.65E-4 ID:SGTC_3067|Compound:9117431|FD-Score:3.49|P-value:1.19E-4 ID:SGTC_3071|Compound:9117417|FD-Score:3.08|P-value:5.83E-4 ID:SGTC_3214|Compound:9129694|FD-Score:4.33|P-value:2.57E-6 ID:SGTC_3236|Compound:9132701|FD-Score:-5.09|P-value:4.75E-8

Top fitness defect scores for YJR024C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1374 2889-5571 4.67 141.0 µM 4.42E-7 RSC complex & mRNA processing 20 1.48E-6
2 SGTC_1820 st053765 4.61 18.6 µM 6.14E-7 RPP1 & pyrimidine depletion 5 1.99E-6
3 SGTC_2610 ononetin 4.54 44.2 µM 8.93E-7 25 2.80E-6
4 SGTC_3214 9129694 4.33 49.5 µM 2.57E-6 19 7.32E-6
5 SGTC_2682 pyrogallin 4.05 40.0 µM 1.02E-5 copper-dependent oxidative stress 25 2.56E-5
6 SGTC_1480 1070-0044 3.93 41.2 µM 1.81E-5 20 4.33E-5
7 SGTC_2561 acetosyringone 3.91 100.0 µM 1.99E-5 27 4.70E-5
8 SGTC_2505 galangin 3.78 7.9 µM 3.46E-5 RPP1 & pyrimidine depletion 11 7.79E-5
9 SGTC_945 3381-0768 3.76 11.3 µM 3.80E-5 endomembrane recycling 39 8.49E-5
10 SGTC_2960 9079389 3.71 6.0 µM 4.82E-5 33 1.05E-4
11 SGTC_2792 7535235 3.68 81.8 µM 5.30E-5 fatty acid desaturase (OLE1) 42 1.15E-4
12 SGTC_1339 1486-1321 3.65 22.7 µM 6.04E-5 ERG2 30 1.29E-4
13 SGTC_2399 5884133 3.63 200.0 µM 6.58E-5 cell wall signaling 85 1.40E-4
14 SGTC_1445 4239-0156 3.59 97.7 µM 7.85E-5 42 1.64E-4
15 SGTC_1293 1000-1278 3.54 195.0 µM 9.79E-5 23 2.01E-4
16 SGTC_517 1365-0151 3.50 113.0 µM 1.16E-4 42 2.35E-4
17 SGTC_3067 9117431 3.49 49.5 µM 1.19E-4 26 2.39E-4
18 SGTC_2789 5281112 3.48 71.4 µM 1.24E-4 62 2.50E-4
19 SGTC_2749 bexarotene 3.22 57.4 µM 3.49E-4 51 6.39E-4
20 SGTC_1780 st038448 3.22 24.5 µM 3.49E-4 iron homeostasis 55 6.40E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.120 2.50E-12 YMR180C CTL1 hom RNA 5'-triphosphatase, localizes to both the nucleus and cytoplasm
0.115 2.40E-11 YPR183W DPM1 het Dolichol phosphate mannose (Dol-P-Man) synthase of the ER membrane, catalyzes the formation of Dol-P-Man from Dol-P and GDP-Man; required for glycosyl phosphatidylinositol membrane anchoring, O mannosylation, and protein glycosylation
0.079 4.10E-6 YOL107W_p YOL107W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and colocalizes in a punctate pattern with the early golgi/COPI vesicles; YOL107W is not an essential protein
0.077 7.94E-6 YPL106C SSE1 hom ATPase component of the heat shock protein Hsp90 chaperone complex; binds unfolded proteins; member of the heat shock protein 70 (HSP70) family; localized to the cytoplasm; SSE1 has a paralog, SSE2, that arose from the whole genome duplication
0.077 8.51E-6 YOR154W_p SLP1_p hom Glycosylated integral ER membrane protein of unknown function; forms an ER-membrane associated protein complex with Emp65p; member of the SUN-like family of proteins; genetic interactions suggest a role in folding of ER membrane proteins; required for nuclear envelope localization of Mps3p
0.076 1.06E-5 YMR236W TAF9 het Subunit (17 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification, similar to histone H3
0.074 1.79E-5 YPL011C TAF3 het TFIID subunit (47 kDa), involved in promoter binding and RNA polymerase II transcription initiation
0.074 1.83E-5 YDL184C RPL41A hom Ribosomal 60S subunit protein L41A; comprises only 25 amino acids; rpl41a rpl41b double null mutant is viable; homologous to mammalian ribosomal protein L41, no bacterial homolog; RPL41A has a paralog, RPL41B, that arose from the whole genome duplication
0.073 2.08E-5 YHR200W RPN10 hom Non-ATPase base subunit of the 19S regulatory particle (RP) of the 26S proteasome; N-terminus plays a role in maintaining the structural integrity of the RP; binds selectively to polyubiquitin chains; homolog of the mammalian S5a protein
0.073 2.33E-5 YAL053W FLC2 hom Putative FAD transporter; required for uptake of FAD into endoplasmic reticulum; involved in cell wall maintenance; FLC2 has a paralog, YOR365C, that arose from the whole genome duplication
0.069 6.24E-5 YHR175W-A_p YHR175W-A_p hom Putative protein of unknown function; identified by fungal homology and RT-PCR
0.069 6.94E-5 YLR101C_d YLR101C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified, essential ORF ERG27/YLR100W
0.068 7.19E-5 YJR005W APL1 hom Beta-adaptin, large subunit of the clathrin associated protein complex (AP-2); involved in vesicle mediated transport; similar to mammalian beta-chain of the clathrin associated protein complex
0.068 8.19E-5 YER063W THO1 hom Conserved nuclear RNA-binding protein; specifically binds to transcribed chromatin in a THO- and RNA-dependent manner, genetically interacts with shuttling hnRNP NAB2; overproduction suppresses transcriptional defect caused by hpr1 mutation
0.067 9.14E-5 YKR018C YKR018C hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; protein abundance increases in response to DNA replication stress; YKR018C has a paralog, IML2, that arose from the whole genome duplication