YJR032W / CPR7

Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds to Hsp82p and contributes to chaperone activity

Zygosity: Homozygous strain
fixedexpanded
Profile for YJR032W / CPR7

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:4.16|P-value:3.82E-5 ID:SGTC_59|Compound:0330-0160|FD-Score:3.49|P-value:4.59E-4 ID:SGTC_210|Compound:3551-0445|FD-Score:3.76|P-value:1.77E-4 ID:SGTC_261|Compound:5-fluorouridine|FD-Score:4.12|P-value:4.40E-5 ID:SGTC_267|Compound:4-Nitroquinoline-1-oxide  (4-NQO)|FD-Score:-3.66|P-value:2.28E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:-3.88|P-value:9.92E-5 ID:SGTC_335|Compound:4077-0256|FD-Score:-3.88|P-value:1.01E-4 ID:SGTC_377|Compound:3970-0964|FD-Score:3.42|P-value:5.83E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:3.31|P-value:8.42E-4 ID:SGTC_548|Compound:1436-0017|FD-Score:5.99|P-value:5.88E-9 ID:SGTC_549|Compound:1661-1316|FD-Score:3.27|P-value:9.44E-4 ID:SGTC_596|Compound:1155-0152|FD-Score:3.64|P-value:2.66E-4 ID:SGTC_612|Compound:0302-0167|FD-Score:4.16|P-value:3.83E-5 ID:SGTC_625|Compound:k213-0058|FD-Score:4.33|P-value:1.87E-5 ID:SGTC_657|Compound:3534-0529|FD-Score:-3.57|P-value:3.15E-4 ID:SGTC_663|Compound:1486-0733|FD-Score:3.91|P-value:1.02E-4 ID:SGTC_729|Compound:4092-0585|FD-Score:3.58|P-value:3.38E-4 ID:SGTC_791|Compound:1348-1292|FD-Score:7.80|P-value:5.27E-14 ID:SGTC_800|Compound:3448-7362|FD-Score:3.84|P-value:1.30E-4 ID:SGTC_832|Compound:4083-0019|FD-Score:3.27|P-value:9.51E-4 ID:SGTC_835|Compound:0312-0010|FD-Score:3.66|P-value:2.56E-4 ID:SGTC_1014|Compound:4130-3005|FD-Score:5.28|P-value:2.55E-7 ID:SGTC_1036|Compound:k216-0215|FD-Score:-3.37|P-value:6.18E-4 ID:SGTC_1038|Compound:k292-0204|FD-Score:3.83|P-value:1.34E-4 ID:SGTC_1251|Compound:0490-5699|FD-Score:3.40|P-value:6.08E-4 ID:SGTC_1263|Compound:0774-1208|FD-Score:4.02|P-value:6.49E-5 ID:SGTC_1265|Compound:0819-1001|FD-Score:-3.48|P-value:4.24E-4 ID:SGTC_1273|Compound:0849-0096|FD-Score:3.51|P-value:4.22E-4 ID:SGTC_1372|Compound:2752-0194|FD-Score:-3.29|P-value:8.11E-4 ID:SGTC_1433|Compound:4060-0023|FD-Score:4.29|P-value:2.24E-5 ID:SGTC_1458|Compound:k015-0034|FD-Score:4.36|P-value:1.67E-5 ID:SGTC_1465|Compound:k213-0056|FD-Score:3.92|P-value:9.49E-5 ID:SGTC_1474|Compound:0330-0125|FD-Score:4.54|P-value:7.67E-6 ID:SGTC_1673|Compound:st016611|FD-Score:-5.42|P-value:1.09E-7 ID:SGTC_1677|Compound:st019204|FD-Score:-3.65|P-value:2.32E-4 ID:SGTC_1799|Compound:st045822|FD-Score:4.42|P-value:1.32E-5 ID:SGTC_1978|Compound:st071761|FD-Score:-3.37|P-value:6.15E-4 ID:SGTC_2000|Compound:st075254|FD-Score:8.19|P-value:3.02E-15 ID:SGTC_2246|Compound:7293507|FD-Score:3.31|P-value:8.29E-4 ID:SGTC_2318|Compound:6029776|FD-Score:4.16|P-value:3.76E-5 ID:SGTC_2479|Compound:5617353|FD-Score:3.70|P-value:2.15E-4 ID:SGTC_2506|Compound:ethyl hematommate|FD-Score:4.22|P-value:3.00E-5 ID:SGTC_2625|Compound:euphol|FD-Score:-4.40|P-value:1.27E-5 ID:SGTC_2628|Compound:lathosterol|FD-Score:3.28|P-value:9.14E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:4.71|P-value:3.70E-6 ID:SGTC_2815|Compound:7968870|FD-Score:3.98|P-value:7.65E-5 ID:SGTC_2896|Compound:9052656|FD-Score:-3.25|P-value:9.02E-4 ID:SGTC_2957|Compound:9076800|FD-Score:3.48|P-value:4.65E-4 ID:SGTC_2985|Compound:9022375|FD-Score:5.01|P-value:9.48E-7 ID:SGTC_2988|Compound:9073640|FD-Score:3.33|P-value:7.74E-4 ID:SGTC_2990|Compound:9074105|FD-Score:-3.38|P-value:6.06E-4 ID:SGTC_3026|Compound:9090633|FD-Score:4.48|P-value:1.02E-5 ID:SGTC_3076|Compound:9116187|FD-Score:4.35|P-value:1.77E-5 ID:SGTC_3096|Compound:9117468|FD-Score:3.81|P-value:1.47E-4 ID:SGTC_3101|Compound:9120531|FD-Score:3.37|P-value:6.91E-4 ID:SGTC_3110|Compound:9122132|FD-Score:-3.56|P-value:3.20E-4 ID:SGTC_3339|Compound:9145883|FD-Score:-3.57|P-value:3.11E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:4.16|P-value:3.82E-5 ID:SGTC_59|Compound:0330-0160|FD-Score:3.49|P-value:4.59E-4 ID:SGTC_210|Compound:3551-0445|FD-Score:3.76|P-value:1.77E-4 ID:SGTC_261|Compound:5-fluorouridine|FD-Score:4.12|P-value:4.40E-5 ID:SGTC_267|Compound:4-Nitroquinoline-1-oxide  (4-NQO)|FD-Score:-3.66|P-value:2.28E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:-3.88|P-value:9.92E-5 ID:SGTC_335|Compound:4077-0256|FD-Score:-3.88|P-value:1.01E-4 ID:SGTC_377|Compound:3970-0964|FD-Score:3.42|P-value:5.83E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:3.31|P-value:8.42E-4 ID:SGTC_548|Compound:1436-0017|FD-Score:5.99|P-value:5.88E-9 ID:SGTC_549|Compound:1661-1316|FD-Score:3.27|P-value:9.44E-4 ID:SGTC_596|Compound:1155-0152|FD-Score:3.64|P-value:2.66E-4 ID:SGTC_612|Compound:0302-0167|FD-Score:4.16|P-value:3.83E-5 ID:SGTC_625|Compound:k213-0058|FD-Score:4.33|P-value:1.87E-5 ID:SGTC_657|Compound:3534-0529|FD-Score:-3.57|P-value:3.15E-4 ID:SGTC_663|Compound:1486-0733|FD-Score:3.91|P-value:1.02E-4 ID:SGTC_729|Compound:4092-0585|FD-Score:3.58|P-value:3.38E-4 ID:SGTC_791|Compound:1348-1292|FD-Score:7.80|P-value:5.27E-14 ID:SGTC_800|Compound:3448-7362|FD-Score:3.84|P-value:1.30E-4 ID:SGTC_832|Compound:4083-0019|FD-Score:3.27|P-value:9.51E-4 ID:SGTC_835|Compound:0312-0010|FD-Score:3.66|P-value:2.56E-4 ID:SGTC_1014|Compound:4130-3005|FD-Score:5.28|P-value:2.55E-7 ID:SGTC_1036|Compound:k216-0215|FD-Score:-3.37|P-value:6.18E-4 ID:SGTC_1038|Compound:k292-0204|FD-Score:3.83|P-value:1.34E-4 ID:SGTC_1251|Compound:0490-5699|FD-Score:3.40|P-value:6.08E-4 ID:SGTC_1263|Compound:0774-1208|FD-Score:4.02|P-value:6.49E-5 ID:SGTC_1265|Compound:0819-1001|FD-Score:-3.48|P-value:4.24E-4 ID:SGTC_1273|Compound:0849-0096|FD-Score:3.51|P-value:4.22E-4 ID:SGTC_1372|Compound:2752-0194|FD-Score:-3.29|P-value:8.11E-4 ID:SGTC_1433|Compound:4060-0023|FD-Score:4.29|P-value:2.24E-5 ID:SGTC_1458|Compound:k015-0034|FD-Score:4.36|P-value:1.67E-5 ID:SGTC_1465|Compound:k213-0056|FD-Score:3.92|P-value:9.49E-5 ID:SGTC_1474|Compound:0330-0125|FD-Score:4.54|P-value:7.67E-6 ID:SGTC_1673|Compound:st016611|FD-Score:-5.42|P-value:1.09E-7 ID:SGTC_1677|Compound:st019204|FD-Score:-3.65|P-value:2.32E-4 ID:SGTC_1799|Compound:st045822|FD-Score:4.42|P-value:1.32E-5 ID:SGTC_1978|Compound:st071761|FD-Score:-3.37|P-value:6.15E-4 ID:SGTC_2000|Compound:st075254|FD-Score:8.19|P-value:3.02E-15 ID:SGTC_2246|Compound:7293507|FD-Score:3.31|P-value:8.29E-4 ID:SGTC_2318|Compound:6029776|FD-Score:4.16|P-value:3.76E-5 ID:SGTC_2479|Compound:5617353|FD-Score:3.70|P-value:2.15E-4 ID:SGTC_2506|Compound:ethyl hematommate|FD-Score:4.22|P-value:3.00E-5 ID:SGTC_2625|Compound:euphol|FD-Score:-4.40|P-value:1.27E-5 ID:SGTC_2628|Compound:lathosterol|FD-Score:3.28|P-value:9.14E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:4.71|P-value:3.70E-6 ID:SGTC_2815|Compound:7968870|FD-Score:3.98|P-value:7.65E-5 ID:SGTC_2896|Compound:9052656|FD-Score:-3.25|P-value:9.02E-4 ID:SGTC_2957|Compound:9076800|FD-Score:3.48|P-value:4.65E-4 ID:SGTC_2985|Compound:9022375|FD-Score:5.01|P-value:9.48E-7 ID:SGTC_2988|Compound:9073640|FD-Score:3.33|P-value:7.74E-4 ID:SGTC_2990|Compound:9074105|FD-Score:-3.38|P-value:6.06E-4 ID:SGTC_3026|Compound:9090633|FD-Score:4.48|P-value:1.02E-5 ID:SGTC_3076|Compound:9116187|FD-Score:4.35|P-value:1.77E-5 ID:SGTC_3096|Compound:9117468|FD-Score:3.81|P-value:1.47E-4 ID:SGTC_3101|Compound:9120531|FD-Score:3.37|P-value:6.91E-4 ID:SGTC_3110|Compound:9122132|FD-Score:-3.56|P-value:3.20E-4 ID:SGTC_3339|Compound:9145883|FD-Score:-3.57|P-value:3.11E-4

Top fitness defect scores for YJR032W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2000 st075254 8.19 36.4 µM 3.02E-15 1 1.31E-16
2 SGTC_791 1348-1292 7.80 225.0 µM 5.27E-14 6 3.02E-15
3 SGTC_548 1436-0017 5.99 110.0 µM 5.88E-9 TSC3-RPN4 12 1.05E-9
4 SGTC_1014 4130-3005 5.28 69.3 µM 2.55E-7 4 6.57E-8
5 SGTC_2985 9022375 5.01 71.4 µM 9.48E-7 RPP1 & pyrimidine depletion 13 2.77E-7
6 SGTC_2651 1327-0036 4.71 5.0 µM 3.70E-6 125 1.24E-6
7 SGTC_1474 0330-0125 4.54 5.3 µM 7.67E-6 16 2.75E-6
8 SGTC_3026 9090633 4.48 49.5 µM 1.02E-5 9 3.75E-6
9 SGTC_1799 st045822 4.42 46.1 µM 1.32E-5 8 4.98E-6
10 SGTC_1458 k015-0034 4.36 6.3 µM 1.67E-5 10 6.44E-6
11 SGTC_3076 9116187 4.35 49.5 µM 1.77E-5 14 6.89E-6
12 SGTC_625 k213-0058 4.33 121.0 µM 1.87E-5 translation 80 7.32E-6
13 SGTC_1433 4060-0023 4.29 7.6 µM 2.24E-5 tubulin folding & SWR complex 15 8.92E-6
14 SGTC_2506 ethyl hematommate 4.22 54.2 µM 3.00E-5 RPP1 & pyrimidine depletion 11 1.23E-5
15 SGTC_2318 6029776 4.16 164.0 µM 3.76E-5 23 1.57E-5
16 SGTC_58 0957-0393 4.16 9.0 µM 3.82E-5 cell wall 360 1.60E-5
17 SGTC_612 0302-0167 4.16 22.4 µM 3.83E-5 copper-dependent oxidative stress 32 1.60E-5
18 SGTC_261 5-fluorouridine 4.12 15.4 µM 4.40E-5 exosome 6 1.87E-5
19 SGTC_1263 0774-1208 4.02 64.8 µM 6.49E-5 44 2.86E-5
20 SGTC_2815 7968870 3.98 71.4 µM 7.65E-5 23 3.43E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.156 1.21E-19 YLR048W RPS0B hom Protein component of the small (40S) ribosomal subunit; RPS0B has a paralog, RPS0A, that arose from the whole genome duplication; required for maturation of 18S rRNA along with Rps0Ap; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal; homologous to human ribosomal protein SA and bacterial S2
0.137 1.59E-15 YOR141C ARP8 hom Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes; has mRNA binding activity
0.136 2.86E-15 YOR085W OST3 hom Gamma subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; Ost3p is important for N-glycosylation of a subset of proteins
0.126 2.79E-13 YKL056C TMA19 hom Protein that associates with ribosomes; homolog of translationally controlled tumor protein; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and relocates to the mitochondrial outer surface upon oxidative stress
0.122 1.12E-12 YIL160C POT1 hom 3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids
0.117 1.00E-11 YER122C GLO3 hom ADP-ribosylation factor GTPase activating protein (ARF GAP), involved in ER-Golgi transport; shares functional similarity with Gcs1p
0.117 1.20E-11 YGR185C TYS1 het Cytoplasmic tyrosyl-tRNA synthetase; required for cytoplasmic protein synthesis; interacts with positions 34 and 35 of the tRNATyr anticodon; mutations in human ortholog YARS are associated with Charcot-Marie-Tooth (CMT) neuropathies; protein abundance increases in response to DNA replication stress
0.111 1.01E-10 YDR205W MSC2 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
0.111 1.06E-10 YKR042W UTH1 hom Protein involved in cell wall biogenesis; required for mitochondrial autophagy; mitochondrial outer membrane and cell wall localized SUN family member; involved in the oxidative stress response, life span during starvation, and cell death; UTH1 has a paralog, NCA3, that arose from the whole genome duplication
0.110 1.47E-10 YFL037W TUB2 het Beta-tubulin; associates with alpha-tubulin (Tub1p and Tub3p) to form tubulin dimer, which polymerizes to form microtubules; mutation in human ortholog is associated with congenital fibrosis of the extraocular muscles (CFEOM) with polymicrogyria
0.110 1.46E-10 YLR403W SFP1 hom Regulates transcription of ribosomal protein and biogenesis genes; regulates response to nutrients and stress, G2/M transitions during mitotic cell cycle and DNA-damage response, and modulates cell size; regulated by TORC1 and Mrs6p; sequence of zinc finger, ChIP localization data, and protein-binding microarray (PBM) data, and computational analyses suggest it binds DNA directly at highly active RP genes and indirectly through Rap1p at others; can form the [ISP+] prion
0.110 1.66E-10 YML103C NUP188 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188
0.106 8.72E-10 YDR385W EFT2 hom Elongation factor 2 (EF-2), also encoded by EFT1; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin; EFT2 has a paralog, EFT1, that arose from the whole genome duplication
0.104 1.63E-9 YOR231W MKK1 hom MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication
0.101 4.87E-9 YDR140W MTQ2 hom S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; subunit of complex with Trm112p that methylates translation release factor Sup45p (eRF1) in the ternary complex eRF1-eRF3-GTP; similar to E.coli PrmC