YJR033C / RAV1

Subunit of the RAVE complex (Rav1p, Rav2p, Skp1p), which promotes assembly of the V-ATPase holoenzyme; required for transport between the early and late endosome/PVC and for localization of TGN membrane proteins; potential Cdc28p substrate

Zygosity: Homozygous strain
fixedexpanded
Profile for YJR033C / RAV1

Click on Significant Values for Screen Details ID:SGTC_2|Compound:0422-0095|FD-Score:5.32|P-value:1.54E-6 ID:SGTC_29|Compound:0299-0004|FD-Score:3.89|P-value:3.26E-4 ID:SGTC_38|Compound:0929-0051|FD-Score:3.62|P-value:7.57E-4 ID:SGTC_44|Compound:0929-0055|FD-Score:4.22|P-value:1.07E-4 ID:SGTC_50|Compound:0929-0078|FD-Score:6.01|P-value:6.88E-8 ID:SGTC_56|Compound:0957-0365|FD-Score:7.92|P-value:1.94E-12 ID:SGTC_58|Compound:0957-0393|FD-Score:-6.56|P-value:4.48E-9 ID:SGTC_70|Compound:0141-0289|FD-Score:5.51|P-value:6.74E-7 ID:SGTC_153|Compound:4077-0274|FD-Score:3.78|P-value:4.58E-4 ID:SGTC_157|Compound:1348-1695|FD-Score:4.56|P-value:3.14E-5 ID:SGTC_164|Compound:4100-3994|FD-Score:8.39|P-value:9.70E-14 ID:SGTC_169|Compound:k015-0017|FD-Score:3.82|P-value:4.07E-4 ID:SGTC_204|Compound:1543-0184|FD-Score:7.89|P-value:2.25E-12 ID:SGTC_209|Compound:4077-0173|FD-Score:5.41|P-value:1.06E-6 ID:SGTC_263|Compound:alizarin|FD-Score:10.30|P-value:8.07E-20 ID:SGTC_308|Compound:4092-1169|FD-Score:6.94|P-value:5.72E-10 ID:SGTC_352|Compound:k048-0007|FD-Score:4.94|P-value:7.35E-6 ID:SGTC_374|Compound:0880-0231|FD-Score:5.11|P-value:3.78E-6 ID:SGTC_391|Compound:gliotoxin|FD-Score:17.40|P-value:1.01E-52 ID:SGTC_431|Compound:k089-0097|FD-Score:4.63|P-value:2.48E-5 ID:SGTC_488|Compound:nitrendipine|FD-Score:4.51|P-value:3.83E-5 ID:SGTC_524|Compound:r073-0010|FD-Score:5.89|P-value:1.18E-7 ID:SGTC_527|Compound:4476-4215|FD-Score:5.57|P-value:5.26E-7 ID:SGTC_528|Compound:3492-0019|FD-Score:7.74|P-value:5.86E-12 ID:SGTC_545|Compound:4218-0007|FD-Score:5.70|P-value:2.95E-7 ID:SGTC_562|Compound:3772-2733|FD-Score:3.68|P-value:6.27E-4 ID:SGTC_697|Compound:0508-1955|FD-Score:4.84|P-value:1.09E-5 ID:SGTC_699|Compound:0375-0592|FD-Score:3.84|P-value:3.79E-4 ID:SGTC_717|Compound:1532-0246|FD-Score:4.19|P-value:1.20E-4 ID:SGTC_768|Compound:0384-0033|FD-Score:7.12|P-value:2.17E-10 ID:SGTC_786|Compound:4544-0069|FD-Score:4.49|P-value:4.11E-5 ID:SGTC_841|Compound:0251-0215|FD-Score:10.30|P-value:7.97E-20 ID:SGTC_922|Compound:1866-0035|FD-Score:6.56|P-value:4.46E-9 ID:SGTC_950|Compound:1165-0508|FD-Score:5.05|P-value:4.79E-6 ID:SGTC_1017|Compound:4239-0030|FD-Score:3.75|P-value:4.99E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.42|P-value:5.45E-5 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:9.78|P-value:5.00E-18 ID:SGTC_1184|Compound:1269-1718|FD-Score:3.69|P-value:6.05E-4 ID:SGTC_1201|Compound:1889-3372|FD-Score:3.78|P-value:4.60E-4 ID:SGTC_1204|Compound:4049-0315|FD-Score:4.59|P-value:2.87E-5 ID:SGTC_1214|Compound:0358-0031|FD-Score:-3.55|P-value:9.41E-4 ID:SGTC_1415|Compound:3966-0071|FD-Score:4.20|P-value:1.13E-4 ID:SGTC_1417|Compound:3966-0327|FD-Score:5.35|P-value:1.34E-6 ID:SGTC_1429|Compound:4049-0205|FD-Score:5.15|P-value:3.08E-6 ID:SGTC_1481|Compound:3346-2004|FD-Score:-3.59|P-value:8.33E-4 ID:SGTC_1489|Compound:4065-0444|FD-Score:3.56|P-value:9.05E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:8.14|P-value:4.66E-13 ID:SGTC_1522|Compound:st012842|FD-Score:-3.89|P-value:3.25E-4 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:5.43|P-value:9.60E-7 ID:SGTC_1529|Compound:apigenin|FD-Score:5.00|P-value:5.86E-6 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:6.46|P-value:7.43E-9 ID:SGTC_1602|Compound:st001878|FD-Score:5.17|P-value:2.84E-6 ID:SGTC_1607|Compound:st000305|FD-Score:3.53|P-value:9.79E-4 ID:SGTC_1658|Compound:st012944|FD-Score:5.07|P-value:4.29E-6 ID:SGTC_1673|Compound:st016611|FD-Score:4.15|P-value:1.38E-4 ID:SGTC_1676|Compound:st018489|FD-Score:3.69|P-value:6.02E-4 ID:SGTC_1687|Compound:st020778|FD-Score:21.60|P-value:1.98E-80 ID:SGTC_1694|Compound:st024011|FD-Score:4.03|P-value:2.06E-4 ID:SGTC_1712|Compound:st032288|FD-Score:-4.36|P-value:6.60E-5 ID:SGTC_1727|Compound:st034309|FD-Score:7.39|P-value:4.60E-11 ID:SGTC_1729|Compound:st035615|FD-Score:7.90|P-value:2.18E-12 ID:SGTC_1730|Compound:st033808|FD-Score:5.11|P-value:3.73E-6 ID:SGTC_1736|Compound:st036774|FD-Score:6.31|P-value:1.58E-8 ID:SGTC_1750|Compound:st081859|FD-Score:4.54|P-value:3.45E-5 ID:SGTC_1818|Compound:st052136|FD-Score:-4.36|P-value:6.60E-5 ID:SGTC_1836|Compound:st055642|FD-Score:3.62|P-value:7.60E-4 ID:SGTC_1916|Compound:st067606|FD-Score:3.52|P-value:9.99E-4 ID:SGTC_1922|Compound:5578187|FD-Score:4.65|P-value:2.28E-5 ID:SGTC_2046|Compound:4110841|FD-Score:5.11|P-value:3.66E-6 ID:SGTC_2077|Compound:5212015|FD-Score:4.64|P-value:2.34E-5 ID:SGTC_2078|Compound:5212016|FD-Score:3.84|P-value:3.84E-4 ID:SGTC_2153|Compound:5569715|FD-Score:4.92|P-value:7.90E-6 ID:SGTC_2248|Compound:tofa|FD-Score:4.64|P-value:2.34E-5 ID:SGTC_2249|Compound:haloperidol|FD-Score:3.54|P-value:9.50E-4 ID:SGTC_2264|Compound:7948757|FD-Score:-4.09|P-value:1.73E-4 ID:SGTC_2275|Compound:7947463|FD-Score:11.70|P-value:6.77E-25 ID:SGTC_2276|Compound:7947513|FD-Score:4.92|P-value:7.86E-6 ID:SGTC_2291|Compound:7917025|FD-Score:10.10|P-value:5.02E-19 ID:SGTC_2371|Compound:9071574|FD-Score:5.81|P-value:1.73E-7 ID:SGTC_2389|Compound:9091542|FD-Score:8.47|P-value:5.53E-14 ID:SGTC_2398|Compound:5228213|FD-Score:3.55|P-value:9.27E-4 ID:SGTC_2399|Compound:5884133|FD-Score:3.85|P-value:3.69E-4 ID:SGTC_2416|Compound:tofa|FD-Score:4.38|P-value:6.09E-5 ID:SGTC_2432|Compound:5630864|FD-Score:-4.09|P-value:1.69E-4 ID:SGTC_2447|Compound:5741742|FD-Score:3.85|P-value:3.72E-4 ID:SGTC_2453|Compound:5731132|FD-Score:3.58|P-value:8.40E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:11.10|P-value:1.04E-22 ID:SGTC_2582|Compound:agaric acid|FD-Score:5.35|P-value:1.36E-6 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:3.73|P-value:5.33E-4 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:6.91|P-value:6.69E-10 ID:SGTC_2666|Compound:tannic acid|FD-Score:6.17|P-value:3.14E-8 ID:SGTC_2675|Compound:theaflavin digallate|FD-Score:5.44|P-value:9.01E-7 ID:SGTC_2679|Compound:rapamycin|FD-Score:3.86|P-value:3.52E-4 ID:SGTC_2710|Compound:st078562|FD-Score:5.06|P-value:4.56E-6 ID:SGTC_2713|Compound:st079149|FD-Score:3.83|P-value:3.85E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:10.20|P-value:2.02E-19 ID:SGTC_2767|Compound:sibutramine|FD-Score:5.44|P-value:9.09E-7 ID:SGTC_2853|Compound:9015042|FD-Score:-5.30|P-value:1.69E-6 ID:SGTC_2855|Compound:9016525|FD-Score:5.22|P-value:2.35E-6 ID:SGTC_2857|Compound:9024691|FD-Score:-9.14|P-value:5.94E-16 ID:SGTC_2858|Compound:9025781|FD-Score:23.00|P-value:1.19E-90 ID:SGTC_2859|Compound:9028643|FD-Score:-4.63|P-value:2.53E-5 ID:SGTC_2870|Compound:9038528|FD-Score:-3.71|P-value:5.79E-4 ID:SGTC_2875|Compound:9039966|FD-Score:3.69|P-value:6.13E-4 ID:SGTC_2884|Compound:9058502|FD-Score:3.72|P-value:5.52E-4 ID:SGTC_2929|Compound:9013348|FD-Score:-4.48|P-value:4.41E-5 ID:SGTC_2981|Compound:9013952|FD-Score:16.10|P-value:1.86E-45 ID:SGTC_2988|Compound:9073640|FD-Score:5.94|P-value:9.72E-8 ID:SGTC_2991|Compound:9074669|FD-Score:5.02|P-value:5.33E-6 ID:SGTC_2994|Compound:9053520|FD-Score:7.41|P-value:3.99E-11 ID:SGTC_3121|Compound:9125696|FD-Score:-3.55|P-value:9.45E-4 ID:SGTC_3142|Compound:9086498|FD-Score:4.33|P-value:7.36E-5 ID:SGTC_3170|Compound:9103054|FD-Score:-3.65|P-value:7.05E-4 ID:SGTC_3174|Compound:9107204|FD-Score:4.85|P-value:1.07E-5 ID:SGTC_3188|Compound:9110789|FD-Score:-3.58|P-value:8.58E-4 ID:SGTC_3200|Compound:9114385|FD-Score:3.90|P-value:3.13E-4 ID:SGTC_2|Compound:0422-0095|FD-Score:5.32|P-value:1.54E-6 ID:SGTC_29|Compound:0299-0004|FD-Score:3.89|P-value:3.26E-4 ID:SGTC_38|Compound:0929-0051|FD-Score:3.62|P-value:7.57E-4 ID:SGTC_44|Compound:0929-0055|FD-Score:4.22|P-value:1.07E-4 ID:SGTC_50|Compound:0929-0078|FD-Score:6.01|P-value:6.88E-8 ID:SGTC_56|Compound:0957-0365|FD-Score:7.92|P-value:1.94E-12 ID:SGTC_58|Compound:0957-0393|FD-Score:-6.56|P-value:4.48E-9 ID:SGTC_70|Compound:0141-0289|FD-Score:5.51|P-value:6.74E-7 ID:SGTC_153|Compound:4077-0274|FD-Score:3.78|P-value:4.58E-4 ID:SGTC_157|Compound:1348-1695|FD-Score:4.56|P-value:3.14E-5 ID:SGTC_164|Compound:4100-3994|FD-Score:8.39|P-value:9.70E-14 ID:SGTC_169|Compound:k015-0017|FD-Score:3.82|P-value:4.07E-4 ID:SGTC_204|Compound:1543-0184|FD-Score:7.89|P-value:2.25E-12 ID:SGTC_209|Compound:4077-0173|FD-Score:5.41|P-value:1.06E-6 ID:SGTC_263|Compound:alizarin|FD-Score:10.30|P-value:8.07E-20 ID:SGTC_308|Compound:4092-1169|FD-Score:6.94|P-value:5.72E-10 ID:SGTC_352|Compound:k048-0007|FD-Score:4.94|P-value:7.35E-6 ID:SGTC_374|Compound:0880-0231|FD-Score:5.11|P-value:3.78E-6 ID:SGTC_391|Compound:gliotoxin|FD-Score:17.40|P-value:1.01E-52 ID:SGTC_431|Compound:k089-0097|FD-Score:4.63|P-value:2.48E-5 ID:SGTC_488|Compound:nitrendipine|FD-Score:4.51|P-value:3.83E-5 ID:SGTC_524|Compound:r073-0010|FD-Score:5.89|P-value:1.18E-7 ID:SGTC_527|Compound:4476-4215|FD-Score:5.57|P-value:5.26E-7 ID:SGTC_528|Compound:3492-0019|FD-Score:7.74|P-value:5.86E-12 ID:SGTC_545|Compound:4218-0007|FD-Score:5.70|P-value:2.95E-7 ID:SGTC_562|Compound:3772-2733|FD-Score:3.68|P-value:6.27E-4 ID:SGTC_697|Compound:0508-1955|FD-Score:4.84|P-value:1.09E-5 ID:SGTC_699|Compound:0375-0592|FD-Score:3.84|P-value:3.79E-4 ID:SGTC_717|Compound:1532-0246|FD-Score:4.19|P-value:1.20E-4 ID:SGTC_768|Compound:0384-0033|FD-Score:7.12|P-value:2.17E-10 ID:SGTC_786|Compound:4544-0069|FD-Score:4.49|P-value:4.11E-5 ID:SGTC_841|Compound:0251-0215|FD-Score:10.30|P-value:7.97E-20 ID:SGTC_922|Compound:1866-0035|FD-Score:6.56|P-value:4.46E-9 ID:SGTC_950|Compound:1165-0508|FD-Score:5.05|P-value:4.79E-6 ID:SGTC_1017|Compound:4239-0030|FD-Score:3.75|P-value:4.99E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.42|P-value:5.45E-5 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:9.78|P-value:5.00E-18 ID:SGTC_1184|Compound:1269-1718|FD-Score:3.69|P-value:6.05E-4 ID:SGTC_1201|Compound:1889-3372|FD-Score:3.78|P-value:4.60E-4 ID:SGTC_1204|Compound:4049-0315|FD-Score:4.59|P-value:2.87E-5 ID:SGTC_1214|Compound:0358-0031|FD-Score:-3.55|P-value:9.41E-4 ID:SGTC_1415|Compound:3966-0071|FD-Score:4.20|P-value:1.13E-4 ID:SGTC_1417|Compound:3966-0327|FD-Score:5.35|P-value:1.34E-6 ID:SGTC_1429|Compound:4049-0205|FD-Score:5.15|P-value:3.08E-6 ID:SGTC_1481|Compound:3346-2004|FD-Score:-3.59|P-value:8.33E-4 ID:SGTC_1489|Compound:4065-0444|FD-Score:3.56|P-value:9.05E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:8.14|P-value:4.66E-13 ID:SGTC_1522|Compound:st012842|FD-Score:-3.89|P-value:3.25E-4 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:5.43|P-value:9.60E-7 ID:SGTC_1529|Compound:apigenin|FD-Score:5.00|P-value:5.86E-6 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:6.46|P-value:7.43E-9 ID:SGTC_1602|Compound:st001878|FD-Score:5.17|P-value:2.84E-6 ID:SGTC_1607|Compound:st000305|FD-Score:3.53|P-value:9.79E-4 ID:SGTC_1658|Compound:st012944|FD-Score:5.07|P-value:4.29E-6 ID:SGTC_1673|Compound:st016611|FD-Score:4.15|P-value:1.38E-4 ID:SGTC_1676|Compound:st018489|FD-Score:3.69|P-value:6.02E-4 ID:SGTC_1687|Compound:st020778|FD-Score:21.60|P-value:1.98E-80 ID:SGTC_1694|Compound:st024011|FD-Score:4.03|P-value:2.06E-4 ID:SGTC_1712|Compound:st032288|FD-Score:-4.36|P-value:6.60E-5 ID:SGTC_1727|Compound:st034309|FD-Score:7.39|P-value:4.60E-11 ID:SGTC_1729|Compound:st035615|FD-Score:7.90|P-value:2.18E-12 ID:SGTC_1730|Compound:st033808|FD-Score:5.11|P-value:3.73E-6 ID:SGTC_1736|Compound:st036774|FD-Score:6.31|P-value:1.58E-8 ID:SGTC_1750|Compound:st081859|FD-Score:4.54|P-value:3.45E-5 ID:SGTC_1818|Compound:st052136|FD-Score:-4.36|P-value:6.60E-5 ID:SGTC_1836|Compound:st055642|FD-Score:3.62|P-value:7.60E-4 ID:SGTC_1916|Compound:st067606|FD-Score:3.52|P-value:9.99E-4 ID:SGTC_1922|Compound:5578187|FD-Score:4.65|P-value:2.28E-5 ID:SGTC_2046|Compound:4110841|FD-Score:5.11|P-value:3.66E-6 ID:SGTC_2077|Compound:5212015|FD-Score:4.64|P-value:2.34E-5 ID:SGTC_2078|Compound:5212016|FD-Score:3.84|P-value:3.84E-4 ID:SGTC_2153|Compound:5569715|FD-Score:4.92|P-value:7.90E-6 ID:SGTC_2248|Compound:tofa|FD-Score:4.64|P-value:2.34E-5 ID:SGTC_2249|Compound:haloperidol|FD-Score:3.54|P-value:9.50E-4 ID:SGTC_2264|Compound:7948757|FD-Score:-4.09|P-value:1.73E-4 ID:SGTC_2275|Compound:7947463|FD-Score:11.70|P-value:6.77E-25 ID:SGTC_2276|Compound:7947513|FD-Score:4.92|P-value:7.86E-6 ID:SGTC_2291|Compound:7917025|FD-Score:10.10|P-value:5.02E-19 ID:SGTC_2371|Compound:9071574|FD-Score:5.81|P-value:1.73E-7 ID:SGTC_2389|Compound:9091542|FD-Score:8.47|P-value:5.53E-14 ID:SGTC_2398|Compound:5228213|FD-Score:3.55|P-value:9.27E-4 ID:SGTC_2399|Compound:5884133|FD-Score:3.85|P-value:3.69E-4 ID:SGTC_2416|Compound:tofa|FD-Score:4.38|P-value:6.09E-5 ID:SGTC_2432|Compound:5630864|FD-Score:-4.09|P-value:1.69E-4 ID:SGTC_2447|Compound:5741742|FD-Score:3.85|P-value:3.72E-4 ID:SGTC_2453|Compound:5731132|FD-Score:3.58|P-value:8.40E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:11.10|P-value:1.04E-22 ID:SGTC_2582|Compound:agaric acid|FD-Score:5.35|P-value:1.36E-6 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:3.73|P-value:5.33E-4 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:6.91|P-value:6.69E-10 ID:SGTC_2666|Compound:tannic acid|FD-Score:6.17|P-value:3.14E-8 ID:SGTC_2675|Compound:theaflavin digallate|FD-Score:5.44|P-value:9.01E-7 ID:SGTC_2679|Compound:rapamycin|FD-Score:3.86|P-value:3.52E-4 ID:SGTC_2710|Compound:st078562|FD-Score:5.06|P-value:4.56E-6 ID:SGTC_2713|Compound:st079149|FD-Score:3.83|P-value:3.85E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:10.20|P-value:2.02E-19 ID:SGTC_2767|Compound:sibutramine|FD-Score:5.44|P-value:9.09E-7 ID:SGTC_2853|Compound:9015042|FD-Score:-5.30|P-value:1.69E-6 ID:SGTC_2855|Compound:9016525|FD-Score:5.22|P-value:2.35E-6 ID:SGTC_2857|Compound:9024691|FD-Score:-9.14|P-value:5.94E-16 ID:SGTC_2858|Compound:9025781|FD-Score:23.00|P-value:1.19E-90 ID:SGTC_2859|Compound:9028643|FD-Score:-4.63|P-value:2.53E-5 ID:SGTC_2870|Compound:9038528|FD-Score:-3.71|P-value:5.79E-4 ID:SGTC_2875|Compound:9039966|FD-Score:3.69|P-value:6.13E-4 ID:SGTC_2884|Compound:9058502|FD-Score:3.72|P-value:5.52E-4 ID:SGTC_2929|Compound:9013348|FD-Score:-4.48|P-value:4.41E-5 ID:SGTC_2981|Compound:9013952|FD-Score:16.10|P-value:1.86E-45 ID:SGTC_2988|Compound:9073640|FD-Score:5.94|P-value:9.72E-8 ID:SGTC_2991|Compound:9074669|FD-Score:5.02|P-value:5.33E-6 ID:SGTC_2994|Compound:9053520|FD-Score:7.41|P-value:3.99E-11 ID:SGTC_3121|Compound:9125696|FD-Score:-3.55|P-value:9.45E-4 ID:SGTC_3142|Compound:9086498|FD-Score:4.33|P-value:7.36E-5 ID:SGTC_3170|Compound:9103054|FD-Score:-3.65|P-value:7.05E-4 ID:SGTC_3174|Compound:9107204|FD-Score:4.85|P-value:1.07E-5 ID:SGTC_3188|Compound:9110789|FD-Score:-3.58|P-value:8.58E-4 ID:SGTC_3200|Compound:9114385|FD-Score:3.90|P-value:3.13E-4

Top fitness defect scores for YJR033C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2858 9025781 23.00 9.0 µM 1.19E-90 sphingolipid biosynthesis & PDR1 2 2.68E-117
2 SGTC_1687 st020778 21.60 55.4 µM 1.98E-80 7 5.28E-104
3 SGTC_391 gliotoxin 17.40 8.3 µM 1.01E-52 3 5.72E-68
4 SGTC_2981 9013952 16.10 39.0 µM 1.86E-45 1 1.59E-58
5 SGTC_2275 7947463 11.70 200.0 µM 6.77E-25 iron homeostasis 3 8.36E-32
6 SGTC_2567 aureobasidin a 11.10 60.0 nM 1.04E-22 11 5.76E-29
7 SGTC_841 0251-0215 10.30 91.2 µM 7.97E-20 13 3.20E-25
8 SGTC_263 alizarin 10.30 107.9 µM 8.07E-20 iron homeostasis 3 3.26E-25
9 SGTC_2752 diclazuril 10.20 33.1 µM 2.02E-19 22 1.07E-24
10 SGTC_2291 7917025 10.10 104.3 µM 5.02E-19 iron homeostasis 6 3.49E-24
11 SGTC_1110 3-hydroxy-3'-methoxyflavone 9.78 1.2 µM 5.00E-18 iron homeostasis 2 6.88E-23
12 SGTC_2389 9091542 8.47 195.5 µM 5.53E-14 iron homeostasis 6 1.21E-17
13 SGTC_164 4100-3994 8.39 89.6 µM 9.70E-14 1 2.51E-17
14 SGTC_1495 4469-0029 8.14 237.0 µM 4.66E-13 23 1.92E-16
15 SGTC_56 0957-0365 7.92 83.2 µM 1.94E-12 Golgi 12 1.22E-15
16 SGTC_1729 st035615 7.90 46.0 µM 2.18E-12 4 1.41E-15
17 SGTC_204 1543-0184 7.89 62.4 µM 2.25E-12 TRP & mitochondrial translation 6 1.47E-15
18 SGTC_528 3492-0019 7.74 172.0 µM 5.86E-12 calcium & mitochondrial duress 79 5.10E-15
19 SGTC_2994 9053520 7.41 71.4 µM 3.99E-11 RPP1 & pyrimidine depletion 1 6.11E-14
20 SGTC_1727 st034309 7.39 9.9 µM 4.60E-11 1 7.35E-14

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.470 4.99E-184 YDR203W_d YDR203W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.354 1.11E-99 YDR202C RAV2 hom Subunit of RAVE (Rav1p, Rav2p, Skp1p), a complex that associates with the V1 domain of the vacuolar membrane (H+)-ATPase (V-ATPase) and promotes assembly and reassembly of the holoenzyme
0.309 1.51E-74 YMR123W PKR1 hom V-ATPase assembly factor; functions with other V-ATPase assembly factors in the ER to efficiently assemble the V-ATPase membrane sector (V0); protein abundance increases in response to DNA replication stress
0.304 1.27E-72 YDL192W ARF1 hom ADP-ribosylation factor; GTPase of the Ras superfamily involved in regulation of coated vesicle formation in intracellular trafficking within the Golgi; ARF1 has a paralog, ARF2, that arose from the whole genome duplication
0.300 5.83E-71 YDR080W VPS41 hom Vacuolar membrane protein that is a subunit of the homotypic vacuole fusion and vacuole protein sorting (HOPS) complex; essential for membrane docking and fusion at the Golgi-to-endosome and endosome-to-vacuole stages of protein transport
0.297 1.75E-69 YJR040W GEF1 hom Voltage-gated chloride channel localized to the golgi, the endosomal system, and plasma membrane, and involved in cation homeostasis; highly homologous to vertebrate voltage-gated chloride channels; modulates TBSV model (+) RNA virus replication by regulating copper metabolism
0.288 6.83E-65 YGL212W VAM7 hom Vacuolar SNARE protein; functions with Vam3p in vacuolar protein trafficking; has an N-terminal PX domain (phosphoinositide-binding module) that binds PtdIns-3-P and mediates membrane binding; SNAP-25 homolog; protein abundance increases in response to DNA replication stress
0.276 9.98E-60 YKL077W_p YKL077W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole
0.258 3.53E-52 YJL024C APS3 hom Small subunit of the clathrin-associated adaptor complex AP-3; involved in vacuolar protein sorting; related to the sigma subunit of the mammalian clathrin AP-3 complex; suppressor of loss of casein kinase 1 function; protein abundance increases in response to DNA replication stress
0.256 3.51E-51 YML001W YPT7 hom Rab family GTPase; GTP-binding protein of the rab family; required for homotypic fusion event in vacuole inheritance, for endosome-endosome fusion; interacts with the cargo selection/retromer complex for retrograde sorting; similar to mammalian Rab7
0.256 3.31E-51 YGR261C APL6 hom Beta3-like subunit of the yeast AP-3 complex; functions in transport of alkaline phosphatase to the vacuole via the alternate pathway; exists in both cytosolic and peripherally associated membrane-bound pools
0.253 3.24E-50 YDL077C VAM6 hom Vacuolar protein that plays a critical role in the tethering steps of vacuolar membrane fusion by facilitating guanine nucleotide exchange on small guanosine triphosphatase Ypt7p
0.253 6.71E-50 YJL094C KHA1 hom Putative K+/H+ antiporter with a probable role in intracellular cation homeostasis, localized to Golgi vesicles and detected in highly purified mitochondria in high-throughput studies
0.249 1.57E-48 YDR270W CCC2 hom Cu(+2)-transporting P-type ATPase; required for export of copper from the cytosol into an extracytosolic compartment; has similarity to human proteins involved in Menkes and Wilsons diseases; protein abundance increases in response to DNA replication stress; affects TBSV model (+)RNA virus replication by regulating copper metabolism
0.244 1.21E-46 YMR058W FET3 hom Ferro-O2-oxidoreductase; required for high-affinity iron uptake and involved in mediating resistance to copper ion toxicity, belongs to class of integral membrane multicopper oxidases; protein abundance increases in response to DNA replication stress