YJR034W / PET191

Protein required for assembly of cytochrome c oxidase; exists as an oligomer; described as both an integral mitochondrial inner membrane protein facing the intermembrane space (IMS) and as a soluble IMS protein; contains a twin Cx9C motif; imported into the IMS via the MIA import machinery

Zygosity: Homozygous strain
fixedexpanded
Profile for YJR034W / PET191

Click on Significant Values for Screen Details ID:SGTC_100|Compound:0086-0128|FD-Score:3.49|P-value:3.71E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:4.00|P-value:5.34E-5 ID:SGTC_119|Compound:0121-0043|FD-Score:4.24|P-value:2.03E-5 ID:SGTC_134|Compound:0269-0018|FD-Score:3.88|P-value:8.79E-5 ID:SGTC_148|Compound:3253-0744|FD-Score:3.27|P-value:7.89E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:-3.58|P-value:2.39E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:5.41|P-value:8.05E-8 ID:SGTC_236|Compound:1509-0011|FD-Score:11.60|P-value:1.49E-29 ID:SGTC_310|Compound:1273-0058|FD-Score:8.82|P-value:5.95E-18 ID:SGTC_386|Compound:1509-0011|FD-Score:3.69|P-value:1.82E-4 ID:SGTC_565|Compound:1418-0001|FD-Score:3.63|P-value:2.21E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:-3.25|P-value:7.76E-4 ID:SGTC_588|Compound:3970-1144|FD-Score:-3.17|P-value:9.88E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:-3.59|P-value:2.36E-4 ID:SGTC_679|Compound:0422-0091|FD-Score:5.34|P-value:1.19E-7 ID:SGTC_738|Compound:1315-0003|FD-Score:3.37|P-value:5.51E-4 ID:SGTC_770|Compound:0389-1121|FD-Score:3.44|P-value:4.39E-4 ID:SGTC_964|Compound:1287-0107|FD-Score:-3.37|P-value:5.10E-4 ID:SGTC_975|Compound:1335-0046|FD-Score:3.37|P-value:5.59E-4 ID:SGTC_1049|Compound:3226-0134|FD-Score:-3.37|P-value:5.05E-4 ID:SGTC_1131|Compound:3454-3128|FD-Score:3.25|P-value:8.44E-4 ID:SGTC_1393|Compound:3470-5649|FD-Score:-3.21|P-value:8.83E-4 ID:SGTC_1481|Compound:3346-2004|FD-Score:3.22|P-value:9.29E-4 ID:SGTC_1514|Compound:1189-1591|FD-Score:5.65|P-value:2.19E-8 ID:SGTC_1782|Compound:st039423|FD-Score:5.43|P-value:7.43E-8 ID:SGTC_1787|Compound:fluconazole|FD-Score:-4.10|P-value:3.24E-5 ID:SGTC_1865|Compound:st057639|FD-Score:3.88|P-value:8.57E-5 ID:SGTC_2075|Compound:5212009|FD-Score:-3.21|P-value:8.85E-4 ID:SGTC_2077|Compound:5212015|FD-Score:3.22|P-value:9.20E-4 ID:SGTC_2092|Compound:5303694|FD-Score:5.17|P-value:2.77E-7 ID:SGTC_2156|Compound:5649887|FD-Score:4.15|P-value:3.00E-5 ID:SGTC_2312|Compound:7706453|FD-Score:-3.45|P-value:3.83E-4 ID:SGTC_2315|Compound:7733312|FD-Score:6.85|P-value:1.65E-11 ID:SGTC_2336|Compound:9001819|FD-Score:-3.65|P-value:1.89E-4 ID:SGTC_2343|Compound:7990716|FD-Score:-3.68|P-value:1.68E-4 ID:SGTC_2378|Compound:9074213|FD-Score:3.31|P-value:6.96E-4 ID:SGTC_2426|Compound:5582046|FD-Score:7.16|P-value:1.96E-12 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:3.94|P-value:6.92E-5 ID:SGTC_2506|Compound:ethyl hematommate|FD-Score:3.49|P-value:3.75E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:3.60|P-value:2.46E-4 ID:SGTC_2705|Compound:st078069|FD-Score:3.37|P-value:5.68E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:-4.74|P-value:1.95E-6 ID:SGTC_2902|Compound:5787006|FD-Score:4.12|P-value:3.33E-5 ID:SGTC_2954|Compound:9074818|FD-Score:4.29|P-value:1.67E-5 ID:SGTC_2961|Compound:9083290|FD-Score:3.46|P-value:4.08E-4 ID:SGTC_2962|Compound:9082311|FD-Score:3.55|P-value:3.02E-4 ID:SGTC_2989|Compound:9073649|FD-Score:-3.33|P-value:5.76E-4 ID:SGTC_2991|Compound:9074669|FD-Score:3.77|P-value:1.35E-4 ID:SGTC_3058|Compound:9093861|FD-Score:3.36|P-value:5.78E-4 ID:SGTC_3140|Compound:9094243|FD-Score:4.92|P-value:9.48E-7 ID:SGTC_3144|Compound:9087057|FD-Score:3.78|P-value:1.28E-4 ID:SGTC_3197|Compound:9113331|FD-Score:-3.97|P-value:5.46E-5 ID:SGTC_3209|Compound:9113616|FD-Score:3.51|P-value:3.40E-4 ID:SGTC_3308|Compound:9128332|FD-Score:3.40|P-value:5.01E-4 ID:SGTC_100|Compound:0086-0128|FD-Score:3.49|P-value:3.71E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:4.00|P-value:5.34E-5 ID:SGTC_119|Compound:0121-0043|FD-Score:4.24|P-value:2.03E-5 ID:SGTC_134|Compound:0269-0018|FD-Score:3.88|P-value:8.79E-5 ID:SGTC_148|Compound:3253-0744|FD-Score:3.27|P-value:7.89E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:-3.58|P-value:2.39E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:5.41|P-value:8.05E-8 ID:SGTC_236|Compound:1509-0011|FD-Score:11.60|P-value:1.49E-29 ID:SGTC_310|Compound:1273-0058|FD-Score:8.82|P-value:5.95E-18 ID:SGTC_386|Compound:1509-0011|FD-Score:3.69|P-value:1.82E-4 ID:SGTC_565|Compound:1418-0001|FD-Score:3.63|P-value:2.21E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:-3.25|P-value:7.76E-4 ID:SGTC_588|Compound:3970-1144|FD-Score:-3.17|P-value:9.88E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:-3.59|P-value:2.36E-4 ID:SGTC_679|Compound:0422-0091|FD-Score:5.34|P-value:1.19E-7 ID:SGTC_738|Compound:1315-0003|FD-Score:3.37|P-value:5.51E-4 ID:SGTC_770|Compound:0389-1121|FD-Score:3.44|P-value:4.39E-4 ID:SGTC_964|Compound:1287-0107|FD-Score:-3.37|P-value:5.10E-4 ID:SGTC_975|Compound:1335-0046|FD-Score:3.37|P-value:5.59E-4 ID:SGTC_1049|Compound:3226-0134|FD-Score:-3.37|P-value:5.05E-4 ID:SGTC_1131|Compound:3454-3128|FD-Score:3.25|P-value:8.44E-4 ID:SGTC_1393|Compound:3470-5649|FD-Score:-3.21|P-value:8.83E-4 ID:SGTC_1481|Compound:3346-2004|FD-Score:3.22|P-value:9.29E-4 ID:SGTC_1514|Compound:1189-1591|FD-Score:5.65|P-value:2.19E-8 ID:SGTC_1782|Compound:st039423|FD-Score:5.43|P-value:7.43E-8 ID:SGTC_1787|Compound:fluconazole|FD-Score:-4.10|P-value:3.24E-5 ID:SGTC_1865|Compound:st057639|FD-Score:3.88|P-value:8.57E-5 ID:SGTC_2075|Compound:5212009|FD-Score:-3.21|P-value:8.85E-4 ID:SGTC_2077|Compound:5212015|FD-Score:3.22|P-value:9.20E-4 ID:SGTC_2092|Compound:5303694|FD-Score:5.17|P-value:2.77E-7 ID:SGTC_2156|Compound:5649887|FD-Score:4.15|P-value:3.00E-5 ID:SGTC_2312|Compound:7706453|FD-Score:-3.45|P-value:3.83E-4 ID:SGTC_2315|Compound:7733312|FD-Score:6.85|P-value:1.65E-11 ID:SGTC_2336|Compound:9001819|FD-Score:-3.65|P-value:1.89E-4 ID:SGTC_2343|Compound:7990716|FD-Score:-3.68|P-value:1.68E-4 ID:SGTC_2378|Compound:9074213|FD-Score:3.31|P-value:6.96E-4 ID:SGTC_2426|Compound:5582046|FD-Score:7.16|P-value:1.96E-12 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:3.94|P-value:6.92E-5 ID:SGTC_2506|Compound:ethyl hematommate|FD-Score:3.49|P-value:3.75E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:3.60|P-value:2.46E-4 ID:SGTC_2705|Compound:st078069|FD-Score:3.37|P-value:5.68E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:-4.74|P-value:1.95E-6 ID:SGTC_2902|Compound:5787006|FD-Score:4.12|P-value:3.33E-5 ID:SGTC_2954|Compound:9074818|FD-Score:4.29|P-value:1.67E-5 ID:SGTC_2961|Compound:9083290|FD-Score:3.46|P-value:4.08E-4 ID:SGTC_2962|Compound:9082311|FD-Score:3.55|P-value:3.02E-4 ID:SGTC_2989|Compound:9073649|FD-Score:-3.33|P-value:5.76E-4 ID:SGTC_2991|Compound:9074669|FD-Score:3.77|P-value:1.35E-4 ID:SGTC_3058|Compound:9093861|FD-Score:3.36|P-value:5.78E-4 ID:SGTC_3140|Compound:9094243|FD-Score:4.92|P-value:9.48E-7 ID:SGTC_3144|Compound:9087057|FD-Score:3.78|P-value:1.28E-4 ID:SGTC_3197|Compound:9113331|FD-Score:-3.97|P-value:5.46E-5 ID:SGTC_3209|Compound:9113616|FD-Score:3.51|P-value:3.40E-4 ID:SGTC_3308|Compound:9128332|FD-Score:3.40|P-value:5.01E-4

Top fitness defect scores for YJR034W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_236 1509-0011 11.60 5.3 µM 1.49E-29 158 2.66E-31
2 SGTC_310 1273-0058 8.82 1.1 µM 5.95E-18 mitochondrial stress 68 5.51E-19
3 SGTC_2426 5582046 7.16 32.2 µM 1.96E-12 3 3.98E-13
4 SGTC_2315 7733312 6.85 200.0 µM 1.65E-11 4 3.81E-12
5 SGTC_1514 1189-1591 5.65 158.0 µM 2.19E-8 13 7.88E-9
6 SGTC_1782 st039423 5.43 80.6 µM 7.43E-8 2 2.89E-8
7 SGTC_173 1273-0061 5.41 2.7 µM 8.05E-8 mitochondrial stress 127 3.14E-8
8 SGTC_679 0422-0091 5.34 41.4 µM 1.19E-7 Golgi 11 4.74E-8
9 SGTC_2092 5303694 5.17 80.7 µM 2.77E-7 TSC3-RPN4 12 1.17E-7
10 SGTC_3140 9094243 4.92 49.5 µM 9.48E-7 15 4.31E-7
11 SGTC_2954 9074818 4.29 52.7 µM 1.67E-5 30 9.06E-6
12 SGTC_119 0121-0043 4.24 24.8 µM 2.03E-5 mitochondrial stress 89 1.11E-5
13 SGTC_2156 5649887 4.15 115.0 µM 3.00E-5 RPP1 & pyrimidine depletion 8 1.68E-5
14 SGTC_2902 5787006 4.12 60.5 µM 3.33E-5 Golgi 25 1.88E-5
15 SGTC_118 0083-0097 4.00 135.3 µM 5.34E-5 translation 127 3.11E-5
16 SGTC_2501 sodium tetradecyl sulfate 3.94 13.4 µM 6.92E-5 32 4.09E-5
17 SGTC_1865 st057639 3.88 52.2 µM 8.57E-5 12 5.13E-5
18 SGTC_134 0269-0018 3.88 6.9 µM 8.79E-5 138 5.27E-5
19 SGTC_3144 9087057 3.78 49.5 µM 1.28E-4 15 7.83E-5
20 SGTC_2991 9074669 3.77 71.4 µM 1.35E-4 azole & statin 74 8.30E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.365 1.49E-106 YML129C COX14 hom Mitochondrial membrane protein, involved in translational regulation of Cox1p and assembly of cytochrome c oxidase (complex IV); associates with complex IV assembly intermediates and complex III/complex IV supercomplexes
0.361 9.88E-104 YGR220C MRPL9 hom Mitochondrial ribosomal protein of the large subunit
0.358 2.17E-101 YMR287C DSS1 hom 3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs
0.350 3.53E-97 YJL023C PET130 hom Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.343 4.44E-93 YHL038C CBP2 hom Required for splicing of the group I intron bI5 of the COB pre-mRNA; nuclear-encoded mitochondrial protein that binds to the RNA to promote splicing; also involved in but not essential for splicing of the COB bI2 intron and the intron in the 21S rRNA gene
0.341 2.22E-92 YDR079W PET100 hom Chaperone that specifically facilitates the assembly of cytochrome c oxidase, integral to the mitochondrial inner membrane; interacts with a subcomplex of subunits VII, VIIa, and VIII (Cox7p, Cox9p, and Cox8p) but not with the holoenzyme
0.340 2.25E-91 YDR518W EUG1 hom Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER
0.339 8.41E-91 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.336 3.96E-89 YDR230W_d YDR230W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.334 2.70E-88 YPL132W COX11 hom Mitochondrial inner membrane protein required for delivery of copper to the Cox1p subunit of cytochrome c oxidase; association with mitochondrial ribosomes suggests that copper delivery may occur during translation of Cox1p
0.332 5.39E-87 YDR231C COX20 hom Mitochondrial inner membrane protein, required for proteolytic processing of Cox2p and its assembly into cytochrome c oxidase
0.330 4.60E-86 YMR035W IMP2 hom Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
0.326 5.92E-84 YIR021W MRS1 hom Protein required for the splicing of two mitochondrial group I introns (BI3 in COB and AI5beta in COX1); forms a splicing complex, containing four subunits of Mrs1p and two subunits of the BI3-encoded maturase, that binds to the BI3 RNA
0.320 6.38E-81 YPL078C ATP4 hom Subunit b of the stator stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; contributes to the oligomerization of the complex; phosphorylated
0.319 1.76E-80 YLL033W IRC19 hom Putative protein of unknown function; YLL033W is not an essential gene but mutant is defective in spore formation; null mutant displays increased levels of spontaneous Rad52p foci