HIPHOP chemogenomics database
YJR035W / RAD26 
Protein involved in transcription-coupled nucleotide excision repair of UV-induced DNA lesions; recruitment to DNA lesions is dependent on an elongating RNA polymerase II; homolog of human CSB protein
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YJR035W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.138 | 9.12E-16 | YER176W | ECM32 | hom | DNA dependent ATPase/DNA helicase belonging to the Dna2p- and Nam7p-like family of helicases that is involved in modulating translation termination; interacts with the translation termination factors, localized to polysomes |
| 0.112 | 8.37E-11 | YKL140W | TGL1 | hom | Steryl ester hydrolase, one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes |
| 0.112 | 8.71E-11 | YGR034W | RPL26B | hom | Ribosomal 60S subunit protein L26B; binds to 5.8S rRNA; homologous to mammalian ribosomal protein L26 and bacterial L24; RPL26B has a paralog, RPL26A, that arose from the whole genome duplication |
| 0.111 | 1.30E-10 | YOL061W | PRS5 | hom | 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase; synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes; forms cytoplasmic foci upon DNA replication stress |
| 0.110 | 1.51E-10 | YLR363W-A | YLR363W-A | hom | Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; relocalizes from nucleus to nucleolus upon DNA replication stress |
| 0.109 | 2.20E-10 | YDL215C | GDH2 | hom | NAD(+)-dependent glutamate dehydrogenase, degrades glutamate to ammonia and alpha-ketoglutarate; expression sensitive to nitrogen catabolite repression and intracellular ammonia levels |
| 0.104 | 2.04E-9 | YFL010C | WWM1 | hom | WW domain containing protein of unknown function; binds to Mca1p, a caspase-related protease that regulates H2O2-induced apoptosis; overexpression causes G1 phase growth arrest and clonal death that is suppressed by overexpression of MCA1 |
| 0.102 | 2.73E-9 | YNL092W_p | YNL092W_p | hom | Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; YNL092W is not an essential gene |
| 0.100 | 7.47E-9 | YBR074W_p | YBR074W_p | hom | Putative metalloprotease |
| 0.094 | 4.40E-8 | YGR196C | FYV8 | hom | Protein of unknown function, required for survival upon exposure to K1 killer toxin |
| 0.093 | 7.66E-8 | YMR074C | YMR074C | hom | Protein with homology to human PDCD5; PDCD5 is involved in programmed cell death; N-terminal region forms a conserved triple-helix bundle structure; overexpression promotes H2O2-induced apoptosis; YMR074C is not an essential gene; protein abundance increases in response to DNA replication stress |
| 0.092 | 9.63E-8 | YKR004C | ECM9 | het | Non-essential protein of unknown function |
| 0.090 | 1.94E-7 | YER003C | PMI40 | het | Mannose-6-phosphate isomerase, catalyzes the interconversion of fructose-6-P and mannose-6-P; required for early steps in protein mannosylation |
| 0.085 | 7.35E-7 | YAL016C-B_d | YAL016C-B_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data |
| 0.084 | 1.22E-6 | YER109C | FLO8 | hom | Transcription factor required for flocculation, diploid filamentous growth, and haploid invasive growth; genome reference strain S288C and most laboratory strains have a mutation in this gene |