YJR035W / RAD26

Protein involved in transcription-coupled nucleotide excision repair of UV-induced DNA lesions; recruitment to DNA lesions is dependent on an elongating RNA polymerase II; homolog of human CSB protein

Zygosity: Homozygous strain
fixedexpanded
Profile for YJR035W / RAD26

Click on Significant Values for Screen Details ID:SGTC_96|Compound:0929-0093|FD-Score:-3.04|P-value:6.96E-4 ID:SGTC_97|Compound:0535-0701|FD-Score:-3.27|P-value:2.98E-4 ID:SGTC_217|Compound:ketoconazole|FD-Score:3.12|P-value:3.69E-4 ID:SGTC_350|Compound:k064-0020|FD-Score:2.98|P-value:6.46E-4 ID:SGTC_433|Compound:pimozide|FD-Score:-3.24|P-value:3.32E-4 ID:SGTC_439|Compound:amiodarone|FD-Score:3.03|P-value:5.36E-4 ID:SGTC_793|Compound:0488-0545|FD-Score:2.99|P-value:6.06E-4 ID:SGTC_892|Compound:0929-0076|FD-Score:-3.08|P-value:6.00E-4 ID:SGTC_905|Compound:2-aminofluorene|FD-Score:-3.80|P-value:3.15E-5 ID:SGTC_939|Compound:1165-0479|FD-Score:4.95|P-value:5.10E-8 ID:SGTC_947|Compound:3447-0010|FD-Score:-3.11|P-value:5.40E-4 ID:SGTC_948|Compound:3448-0295|FD-Score:-6.31|P-value:1.27E-11 ID:SGTC_952|Compound:1185-0122|FD-Score:-6.39|P-value:7.08E-12 ID:SGTC_1091|Compound:telmisartan|FD-Score:3.64|P-value:4.29E-5 ID:SGTC_1248|Compound:0469-0687|FD-Score:3.04|P-value:5.15E-4 ID:SGTC_1255|Compound:0566-0045|FD-Score:3.17|P-value:3.07E-4 ID:SGTC_1259|Compound:0671-0132|FD-Score:3.30|P-value:1.82E-4 ID:SGTC_1271|Compound:0832-2808|FD-Score:2.95|P-value:7.18E-4 ID:SGTC_1292|Compound:0kpi-0043|FD-Score:3.46|P-value:9.43E-5 ID:SGTC_1294|Compound:1000-1494|FD-Score:2.88|P-value:9.31E-4 ID:SGTC_1520|Compound:flindersine|FD-Score:3.28|P-value:2.00E-4 ID:SGTC_1529|Compound:apigenin|FD-Score:4.41|P-value:1.05E-6 ID:SGTC_1538|Compound:2',3',6-trimethoxyflavanone|FD-Score:-3.23|P-value:3.38E-4 ID:SGTC_1583|Compound:clindamycin|FD-Score:3.27|P-value:2.09E-4 ID:SGTC_1636|Compound:st007707|FD-Score:4.45|P-value:8.37E-7 ID:SGTC_1839|Compound:st053978|FD-Score:3.18|P-value:2.99E-4 ID:SGTC_1840|Compound:st055363|FD-Score:3.70|P-value:3.34E-5 ID:SGTC_1908|Compound:st060353|FD-Score:3.06|P-value:4.73E-4 ID:SGTC_1914|Compound:st062367|FD-Score:3.18|P-value:2.99E-4 ID:SGTC_2009|Compound:4012297|FD-Score:-3.05|P-value:6.69E-4 ID:SGTC_2026|Compound:5148700|FD-Score:-3.57|P-value:8.61E-5 ID:SGTC_2028|Compound:5153890|FD-Score:-3.05|P-value:6.86E-4 ID:SGTC_2035|Compound:5154463|FD-Score:3.35|P-value:1.48E-4 ID:SGTC_2036|Compound:5160441|FD-Score:-3.84|P-value:2.56E-5 ID:SGTC_2038|Compound:4100038|FD-Score:3.43|P-value:1.08E-4 ID:SGTC_2042|Compound:p-Dimethylaminoacetophenone|FD-Score:-5.05|P-value:4.83E-8 ID:SGTC_2054|Compound:5233173|FD-Score:3.21|P-value:2.63E-4 ID:SGTC_2059|Compound:5238311|FD-Score:3.34|P-value:1.58E-4 ID:SGTC_2096|Compound:5468907|FD-Score:3.42|P-value:1.11E-4 ID:SGTC_2211|Compound:7117706|FD-Score:3.06|P-value:4.70E-4 ID:SGTC_2280|Compound:7785178|FD-Score:-3.04|P-value:7.07E-4 ID:SGTC_2395|Compound:5646831|FD-Score:3.71|P-value:3.10E-5 ID:SGTC_2399|Compound:5884133|FD-Score:4.37|P-value:1.27E-6 ID:SGTC_2448|Compound:5185112|FD-Score:3.13|P-value:3.54E-4 ID:SGTC_2739|Compound:tacrine|FD-Score:3.70|P-value:3.38E-5 ID:SGTC_2830|Compound:7992007|FD-Score:-3.43|P-value:1.56E-4 ID:SGTC_2832|Compound:7992762|FD-Score:9.90|P-value:1.57E-26 ID:SGTC_2844|Compound:9010103|FD-Score:3.04|P-value:5.14E-4 ID:SGTC_2847|Compound:9005661|FD-Score:5.66|P-value:6.29E-10 ID:SGTC_3081|Compound:9117243|FD-Score:3.45|P-value:9.84E-5 ID:SGTC_3103|Compound:9120822|FD-Score:3.84|P-value:1.73E-5 ID:SGTC_3268|Compound:9137683|FD-Score:-3.00|P-value:8.17E-4 ID:SGTC_3319|Compound:9138450|FD-Score:3.38|P-value:1.33E-4 ID:SGTC_96|Compound:0929-0093|FD-Score:-3.04|P-value:6.96E-4 ID:SGTC_97|Compound:0535-0701|FD-Score:-3.27|P-value:2.98E-4 ID:SGTC_217|Compound:ketoconazole|FD-Score:3.12|P-value:3.69E-4 ID:SGTC_350|Compound:k064-0020|FD-Score:2.98|P-value:6.46E-4 ID:SGTC_433|Compound:pimozide|FD-Score:-3.24|P-value:3.32E-4 ID:SGTC_439|Compound:amiodarone|FD-Score:3.03|P-value:5.36E-4 ID:SGTC_793|Compound:0488-0545|FD-Score:2.99|P-value:6.06E-4 ID:SGTC_892|Compound:0929-0076|FD-Score:-3.08|P-value:6.00E-4 ID:SGTC_905|Compound:2-aminofluorene|FD-Score:-3.80|P-value:3.15E-5 ID:SGTC_939|Compound:1165-0479|FD-Score:4.95|P-value:5.10E-8 ID:SGTC_947|Compound:3447-0010|FD-Score:-3.11|P-value:5.40E-4 ID:SGTC_948|Compound:3448-0295|FD-Score:-6.31|P-value:1.27E-11 ID:SGTC_952|Compound:1185-0122|FD-Score:-6.39|P-value:7.08E-12 ID:SGTC_1091|Compound:telmisartan|FD-Score:3.64|P-value:4.29E-5 ID:SGTC_1248|Compound:0469-0687|FD-Score:3.04|P-value:5.15E-4 ID:SGTC_1255|Compound:0566-0045|FD-Score:3.17|P-value:3.07E-4 ID:SGTC_1259|Compound:0671-0132|FD-Score:3.30|P-value:1.82E-4 ID:SGTC_1271|Compound:0832-2808|FD-Score:2.95|P-value:7.18E-4 ID:SGTC_1292|Compound:0kpi-0043|FD-Score:3.46|P-value:9.43E-5 ID:SGTC_1294|Compound:1000-1494|FD-Score:2.88|P-value:9.31E-4 ID:SGTC_1520|Compound:flindersine|FD-Score:3.28|P-value:2.00E-4 ID:SGTC_1529|Compound:apigenin|FD-Score:4.41|P-value:1.05E-6 ID:SGTC_1538|Compound:2',3',6-trimethoxyflavanone|FD-Score:-3.23|P-value:3.38E-4 ID:SGTC_1583|Compound:clindamycin|FD-Score:3.27|P-value:2.09E-4 ID:SGTC_1636|Compound:st007707|FD-Score:4.45|P-value:8.37E-7 ID:SGTC_1839|Compound:st053978|FD-Score:3.18|P-value:2.99E-4 ID:SGTC_1840|Compound:st055363|FD-Score:3.70|P-value:3.34E-5 ID:SGTC_1908|Compound:st060353|FD-Score:3.06|P-value:4.73E-4 ID:SGTC_1914|Compound:st062367|FD-Score:3.18|P-value:2.99E-4 ID:SGTC_2009|Compound:4012297|FD-Score:-3.05|P-value:6.69E-4 ID:SGTC_2026|Compound:5148700|FD-Score:-3.57|P-value:8.61E-5 ID:SGTC_2028|Compound:5153890|FD-Score:-3.05|P-value:6.86E-4 ID:SGTC_2035|Compound:5154463|FD-Score:3.35|P-value:1.48E-4 ID:SGTC_2036|Compound:5160441|FD-Score:-3.84|P-value:2.56E-5 ID:SGTC_2038|Compound:4100038|FD-Score:3.43|P-value:1.08E-4 ID:SGTC_2042|Compound:p-Dimethylaminoacetophenone|FD-Score:-5.05|P-value:4.83E-8 ID:SGTC_2054|Compound:5233173|FD-Score:3.21|P-value:2.63E-4 ID:SGTC_2059|Compound:5238311|FD-Score:3.34|P-value:1.58E-4 ID:SGTC_2096|Compound:5468907|FD-Score:3.42|P-value:1.11E-4 ID:SGTC_2211|Compound:7117706|FD-Score:3.06|P-value:4.70E-4 ID:SGTC_2280|Compound:7785178|FD-Score:-3.04|P-value:7.07E-4 ID:SGTC_2395|Compound:5646831|FD-Score:3.71|P-value:3.10E-5 ID:SGTC_2399|Compound:5884133|FD-Score:4.37|P-value:1.27E-6 ID:SGTC_2448|Compound:5185112|FD-Score:3.13|P-value:3.54E-4 ID:SGTC_2739|Compound:tacrine|FD-Score:3.70|P-value:3.38E-5 ID:SGTC_2830|Compound:7992007|FD-Score:-3.43|P-value:1.56E-4 ID:SGTC_2832|Compound:7992762|FD-Score:9.90|P-value:1.57E-26 ID:SGTC_2844|Compound:9010103|FD-Score:3.04|P-value:5.14E-4 ID:SGTC_2847|Compound:9005661|FD-Score:5.66|P-value:6.29E-10 ID:SGTC_3081|Compound:9117243|FD-Score:3.45|P-value:9.84E-5 ID:SGTC_3103|Compound:9120822|FD-Score:3.84|P-value:1.73E-5 ID:SGTC_3268|Compound:9137683|FD-Score:-3.00|P-value:8.17E-4 ID:SGTC_3319|Compound:9138450|FD-Score:3.38|P-value:1.33E-4

Top fitness defect scores for YJR035W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2832 7992762 9.90 52.0 µM 1.57E-26 2 2.08E-23
2 SGTC_2847 9005661 5.66 71.4 µM 6.29E-10 2 7.77E-9
3 SGTC_939 1165-0479 4.95 45.3 µM 5.10E-8 10 3.67E-7
4 SGTC_1636 st007707 4.45 68.9 µM 8.37E-7 39 4.28E-6
5 SGTC_1529 apigenin 4.41 74.0 µM 1.05E-6 24 5.22E-6
6 SGTC_2399 5884133 4.37 200.0 µM 1.27E-6 cell wall signaling 56 6.18E-6
7 SGTC_3103 9120822 3.84 49.5 µM 1.73E-5 17 6.09E-5
8 SGTC_2395 5646831 3.71 180.2 µM 3.10E-5 30 1.02E-4
9 SGTC_1840 st055363 3.70 71.0 µM 3.34E-5 15 1.08E-4
10 SGTC_2739 tacrine 3.70 100.9 µM 3.38E-5 heme requiring 22 1.10E-4
11 SGTC_1091 telmisartan 3.64 47.6 µM 4.29E-5 23 1.35E-4
12 SGTC_1292 0kpi-0043 3.46 232.0 µM 9.43E-5 23 2.70E-4
13 SGTC_3081 9117243 3.45 49.5 µM 9.84E-5 fatty acid desaturase (OLE1) 38 2.80E-4
14 SGTC_2038 4100038 3.43 31.0 µM 1.08E-4 plasma membrane duress 75 3.04E-4
15 SGTC_2096 5468907 3.42 200.0 µM 1.11E-4 20 3.10E-4
16 SGTC_3319 9138450 3.38 16.8 µM 1.33E-4 36 3.65E-4
17 SGTC_2035 5154463 3.35 94.6 µM 1.48E-4 31 4.02E-4
18 SGTC_2059 5238311 3.34 157.0 µM 1.58E-4 49 4.24E-4
19 SGTC_1259 0671-0132 3.30 43.0 µM 1.82E-4 51 4.80E-4
20 SGTC_1520 flindersine 3.28 88.0 µM 2.00E-4 53 5.22E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.138 9.12E-16 YER176W ECM32 hom DNA dependent ATPase/DNA helicase belonging to the Dna2p- and Nam7p-like family of helicases that is involved in modulating translation termination; interacts with the translation termination factors, localized to polysomes
0.112 8.37E-11 YKL140W TGL1 hom Steryl ester hydrolase, one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes
0.112 8.71E-11 YGR034W RPL26B hom Ribosomal 60S subunit protein L26B; binds to 5.8S rRNA; homologous to mammalian ribosomal protein L26 and bacterial L24; RPL26B has a paralog, RPL26A, that arose from the whole genome duplication
0.111 1.30E-10 YOL061W PRS5 hom 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase; synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes; forms cytoplasmic foci upon DNA replication stress
0.110 1.51E-10 YLR363W-A YLR363W-A hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; relocalizes from nucleus to nucleolus upon DNA replication stress
0.109 2.20E-10 YDL215C GDH2 hom NAD(+)-dependent glutamate dehydrogenase, degrades glutamate to ammonia and alpha-ketoglutarate; expression sensitive to nitrogen catabolite repression and intracellular ammonia levels
0.104 2.04E-9 YFL010C WWM1 hom WW domain containing protein of unknown function; binds to Mca1p, a caspase-related protease that regulates H2O2-induced apoptosis; overexpression causes G1 phase growth arrest and clonal death that is suppressed by overexpression of MCA1
0.102 2.73E-9 YNL092W_p YNL092W_p hom Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; YNL092W is not an essential gene
0.100 7.47E-9 YBR074W_p YBR074W_p hom Putative metalloprotease
0.094 4.40E-8 YGR196C FYV8 hom Protein of unknown function, required for survival upon exposure to K1 killer toxin
0.093 7.66E-8 YMR074C YMR074C hom Protein with homology to human PDCD5; PDCD5 is involved in programmed cell death; N-terminal region forms a conserved triple-helix bundle structure; overexpression promotes H2O2-induced apoptosis; YMR074C is not an essential gene; protein abundance increases in response to DNA replication stress
0.092 9.63E-8 YKR004C ECM9 het Non-essential protein of unknown function
0.090 1.94E-7 YER003C PMI40 het Mannose-6-phosphate isomerase, catalyzes the interconversion of fructose-6-P and mannose-6-P; required for early steps in protein mannosylation
0.085 7.35E-7 YAL016C-B_d YAL016C-B_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.084 1.22E-6 YER109C FLO8 hom Transcription factor required for flocculation, diploid filamentous growth, and haploid invasive growth; genome reference strain S288C and most laboratory strains have a mutation in this gene