YJR037W_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene HUL4/YJR036C; deletion mutant has decreased spore survival in Drosophila feces

Zygosity: Homozygous strain
fixedexpanded
Profile for YJR037W / YJR037W

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:3.26|P-value:2.24E-4 ID:SGTC_148|Compound:3253-0744|FD-Score:-3.52|P-value:8.50E-5 ID:SGTC_494|Compound:Boc-Gly-Val-Val-CHO|FD-Score:-3.74|P-value:3.19E-5 ID:SGTC_496|Compound:calpeptin|FD-Score:-3.18|P-value:3.45E-4 ID:SGTC_497|Compound:capsazepine|FD-Score:-3.03|P-value:6.23E-4 ID:SGTC_503|Compound:tyrphostin 8|FD-Score:3.94|P-value:1.13E-5 ID:SGTC_511|Compound:blebbistatin|FD-Score:3.95|P-value:1.06E-5 ID:SGTC_550|Compound:4123-0385|FD-Score:-3.10|P-value:4.66E-4 ID:SGTC_621|Compound:3584-0052|FD-Score:2.90|P-value:8.90E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:6.18|P-value:1.54E-11 ID:SGTC_705|Compound:1124-0212|FD-Score:3.08|P-value:4.52E-4 ID:SGTC_810|Compound:3825-7150|FD-Score:3.17|P-value:3.14E-4 ID:SGTC_940|Compound:3232-1287|FD-Score:3.77|P-value:2.45E-5 ID:SGTC_947|Compound:3447-0010|FD-Score:-4.25|P-value:2.87E-6 ID:SGTC_954|Compound:1189-0853|FD-Score:-4.39|P-value:1.33E-6 ID:SGTC_956|Compound:1185-0240|FD-Score:-3.74|P-value:3.19E-5 ID:SGTC_1169|Compound:aniline yellow|FD-Score:-3.20|P-value:3.20E-4 ID:SGTC_1177|Compound:0983-0204|FD-Score:3.96|P-value:1.02E-5 ID:SGTC_1347|Compound:1493-0251|FD-Score:3.33|P-value:1.67E-4 ID:SGTC_1445|Compound:4239-0156|FD-Score:-4.09|P-value:6.21E-6 ID:SGTC_1463|Compound:k081-0032|FD-Score:-4.60|P-value:4.49E-7 ID:SGTC_1468|Compound:k284-1086|FD-Score:3.05|P-value:5.13E-4 ID:SGTC_1522|Compound:st012842|FD-Score:-5.00|P-value:4.61E-8 ID:SGTC_1908|Compound:st060353|FD-Score:3.37|P-value:1.42E-4 ID:SGTC_2032|Compound:5185112|FD-Score:-3.24|P-value:2.72E-4 ID:SGTC_2248|Compound:tofa|FD-Score:-3.32|P-value:2.00E-4 ID:SGTC_2262|Compound:9014885|FD-Score:-3.12|P-value:4.40E-4 ID:SGTC_2346|Compound:9031566|FD-Score:-2.94|P-value:8.59E-4 ID:SGTC_2414|Compound:st077232|FD-Score:4.02|P-value:7.73E-6 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.37|P-value:1.39E-4 ID:SGTC_2543|Compound:pimpinellin|FD-Score:-3.06|P-value:5.40E-4 ID:SGTC_2546|Compound:rhodinyl acetate|FD-Score:3.70|P-value:3.42E-5 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:-4.15|P-value:4.59E-6 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:5.20|P-value:1.10E-8 ID:SGTC_2607|Compound:solasodine|FD-Score:4.05|P-value:6.61E-6 ID:SGTC_2840|Compound:9008771|FD-Score:-3.83|P-value:2.18E-5 ID:SGTC_2853|Compound:9015042|FD-Score:-4.22|P-value:3.30E-6 ID:SGTC_2859|Compound:9028643|FD-Score:-5.46|P-value:2.63E-9 ID:SGTC_2942|Compound:9052777|FD-Score:3.45|P-value:1.00E-4 ID:SGTC_3145|Compound:9085516|FD-Score:3.36|P-value:1.50E-4 ID:SGTC_3213|Compound:9129884|FD-Score:-2.94|P-value:8.71E-4 ID:SGTC_6|Compound:0844-0013|FD-Score:3.26|P-value:2.24E-4 ID:SGTC_148|Compound:3253-0744|FD-Score:-3.52|P-value:8.50E-5 ID:SGTC_494|Compound:Boc-Gly-Val-Val-CHO|FD-Score:-3.74|P-value:3.19E-5 ID:SGTC_496|Compound:calpeptin|FD-Score:-3.18|P-value:3.45E-4 ID:SGTC_497|Compound:capsazepine|FD-Score:-3.03|P-value:6.23E-4 ID:SGTC_503|Compound:tyrphostin 8|FD-Score:3.94|P-value:1.13E-5 ID:SGTC_511|Compound:blebbistatin|FD-Score:3.95|P-value:1.06E-5 ID:SGTC_550|Compound:4123-0385|FD-Score:-3.10|P-value:4.66E-4 ID:SGTC_621|Compound:3584-0052|FD-Score:2.90|P-value:8.90E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:6.18|P-value:1.54E-11 ID:SGTC_705|Compound:1124-0212|FD-Score:3.08|P-value:4.52E-4 ID:SGTC_810|Compound:3825-7150|FD-Score:3.17|P-value:3.14E-4 ID:SGTC_940|Compound:3232-1287|FD-Score:3.77|P-value:2.45E-5 ID:SGTC_947|Compound:3447-0010|FD-Score:-4.25|P-value:2.87E-6 ID:SGTC_954|Compound:1189-0853|FD-Score:-4.39|P-value:1.33E-6 ID:SGTC_956|Compound:1185-0240|FD-Score:-3.74|P-value:3.19E-5 ID:SGTC_1169|Compound:aniline yellow|FD-Score:-3.20|P-value:3.20E-4 ID:SGTC_1177|Compound:0983-0204|FD-Score:3.96|P-value:1.02E-5 ID:SGTC_1347|Compound:1493-0251|FD-Score:3.33|P-value:1.67E-4 ID:SGTC_1445|Compound:4239-0156|FD-Score:-4.09|P-value:6.21E-6 ID:SGTC_1463|Compound:k081-0032|FD-Score:-4.60|P-value:4.49E-7 ID:SGTC_1468|Compound:k284-1086|FD-Score:3.05|P-value:5.13E-4 ID:SGTC_1522|Compound:st012842|FD-Score:-5.00|P-value:4.61E-8 ID:SGTC_1908|Compound:st060353|FD-Score:3.37|P-value:1.42E-4 ID:SGTC_2032|Compound:5185112|FD-Score:-3.24|P-value:2.72E-4 ID:SGTC_2248|Compound:tofa|FD-Score:-3.32|P-value:2.00E-4 ID:SGTC_2262|Compound:9014885|FD-Score:-3.12|P-value:4.40E-4 ID:SGTC_2346|Compound:9031566|FD-Score:-2.94|P-value:8.59E-4 ID:SGTC_2414|Compound:st077232|FD-Score:4.02|P-value:7.73E-6 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.37|P-value:1.39E-4 ID:SGTC_2543|Compound:pimpinellin|FD-Score:-3.06|P-value:5.40E-4 ID:SGTC_2546|Compound:rhodinyl acetate|FD-Score:3.70|P-value:3.42E-5 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:-4.15|P-value:4.59E-6 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:5.20|P-value:1.10E-8 ID:SGTC_2607|Compound:solasodine|FD-Score:4.05|P-value:6.61E-6 ID:SGTC_2840|Compound:9008771|FD-Score:-3.83|P-value:2.18E-5 ID:SGTC_2853|Compound:9015042|FD-Score:-4.22|P-value:3.30E-6 ID:SGTC_2859|Compound:9028643|FD-Score:-5.46|P-value:2.63E-9 ID:SGTC_2942|Compound:9052777|FD-Score:3.45|P-value:1.00E-4 ID:SGTC_3145|Compound:9085516|FD-Score:3.36|P-value:1.50E-4 ID:SGTC_3213|Compound:9129884|FD-Score:-2.94|P-value:8.71E-4

Top fitness defect scores for YJR037W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_625 k213-0058 6.18 121.0 µM 1.54E-11 translation 30 3.20E-10
2 SGTC_2604 4'-hydroxychalcone 5.20 11.3 µM 1.10E-8 13 9.76E-8
3 SGTC_2607 solasodine 4.05 47.4 µM 6.61E-6 54 2.59E-5
4 SGTC_2414 st077232 4.02 92.9 µM 7.73E-6 19 2.96E-5
5 SGTC_1177 0983-0204 3.96 23.6 µM 1.02E-5 16 3.77E-5
6 SGTC_511 blebbistatin 3.95 171.0 µM 1.06E-5 DNA intercalators 23 3.92E-5
7 SGTC_503 tyrphostin 8 3.94 294.0 µM 1.13E-5 TSC3-RPN4 27 4.13E-5
8 SGTC_940 3232-1287 3.77 54.8 µM 2.45E-5 NEO1 48 8.11E-5
9 SGTC_2546 rhodinyl acetate 3.70 100.0 µM 3.42E-5 17 1.09E-4
10 SGTC_2942 9052777 3.45 62.2 µM 1.00E-4 56 2.78E-4
11 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.37 3.7 µM 1.39E-4 143 3.70E-4
12 SGTC_1908 st060353 3.37 56.5 µM 1.42E-4 RPP1 & pyrimidine depletion 61 3.76E-4
13 SGTC_3145 9085516 3.36 49.5 µM 1.50E-4 fatty acid desaturase (OLE1) 49 3.94E-4
14 SGTC_1347 1493-0251 3.33 600.0 nM 1.67E-4 mitochondrial response to ROS 36 4.35E-4
15 SGTC_6 0844-0013 3.26 19.8 µM 2.24E-4 167 5.61E-4
16 SGTC_810 3825-7150 3.17 143.0 µM 3.14E-4 60S ribosome export 27 7.53E-4
17 SGTC_705 1124-0212 3.08 310.0 µM 4.52E-4 47 0.00104
18 SGTC_1468 k284-1086 3.05 134.0 µM 5.13E-4 DNA intercalators 97 0.00116
19 SGTC_621 3584-0052 2.90 32.1 µM 8.90E-4 71 0.00187
20 SGTC_2182 6325192 2.84 200.0 µM 0.00109 Golgi 46 0.00224

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.170 4.98E-23 YJR046W TAH11 het DNA replication licensing factor, required for pre-replication complex assembly
0.150 2.37E-18 YOR155C ISN1 hom Inosine 5'-monophosphate (IMP)-specific 5'-nucleotidase, catalyzes the breakdown of IMP to inosine, does not show similarity to known 5'-nucleotidases from other organisms
0.146 1.64E-17 YDR051C DET1 hom Acid phosphatase involved in the non-vesicular transport of sterols in both directions between the endoplasmic reticulum and plasma membrane; deletion confers sensitivity to nickel
0.141 1.98E-16 YNL218W MGS1 hom Protein with DNA-dependent ATPase and ssDNA annealing activities; involved in maintenance of genome; interacts functionally with DNA polymerase delta; homolog of human Werner helicase interacting protein (WHIP); forms nuclear foci upon DNA replication stress
0.134 8.82E-15 YDR197W CBS2 hom Mitochondrial translational activator of the COB mRNA; interacts with translating ribosomes, acts on the COB mRNA 5'-untranslated leader
0.131 3.42E-14 YDR530C APA2 hom Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase II; AP4A phosphorylase involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; APA2 has a paralog, APA1, that arose from the whole genome duplication
0.128 1.11E-13 YLR136C TIS11 hom mRNA-binding protein expressed during iron starvation; binds to a sequence element in the 3'-untranslated regions of specific mRNAs to mediate their degradation; involved in iron homeostasis; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress
0.124 5.05E-13 YKL010C UFD4 hom Ubiquitin-protein ligase (E3); interacts with Rpt4p and Rpt6p, two subunits of the 19S particle of the 26S proteasome; cytoplasmic E3 involved in the degradation of ubiquitin fusion proteins; relative distribution to the nucleus increases upon DNA replication stress
0.122 1.74E-12 YNL166C BNI5 hom Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner
0.120 3.33E-12 YKR069W MET1 hom S-adenosyl-L-methionine uroporphyrinogen III transmethylase, involved in the biosynthesis of siroheme, a prosthetic group used by sulfite reductase; required for sulfate assimilation and methionine biosynthesis
0.120 3.68E-12 YJR152W DAL5 hom Allantoate permease; ureidosuccinate permease; also transports dipeptides, though with lower affinity than for allantoate and ureidosuccinate; expression is constitutive but sensitive to nitrogen catabolite repression
0.116 1.99E-11 YNL034W_p YNL034W_p hom Putative protein of unknown function; YNL034W is not an essential gene
0.115 2.25E-11 YDL049C KNH1 hom Protein with similarity to Kre9p, which is involved in cell wall beta 1,6-glucan synthesis; overproduction suppresses growth defects of a kre9 null mutant; required for propionic acid resistance
0.113 6.16E-11 YDL230W PTP1 hom Phosphotyrosine-specific protein phosphatase that dephosphorylates a broad range of substrates in vivo, including Fpr3p; localized to the cytoplasm and the mitochondria; proposed to be a negative regulator of filamentation
0.113 6.54E-11 YDR521W_d YDR521W_d hom Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol