YJR038C_d

Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YJR038C / YJR038C

Click on Significant Values for Screen Details ID:SGTC_57|Compound:miconazole|FD-Score:3.06|P-value:6.70E-4 ID:SGTC_424|Compound:splitomicin|FD-Score:3.14|P-value:5.02E-4 ID:SGTC_561|Compound:1550-0330|FD-Score:5.92|P-value:2.71E-10 ID:SGTC_603|Compound:3794-0023|FD-Score:3.09|P-value:6.10E-4 ID:SGTC_613|Compound:3914-0030|FD-Score:-2.97|P-value:9.01E-4 ID:SGTC_641|Compound:4092-0595|FD-Score:3.01|P-value:7.91E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:7.48|P-value:2.11E-15 ID:SGTC_1204|Compound:4049-0315|FD-Score:-3.25|P-value:3.18E-4 ID:SGTC_1449|Compound:4112-4002|FD-Score:4.75|P-value:3.13E-7 ID:SGTC_1451|Compound:4152-0210|FD-Score:3.25|P-value:3.31E-4 ID:SGTC_1453|Compound:4237-0541|FD-Score:4.73|P-value:3.42E-7 ID:SGTC_1457|Compound:k015-0032|FD-Score:-3.89|P-value:2.20E-5 ID:SGTC_1571|Compound:st070080|FD-Score:-3.32|P-value:2.42E-4 ID:SGTC_1606|Compound:st000094|FD-Score:3.02|P-value:7.76E-4 ID:SGTC_1686|Compound:st019653|FD-Score:4.35|P-value:2.57E-6 ID:SGTC_1696|Compound:st025591|FD-Score:-3.81|P-value:3.11E-5 ID:SGTC_1697|Compound:st025554|FD-Score:3.49|P-value:1.25E-4 ID:SGTC_1699|Compound:st031318|FD-Score:-3.42|P-value:1.60E-4 ID:SGTC_1910|Compound:st062352|FD-Score:3.98|P-value:1.53E-5 ID:SGTC_1913|Compound:st060213|FD-Score:4.72|P-value:3.66E-7 ID:SGTC_2030|Compound:5175110|FD-Score:-3.37|P-value:1.93E-4 ID:SGTC_2040|Compound:5100729|FD-Score:-3.24|P-value:3.32E-4 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:3.25|P-value:3.27E-4 ID:SGTC_2244|Compound:6635614|FD-Score:-4.26|P-value:3.68E-6 ID:SGTC_2245|Compound:6637752|FD-Score:3.30|P-value:2.75E-4 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:3.08|P-value:6.24E-4 ID:SGTC_2549|Compound:cedrol|FD-Score:2.96|P-value:9.54E-4 ID:SGTC_2605|Compound:digitonin|FD-Score:4.49|P-value:1.28E-6 ID:SGTC_2607|Compound:solasodine|FD-Score:-3.49|P-value:1.20E-4 ID:SGTC_2608|Compound:thymoquinone|FD-Score:4.31|P-value:3.17E-6 ID:SGTC_2762|Compound:leflunomide|FD-Score:-4.29|P-value:3.30E-6 ID:SGTC_2763|Compound:lisinopril|FD-Score:4.99|P-value:8.55E-8 ID:SGTC_2769|Compound:toremifene|FD-Score:-3.57|P-value:8.66E-5 ID:SGTC_2770|Compound:toltrazuril|FD-Score:4.22|P-value:4.78E-6 ID:SGTC_2772|Compound:vinpocetine|FD-Score:-3.72|P-value:4.58E-5 ID:SGTC_2814|Compound:7977482|FD-Score:3.06|P-value:6.67E-4 ID:SGTC_2959|Compound:9079155|FD-Score:3.79|P-value:3.55E-5 ID:SGTC_2990|Compound:9074105|FD-Score:-7.25|P-value:1.31E-14 ID:SGTC_2992|Compound:9074591|FD-Score:-3.78|P-value:3.48E-5 ID:SGTC_2994|Compound:9053520|FD-Score:5.15|P-value:3.22E-8 ID:SGTC_3041|Compound:9091929|FD-Score:3.52|P-value:1.14E-4 ID:SGTC_3044|Compound:9093193|FD-Score:3.24|P-value:3.42E-4 ID:SGTC_3130|Compound:9127414|FD-Score:-3.35|P-value:2.16E-4 ID:SGTC_3265|Compound:9137266|FD-Score:3.06|P-value:6.75E-4 ID:SGTC_3322|Compound:9139058|FD-Score:3.35|P-value:2.25E-4 ID:SGTC_57|Compound:miconazole|FD-Score:3.06|P-value:6.70E-4 ID:SGTC_424|Compound:splitomicin|FD-Score:3.14|P-value:5.02E-4 ID:SGTC_561|Compound:1550-0330|FD-Score:5.92|P-value:2.71E-10 ID:SGTC_603|Compound:3794-0023|FD-Score:3.09|P-value:6.10E-4 ID:SGTC_613|Compound:3914-0030|FD-Score:-2.97|P-value:9.01E-4 ID:SGTC_641|Compound:4092-0595|FD-Score:3.01|P-value:7.91E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:7.48|P-value:2.11E-15 ID:SGTC_1204|Compound:4049-0315|FD-Score:-3.25|P-value:3.18E-4 ID:SGTC_1449|Compound:4112-4002|FD-Score:4.75|P-value:3.13E-7 ID:SGTC_1451|Compound:4152-0210|FD-Score:3.25|P-value:3.31E-4 ID:SGTC_1453|Compound:4237-0541|FD-Score:4.73|P-value:3.42E-7 ID:SGTC_1457|Compound:k015-0032|FD-Score:-3.89|P-value:2.20E-5 ID:SGTC_1571|Compound:st070080|FD-Score:-3.32|P-value:2.42E-4 ID:SGTC_1606|Compound:st000094|FD-Score:3.02|P-value:7.76E-4 ID:SGTC_1686|Compound:st019653|FD-Score:4.35|P-value:2.57E-6 ID:SGTC_1696|Compound:st025591|FD-Score:-3.81|P-value:3.11E-5 ID:SGTC_1697|Compound:st025554|FD-Score:3.49|P-value:1.25E-4 ID:SGTC_1699|Compound:st031318|FD-Score:-3.42|P-value:1.60E-4 ID:SGTC_1910|Compound:st062352|FD-Score:3.98|P-value:1.53E-5 ID:SGTC_1913|Compound:st060213|FD-Score:4.72|P-value:3.66E-7 ID:SGTC_2030|Compound:5175110|FD-Score:-3.37|P-value:1.93E-4 ID:SGTC_2040|Compound:5100729|FD-Score:-3.24|P-value:3.32E-4 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:3.25|P-value:3.27E-4 ID:SGTC_2244|Compound:6635614|FD-Score:-4.26|P-value:3.68E-6 ID:SGTC_2245|Compound:6637752|FD-Score:3.30|P-value:2.75E-4 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:3.08|P-value:6.24E-4 ID:SGTC_2549|Compound:cedrol|FD-Score:2.96|P-value:9.54E-4 ID:SGTC_2605|Compound:digitonin|FD-Score:4.49|P-value:1.28E-6 ID:SGTC_2607|Compound:solasodine|FD-Score:-3.49|P-value:1.20E-4 ID:SGTC_2608|Compound:thymoquinone|FD-Score:4.31|P-value:3.17E-6 ID:SGTC_2762|Compound:leflunomide|FD-Score:-4.29|P-value:3.30E-6 ID:SGTC_2763|Compound:lisinopril|FD-Score:4.99|P-value:8.55E-8 ID:SGTC_2769|Compound:toremifene|FD-Score:-3.57|P-value:8.66E-5 ID:SGTC_2770|Compound:toltrazuril|FD-Score:4.22|P-value:4.78E-6 ID:SGTC_2772|Compound:vinpocetine|FD-Score:-3.72|P-value:4.58E-5 ID:SGTC_2814|Compound:7977482|FD-Score:3.06|P-value:6.67E-4 ID:SGTC_2959|Compound:9079155|FD-Score:3.79|P-value:3.55E-5 ID:SGTC_2990|Compound:9074105|FD-Score:-7.25|P-value:1.31E-14 ID:SGTC_2992|Compound:9074591|FD-Score:-3.78|P-value:3.48E-5 ID:SGTC_2994|Compound:9053520|FD-Score:5.15|P-value:3.22E-8 ID:SGTC_3041|Compound:9091929|FD-Score:3.52|P-value:1.14E-4 ID:SGTC_3044|Compound:9093193|FD-Score:3.24|P-value:3.42E-4 ID:SGTC_3130|Compound:9127414|FD-Score:-3.35|P-value:2.16E-4 ID:SGTC_3265|Compound:9137266|FD-Score:3.06|P-value:6.75E-4 ID:SGTC_3322|Compound:9139058|FD-Score:3.35|P-value:2.25E-4

Top fitness defect scores for YJR038C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_996 3970-0799 7.48 1.8 µM 2.11E-15 24 3.71E-14
2 SGTC_561 1550-0330 5.92 72.9 µM 2.71E-10 2 1.64E-9
3 SGTC_2994 9053520 5.15 71.4 µM 3.22E-8 RPP1 & pyrimidine depletion 7 1.27E-7
4 SGTC_2763 lisinopril 4.99 49.3 µM 8.55E-8 3 3.10E-7
5 SGTC_1449 4112-4002 4.75 201.0 µM 3.13E-7 RPP1 & pyrimidine depletion 13 1.01E-6
6 SGTC_1453 4237-0541 4.73 195.0 µM 3.42E-7 heme biosynthesis & mitochondrial translocase 14 1.10E-6
7 SGTC_1913 st060213 4.72 96.1 µM 3.66E-7 15 1.16E-6
8 SGTC_2605 digitonin 4.49 300.0 nM 1.28E-6 14 3.64E-6
9 SGTC_1686 st019653 4.35 115.5 µM 2.57E-6 mitochondrial processes 5 6.87E-6
10 SGTC_2608 thymoquinone 4.31 42.7 µM 3.17E-6 11 8.32E-6
11 SGTC_2770 toltrazuril 4.22 17.5 µM 4.78E-6 19 1.21E-5
12 SGTC_1910 st062352 3.98 60.4 µM 1.53E-5 36 3.51E-5
13 SGTC_2959 9079155 3.79 11.0 µM 3.55E-5 32 7.55E-5
14 SGTC_3041 9091929 3.52 49.5 µM 1.14E-4 redox potentiating 35 2.19E-4
15 SGTC_1697 st025554 3.49 27.7 µM 1.25E-4 32 2.39E-4
16 SGTC_3322 9139058 3.35 2.1 µM 2.25E-4 cell wall 50 4.07E-4
17 SGTC_2245 6637752 3.30 200.0 µM 2.75E-4 28 4.90E-4
18 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 3.25 49.5 µM 3.27E-4 49 5.74E-4
19 SGTC_1451 4152-0210 3.25 104.0 µM 3.31E-4 53 5.80E-4
20 SGTC_3044 9093193 3.24 49.5 µM 3.42E-4 61 5.98E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.262 1.19E-53 YML118W NGL3 hom 3'-5' exonuclease specific for poly-A RNAs; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p; NGL3 has a paralog, NGL2, that arose from the whole genome duplication
0.208 3.51E-34 YDL099W BUG1 hom Cis-golgi localized protein involved in ER to Golgi transport; forms a complex with the mammalian GRASP65 homolog, Grh1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes
0.191 5.76E-29 YJL149W DAS1 hom Putative SCF ubiquitin ligase F-box protein; interacts physically with both Cdc53p and Skp1 and genetically with CDC34; similar to putative F-box protein YDR131C
0.190 1.43E-28 YGL040C HEM2 het Aminolevulinate dehydratase, a homo-octameric enzyme, catalyzes the conversion of 5-aminolevulinate to porphobilinogen, the second step in heme biosynthesis; enzymatic activity is zinc-dependent; localizes to the cytoplasm and nucleus
0.185 3.49E-27 YDR505C PSP1 hom Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition; PSP1 has a paralog, YLR177W, that arose from the whole genome duplication
0.176 8.60E-25 YNL187W SWT21 hom Protein involved in mRNA splicing; contains a consensus nuclear export signal (NES) sequence similar to the consensus sequence recognized by Crm1p; interacts genetically with Prp40p and Tgs1p; contains WD40 repeats
0.170 4.30E-23 YGL222C EDC1 hom RNA-binding protein that activates mRNA decapping directly; binds to the mRNA substrate and enhances the activity of the decapping proteins Dcp1p and Dcp2p; has a role in translation during heat stress; protein becomes more abundant and forms cytoplasmic foci in response to DNA replication stress
0.168 1.37E-22 YBR067C TIP1 hom Major cell wall mannoprotein with possible lipase activity; transcription is induced by heat- and cold-shock; member of the Srp1p/Tip1p family of serine-alanine-rich proteins
0.168 1.74E-22 YDL186W_p YDL186W_p hom Putative protein of unknown function; YDL186W is not an essential gene
0.167 2.05E-22 YGL096W TOS8 hom Homeodomain-containing protein and putative transcription factor; found associated with chromatin; target of SBF transcription factor; induced during meiosis and under cell-damaging conditions; TOS8 has a paralog, CUP9, that arose from the whole genome duplication
0.166 3.97E-22 YOR037W CYC2 hom Mitochondrial peripheral inner membrane protein, contains a FAD cofactor in a domain exposed in the intermembrane space; exhibits redox activity in vitro; likely participates in ligation of heme to acytochromes c and c1 (Cyc1p and Cyt1p)
0.160 1.19E-20 YGL205W POX1 hom Fatty-acyl coenzyme A oxidase, involved in the fatty acid beta-oxidation pathway; localized to the peroxisomal matrix
0.150 2.76E-18 YMR006C PLB2 hom Phospholipase B (lysophospholipase) involved in phospholipid metabolism; displays transacylase activity in vitro; overproduction confers resistance to lysophosphatidylcholine
0.145 3.28E-17 YNR033W ABZ1 hom Para-aminobenzoate (PABA) synthase; has similarity to Escherichia coli PABA synthase components PabA and PabB; required for the synthesis of para-aminobenzoic acid, an important intermediate for folate and ubiquinone Q biosynthesis; protein abundance increases in response to DNA replication stress
0.145 3.83E-17 YHR109W CTM1 hom Cytochrome c lysine methyltransferase, trimethylates residue 72 of apo-cytochrome c (Cyc1p) in the cytosol; not required for normal respiratory growth