YJR039W_p

Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies

Zygosity: Homozygous strain
fixedexpanded
Profile for YJR039W / YJR039W

Click on Significant Values for Screen Details ID:SGTC_141|Compound:0443-0274|FD-Score:-3.36|P-value:1.13E-4 ID:SGTC_409|Compound:arachidonic acid|FD-Score:-3.17|P-value:2.61E-4 ID:SGTC_458|Compound:nppb|FD-Score:3.21|P-value:1.48E-4 ID:SGTC_567|Compound:1080-0542|FD-Score:2.78|P-value:8.32E-4 ID:SGTC_581|Compound:0958-0271|FD-Score:3.56|P-value:3.03E-5 ID:SGTC_582|Compound:0987-0078|FD-Score:-3.35|P-value:1.19E-4 ID:SGTC_608|Compound:k048-0125|FD-Score:3.20|P-value:1.56E-4 ID:SGTC_647|Compound:0140-0236|FD-Score:-2.87|P-value:8.49E-4 ID:SGTC_825|Compound:1988-2224|FD-Score:-2.92|P-value:6.91E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:3.23|P-value:1.35E-4 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:-2.90|P-value:7.58E-4 ID:SGTC_1079|Compound:idarubicin|FD-Score:5.10|P-value:5.34E-9 ID:SGTC_1217|Compound:1183-1422|FD-Score:2.94|P-value:4.45E-4 ID:SGTC_1250|Compound:0485-0349|FD-Score:3.69|P-value:1.68E-5 ID:SGTC_1309|Compound:pyrazolanthrone|FD-Score:3.74|P-value:1.27E-5 ID:SGTC_1332|Compound:1480-0653|FD-Score:2.82|P-value:7.33E-4 ID:SGTC_1334|Compound:1486-0610|FD-Score:3.32|P-value:9.27E-5 ID:SGTC_1335|Compound:1486-0900|FD-Score:-3.04|P-value:4.37E-4 ID:SGTC_1430|Compound:4049-0248|FD-Score:2.93|P-value:4.80E-4 ID:SGTC_1454|Compound:4239-0054|FD-Score:2.90|P-value:5.36E-4 ID:SGTC_1642|Compound:st009582|FD-Score:2.86|P-value:6.28E-4 ID:SGTC_1879|Compound:gemcitabine|FD-Score:-3.64|P-value:3.17E-5 ID:SGTC_1944|Compound:st076371|FD-Score:-2.83|P-value:9.90E-4 ID:SGTC_2085|Compound:5307070|FD-Score:-3.08|P-value:3.72E-4 ID:SGTC_2300|Compound:7976697|FD-Score:-2.98|P-value:5.41E-4 ID:SGTC_2302|Compound:7771753|FD-Score:-3.28|P-value:1.59E-4 ID:SGTC_2350|Compound:9023895|FD-Score:6.34|P-value:6.43E-13 ID:SGTC_2461|Compound:5755302|FD-Score:2.74|P-value:9.85E-4 ID:SGTC_2483|Compound:5729050|FD-Score:3.82|P-value:8.58E-6 ID:SGTC_2484|Compound:5809818|FD-Score:-2.94|P-value:6.36E-4 ID:SGTC_2562|Compound:3',7'-dimethoxyflavone|FD-Score:-3.46|P-value:7.32E-5 ID:SGTC_2929|Compound:9013348|FD-Score:-3.14|P-value:2.87E-4 ID:SGTC_2930|Compound:9013230|FD-Score:-2.85|P-value:9.07E-4 ID:SGTC_2935|Compound:9038016|FD-Score:4.76|P-value:4.75E-8 ID:SGTC_3001|Compound:9076041|FD-Score:2.93|P-value:4.74E-4 ID:SGTC_3007|Compound:9078383|FD-Score:3.00|P-value:3.51E-4 ID:SGTC_3069|Compound:9117009|FD-Score:5.15|P-value:3.84E-9 ID:SGTC_3073|Compound:9114972|FD-Score:2.77|P-value:8.78E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:-3.36|P-value:1.13E-4 ID:SGTC_409|Compound:arachidonic acid|FD-Score:-3.17|P-value:2.61E-4 ID:SGTC_458|Compound:nppb|FD-Score:3.21|P-value:1.48E-4 ID:SGTC_567|Compound:1080-0542|FD-Score:2.78|P-value:8.32E-4 ID:SGTC_581|Compound:0958-0271|FD-Score:3.56|P-value:3.03E-5 ID:SGTC_582|Compound:0987-0078|FD-Score:-3.35|P-value:1.19E-4 ID:SGTC_608|Compound:k048-0125|FD-Score:3.20|P-value:1.56E-4 ID:SGTC_647|Compound:0140-0236|FD-Score:-2.87|P-value:8.49E-4 ID:SGTC_825|Compound:1988-2224|FD-Score:-2.92|P-value:6.91E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:3.23|P-value:1.35E-4 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:-2.90|P-value:7.58E-4 ID:SGTC_1079|Compound:idarubicin|FD-Score:5.10|P-value:5.34E-9 ID:SGTC_1217|Compound:1183-1422|FD-Score:2.94|P-value:4.45E-4 ID:SGTC_1250|Compound:0485-0349|FD-Score:3.69|P-value:1.68E-5 ID:SGTC_1309|Compound:pyrazolanthrone|FD-Score:3.74|P-value:1.27E-5 ID:SGTC_1332|Compound:1480-0653|FD-Score:2.82|P-value:7.33E-4 ID:SGTC_1334|Compound:1486-0610|FD-Score:3.32|P-value:9.27E-5 ID:SGTC_1335|Compound:1486-0900|FD-Score:-3.04|P-value:4.37E-4 ID:SGTC_1430|Compound:4049-0248|FD-Score:2.93|P-value:4.80E-4 ID:SGTC_1454|Compound:4239-0054|FD-Score:2.90|P-value:5.36E-4 ID:SGTC_1642|Compound:st009582|FD-Score:2.86|P-value:6.28E-4 ID:SGTC_1879|Compound:gemcitabine|FD-Score:-3.64|P-value:3.17E-5 ID:SGTC_1944|Compound:st076371|FD-Score:-2.83|P-value:9.90E-4 ID:SGTC_2085|Compound:5307070|FD-Score:-3.08|P-value:3.72E-4 ID:SGTC_2300|Compound:7976697|FD-Score:-2.98|P-value:5.41E-4 ID:SGTC_2302|Compound:7771753|FD-Score:-3.28|P-value:1.59E-4 ID:SGTC_2350|Compound:9023895|FD-Score:6.34|P-value:6.43E-13 ID:SGTC_2461|Compound:5755302|FD-Score:2.74|P-value:9.85E-4 ID:SGTC_2483|Compound:5729050|FD-Score:3.82|P-value:8.58E-6 ID:SGTC_2484|Compound:5809818|FD-Score:-2.94|P-value:6.36E-4 ID:SGTC_2562|Compound:3',7'-dimethoxyflavone|FD-Score:-3.46|P-value:7.32E-5 ID:SGTC_2929|Compound:9013348|FD-Score:-3.14|P-value:2.87E-4 ID:SGTC_2930|Compound:9013230|FD-Score:-2.85|P-value:9.07E-4 ID:SGTC_2935|Compound:9038016|FD-Score:4.76|P-value:4.75E-8 ID:SGTC_3001|Compound:9076041|FD-Score:2.93|P-value:4.74E-4 ID:SGTC_3007|Compound:9078383|FD-Score:3.00|P-value:3.51E-4 ID:SGTC_3069|Compound:9117009|FD-Score:5.15|P-value:3.84E-9 ID:SGTC_3073|Compound:9114972|FD-Score:2.77|P-value:8.78E-4

Top fitness defect scores for YJR039W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2350 9023895 6.34 38.9 µM 6.43E-13 ergosterol biosynthesis 8 1.16E-10
2 SGTC_3069 9117009 5.15 49.5 µM 3.84E-9 60S ribosome export 5 1.30E-7
3 SGTC_1079 idarubicin 5.10 2.4 µM 5.34E-9 DNA damage response 12 1.69E-7
4 SGTC_2935 9038016 4.76 30.0 µM 4.75E-8 7 9.89E-7
5 SGTC_2483 5729050 3.82 27.2 µM 8.58E-6 31 6.60E-5
6 SGTC_1309 pyrazolanthrone 3.74 13.4 µM 1.27E-5 26 9.07E-5
7 SGTC_1250 0485-0349 3.69 40.2 µM 1.68E-5 43 1.13E-4
8 SGTC_581 0958-0271 3.56 211.0 µM 3.03E-5 65 1.83E-4
9 SGTC_1334 1486-0610 3.32 236.0 µM 9.27E-5 60S ribosome export 39 4.53E-4
10 SGTC_893 0958-0369 3.23 48.9 µM 1.35E-4 56 6.14E-4
11 SGTC_458 nppb 3.21 133.0 µM 1.48E-4 30 6.61E-4
12 SGTC_608 k048-0125 3.20 159.0 µM 1.56E-4 57 6.91E-4
13 SGTC_3007 9078383 3.00 71.4 µM 3.51E-4 51 0.00133
14 SGTC_1217 1183-1422 2.94 255.0 µM 4.45E-4 53 0.00161
15 SGTC_3001 9076041 2.93 71.4 µM 4.74E-4 51 0.00170
16 SGTC_1430 4049-0248 2.93 69.1 µM 4.80E-4 71 0.00172
17 SGTC_1454 4239-0054 2.90 42.6 µM 5.36E-4 88 0.00188
18 SGTC_1642 st009582 2.86 77.7 µM 6.28E-4 RPP1 & pyrimidine depletion 64 0.00214
19 SGTC_1332 1480-0653 2.82 17.5 µM 7.33E-4 TSC3-RPN4 72 0.00242
20 SGTC_567 1080-0542 2.78 68.4 µM 8.32E-4 54 0.00268

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.126 2.61E-13 YLR151C PCD1 hom Peroxisomal pyrophosphatase with specificity for coenzyme A and CoA derivatives, may function to remove potentially toxic oxidized CoA disulfide from peroxisomes to maintain the capacity for beta-oxidation of fatty acids; nudix hydrolase family member
0.125 3.70E-13 YIL107C PFK26 hom 6-phosphofructo-2-kinase, inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate; has negligible fructose-2,6-bisphosphatase activity; transcriptional regulation involves protein kinase A
0.112 7.93E-11 YDR286C_p YDR286C_p hom Putative protein of unknown function; predicted to have thiol-disulfide oxidoreductase active site
0.098 1.34E-8 YNL168C_p FMP41_p hom Putative protein of unknown function; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.094 4.50E-8 YLR071C RGR1 het Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for glucose repression, HO repression, RME1 repression and sporulation
0.093 5.76E-8 YIL045W PIG2 hom Putative type-1 protein phosphatase targeting subunit that tethers Glc7p type-1 protein phosphatase to Gsy2p glycogen synthase
0.092 9.22E-8 YOL011W PLB3 hom Phospholipase B (lysophospholipase) involved in phospholipid metabolism; hydrolyzes phosphatidylinositol and phosphatidylserine and displays transacylase activity in vitro
0.091 1.29E-7 YKR090W PXL1 hom Protein that localizes to sites of polarized growth; required for selection and/or maintenance of polarized growth sites, may modulate signaling by the GTPases Cdc42p and Rho1p; contains LIM domains and has similarity to metazoan paxillin; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.091 1.40E-7 YLL002W RTT109 hom Histone acetyltransferase critical for cell survival in the presence of DNA damage during S phase; acetylates H3-K56 and H3-K9; involved in non-homologous end joining and in regulation of Ty1 transposition; interacts physically with Vps75p
0.091 1.47E-7 YLR117C CLF1 het Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; homolog of Drosophila crooked neck protein; interacts with U1 snRNP proteins
0.090 1.98E-7 YER013W PRP22 het DEAH-box RNA-dependent ATPase/ATP-dependent RNA helicase, associates with lariat intermediates before the second catalytic step of splicing; mediates ATP-dependent mRNA release from the spliceosome and unwinds RNA duplexes
0.089 2.45E-7 YOR159C SME1 het Core Sm protein Sm E; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm E
0.085 7.60E-7 YJR065C ARP3 het Essential component of the Arp2/3 complex, which is a highly conserved actin nucleation center required for the motility and integrity of actin patches; involved in endocytosis and membrane growth and polarity
0.084 9.99E-7 YKL024C URA6 het Uridylate kinase, catalyzes the seventh enzymatic step in the de novo biosynthesis of pyrimidines, converting uridine monophosphate (UMP) into uridine-5'-diphosphate (UDP)
0.084 1.08E-6 YMR025W CSI1 hom Subunit of the Cop9 signalosome, which is required for deneddylation, or removal of the ubiquitin-like protein Rub1p from Cdc53p (cullin); involved in adaptation to pheromone signaling; functional equivalent of canonical Csn6 subunit of the COP9 signalosome