YJR040W / GEF1

Voltage-gated chloride channel localized to the golgi, the endosomal system, and plasma membrane, and involved in cation homeostasis; highly homologous to vertebrate voltage-gated chloride channels; modulates TBSV model (+) RNA virus replication by regulating copper metabolism

Zygosity: Homozygous strain
fixedexpanded
Profile for YJR040W / GEF1

Click on Significant Values for Screen Details ID:SGTC_15|Compound:0266-0086|FD-Score:4.70|P-value:3.35E-6 ID:SGTC_54|Compound:0159-0055|FD-Score:-3.52|P-value:4.29E-4 ID:SGTC_56|Compound:0957-0365|FD-Score:-4.61|P-value:5.91E-6 ID:SGTC_58|Compound:0957-0393|FD-Score:-12.30|P-value:5.64E-32 ID:SGTC_146|Compound:3448-8650|FD-Score:6.83|P-value:3.11E-11 ID:SGTC_157|Compound:1348-1695|FD-Score:24.60|P-value:1.34E-122 ID:SGTC_178|Compound:4092-0806|FD-Score:3.86|P-value:1.06E-4 ID:SGTC_197|Compound:4544-0043|FD-Score:6.80|P-value:3.72E-11 ID:SGTC_207|Compound:4185-0010|FD-Score:5.47|P-value:8.22E-8 ID:SGTC_255|Compound:tunicamycin|FD-Score:3.25|P-value:8.95E-4 ID:SGTC_263|Compound:alizarin|FD-Score:9.60|P-value:2.25E-20 ID:SGTC_308|Compound:4092-1169|FD-Score:5.91|P-value:7.63E-9 ID:SGTC_310|Compound:1273-0058|FD-Score:-3.66|P-value:2.55E-4 ID:SGTC_327|Compound:1273-0057|FD-Score:-3.89|P-value:1.11E-4 ID:SGTC_339|Compound:3091-4833|FD-Score:6.51|P-value:2.36E-10 ID:SGTC_351|Compound:caspofungin|FD-Score:3.45|P-value:4.56E-4 ID:SGTC_374|Compound:0880-0231|FD-Score:5.15|P-value:4.07E-7 ID:SGTC_431|Compound:k089-0097|FD-Score:4.17|P-value:3.20E-5 ID:SGTC_444|Compound:curcumin|FD-Score:5.95|P-value:6.03E-9 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.84|P-value:1.33E-4 ID:SGTC_481|Compound:bay k-8644|FD-Score:4.01|P-value:5.92E-5 ID:SGTC_525|Compound:k781-2675|FD-Score:4.92|P-value:1.19E-6 ID:SGTC_528|Compound:3492-0019|FD-Score:11.50|P-value:2.71E-28 ID:SGTC_649|Compound:1123-0311|FD-Score:3.87|P-value:1.02E-4 ID:SGTC_699|Compound:0375-0592|FD-Score:5.14|P-value:4.13E-7 ID:SGTC_841|Compound:0251-0215|FD-Score:5.58|P-value:4.46E-8 ID:SGTC_848|Compound:0368-0089|FD-Score:3.68|P-value:2.07E-4 ID:SGTC_855|Compound:0428-0020|FD-Score:-3.60|P-value:3.15E-4 ID:SGTC_953|Compound:1188-0045|FD-Score:-4.41|P-value:1.40E-5 ID:SGTC_963|Compound:1269-2853|FD-Score:5.26|P-value:2.29E-7 ID:SGTC_975|Compound:1335-0046|FD-Score:4.48|P-value:8.69E-6 ID:SGTC_984|Compound:1492-0255|FD-Score:5.03|P-value:7.11E-7 ID:SGTC_1026|Compound:k007-1105|FD-Score:3.87|P-value:1.01E-4 ID:SGTC_1034|Compound:k072-0165|FD-Score:3.87|P-value:1.03E-4 ID:SGTC_1038|Compound:k292-0204|FD-Score:-3.27|P-value:9.85E-4 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:6.81|P-value:3.61E-11 ID:SGTC_1161|Compound:k007-0610|FD-Score:6.67|P-value:8.79E-11 ID:SGTC_1230|Compound:0170-0365|FD-Score:4.43|P-value:1.07E-5 ID:SGTC_1578|Compound:josamycin|FD-Score:4.56|P-value:6.19E-6 ID:SGTC_1581|Compound:himbacine|FD-Score:7.40|P-value:7.42E-13 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:6.63|P-value:1.09E-10 ID:SGTC_1600|Compound:coumarin 106|FD-Score:7.84|P-value:3.14E-14 ID:SGTC_1658|Compound:st012944|FD-Score:7.66|P-value:1.17E-13 ID:SGTC_1660|Compound:st012960|FD-Score:4.93|P-value:1.16E-6 ID:SGTC_1687|Compound:st020778|FD-Score:7.27|P-value:1.73E-12 ID:SGTC_1699|Compound:st031318|FD-Score:3.41|P-value:5.37E-4 ID:SGTC_1750|Compound:st081859|FD-Score:5.26|P-value:2.29E-7 ID:SGTC_1757|Compound:st041620|FD-Score:-3.48|P-value:4.77E-4 ID:SGTC_1780|Compound:st038448|FD-Score:4.45|P-value:1.01E-5 ID:SGTC_1834|Compound:st055981|FD-Score:6.93|P-value:1.60E-11 ID:SGTC_1854|Compound:st056233|FD-Score:3.46|P-value:4.51E-4 ID:SGTC_1922|Compound:5578187|FD-Score:4.53|P-value:7.01E-6 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:4.52|P-value:7.40E-6 ID:SGTC_2006|Compound:4011487|FD-Score:10.40|P-value:8.65E-24 ID:SGTC_2021|Compound:4019055|FD-Score:6.26|P-value:1.00E-9 ID:SGTC_2036|Compound:5160441|FD-Score:7.80|P-value:4.19E-14 ID:SGTC_2046|Compound:4110841|FD-Score:6.82|P-value:3.41E-11 ID:SGTC_2068|Compound:5226020|FD-Score:4.90|P-value:1.31E-6 ID:SGTC_2149|Compound:5554786|FD-Score:4.27|P-value:2.13E-5 ID:SGTC_2153|Compound:5569715|FD-Score:3.68|P-value:2.06E-4 ID:SGTC_2225|Compound:6654152|FD-Score:3.41|P-value:5.36E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:10.40|P-value:8.42E-24 ID:SGTC_2257|Compound:7960413|FD-Score:4.25|P-value:2.30E-5 ID:SGTC_2275|Compound:7947463|FD-Score:6.73|P-value:5.76E-11 ID:SGTC_2286|Compound:7945697|FD-Score:5.23|P-value:2.70E-7 ID:SGTC_2291|Compound:7917025|FD-Score:7.97|P-value:1.23E-14 ID:SGTC_2316|Compound:5844804|FD-Score:-3.71|P-value:2.14E-4 ID:SGTC_2389|Compound:9091542|FD-Score:5.55|P-value:5.30E-8 ID:SGTC_2418|Compound:pentamidine|FD-Score:3.85|P-value:1.11E-4 ID:SGTC_2431|Compound:5490079|FD-Score:6.59|P-value:1.43E-10 ID:SGTC_2442|Compound:5158906|FD-Score:-3.29|P-value:9.04E-4 ID:SGTC_2452|Compound:5863136|FD-Score:4.50|P-value:7.94E-6 ID:SGTC_2504|Compound:purpurogallin|FD-Score:4.60|P-value:5.24E-6 ID:SGTC_2507|Compound:purpurin|FD-Score:5.85|P-value:1.05E-8 ID:SGTC_2516|Compound:gossypol|FD-Score:8.32|P-value:8.90E-16 ID:SGTC_2576|Compound:guaiol|FD-Score:-4.32|P-value:2.02E-5 ID:SGTC_2586|Compound:curcumin|FD-Score:5.64|P-value:3.34E-8 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:6.43|P-value:3.65E-10 ID:SGTC_2619|Compound:obliquin|FD-Score:3.36|P-value:6.35E-4 ID:SGTC_2640|Compound:pentamidine|FD-Score:3.72|P-value:1.80E-4 ID:SGTC_2666|Compound:tannic acid|FD-Score:5.05|P-value:6.40E-7 ID:SGTC_2675|Compound:theaflavin digallate|FD-Score:8.29|P-value:1.08E-15 ID:SGTC_2686|Compound:alizarin|FD-Score:5.26|P-value:2.37E-7 ID:SGTC_2688|Compound:kanamycin b|FD-Score:8.09|P-value:4.95E-15 ID:SGTC_2721|Compound:ifenprodil|FD-Score:3.22|P-value:9.89E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:4.49|P-value:8.52E-6 ID:SGTC_2819|Compound:7996655|FD-Score:-3.73|P-value:2.01E-4 ID:SGTC_2824|Compound:7998404|FD-Score:3.62|P-value:2.58E-4 ID:SGTC_2956|Compound:9076196|FD-Score:3.67|P-value:2.12E-4 ID:SGTC_2968|Compound:9090663|FD-Score:8.75|P-value:2.93E-17 ID:SGTC_2969|Compound:9091408|FD-Score:5.30|P-value:1.96E-7 ID:SGTC_2981|Compound:9013952|FD-Score:4.16|P-value:3.36E-5 ID:SGTC_2991|Compound:9074669|FD-Score:4.61|P-value:4.97E-6 ID:SGTC_3037|Compound:9091026|FD-Score:6.68|P-value:7.90E-11 ID:SGTC_3141|Compound:9094609|FD-Score:8.78|P-value:2.23E-17 ID:SGTC_3142|Compound:9086498|FD-Score:5.23|P-value:2.66E-7 ID:SGTC_3148|Compound:9097893|FD-Score:3.35|P-value:6.56E-4 ID:SGTC_3152|Compound:9099253|FD-Score:4.79|P-value:2.21E-6 ID:SGTC_3195|Compound:9113082|FD-Score:-3.52|P-value:4.17E-4 ID:SGTC_3223|Compound:9129970|FD-Score:4.40|P-value:1.24E-5 ID:SGTC_3256|Compound:9138902|FD-Score:3.47|P-value:4.28E-4 ID:SGTC_3308|Compound:9128332|FD-Score:3.94|P-value:7.83E-5 ID:SGTC_3349|Compound:9149703|FD-Score:-4.14|P-value:4.18E-5 ID:SGTC_15|Compound:0266-0086|FD-Score:4.70|P-value:3.35E-6 ID:SGTC_54|Compound:0159-0055|FD-Score:-3.52|P-value:4.29E-4 ID:SGTC_56|Compound:0957-0365|FD-Score:-4.61|P-value:5.91E-6 ID:SGTC_58|Compound:0957-0393|FD-Score:-12.30|P-value:5.64E-32 ID:SGTC_146|Compound:3448-8650|FD-Score:6.83|P-value:3.11E-11 ID:SGTC_157|Compound:1348-1695|FD-Score:24.60|P-value:1.34E-122 ID:SGTC_178|Compound:4092-0806|FD-Score:3.86|P-value:1.06E-4 ID:SGTC_197|Compound:4544-0043|FD-Score:6.80|P-value:3.72E-11 ID:SGTC_207|Compound:4185-0010|FD-Score:5.47|P-value:8.22E-8 ID:SGTC_255|Compound:tunicamycin|FD-Score:3.25|P-value:8.95E-4 ID:SGTC_263|Compound:alizarin|FD-Score:9.60|P-value:2.25E-20 ID:SGTC_308|Compound:4092-1169|FD-Score:5.91|P-value:7.63E-9 ID:SGTC_310|Compound:1273-0058|FD-Score:-3.66|P-value:2.55E-4 ID:SGTC_327|Compound:1273-0057|FD-Score:-3.89|P-value:1.11E-4 ID:SGTC_339|Compound:3091-4833|FD-Score:6.51|P-value:2.36E-10 ID:SGTC_351|Compound:caspofungin|FD-Score:3.45|P-value:4.56E-4 ID:SGTC_374|Compound:0880-0231|FD-Score:5.15|P-value:4.07E-7 ID:SGTC_431|Compound:k089-0097|FD-Score:4.17|P-value:3.20E-5 ID:SGTC_444|Compound:curcumin|FD-Score:5.95|P-value:6.03E-9 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.84|P-value:1.33E-4 ID:SGTC_481|Compound:bay k-8644|FD-Score:4.01|P-value:5.92E-5 ID:SGTC_525|Compound:k781-2675|FD-Score:4.92|P-value:1.19E-6 ID:SGTC_528|Compound:3492-0019|FD-Score:11.50|P-value:2.71E-28 ID:SGTC_649|Compound:1123-0311|FD-Score:3.87|P-value:1.02E-4 ID:SGTC_699|Compound:0375-0592|FD-Score:5.14|P-value:4.13E-7 ID:SGTC_841|Compound:0251-0215|FD-Score:5.58|P-value:4.46E-8 ID:SGTC_848|Compound:0368-0089|FD-Score:3.68|P-value:2.07E-4 ID:SGTC_855|Compound:0428-0020|FD-Score:-3.60|P-value:3.15E-4 ID:SGTC_953|Compound:1188-0045|FD-Score:-4.41|P-value:1.40E-5 ID:SGTC_963|Compound:1269-2853|FD-Score:5.26|P-value:2.29E-7 ID:SGTC_975|Compound:1335-0046|FD-Score:4.48|P-value:8.69E-6 ID:SGTC_984|Compound:1492-0255|FD-Score:5.03|P-value:7.11E-7 ID:SGTC_1026|Compound:k007-1105|FD-Score:3.87|P-value:1.01E-4 ID:SGTC_1034|Compound:k072-0165|FD-Score:3.87|P-value:1.03E-4 ID:SGTC_1038|Compound:k292-0204|FD-Score:-3.27|P-value:9.85E-4 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:6.81|P-value:3.61E-11 ID:SGTC_1161|Compound:k007-0610|FD-Score:6.67|P-value:8.79E-11 ID:SGTC_1230|Compound:0170-0365|FD-Score:4.43|P-value:1.07E-5 ID:SGTC_1578|Compound:josamycin|FD-Score:4.56|P-value:6.19E-6 ID:SGTC_1581|Compound:himbacine|FD-Score:7.40|P-value:7.42E-13 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:6.63|P-value:1.09E-10 ID:SGTC_1600|Compound:coumarin 106|FD-Score:7.84|P-value:3.14E-14 ID:SGTC_1658|Compound:st012944|FD-Score:7.66|P-value:1.17E-13 ID:SGTC_1660|Compound:st012960|FD-Score:4.93|P-value:1.16E-6 ID:SGTC_1687|Compound:st020778|FD-Score:7.27|P-value:1.73E-12 ID:SGTC_1699|Compound:st031318|FD-Score:3.41|P-value:5.37E-4 ID:SGTC_1750|Compound:st081859|FD-Score:5.26|P-value:2.29E-7 ID:SGTC_1757|Compound:st041620|FD-Score:-3.48|P-value:4.77E-4 ID:SGTC_1780|Compound:st038448|FD-Score:4.45|P-value:1.01E-5 ID:SGTC_1834|Compound:st055981|FD-Score:6.93|P-value:1.60E-11 ID:SGTC_1854|Compound:st056233|FD-Score:3.46|P-value:4.51E-4 ID:SGTC_1922|Compound:5578187|FD-Score:4.53|P-value:7.01E-6 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:4.52|P-value:7.40E-6 ID:SGTC_2006|Compound:4011487|FD-Score:10.40|P-value:8.65E-24 ID:SGTC_2021|Compound:4019055|FD-Score:6.26|P-value:1.00E-9 ID:SGTC_2036|Compound:5160441|FD-Score:7.80|P-value:4.19E-14 ID:SGTC_2046|Compound:4110841|FD-Score:6.82|P-value:3.41E-11 ID:SGTC_2068|Compound:5226020|FD-Score:4.90|P-value:1.31E-6 ID:SGTC_2149|Compound:5554786|FD-Score:4.27|P-value:2.13E-5 ID:SGTC_2153|Compound:5569715|FD-Score:3.68|P-value:2.06E-4 ID:SGTC_2225|Compound:6654152|FD-Score:3.41|P-value:5.36E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:10.40|P-value:8.42E-24 ID:SGTC_2257|Compound:7960413|FD-Score:4.25|P-value:2.30E-5 ID:SGTC_2275|Compound:7947463|FD-Score:6.73|P-value:5.76E-11 ID:SGTC_2286|Compound:7945697|FD-Score:5.23|P-value:2.70E-7 ID:SGTC_2291|Compound:7917025|FD-Score:7.97|P-value:1.23E-14 ID:SGTC_2316|Compound:5844804|FD-Score:-3.71|P-value:2.14E-4 ID:SGTC_2389|Compound:9091542|FD-Score:5.55|P-value:5.30E-8 ID:SGTC_2418|Compound:pentamidine|FD-Score:3.85|P-value:1.11E-4 ID:SGTC_2431|Compound:5490079|FD-Score:6.59|P-value:1.43E-10 ID:SGTC_2442|Compound:5158906|FD-Score:-3.29|P-value:9.04E-4 ID:SGTC_2452|Compound:5863136|FD-Score:4.50|P-value:7.94E-6 ID:SGTC_2504|Compound:purpurogallin|FD-Score:4.60|P-value:5.24E-6 ID:SGTC_2507|Compound:purpurin|FD-Score:5.85|P-value:1.05E-8 ID:SGTC_2516|Compound:gossypol|FD-Score:8.32|P-value:8.90E-16 ID:SGTC_2576|Compound:guaiol|FD-Score:-4.32|P-value:2.02E-5 ID:SGTC_2586|Compound:curcumin|FD-Score:5.64|P-value:3.34E-8 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:6.43|P-value:3.65E-10 ID:SGTC_2619|Compound:obliquin|FD-Score:3.36|P-value:6.35E-4 ID:SGTC_2640|Compound:pentamidine|FD-Score:3.72|P-value:1.80E-4 ID:SGTC_2666|Compound:tannic acid|FD-Score:5.05|P-value:6.40E-7 ID:SGTC_2675|Compound:theaflavin digallate|FD-Score:8.29|P-value:1.08E-15 ID:SGTC_2686|Compound:alizarin|FD-Score:5.26|P-value:2.37E-7 ID:SGTC_2688|Compound:kanamycin b|FD-Score:8.09|P-value:4.95E-15 ID:SGTC_2721|Compound:ifenprodil|FD-Score:3.22|P-value:9.89E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:4.49|P-value:8.52E-6 ID:SGTC_2819|Compound:7996655|FD-Score:-3.73|P-value:2.01E-4 ID:SGTC_2824|Compound:7998404|FD-Score:3.62|P-value:2.58E-4 ID:SGTC_2956|Compound:9076196|FD-Score:3.67|P-value:2.12E-4 ID:SGTC_2968|Compound:9090663|FD-Score:8.75|P-value:2.93E-17 ID:SGTC_2969|Compound:9091408|FD-Score:5.30|P-value:1.96E-7 ID:SGTC_2981|Compound:9013952|FD-Score:4.16|P-value:3.36E-5 ID:SGTC_2991|Compound:9074669|FD-Score:4.61|P-value:4.97E-6 ID:SGTC_3037|Compound:9091026|FD-Score:6.68|P-value:7.90E-11 ID:SGTC_3141|Compound:9094609|FD-Score:8.78|P-value:2.23E-17 ID:SGTC_3142|Compound:9086498|FD-Score:5.23|P-value:2.66E-7 ID:SGTC_3148|Compound:9097893|FD-Score:3.35|P-value:6.56E-4 ID:SGTC_3152|Compound:9099253|FD-Score:4.79|P-value:2.21E-6 ID:SGTC_3195|Compound:9113082|FD-Score:-3.52|P-value:4.17E-4 ID:SGTC_3223|Compound:9129970|FD-Score:4.40|P-value:1.24E-5 ID:SGTC_3256|Compound:9138902|FD-Score:3.47|P-value:4.28E-4 ID:SGTC_3308|Compound:9128332|FD-Score:3.94|P-value:7.83E-5 ID:SGTC_3349|Compound:9149703|FD-Score:-4.14|P-value:4.18E-5

Top fitness defect scores for YJR040W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_157 1348-1695 24.60 65.8 µM 1.34E-122 iron homeostasis 3 3.08E-134
2 SGTC_528 3492-0019 11.50 172.0 µM 2.71E-28 calcium & mitochondrial duress 32 8.80E-31
3 SGTC_2249 haloperidol 10.40 116.4 µM 8.42E-24 ergosterol depletion effects on membrane 12 7.35E-26
4 SGTC_2006 4011487 10.40 200.0 µM 8.65E-24 endomembrane recycling 16 7.58E-26
5 SGTC_263 alizarin 9.60 107.9 µM 2.25E-20 iron homeostasis 5 4.16E-22
6 SGTC_3141 9094609 8.78 49.5 µM 2.23E-17 iron homeostasis 2 7.96E-19
7 SGTC_2968 9090663 8.75 33.4 µM 2.93E-17 1 1.07E-18
8 SGTC_2516 gossypol 8.32 71.5 µM 8.90E-16 1 4.50E-17
9 SGTC_2675 theaflavin digallate 8.29 100.0 µM 1.08E-15 iron homeostasis 5 5.55E-17
10 SGTC_2688 kanamycin b 8.09 96.7 µM 4.95E-15 calcium & mitochondrial duress 60 2.94E-16
11 SGTC_2291 7917025 7.97 104.3 µM 1.23E-14 iron homeostasis 17 7.95E-16
12 SGTC_1600 coumarin 106 7.84 71.1 µM 3.14E-14 3 2.22E-15
13 SGTC_2036 5160441 7.80 105.0 µM 4.19E-14 NEO1 30 3.05E-15
14 SGTC_1658 st012944 7.66 20.0 µM 1.17E-13 iron homeostasis 11 9.37E-15
15 SGTC_1581 himbacine 7.40 57.9 µM 7.42E-13 Golgi 12 7.06E-14
16 SGTC_1687 st020778 7.27 55.4 µM 1.73E-12 83 1.78E-13
17 SGTC_1834 st055981 6.93 52.8 µM 1.60E-11 RPP1 & pyrimidine depletion 3 2.03E-12
18 SGTC_146 3448-8650 6.83 53.1 µM 3.11E-11 NEO1-PIK1 40 4.19E-12
19 SGTC_2046 4110841 6.82 106.0 µM 3.41E-11 iron homeostasis 4 4.64E-12
20 SGTC_1110 3-hydroxy-3'-methoxyflavone 6.81 1.2 µM 3.61E-11 iron homeostasis 8 4.94E-12

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.575 6.20E-294 YJL094C KHA1 hom Putative K+/H+ antiporter with a probable role in intracellular cation homeostasis, localized to Golgi vesicles and detected in highly purified mitochondria in high-throughput studies
0.503 1.38E-214 YDR270W CCC2 hom Cu(+2)-transporting P-type ATPase; required for export of copper from the cytosol into an extracytosolic compartment; has similarity to human proteins involved in Menkes and Wilsons diseases; protein abundance increases in response to DNA replication stress; affects TBSV model (+)RNA virus replication by regulating copper metabolism
0.499 5.49E-211 YDR269C_d YDR269C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.362 9.51E-105 YMR058W FET3 hom Ferro-O2-oxidoreductase; required for high-affinity iron uptake and involved in mediating resistance to copper ion toxicity, belongs to class of integral membrane multicopper oxidases; protein abundance increases in response to DNA replication stress
0.355 2.13E-100 YDR271C_d YDR271C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CCC2/YDR270W
0.349 5.60E-97 YDR203W_d YDR203W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.324 1.21E-82 YNL259C ATX1 hom Cytosolic copper metallochaperone that transports copper to the secretory vesicle copper transporter Ccc2p for eventual insertion into Fet3p, which is a multicopper oxidase required for high-affinity iron uptake
0.297 1.75E-69 YJR033C RAV1 hom Subunit of the RAVE complex (Rav1p, Rav2p, Skp1p), which promotes assembly of the V-ATPase holoenzyme; required for transport between the early and late endosome/PVC and for localization of TGN membrane proteins; potential Cdc28p substrate
0.292 4.99E-67 YER145C FTR1 hom High affinity iron permease; involved in the transport of iron across the plasma membrane; forms complex with Fet3p; expression is regulated by iron; protein abundance increases in response to DNA replication stress
0.268 2.70E-56 YGR261C APL6 hom Beta3-like subunit of the yeast AP-3 complex; functions in transport of alkaline phosphatase to the vacuole via the alternate pathway; exists in both cytosolic and peripherally associated membrane-bound pools
0.238 1.40E-44 YMR057C_d YMR057C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF AAC1
0.237 3.90E-44 YGL045W RIM8 hom Protein involved in proteolytic activation of Rim101p in response to alkaline pH; interacts with ESCRT-1 subunits Stp22p and Vps28p; essential for anaerobic growth; member of the arrestin-related trafficking adaptor family
0.229 4.56E-41 YOR089C VPS21 hom Rab family GTPase; required for endocytic transport and for sorting of vacuolar hydrolases; localized in endocytic intermediates; detected in mitochondria; geranylgeranylation required for membrane association; mammalian Rab5 homolog; protein abundance increases in response to DNA replication stress; VPS21 has a paralog, YPT53, that arose from the whole genome duplication
0.224 1.70E-39 YAL009W SPO7 hom Putative regulatory subunit of Nem1p-Spo7p phosphatase holoenzyme, regulates nuclear growth by controlling phospholipid biosynthesis, required for normal nuclear envelope morphology, premeiotic replication, and sporulation
0.224 2.09E-39 YAL002W VPS8 hom Membrane-binding component of the CORVET complex; involved in endosomal vesicle tethering and fusion in the endosome to vacuole protein targeting pathway; interacts with Vps21p; contains RING finger motif