YJR041C / URB2

Nucleolar protein required for normal metabolism of the rRNA primary transcript, proposed to be involved in ribosome biogenesis

Zygosity: Heterozygous strain
fixedexpanded
Profile for YJR041C / URB2

Click on Significant Values for Screen Details ID:SGTC_67|Compound:0335-0847|FD-Score:4.04|P-value:2.87E-6 ID:SGTC_145|Compound:3737-0113|FD-Score:2.76|P-value:9.25E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:-3.08|P-value:3.43E-4 ID:SGTC_396|Compound:dithiazanine|FD-Score:-3.03|P-value:4.15E-4 ID:SGTC_524|Compound:r073-0010|FD-Score:-3.74|P-value:1.77E-5 ID:SGTC_535|Compound:2293-4129|FD-Score:5.30|P-value:1.35E-9 ID:SGTC_541|Compound:4513-1321|FD-Score:3.75|P-value:1.21E-5 ID:SGTC_542|Compound:3381-0244|FD-Score:2.85|P-value:6.47E-4 ID:SGTC_643|Compound:k048-0106|FD-Score:3.73|P-value:1.33E-5 ID:SGTC_646|Compound:4092-0839|FD-Score:2.99|P-value:3.72E-4 ID:SGTC_782|Compound:0083-0095|FD-Score:-2.91|P-value:6.64E-4 ID:SGTC_785|Compound:1270-0111|FD-Score:-3.12|P-value:2.91E-4 ID:SGTC_808|Compound:0711-0032|FD-Score:3.04|P-value:3.09E-4 ID:SGTC_1137|Compound:ixabepilone|FD-Score:-3.30|P-value:1.34E-4 ID:SGTC_1204|Compound:4049-0315|FD-Score:-2.97|P-value:5.19E-4 ID:SGTC_1213|Compound:1315-0166|FD-Score:-2.92|P-value:6.36E-4 ID:SGTC_1241|Compound:0364-0022|FD-Score:-3.27|P-value:1.52E-4 ID:SGTC_1251|Compound:0490-5699|FD-Score:3.81|P-value:8.97E-6 ID:SGTC_1455|Compound:4262-0120|FD-Score:3.76|P-value:1.16E-5 ID:SGTC_1543|Compound:azetidyl-2-carboxylic acid|FD-Score:-2.96|P-value:5.42E-4 ID:SGTC_1683|Compound:st010134|FD-Score:-3.59|P-value:3.64E-5 ID:SGTC_1736|Compound:st036774|FD-Score:3.51|P-value:3.87E-5 ID:SGTC_1848|Compound:st056003|FD-Score:-5.18|P-value:4.73E-9 ID:SGTC_1857|Compound:st056007|FD-Score:-3.27|P-value:1.50E-4 ID:SGTC_1861|Compound:st057647|FD-Score:5.10|P-value:5.08E-9 ID:SGTC_1888|Compound:azatryptophan|FD-Score:-2.99|P-value:4.87E-4 ID:SGTC_2026|Compound:5148700|FD-Score:-2.85|P-value:8.27E-4 ID:SGTC_2039|Compound:Aminomethylbenzodioxan|FD-Score:-2.86|P-value:8.00E-4 ID:SGTC_2091|Compound:4-phenylthiadiazole|FD-Score:-2.99|P-value:4.83E-4 ID:SGTC_2291|Compound:7917025|FD-Score:-3.46|P-value:6.51E-5 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:3.26|P-value:1.22E-4 ID:SGTC_2576|Compound:guaiol|FD-Score:3.10|P-value:2.41E-4 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:-3.24|P-value:1.72E-4 ID:SGTC_2691|Compound:st077356|FD-Score:6.33|P-value:6.21E-13 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:3.98|P-value:3.91E-6 ID:SGTC_2764|Compound:methyldopa|FD-Score:3.07|P-value:2.75E-4 ID:SGTC_2802|Compound:7925815|FD-Score:-2.96|P-value:5.52E-4 ID:SGTC_2935|Compound:9038016|FD-Score:2.86|P-value:6.25E-4 ID:SGTC_67|Compound:0335-0847|FD-Score:4.04|P-value:2.87E-6 ID:SGTC_145|Compound:3737-0113|FD-Score:2.76|P-value:9.25E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:-3.08|P-value:3.43E-4 ID:SGTC_396|Compound:dithiazanine|FD-Score:-3.03|P-value:4.15E-4 ID:SGTC_524|Compound:r073-0010|FD-Score:-3.74|P-value:1.77E-5 ID:SGTC_535|Compound:2293-4129|FD-Score:5.30|P-value:1.35E-9 ID:SGTC_541|Compound:4513-1321|FD-Score:3.75|P-value:1.21E-5 ID:SGTC_542|Compound:3381-0244|FD-Score:2.85|P-value:6.47E-4 ID:SGTC_643|Compound:k048-0106|FD-Score:3.73|P-value:1.33E-5 ID:SGTC_646|Compound:4092-0839|FD-Score:2.99|P-value:3.72E-4 ID:SGTC_782|Compound:0083-0095|FD-Score:-2.91|P-value:6.64E-4 ID:SGTC_785|Compound:1270-0111|FD-Score:-3.12|P-value:2.91E-4 ID:SGTC_808|Compound:0711-0032|FD-Score:3.04|P-value:3.09E-4 ID:SGTC_1137|Compound:ixabepilone|FD-Score:-3.30|P-value:1.34E-4 ID:SGTC_1204|Compound:4049-0315|FD-Score:-2.97|P-value:5.19E-4 ID:SGTC_1213|Compound:1315-0166|FD-Score:-2.92|P-value:6.36E-4 ID:SGTC_1241|Compound:0364-0022|FD-Score:-3.27|P-value:1.52E-4 ID:SGTC_1251|Compound:0490-5699|FD-Score:3.81|P-value:8.97E-6 ID:SGTC_1455|Compound:4262-0120|FD-Score:3.76|P-value:1.16E-5 ID:SGTC_1543|Compound:azetidyl-2-carboxylic acid|FD-Score:-2.96|P-value:5.42E-4 ID:SGTC_1683|Compound:st010134|FD-Score:-3.59|P-value:3.64E-5 ID:SGTC_1736|Compound:st036774|FD-Score:3.51|P-value:3.87E-5 ID:SGTC_1848|Compound:st056003|FD-Score:-5.18|P-value:4.73E-9 ID:SGTC_1857|Compound:st056007|FD-Score:-3.27|P-value:1.50E-4 ID:SGTC_1861|Compound:st057647|FD-Score:5.10|P-value:5.08E-9 ID:SGTC_1888|Compound:azatryptophan|FD-Score:-2.99|P-value:4.87E-4 ID:SGTC_2026|Compound:5148700|FD-Score:-2.85|P-value:8.27E-4 ID:SGTC_2039|Compound:Aminomethylbenzodioxan|FD-Score:-2.86|P-value:8.00E-4 ID:SGTC_2091|Compound:4-phenylthiadiazole|FD-Score:-2.99|P-value:4.83E-4 ID:SGTC_2291|Compound:7917025|FD-Score:-3.46|P-value:6.51E-5 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:3.26|P-value:1.22E-4 ID:SGTC_2576|Compound:guaiol|FD-Score:3.10|P-value:2.41E-4 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:-3.24|P-value:1.72E-4 ID:SGTC_2691|Compound:st077356|FD-Score:6.33|P-value:6.21E-13 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:3.98|P-value:3.91E-6 ID:SGTC_2764|Compound:methyldopa|FD-Score:3.07|P-value:2.75E-4 ID:SGTC_2802|Compound:7925815|FD-Score:-2.96|P-value:5.52E-4 ID:SGTC_2935|Compound:9038016|FD-Score:2.86|P-value:6.25E-4

Top fitness defect scores for YJR041C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2691 st077356 6.33 60.2 µM 6.21E-13 1 1.19E-10 1.04
2 SGTC_535 2293-4129 5.30 48.2 µM 1.35E-9 NEO1 4 5.72E-8 0.74
3 SGTC_1861 st057647 5.10 17.4 µM 5.08E-9 1 1.66E-7 0.51
4 SGTC_67 0335-0847 4.04 266.0 µM 2.87E-6 ubiquinone biosynthesis & proteasome 21 2.73E-5 0.13
5 SGTC_2697 mebhydrolin 3.98 72.4 µM 3.91E-6 NEO1 7 3.50E-5 0.29
6 SGTC_1251 0490-5699 3.81 265.0 µM 8.97E-6 9 6.83E-5 0.24
7 SGTC_1455 4262-0120 3.76 131.0 µM 1.16E-5 plasma membrane duress 6 8.38E-5 0.14
8 SGTC_541 4513-1321 3.75 94.0 µM 1.21E-5 10 8.71E-5 0.02
9 SGTC_643 k048-0106 3.73 28.4 µM 1.33E-5 RSC & ERG11 16 9.39E-5 0.11
10 SGTC_1736 st036774 3.51 51.0 µM 3.87E-5 5 2.22E-4 0.13
11 SGTC_2566 crystal violet carbinol 3.26 226.0 nM 1.22E-4 33 5.60E-4 0.02
12 SGTC_2576 guaiol 3.10 23.1 µM 2.41E-4 25 9.73E-4 0.18
13 SGTC_2764 methyldopa 3.07 94.7 µM 2.75E-4 10 0.00108 0.08
14 SGTC_808 0711-0032 3.04 135.0 µM 3.09E-4 21 0.00119 0.03
15 SGTC_646 4092-0839 2.99 27.3 µM 3.72E-4 plasma membrane duress 18 0.00138 0.03
16 SGTC_2935 9038016 2.86 30.0 µM 6.25E-4 18 0.00210 0.17
17 SGTC_542 3381-0244 2.85 89.3 µM 6.47E-4 19 0.00216 0.00
18 SGTC_145 3737-0113 2.76 38.4 µM 9.25E-4 DNA intercalators 86 0.00289 3.94E-4
19 SGTC_2605 digitonin 2.71 300.0 nM 0.00110 22 0.00332 0.01
20 SGTC_2479 5617353 2.64 43.9 µM 0.00142 31 0.00410 0.00

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.202 3.15E-32 YCR012W PGK1 het 3-phosphoglycerate kinase, catalyzes transfer of high-energy phosphoryl groups from the acyl phosphate of 1,3-bisphosphoglycerate to ADP to produce ATP; key enzyme in glycolysis and gluconeogenesis
0.186 1.54E-27 YEL063C CAN1 hom Plasma membrane arginine permease; requires phosphatidyl ethanolamine (PE) for localization, exclusively associated with lipid rafts; mutation confers canavanine resistance; CAN1 has a paralog, ALP1, that arose from the whole genome duplication
0.127 1.90E-13 YDL199C_p YDL199C_p hom Putative transporter, member of the sugar porter family
0.122 1.57E-12 YDR026C NSI1 hom RNA polymerase I termination factor; binds to rDNA terminator element, required for efficient Pol I termination; required for rDNA silencing at NTS1; facilities association of Sir2p with NTS1, contributes to rDNA stability and cell longevity; interacts physically with Fob1p and RENT subunits, Sir2p and Net1p; may interact with ribosomes, based on co-purification experiments; Myb-like DNA-binding protein; NSI1 has a paralog, REB1, that arose from the whole genome duplication
0.119 3.93E-12 YFL044C OTU1 hom Deubiquitylation enzyme that binds to the chaperone-ATPase Cdc48p; may contribute to regulation of protein degradation by deubiquitylating substrates that have been ubiquitylated by Ufd2p; member of the Ovarian Tumor (OTU) family; protein abundance increases in response to DNA replication stress
0.119 5.56E-12 YOR303W CPA1 hom Small subunit of carbamoyl phosphate synthetase, which catalyzes a step in the synthesis of citrulline, an arginine precursor; translationally regulated by an attenuator peptide encoded by YOR302W within the CPA1 mRNA 5'-leader
0.118 7.14E-12 YMR133W REC114 hom Protein involved in early stages of meiotic recombination; possibly involved in the coordination of recombination and meiotic division; mutations lead to premature initiation of the first meiotic division
0.117 1.17E-11 YMR110C HFD1 hom Hexadecenal dehydrogenase; involved in the conversion of sphingosine 1-phosphate breakdown product hexadecenal to hexadecenoic acid; located in the mitochondrial outer membrane and also in lipid particles; has similarity to ALDH3A2, a human fatty aldehyde dehydrogenase (FALDH) mutated in Sjogren-Larsson syndrome, a neurocutaneous disorder
0.117 1.23E-11 YJL212C OPT1 hom Proton-coupled oligopeptide transporter of the plasma membrane; also transports glutathione and phytochelatin; member of the OPT family
0.116 1.54E-11 YNL105W_d RRT16_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene INP52; identified in a screen for mutants with decreased levels of rDNA transcription
0.113 5.39E-11 YBR080C SEC18 het ATPase required for vesicular transport between ER and Golgi, the 'priming' step in homotypic vacuole fusion, autophagy, and protein secretion; releases Sec17p from SNAP complexes; has similarity to mammalian NSF
0.112 8.49E-11 YDR455C_d YDR455C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YDR456W
0.111 1.04E-10 YKR054C DYN1 hom Cytoplasmic heavy chain dynein, microtubule motor protein, required for anaphase spindle elongation; involved in spindle assembly, chromosome movement, and spindle orientation during cell division, targeted to microtubule tips by Pac1p
0.109 2.97E-10 YPR024W YME1 hom Catalytic subunit of the mitochondrial inner membrane i-AAA protease complex, which is responsible for degradation of unfolded or misfolded mitochondrial gene products; also has a role in intermembrane space protein folding; mutation causes an elevated rate of mitochondrial turnover
0.107 4.70E-10 YJL154C VPS35 hom Endosomal subunit of membrane-associated retromer complex required for retrograde transport; receptor that recognizes retrieval signals on cargo proteins, forms subcomplex with Vps26p and Vps29p that selects cargo proteins for retrieval; interacts with Ypt7p