YJR042W / NUP85

Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport and NPC biogenesis and is involved in establishment of a normal nucleocytoplasmic concentration gradient of the GTPase Gsp1p; also plays roles in several processes that may require localization of genes or chromosomes at the nuclear periphery, including double-strand break repair, transcription and chromatin silencing; homologous to human NUP85 aka NUP75

Zygosity: Heterozygous strain
fixedexpanded
Profile for YJR042W / NUP85

Click on Significant Values for Screen Details ID:SGTC_1|Compound:0258-0098|FD-Score:-4.20|P-value:1.27E-4 ID:SGTC_55|Compound:0767-0285|FD-Score:3.68|P-value:6.17E-4 ID:SGTC_95|Compound:0471-0001|FD-Score:5.71|P-value:2.80E-7 ID:SGTC_99|Compound:0109-0120|FD-Score:3.81|P-value:4.18E-4 ID:SGTC_101|Compound:0490-5701|FD-Score:4.31|P-value:7.73E-5 ID:SGTC_102|Compound:gallobenzophenone|FD-Score:-4.05|P-value:2.10E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:13.00|P-value:2.29E-30 ID:SGTC_106|Compound:0092-0003|FD-Score:-3.86|P-value:3.91E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:-4.04|P-value:2.24E-4 ID:SGTC_159|Compound:3970-0959|FD-Score:12.60|P-value:1.31E-28 ID:SGTC_164|Compound:4100-3994|FD-Score:3.80|P-value:4.23E-4 ID:SGTC_188|Compound:3229-0966|FD-Score:8.30|P-value:1.81E-13 ID:SGTC_192|Compound:3455-0609|FD-Score:3.58|P-value:8.47E-4 ID:SGTC_214|Compound:4373-3496|FD-Score:10.60|P-value:1.02E-20 ID:SGTC_227|Compound:fluconazole|FD-Score:6.26|P-value:2.10E-8 ID:SGTC_268|Compound:camptothecin|FD-Score:4.39|P-value:5.86E-5 ID:SGTC_377|Compound:3970-0964|FD-Score:4.19|P-value:1.21E-4 ID:SGTC_432|Compound:NS 1619|FD-Score:3.64|P-value:7.01E-4 ID:SGTC_462|Compound:ag-879|FD-Score:-3.64|P-value:7.82E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:7.80|P-value:4.25E-12 ID:SGTC_676|Compound:falcarinol|FD-Score:5.35|P-value:1.37E-6 ID:SGTC_778|Compound:3456-2434|FD-Score:-6.47|P-value:8.74E-9 ID:SGTC_800|Compound:3448-7362|FD-Score:4.26|P-value:9.20E-5 ID:SGTC_852|Compound:0418-0143|FD-Score:4.71|P-value:1.81E-5 ID:SGTC_997|Compound:3996-0078|FD-Score:3.82|P-value:3.97E-4 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:3.72|P-value:5.55E-4 ID:SGTC_1187|Compound:1391-0724|FD-Score:3.74|P-value:5.12E-4 ID:SGTC_1255|Compound:0566-0045|FD-Score:-3.57|P-value:9.52E-4 ID:SGTC_1374|Compound:2889-5571|FD-Score:7.41|P-value:4.49E-11 ID:SGTC_1413|Compound:3910-0535|FD-Score:-3.99|P-value:2.59E-4 ID:SGTC_1426|Compound:4048-4480|FD-Score:3.90|P-value:3.12E-4 ID:SGTC_1441|Compound:4106-0040|FD-Score:4.27|P-value:9.10E-5 ID:SGTC_1466|Compound:k213-0079|FD-Score:3.66|P-value:6.59E-4 ID:SGTC_1493|Compound:4348-0038|FD-Score:5.97|P-value:8.42E-8 ID:SGTC_1520|Compound:flindersine|FD-Score:-3.76|P-value:5.41E-4 ID:SGTC_1527|Compound:coumarin|FD-Score:4.82|P-value:1.18E-5 ID:SGTC_1532|Compound:4',5'-dihydroxyflavone|FD-Score:-3.72|P-value:6.00E-4 ID:SGTC_1554|Compound:st069299|FD-Score:5.14|P-value:3.39E-6 ID:SGTC_1605|Compound:st000082|FD-Score:5.92|P-value:1.09E-7 ID:SGTC_1652|Compound:st011932|FD-Score:4.65|P-value:2.30E-5 ID:SGTC_1664|Compound:st014217|FD-Score:3.53|P-value:9.66E-4 ID:SGTC_1745|Compound:st081495|FD-Score:4.04|P-value:2.00E-4 ID:SGTC_1784|Compound:st039334|FD-Score:5.42|P-value:1.00E-6 ID:SGTC_1880|Compound:MG-132|FD-Score:6.70|P-value:2.19E-9 ID:SGTC_1953|Compound:st076800|FD-Score:4.50|P-value:3.93E-5 ID:SGTC_1960|Compound:st011366|FD-Score:4.09|P-value:1.67E-4 ID:SGTC_2013|Compound:4024628|FD-Score:4.80|P-value:1.28E-5 ID:SGTC_2073|Compound:5212005|FD-Score:-3.61|P-value:8.55E-4 ID:SGTC_2109|Compound:5483026|FD-Score:4.66|P-value:2.19E-5 ID:SGTC_2111|Compound:5486399|FD-Score:4.00|P-value:2.28E-4 ID:SGTC_2282|Compound:7944268|FD-Score:6.02|P-value:6.68E-8 ID:SGTC_2286|Compound:7945697|FD-Score:-5.77|P-value:2.50E-7 ID:SGTC_2288|Compound:7946289|FD-Score:-4.56|P-value:3.60E-5 ID:SGTC_2417|Compound:cerulenin|FD-Score:8.80|P-value:6.95E-15 ID:SGTC_2652|Compound:actinonin|FD-Score:4.12|P-value:1.52E-4 ID:SGTC_2657|Compound:nystatin|FD-Score:4.32|P-value:7.61E-5 ID:SGTC_2662|Compound:daunorubicin|FD-Score:-3.90|P-value:3.47E-4 ID:SGTC_2674|Compound:ligustilide|FD-Score:5.04|P-value:4.95E-6 ID:SGTC_2765|Compound:myclobutanil|FD-Score:3.95|P-value:2.64E-4 ID:SGTC_2849|Compound:9019321|FD-Score:4.34|P-value:7.07E-5 ID:SGTC_2858|Compound:9025781|FD-Score:4.98|P-value:6.38E-6 ID:SGTC_2860|Compound:9025725|FD-Score:-4.16|P-value:1.48E-4 ID:SGTC_2890|Compound:9046729|FD-Score:6.24|P-value:2.35E-8 ID:SGTC_3148|Compound:9097893|FD-Score:4.09|P-value:1.68E-4 ID:SGTC_3213|Compound:9129884|FD-Score:-3.77|P-value:5.27E-4 ID:SGTC_3216|Compound:9129716|FD-Score:-4.28|P-value:9.70E-5 ID:SGTC_3221|Compound:9128209|FD-Score:4.37|P-value:6.44E-5 ID:SGTC_3222|Compound:9128301|FD-Score:7.35|P-value:6.05E-11 ID:SGTC_3286|Compound:9117135|FD-Score:3.82|P-value:4.05E-4 ID:SGTC_3306|Compound:9127676|FD-Score:-4.56|P-value:3.61E-5 ID:SGTC_3337|Compound:9144342|FD-Score:6.39|P-value:1.11E-8 ID:SGTC_1|Compound:0258-0098|FD-Score:-4.20|P-value:1.27E-4 ID:SGTC_55|Compound:0767-0285|FD-Score:3.68|P-value:6.17E-4 ID:SGTC_95|Compound:0471-0001|FD-Score:5.71|P-value:2.80E-7 ID:SGTC_99|Compound:0109-0120|FD-Score:3.81|P-value:4.18E-4 ID:SGTC_101|Compound:0490-5701|FD-Score:4.31|P-value:7.73E-5 ID:SGTC_102|Compound:gallobenzophenone|FD-Score:-4.05|P-value:2.10E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:13.00|P-value:2.29E-30 ID:SGTC_106|Compound:0092-0003|FD-Score:-3.86|P-value:3.91E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:-4.04|P-value:2.24E-4 ID:SGTC_159|Compound:3970-0959|FD-Score:12.60|P-value:1.31E-28 ID:SGTC_164|Compound:4100-3994|FD-Score:3.80|P-value:4.23E-4 ID:SGTC_188|Compound:3229-0966|FD-Score:8.30|P-value:1.81E-13 ID:SGTC_192|Compound:3455-0609|FD-Score:3.58|P-value:8.47E-4 ID:SGTC_214|Compound:4373-3496|FD-Score:10.60|P-value:1.02E-20 ID:SGTC_227|Compound:fluconazole|FD-Score:6.26|P-value:2.10E-8 ID:SGTC_268|Compound:camptothecin|FD-Score:4.39|P-value:5.86E-5 ID:SGTC_377|Compound:3970-0964|FD-Score:4.19|P-value:1.21E-4 ID:SGTC_432|Compound:NS 1619|FD-Score:3.64|P-value:7.01E-4 ID:SGTC_462|Compound:ag-879|FD-Score:-3.64|P-value:7.82E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:7.80|P-value:4.25E-12 ID:SGTC_676|Compound:falcarinol|FD-Score:5.35|P-value:1.37E-6 ID:SGTC_778|Compound:3456-2434|FD-Score:-6.47|P-value:8.74E-9 ID:SGTC_800|Compound:3448-7362|FD-Score:4.26|P-value:9.20E-5 ID:SGTC_852|Compound:0418-0143|FD-Score:4.71|P-value:1.81E-5 ID:SGTC_997|Compound:3996-0078|FD-Score:3.82|P-value:3.97E-4 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:3.72|P-value:5.55E-4 ID:SGTC_1187|Compound:1391-0724|FD-Score:3.74|P-value:5.12E-4 ID:SGTC_1255|Compound:0566-0045|FD-Score:-3.57|P-value:9.52E-4 ID:SGTC_1374|Compound:2889-5571|FD-Score:7.41|P-value:4.49E-11 ID:SGTC_1413|Compound:3910-0535|FD-Score:-3.99|P-value:2.59E-4 ID:SGTC_1426|Compound:4048-4480|FD-Score:3.90|P-value:3.12E-4 ID:SGTC_1441|Compound:4106-0040|FD-Score:4.27|P-value:9.10E-5 ID:SGTC_1466|Compound:k213-0079|FD-Score:3.66|P-value:6.59E-4 ID:SGTC_1493|Compound:4348-0038|FD-Score:5.97|P-value:8.42E-8 ID:SGTC_1520|Compound:flindersine|FD-Score:-3.76|P-value:5.41E-4 ID:SGTC_1527|Compound:coumarin|FD-Score:4.82|P-value:1.18E-5 ID:SGTC_1532|Compound:4',5'-dihydroxyflavone|FD-Score:-3.72|P-value:6.00E-4 ID:SGTC_1554|Compound:st069299|FD-Score:5.14|P-value:3.39E-6 ID:SGTC_1605|Compound:st000082|FD-Score:5.92|P-value:1.09E-7 ID:SGTC_1652|Compound:st011932|FD-Score:4.65|P-value:2.30E-5 ID:SGTC_1664|Compound:st014217|FD-Score:3.53|P-value:9.66E-4 ID:SGTC_1745|Compound:st081495|FD-Score:4.04|P-value:2.00E-4 ID:SGTC_1784|Compound:st039334|FD-Score:5.42|P-value:1.00E-6 ID:SGTC_1880|Compound:MG-132|FD-Score:6.70|P-value:2.19E-9 ID:SGTC_1953|Compound:st076800|FD-Score:4.50|P-value:3.93E-5 ID:SGTC_1960|Compound:st011366|FD-Score:4.09|P-value:1.67E-4 ID:SGTC_2013|Compound:4024628|FD-Score:4.80|P-value:1.28E-5 ID:SGTC_2073|Compound:5212005|FD-Score:-3.61|P-value:8.55E-4 ID:SGTC_2109|Compound:5483026|FD-Score:4.66|P-value:2.19E-5 ID:SGTC_2111|Compound:5486399|FD-Score:4.00|P-value:2.28E-4 ID:SGTC_2282|Compound:7944268|FD-Score:6.02|P-value:6.68E-8 ID:SGTC_2286|Compound:7945697|FD-Score:-5.77|P-value:2.50E-7 ID:SGTC_2288|Compound:7946289|FD-Score:-4.56|P-value:3.60E-5 ID:SGTC_2417|Compound:cerulenin|FD-Score:8.80|P-value:6.95E-15 ID:SGTC_2652|Compound:actinonin|FD-Score:4.12|P-value:1.52E-4 ID:SGTC_2657|Compound:nystatin|FD-Score:4.32|P-value:7.61E-5 ID:SGTC_2662|Compound:daunorubicin|FD-Score:-3.90|P-value:3.47E-4 ID:SGTC_2674|Compound:ligustilide|FD-Score:5.04|P-value:4.95E-6 ID:SGTC_2765|Compound:myclobutanil|FD-Score:3.95|P-value:2.64E-4 ID:SGTC_2849|Compound:9019321|FD-Score:4.34|P-value:7.07E-5 ID:SGTC_2858|Compound:9025781|FD-Score:4.98|P-value:6.38E-6 ID:SGTC_2860|Compound:9025725|FD-Score:-4.16|P-value:1.48E-4 ID:SGTC_2890|Compound:9046729|FD-Score:6.24|P-value:2.35E-8 ID:SGTC_3148|Compound:9097893|FD-Score:4.09|P-value:1.68E-4 ID:SGTC_3213|Compound:9129884|FD-Score:-3.77|P-value:5.27E-4 ID:SGTC_3216|Compound:9129716|FD-Score:-4.28|P-value:9.70E-5 ID:SGTC_3221|Compound:9128209|FD-Score:4.37|P-value:6.44E-5 ID:SGTC_3222|Compound:9128301|FD-Score:7.35|P-value:6.05E-11 ID:SGTC_3286|Compound:9117135|FD-Score:3.82|P-value:4.05E-4 ID:SGTC_3306|Compound:9127676|FD-Score:-4.56|P-value:3.61E-5 ID:SGTC_3337|Compound:9144342|FD-Score:6.39|P-value:1.11E-8

Top fitness defect scores for YJR042W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_103 0844-0104 13.00 51.8 µM 2.29E-30 ERAD & cell cycle 6 4.43E-39 0.80
2 SGTC_159 3970-0959 12.60 50.0 µM 1.31E-28 1 8.78E-37 2.98
3 SGTC_214 4373-3496 10.60 70.0 µM 1.02E-20 2 1.77E-26 2.77
4 SGTC_2417 cerulenin 8.80 830.0 nM 6.95E-15 2 7.15E-19 2.00
5 SGTC_188 3229-0966 8.30 278.5 µM 1.81E-13 2 5.02E-17 1.56
6 SGTC_673 1082-0474 7.80 110.0 µM 4.25E-12 RSC complex & mRNA processing 20 3.05E-15 0.43
7 SGTC_1374 2889-5571 7.41 141.0 µM 4.49E-11 RSC complex & mRNA processing 17 6.55E-14 0.51
8 SGTC_3222 9128301 7.35 49.5 µM 6.05E-11 60S ribosome export 2 9.64E-14 0.22
9 SGTC_1880 MG-132 6.70 525.0 µM 2.19E-9 7 1.03E-11 0.19
10 SGTC_3337 9144342 6.39 33.5 µM 1.11E-8 6 8.46E-11 1.40
11 SGTC_227 fluconazole 6.26 33.5 µM 2.10E-8 azole & statin 27 1.94E-10 0.09
12 SGTC_2890 9046729 6.24 58.4 µM 2.35E-8 Golgi 6 2.24E-10 0.20
13 SGTC_2282 7944268 6.02 200.0 µM 6.68E-8 RPP1 & pyrimidine depletion 4 8.68E-10 0.18
14 SGTC_1493 4348-0038 5.97 111.0 µM 8.42E-8 RSC complex & mRNA processing 19 1.17E-9 0.41
15 SGTC_1605 st000082 5.92 49.1 µM 1.09E-7 60S ribosome export 1 1.63E-9 1.05
16 SGTC_95 0471-0001 5.71 561.1 µM 2.80E-7 1 5.57E-9 1.03
17 SGTC_1784 st039334 5.42 36.3 µM 1.00E-6 3 2.90E-8 0.48
18 SGTC_676 falcarinol 5.35 140.0 µM 1.37E-6 4 4.35E-8 0.64
19 SGTC_1554 st069299 5.14 38.7 µM 3.39E-6 2 1.41E-7 0.01
20 SGTC_2674 ligustilide 5.04 100.0 µM 4.95E-6 1 2.29E-7 0.73

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.202 3.15E-32 YFR002W NIC96 het Linker nucleoporin component of the nuclear pore complex (NPC); also part of the NPC nuclear basket; contributes to nucleocytoplasmic transport and NPC biogenesis; forms stable associations with three FG-nucleoporins (Nsp1p, Nup57p, and Nup49p)
0.194 6.06E-30 YGL092W NUP145 het Essential protein with distinct roles in two nuclear pore subcomplexes; catalyzes its own proteolytic cleavage in vivo to generate a C-terminal fragment that is a structural component of the Nup84p subcomplex (with roles in NPC biogenesis and localization of genes to the nuclear periphery), and an N-terminal fragment that is one of several FG-nucleoporins within the NPC central core directly responsible for nucleocytoplasmic transport; homologous to human NUP98
0.184 4.76E-27 YDR049W VMS1 hom Component of a Cdc48p-complex involved in protein quality control; exhibits cytosolic and ER-membrane localization, with Cdc48p, during normal growth, and contributes to ER-associated degradation (ERAD) of specific substrates at a step after their ubiquitination; forms a mitochondrially-associated complex with Cdc48p and Npl4p under oxidative stress that is required for ubiquitin-mediated mitochondria-associated protein degradation (MAD); conserved in C. elegans and humans
0.148 5.32E-18 YKL186C MTR2 het mRNA transport regulator, essential nuclear protein; Mex67p and Mtr2p form a mRNA export complex which binds to RNA
0.146 1.98E-17 YBR143C SUP45 het Polypeptide release factor (eRF1) in translation termination; mutant form acts as a recessive omnipotent suppressor; methylated by Mtq2p-Trm112p in ternary complex eRF1-eRF3-GTP; mutation of methylation site confers resistance to zymocin; has a role in cytokinesis through interaction with Mlc1p
0.145 3.13E-17 YDL122W UBP1 hom Ubiquitin-specific protease that removes ubiquitin from ubiquitinated proteins; cleaves at the C terminus of ubiquitin fusions irrespective of their size; capable of cleaving polyubiquitin chains
0.140 4.23E-16 YDL148C NOP14 het Nucleolar protein, forms a complex with Noc4p that mediates maturation and nuclear export of 40S ribosomal subunits; also present in the small subunit processome complex, which is required for processing of pre-18S rRNA
0.139 5.70E-16 YOR236W DFR1 het Dihydrofolate reductase involved in tetrahydrofolate biosynthesis; required for respiratory metabolism
0.139 7.75E-16 YGR157W CHO2 hom Phosphatidylethanolamine methyltransferase (PEMT), catalyzes the first step in the conversion of phosphatidylethanolamine to phosphatidylcholine during the methylation pathway of phosphatidylcholine biosynthesis
0.136 3.02E-15 YOL065C INP54 hom Phosphatidylinositol 4,5-bisphosphate 5-phosphatase with a role in secretion, localizes to the endoplasmic reticulum via the C-terminal tail; lacks the Sac1 domain and proline-rich region found in the other 3 INP proteins
0.134 7.47E-15 YDR001C NTH1 hom Neutral trehalase, degrades trehalose; required for thermotolerance and may mediate resistance to other cellular stresses; may be phosphorylated by Cdc28p; NTH1 has a paralog, NTH2, that arose from the whole genome duplication
0.133 1.00E-14 YBL092W RPL32 het Ribosomal 60S subunit protein L32; overexpression disrupts telomeric silencing; homologous to mammalian ribosomal protein L32, no bacterial homolog
0.132 1.39E-14 YMR268C PRP24 het Splicing factor that reanneals U4 and U6 snRNPs during spliceosome recycling
0.132 1.41E-14 YPR034W ARP7 het Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation
0.126 2.43E-13 YOR174W MED4 het Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation