YJR043C / POL32

Third subunit of DNA polymerase delta, involved in chromosomal DNA replication; required for error-prone DNA synthesis in the presence of DNA damage and processivity; interacts with Hys2p, PCNA (Pol30p), and Pol1p

Zygosity: Homozygous strain
fixedexpanded
Profile for YJR043C / POL32

Click on Significant Values for Screen Details ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:3.47|P-value:8.19E-4 ID:SGTC_29|Compound:0299-0004|FD-Score:3.58|P-value:5.80E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:4.89|P-value:4.43E-6 ID:SGTC_67|Compound:0335-0847|FD-Score:4.26|P-value:5.59E-5 ID:SGTC_79|Compound:0052-0007|FD-Score:4.07|P-value:1.10E-4 ID:SGTC_86|Compound:0417-1630|FD-Score:9.50|P-value:2.93E-18 ID:SGTC_87|Compound:0100-0052|FD-Score:5.39|P-value:4.82E-7 ID:SGTC_129|Compound:0088-0017|FD-Score:3.77|P-value:3.14E-4 ID:SGTC_142|Compound:0335-0849|FD-Score:6.01|P-value:2.35E-8 ID:SGTC_177|Compound:1327-0068|FD-Score:9.42|P-value:5.75E-18 ID:SGTC_195|Compound:4234-0266|FD-Score:3.98|P-value:1.53E-4 ID:SGTC_212|Compound:3807-4682|FD-Score:5.75|P-value:8.63E-8 ID:SGTC_216|Compound:k038-0035|FD-Score:3.60|P-value:5.39E-4 ID:SGTC_247|Compound:mechlorethamine|FD-Score:5.62|P-value:1.63E-7 ID:SGTC_248|Compound:streptozotocin|FD-Score:3.50|P-value:7.41E-4 ID:SGTC_368|Compound:fentichlor|FD-Score:4.89|P-value:4.58E-6 ID:SGTC_428|Compound:3448-4153|FD-Score:6.40|P-value:3.02E-9 ID:SGTC_514|Compound:4466-0038|FD-Score:4.59|P-value:1.54E-5 ID:SGTC_752|Compound:1896-0090|FD-Score:4.01|P-value:1.38E-4 ID:SGTC_767|Compound:0929-0023|FD-Score:-4.80|P-value:6.15E-6 ID:SGTC_771|Compound:0250-0039|FD-Score:7.94|P-value:2.72E-13 ID:SGTC_773|Compound:4358-1457|FD-Score:4.94|P-value:3.67E-6 ID:SGTC_789|Compound:1309-1135|FD-Score:3.57|P-value:5.89E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:3.41|P-value:9.98E-4 ID:SGTC_871|Compound:0574-0004|FD-Score:4.73|P-value:8.68E-6 ID:SGTC_879|Compound:0831-1030|FD-Score:3.48|P-value:8.02E-4 ID:SGTC_1029|Compound:k015-0030|FD-Score:4.05|P-value:1.20E-4 ID:SGTC_1056|Compound:3448-1962|FD-Score:4.94|P-value:3.56E-6 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:3.67|P-value:4.27E-4 ID:SGTC_1179|Compound:1021-1431|FD-Score:3.63|P-value:5.01E-4 ID:SGTC_1258|Compound:0671-0043|FD-Score:-5.44|P-value:3.59E-7 ID:SGTC_1585|Compound:2',4'-dihydroxychalcone|FD-Score:4.22|P-value:6.41E-5 ID:SGTC_1634|Compound:st006576|FD-Score:4.71|P-value:9.58E-6 ID:SGTC_1651|Compound:st011928|FD-Score:3.60|P-value:5.51E-4 ID:SGTC_1682|Compound:st012968|FD-Score:4.01|P-value:1.35E-4 ID:SGTC_1742|Compound:st038235|FD-Score:-4.82|P-value:5.56E-6 ID:SGTC_1807|Compound:st050092|FD-Score:3.67|P-value:4.37E-4 ID:SGTC_1817|Compound:st052116|FD-Score:4.04|P-value:1.21E-4 ID:SGTC_1901|Compound:st060216|FD-Score:3.67|P-value:4.38E-4 ID:SGTC_1904|Compound:st060225|FD-Score:3.53|P-value:6.71E-4 ID:SGTC_1964|Compound:st076914|FD-Score:4.13|P-value:8.98E-5 ID:SGTC_2018|Compound:5133068|FD-Score:4.76|P-value:7.80E-6 ID:SGTC_2023|Compound:5144124|FD-Score:5.19|P-value:1.22E-6 ID:SGTC_2073|Compound:5212005|FD-Score:4.80|P-value:6.65E-6 ID:SGTC_2210|Compound:7115885|FD-Score:3.90|P-value:2.02E-4 ID:SGTC_2225|Compound:6654152|FD-Score:4.05|P-value:1.20E-4 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:3.90|P-value:1.99E-4 ID:SGTC_2233|Compound:sulbentine|FD-Score:7.55|P-value:3.55E-12 ID:SGTC_2246|Compound:7293507|FD-Score:4.50|P-value:2.16E-5 ID:SGTC_2323|Compound:6148992|FD-Score:5.19|P-value:1.22E-6 ID:SGTC_2344|Compound:7990960|FD-Score:8.49|P-value:6.09E-15 ID:SGTC_2370|Compound:9071495|FD-Score:4.32|P-value:4.46E-5 ID:SGTC_2408|Compound:sulbentine|FD-Score:6.64|P-value:8.06E-10 ID:SGTC_2428|Compound:5615643|FD-Score:4.51|P-value:2.16E-5 ID:SGTC_2483|Compound:5729050|FD-Score:3.66|P-value:4.53E-4 ID:SGTC_2484|Compound:5809818|FD-Score:5.10|P-value:1.78E-6 ID:SGTC_2584|Compound:androsterone|FD-Score:3.89|P-value:2.09E-4 ID:SGTC_2600|Compound:tangeritin|FD-Score:3.68|P-value:4.21E-4 ID:SGTC_2616|Compound:abietic acid|FD-Score:-3.47|P-value:7.79E-4 ID:SGTC_2619|Compound:obliquin|FD-Score:6.86|P-value:2.25E-10 ID:SGTC_2750|Compound:bromebric acid|FD-Score:3.47|P-value:8.09E-4 ID:SGTC_2799|Compound:7812892|FD-Score:3.96|P-value:1.63E-4 ID:SGTC_2849|Compound:9019321|FD-Score:3.91|P-value:1.95E-4 ID:SGTC_2921|Compound:7974240|FD-Score:4.13|P-value:8.87E-5 ID:SGTC_3135|Compound:9127742|FD-Score:5.77|P-value:7.82E-8 ID:SGTC_3221|Compound:9128209|FD-Score:3.88|P-value:2.16E-4 ID:SGTC_3222|Compound:9128301|FD-Score:3.58|P-value:5.73E-4 ID:SGTC_3299|Compound:9121982|FD-Score:5.36|P-value:5.67E-7 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:3.47|P-value:8.19E-4 ID:SGTC_29|Compound:0299-0004|FD-Score:3.58|P-value:5.80E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:4.89|P-value:4.43E-6 ID:SGTC_67|Compound:0335-0847|FD-Score:4.26|P-value:5.59E-5 ID:SGTC_79|Compound:0052-0007|FD-Score:4.07|P-value:1.10E-4 ID:SGTC_86|Compound:0417-1630|FD-Score:9.50|P-value:2.93E-18 ID:SGTC_87|Compound:0100-0052|FD-Score:5.39|P-value:4.82E-7 ID:SGTC_129|Compound:0088-0017|FD-Score:3.77|P-value:3.14E-4 ID:SGTC_142|Compound:0335-0849|FD-Score:6.01|P-value:2.35E-8 ID:SGTC_177|Compound:1327-0068|FD-Score:9.42|P-value:5.75E-18 ID:SGTC_195|Compound:4234-0266|FD-Score:3.98|P-value:1.53E-4 ID:SGTC_212|Compound:3807-4682|FD-Score:5.75|P-value:8.63E-8 ID:SGTC_216|Compound:k038-0035|FD-Score:3.60|P-value:5.39E-4 ID:SGTC_247|Compound:mechlorethamine|FD-Score:5.62|P-value:1.63E-7 ID:SGTC_248|Compound:streptozotocin|FD-Score:3.50|P-value:7.41E-4 ID:SGTC_368|Compound:fentichlor|FD-Score:4.89|P-value:4.58E-6 ID:SGTC_428|Compound:3448-4153|FD-Score:6.40|P-value:3.02E-9 ID:SGTC_514|Compound:4466-0038|FD-Score:4.59|P-value:1.54E-5 ID:SGTC_752|Compound:1896-0090|FD-Score:4.01|P-value:1.38E-4 ID:SGTC_767|Compound:0929-0023|FD-Score:-4.80|P-value:6.15E-6 ID:SGTC_771|Compound:0250-0039|FD-Score:7.94|P-value:2.72E-13 ID:SGTC_773|Compound:4358-1457|FD-Score:4.94|P-value:3.67E-6 ID:SGTC_789|Compound:1309-1135|FD-Score:3.57|P-value:5.89E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:3.41|P-value:9.98E-4 ID:SGTC_871|Compound:0574-0004|FD-Score:4.73|P-value:8.68E-6 ID:SGTC_879|Compound:0831-1030|FD-Score:3.48|P-value:8.02E-4 ID:SGTC_1029|Compound:k015-0030|FD-Score:4.05|P-value:1.20E-4 ID:SGTC_1056|Compound:3448-1962|FD-Score:4.94|P-value:3.56E-6 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:3.67|P-value:4.27E-4 ID:SGTC_1179|Compound:1021-1431|FD-Score:3.63|P-value:5.01E-4 ID:SGTC_1258|Compound:0671-0043|FD-Score:-5.44|P-value:3.59E-7 ID:SGTC_1585|Compound:2',4'-dihydroxychalcone|FD-Score:4.22|P-value:6.41E-5 ID:SGTC_1634|Compound:st006576|FD-Score:4.71|P-value:9.58E-6 ID:SGTC_1651|Compound:st011928|FD-Score:3.60|P-value:5.51E-4 ID:SGTC_1682|Compound:st012968|FD-Score:4.01|P-value:1.35E-4 ID:SGTC_1742|Compound:st038235|FD-Score:-4.82|P-value:5.56E-6 ID:SGTC_1807|Compound:st050092|FD-Score:3.67|P-value:4.37E-4 ID:SGTC_1817|Compound:st052116|FD-Score:4.04|P-value:1.21E-4 ID:SGTC_1901|Compound:st060216|FD-Score:3.67|P-value:4.38E-4 ID:SGTC_1904|Compound:st060225|FD-Score:3.53|P-value:6.71E-4 ID:SGTC_1964|Compound:st076914|FD-Score:4.13|P-value:8.98E-5 ID:SGTC_2018|Compound:5133068|FD-Score:4.76|P-value:7.80E-6 ID:SGTC_2023|Compound:5144124|FD-Score:5.19|P-value:1.22E-6 ID:SGTC_2073|Compound:5212005|FD-Score:4.80|P-value:6.65E-6 ID:SGTC_2210|Compound:7115885|FD-Score:3.90|P-value:2.02E-4 ID:SGTC_2225|Compound:6654152|FD-Score:4.05|P-value:1.20E-4 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:3.90|P-value:1.99E-4 ID:SGTC_2233|Compound:sulbentine|FD-Score:7.55|P-value:3.55E-12 ID:SGTC_2246|Compound:7293507|FD-Score:4.50|P-value:2.16E-5 ID:SGTC_2323|Compound:6148992|FD-Score:5.19|P-value:1.22E-6 ID:SGTC_2344|Compound:7990960|FD-Score:8.49|P-value:6.09E-15 ID:SGTC_2370|Compound:9071495|FD-Score:4.32|P-value:4.46E-5 ID:SGTC_2408|Compound:sulbentine|FD-Score:6.64|P-value:8.06E-10 ID:SGTC_2428|Compound:5615643|FD-Score:4.51|P-value:2.16E-5 ID:SGTC_2483|Compound:5729050|FD-Score:3.66|P-value:4.53E-4 ID:SGTC_2484|Compound:5809818|FD-Score:5.10|P-value:1.78E-6 ID:SGTC_2584|Compound:androsterone|FD-Score:3.89|P-value:2.09E-4 ID:SGTC_2600|Compound:tangeritin|FD-Score:3.68|P-value:4.21E-4 ID:SGTC_2616|Compound:abietic acid|FD-Score:-3.47|P-value:7.79E-4 ID:SGTC_2619|Compound:obliquin|FD-Score:6.86|P-value:2.25E-10 ID:SGTC_2750|Compound:bromebric acid|FD-Score:3.47|P-value:8.09E-4 ID:SGTC_2799|Compound:7812892|FD-Score:3.96|P-value:1.63E-4 ID:SGTC_2849|Compound:9019321|FD-Score:3.91|P-value:1.95E-4 ID:SGTC_2921|Compound:7974240|FD-Score:4.13|P-value:8.87E-5 ID:SGTC_3135|Compound:9127742|FD-Score:5.77|P-value:7.82E-8 ID:SGTC_3221|Compound:9128209|FD-Score:3.88|P-value:2.16E-4 ID:SGTC_3222|Compound:9128301|FD-Score:3.58|P-value:5.73E-4 ID:SGTC_3299|Compound:9121982|FD-Score:5.36|P-value:5.67E-7

Top fitness defect scores for YJR043C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_86 0417-1630 9.50 471.9 µM 2.93E-18 ubiquinone biosynthesis & proteasome 45 1.02E-21
2 SGTC_177 1327-0068 9.42 8.4 µM 5.75E-18 8 2.31E-21
3 SGTC_2344 7990960 8.49 77.0 µM 6.09E-15 3 1.03E-17
4 SGTC_771 0250-0039 7.94 27.3 µM 2.72E-13 2 1.01E-15
5 SGTC_2233 sulbentine 7.55 40.4 µM 3.55E-12 15 2.24E-14
6 SGTC_2619 obliquin 6.86 87.9 µM 2.25E-10 cell wall 62 3.35E-12
7 SGTC_2408 sulbentine 6.64 18.4 µM 8.06E-10 16 1.56E-11
8 SGTC_428 3448-4153 6.40 16.5 µM 3.02E-9 TSC3-RPN4 7 7.65E-11
9 SGTC_142 0335-0849 6.01 62.7 µM 2.35E-8 ubiquinone biosynthesis & proteasome 63 9.06E-10
10 SGTC_3135 9127742 5.77 49.5 µM 7.82E-8 4 3.85E-9
11 SGTC_212 3807-4682 5.75 38.8 µM 8.63E-8 tubulin folding & SWR complex 30 4.34E-9
12 SGTC_247 mechlorethamine 5.62 29.7 µM 1.63E-7 DNA damage response 6 9.32E-9
13 SGTC_87 0100-0052 5.39 35.5 µM 4.82E-7 45 3.44E-8
14 SGTC_3299 9121982 5.36 43.1 µM 5.67E-7 9 4.18E-8
15 SGTC_2023 5144124 5.19 124.0 µM 1.22E-6 6 1.05E-7
16 SGTC_2323 6148992 5.19 148.3 µM 1.22E-6 11 1.06E-7
17 SGTC_2484 5809818 5.10 12.0 µM 1.78E-6 8 1.65E-7
18 SGTC_1056 3448-1962 4.94 115.0 µM 3.56E-6 amide catabolism 10 3.82E-7
19 SGTC_773 4358-1457 4.94 44.6 µM 3.67E-6 20 3.95E-7
20 SGTC_64 000l-0018 4.89 272.1 µM 4.43E-6 ubiquinone biosynthesis & proteasome 112 4.96E-7

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.219 1.05E-37 YDR204W COQ4 hom Protein with a role in ubiquinone (Coenzyme Q) biosynthesis, possibly functioning in stabilization of Coq7p; located on the matrix face of the mitochondrial inner membrane; component of a mitochondrial ubiquinone-synthesizing complex
0.214 4.06E-36 YLR202C_d YLR202C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YLR201C; ORF contains a putative intron
0.209 2.50E-34 YPR146C_d YPR146C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.208 3.12E-34 YIL090W ICE2 hom Integral ER membrane protein with type-III transmembrane domains; required for maintenance of ER zinc homeostasis; necessary for efficient targeting of Trm1p tRNA methyltransferase to inner nuclear membrane; mutations cause defects in cortical ER morphology in both the mother and daughter cells
0.208 3.86E-34 YBR003W COQ1 hom Hexaprenyl pyrophosphate synthetase, catalyzes the first step in ubiquinone (coenzyme Q) biosynthesis
0.208 3.90E-34 YOR254C SEC63 het Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
0.203 1.53E-32 YNR041C COQ2 hom Para hydroxybenzoate: polyprenyl transferase, catalyzes the second step in ubiquinone (coenzyme Q) biosynthesis
0.201 1.05E-31 YGL119W COQ8 hom Protein required for ubiquinone biosynthesis and respiratory growth; exhibits genetic interaction with COQ9, suggesting a common function; similar to prokaryotic proteins involved in early steps of ubiquinone biosynthesis; COQ8 has a paralog, YBR230W-A, that arose from the whole genome duplication
0.200 1.81E-31 YNL111C CYB5 hom Cytochrome b5, involved in the sterol and lipid biosynthesis pathways; acts as an electron donor to support sterol C5-6 desaturation
0.196 1.67E-30 YJL168C SET2 hom Histone methyltransferase with a role in transcriptional elongation; methylates H3 lysine 36, which suppresses incorporation of acetylated histones and signals for the deacetylation of these histones within transcribed genes; associates with the C-terminal domain of Rpo21p; histone methylation activity is regulated by phosphorylation status of Rpo21p
0.194 6.46E-30 YOL096C COQ3 hom O-methyltransferase, catalyzes two different O-methylation steps in ubiquinone (Coenzyme Q) biosynthesis; component of a mitochondrial ubiquinone-synthesizing complex; phosphoprotein
0.193 1.49E-29 YOR125C CAT5 hom Protein required for ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes; required for gluconeogenic gene activation
0.188 6.75E-28 YLR201C COQ9 hom Protein required for ubiquinone (coenzyme Q) biosynthesis and respiratory growth; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes
0.187 9.71E-28 YOR207C RET1 het Second-largest subunit of RNA polymerase III, which is responsible for the transcription of tRNA and 5S RNA genes, and other low molecular weight RNAs
0.187 1.12E-27 YJL193W_p YJL193W_p hom Putative protein of unknown function, predicted to encode a triose phosphate transporter subfamily member based on phylogenetic analysis; similar to YOR307C/SLY41; deletion mutant has a respiratory growth defect