YJR045C / SSC1

Hsp70 family ATPase; constituent of the import motor component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); involved in protein translocation and folding; subunit of SceI endonuclease; SSC1 has a paralog, ECM10, that arose from the whole genome duplication

Zygosity: Heterozygous strain
fixedexpanded
Profile for YJR045C / SSC1

Click on Significant Values for Screen Details ID:SGTC_190|Compound:3970-0790|FD-Score:3.48|P-value:3.08E-4 ID:SGTC_200|Compound:k038-0079|FD-Score:4.37|P-value:9.30E-6 ID:SGTC_353|Compound:1988-1175|FD-Score:3.34|P-value:5.05E-4 ID:SGTC_359|Compound:0081-0058|FD-Score:3.37|P-value:4.61E-4 ID:SGTC_429|Compound:1112-0049|FD-Score:-3.35|P-value:8.19E-4 ID:SGTC_554|Compound:4483-2211|FD-Score:3.29|P-value:5.97E-4 ID:SGTC_598|Compound:3937-0236|FD-Score:3.29|P-value:5.99E-4 ID:SGTC_761|Compound:k216-0224|FD-Score:3.23|P-value:7.45E-4 ID:SGTC_777|Compound:1315-0167|FD-Score:-4.23|P-value:3.21E-5 ID:SGTC_792|Compound:4534-1957|FD-Score:4.17|P-value:2.17E-5 ID:SGTC_845|Compound:0330-0138|FD-Score:5.31|P-value:1.08E-7 ID:SGTC_852|Compound:0418-0143|FD-Score:-6.18|P-value:2.06E-9 ID:SGTC_874|Compound:0599-0792|FD-Score:3.45|P-value:3.47E-4 ID:SGTC_953|Compound:1188-0045|FD-Score:3.96|P-value:5.17E-5 ID:SGTC_959|Compound:1222-0044|FD-Score:3.27|P-value:6.39E-4 ID:SGTC_1009|Compound:4106-0057|FD-Score:-3.37|P-value:7.67E-4 ID:SGTC_1013|Compound:4112-3890|FD-Score:-4.56|P-value:7.93E-6 ID:SGTC_1184|Compound:1269-1718|FD-Score:4.26|P-value:1.51E-5 ID:SGTC_1367|Compound:1812-0510|FD-Score:4.56|P-value:4.04E-6 ID:SGTC_1469|Compound:k284-2957|FD-Score:-6.08|P-value:3.67E-9 ID:SGTC_1529|Compound:apigenin|FD-Score:3.19|P-value:8.43E-4 ID:SGTC_1530|Compound:rhein|FD-Score:-3.71|P-value:2.35E-4 ID:SGTC_1556|Compound:plumbagin|FD-Score:-3.42|P-value:6.53E-4 ID:SGTC_1601|Compound:4'-hydroxyflavanone|FD-Score:3.97|P-value:4.87E-5 ID:SGTC_1784|Compound:st039334|FD-Score:3.28|P-value:6.22E-4 ID:SGTC_2191|Compound:5911152|FD-Score:-5.71|P-value:2.94E-8 ID:SGTC_2192|Compound:5915882|FD-Score:-3.40|P-value:6.80E-4 ID:SGTC_2198|Compound:6589944|FD-Score:-3.70|P-value:2.44E-4 ID:SGTC_2203|Compound:7227154|FD-Score:4.21|P-value:1.88E-5 ID:SGTC_2204|Compound:7233102|FD-Score:-4.18|P-value:3.87E-5 ID:SGTC_2243|Compound:6634756|FD-Score:9.13|P-value:3.99E-19 ID:SGTC_2281|Compound:7943571|FD-Score:3.58|P-value:2.18E-4 ID:SGTC_2305|Compound:7443522|FD-Score:3.81|P-value:9.12E-5 ID:SGTC_2307|Compound:7538926|FD-Score:4.11|P-value:2.77E-5 ID:SGTC_2336|Compound:9001819|FD-Score:-3.81|P-value:1.61E-4 ID:SGTC_2371|Compound:9071574|FD-Score:3.91|P-value:6.29E-5 ID:SGTC_2421|Compound:5690543|FD-Score:3.52|P-value:2.72E-4 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:9.36|P-value:5.58E-20 ID:SGTC_2585|Compound:alliin|FD-Score:-3.83|P-value:1.52E-4 ID:SGTC_2586|Compound:curcumin|FD-Score:4.64|P-value:2.80E-6 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:5.43|P-value:5.95E-8 ID:SGTC_2687|Compound:chenodiol|FD-Score:3.44|P-value:3.53E-4 ID:SGTC_2696|Compound:st077691|FD-Score:-3.66|P-value:2.82E-4 ID:SGTC_2804|Compound:7954240|FD-Score:4.16|P-value:2.30E-5 ID:SGTC_2894|Compound:9048625|FD-Score:-5.17|P-value:4.65E-7 ID:SGTC_2905|Compound:7799065|FD-Score:-3.32|P-value:8.98E-4 ID:SGTC_2975|Compound:9084847|FD-Score:-3.85|P-value:1.39E-4 ID:SGTC_3067|Compound:9117431|FD-Score:3.52|P-value:2.67E-4 ID:SGTC_3069|Compound:9117009|FD-Score:3.74|P-value:1.20E-4 ID:SGTC_3138|Compound:9097216|FD-Score:-4.57|P-value:7.53E-6 ID:SGTC_3233|Compound:9132340|FD-Score:-3.53|P-value:4.40E-4 ID:SGTC_3249|Compound:9135183|FD-Score:3.47|P-value:3.23E-4 ID:SGTC_3340|Compound:9146634|FD-Score:3.71|P-value:1.37E-4 ID:SGTC_3353|Compound:9151644|FD-Score:3.62|P-value:1.85E-4 ID:SGTC_190|Compound:3970-0790|FD-Score:3.48|P-value:3.08E-4 ID:SGTC_200|Compound:k038-0079|FD-Score:4.37|P-value:9.30E-6 ID:SGTC_353|Compound:1988-1175|FD-Score:3.34|P-value:5.05E-4 ID:SGTC_359|Compound:0081-0058|FD-Score:3.37|P-value:4.61E-4 ID:SGTC_429|Compound:1112-0049|FD-Score:-3.35|P-value:8.19E-4 ID:SGTC_554|Compound:4483-2211|FD-Score:3.29|P-value:5.97E-4 ID:SGTC_598|Compound:3937-0236|FD-Score:3.29|P-value:5.99E-4 ID:SGTC_761|Compound:k216-0224|FD-Score:3.23|P-value:7.45E-4 ID:SGTC_777|Compound:1315-0167|FD-Score:-4.23|P-value:3.21E-5 ID:SGTC_792|Compound:4534-1957|FD-Score:4.17|P-value:2.17E-5 ID:SGTC_845|Compound:0330-0138|FD-Score:5.31|P-value:1.08E-7 ID:SGTC_852|Compound:0418-0143|FD-Score:-6.18|P-value:2.06E-9 ID:SGTC_874|Compound:0599-0792|FD-Score:3.45|P-value:3.47E-4 ID:SGTC_953|Compound:1188-0045|FD-Score:3.96|P-value:5.17E-5 ID:SGTC_959|Compound:1222-0044|FD-Score:3.27|P-value:6.39E-4 ID:SGTC_1009|Compound:4106-0057|FD-Score:-3.37|P-value:7.67E-4 ID:SGTC_1013|Compound:4112-3890|FD-Score:-4.56|P-value:7.93E-6 ID:SGTC_1184|Compound:1269-1718|FD-Score:4.26|P-value:1.51E-5 ID:SGTC_1367|Compound:1812-0510|FD-Score:4.56|P-value:4.04E-6 ID:SGTC_1469|Compound:k284-2957|FD-Score:-6.08|P-value:3.67E-9 ID:SGTC_1529|Compound:apigenin|FD-Score:3.19|P-value:8.43E-4 ID:SGTC_1530|Compound:rhein|FD-Score:-3.71|P-value:2.35E-4 ID:SGTC_1556|Compound:plumbagin|FD-Score:-3.42|P-value:6.53E-4 ID:SGTC_1601|Compound:4'-hydroxyflavanone|FD-Score:3.97|P-value:4.87E-5 ID:SGTC_1784|Compound:st039334|FD-Score:3.28|P-value:6.22E-4 ID:SGTC_2191|Compound:5911152|FD-Score:-5.71|P-value:2.94E-8 ID:SGTC_2192|Compound:5915882|FD-Score:-3.40|P-value:6.80E-4 ID:SGTC_2198|Compound:6589944|FD-Score:-3.70|P-value:2.44E-4 ID:SGTC_2203|Compound:7227154|FD-Score:4.21|P-value:1.88E-5 ID:SGTC_2204|Compound:7233102|FD-Score:-4.18|P-value:3.87E-5 ID:SGTC_2243|Compound:6634756|FD-Score:9.13|P-value:3.99E-19 ID:SGTC_2281|Compound:7943571|FD-Score:3.58|P-value:2.18E-4 ID:SGTC_2305|Compound:7443522|FD-Score:3.81|P-value:9.12E-5 ID:SGTC_2307|Compound:7538926|FD-Score:4.11|P-value:2.77E-5 ID:SGTC_2336|Compound:9001819|FD-Score:-3.81|P-value:1.61E-4 ID:SGTC_2371|Compound:9071574|FD-Score:3.91|P-value:6.29E-5 ID:SGTC_2421|Compound:5690543|FD-Score:3.52|P-value:2.72E-4 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:9.36|P-value:5.58E-20 ID:SGTC_2585|Compound:alliin|FD-Score:-3.83|P-value:1.52E-4 ID:SGTC_2586|Compound:curcumin|FD-Score:4.64|P-value:2.80E-6 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:5.43|P-value:5.95E-8 ID:SGTC_2687|Compound:chenodiol|FD-Score:3.44|P-value:3.53E-4 ID:SGTC_2696|Compound:st077691|FD-Score:-3.66|P-value:2.82E-4 ID:SGTC_2804|Compound:7954240|FD-Score:4.16|P-value:2.30E-5 ID:SGTC_2894|Compound:9048625|FD-Score:-5.17|P-value:4.65E-7 ID:SGTC_2905|Compound:7799065|FD-Score:-3.32|P-value:8.98E-4 ID:SGTC_2975|Compound:9084847|FD-Score:-3.85|P-value:1.39E-4 ID:SGTC_3067|Compound:9117431|FD-Score:3.52|P-value:2.67E-4 ID:SGTC_3069|Compound:9117009|FD-Score:3.74|P-value:1.20E-4 ID:SGTC_3138|Compound:9097216|FD-Score:-4.57|P-value:7.53E-6 ID:SGTC_3233|Compound:9132340|FD-Score:-3.53|P-value:4.40E-4 ID:SGTC_3249|Compound:9135183|FD-Score:3.47|P-value:3.23E-4 ID:SGTC_3340|Compound:9146634|FD-Score:3.71|P-value:1.37E-4 ID:SGTC_3353|Compound:9151644|FD-Score:3.62|P-value:1.85E-4

Top fitness defect scores for YJR045C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2566 crystal violet carbinol 9.36 226.0 nM 5.58E-20 2 4.17E-21 0.36
2 SGTC_2243 6634756 9.13 200.0 µM 3.99E-19 1 3.42E-20 2.74
3 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 5.43 100.0 µM 5.95E-8 60S ribosome export 6 2.88E-8 0.52
4 SGTC_845 0330-0138 5.31 4.5 µM 1.08E-7 2 5.44E-8 0.75
5 SGTC_2586 curcumin 4.64 80.0 µM 2.80E-6 iron homeostasis 6 1.72E-6 0.51
6 SGTC_1367 1812-0510 4.56 76.9 µM 4.04E-6 4 2.54E-6 0.33
7 SGTC_200 k038-0079 4.37 37.5 µM 9.30E-6 ubiquinone biosynthesis & proteasome 9 6.14E-6 0.15
8 SGTC_1184 1269-1718 4.26 139.0 µM 1.51E-5 4 1.02E-5 0.43
9 SGTC_2203 7227154 4.21 166.4 µM 1.88E-5 2 1.30E-5 0.89
10 SGTC_792 4534-1957 4.17 155.0 µM 2.17E-5 4 1.51E-5 0.31
11 SGTC_2804 7954240 4.16 19.5 µM 2.30E-5 9 1.60E-5 0.11
12 SGTC_2307 7538926 4.11 6.3 µM 2.77E-5 20 1.95E-5 0.09
13 SGTC_1601 4'-hydroxyflavanone 3.97 55.5 µM 4.87E-5 RPP1 & pyrimidine depletion 6 3.55E-5 0.23
14 SGTC_953 1188-0045 3.96 9.7 µM 5.17E-5 60S ribosome export 6 3.77E-5 0.19
15 SGTC_2371 9071574 3.91 200.0 µM 6.29E-5 2 4.64E-5 0.35
16 SGTC_2305 7443522 3.81 69.2 µM 9.12E-5 8 6.87E-5 0.01
17 SGTC_3069 9117009 3.74 49.5 µM 1.20E-4 60S ribosome export 3 9.17E-5 0.24
18 SGTC_3340 9146634 3.71 11.1 µM 1.37E-4 3 1.06E-4 0.17
19 SGTC_3353 9151644 3.62 39.3 µM 1.85E-4 3 1.45E-4 0.12
20 SGTC_2281 7943571 3.58 200.0 µM 2.18E-4 7 1.72E-4 0.11

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.130 3.55E-14 YER053C-A YER053C-A hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; protein abundance increases in response to DNA replication stress
0.116 1.83E-11 YCR008W SAT4 hom Ser/Thr protein kinase involved in salt tolerance; funtions in regulation of Trk1p-Trk2p potassium transporter; partially redundant with Hal5p; has similarity to Npr1p
0.107 5.86E-10 YJR023C_d YJR023C_d het Putative protein of unknown function; open reading frame overlaps LSM8/YJR022W encoding an essential snRNP protein required for RNA processing and splicing
0.095 3.25E-8 YDR399W HPT1 hom Dimeric hypoxanthine-guanine phosphoribosyltransferase, catalyzes the transfer of the phosphoribosyl portion of 5-phosphoribosyl-alpha-1-pyrophosphate to a purine base (either guanine or hypoxanthine) to form pyrophosphate and a purine nucleotide (either guanosine monophosphate or inosine monophosphate); mutations in the human homolog HPRT1 can cause Lesch-Nyhan syndrome and Kelley-Seegmiller syndrome
0.090 1.69E-7 YPL061W ALD6 hom Cytosolic aldehyde dehydrogenase, activated by Mg2+ and utilizes NADP+ as the preferred coenzyme; required for conversion of acetaldehyde to acetate; constitutively expressed; locates to the mitochondrial outer surface upon oxidative stress
0.085 7.45E-7 YPL011C TAF3 het TFIID subunit (47 kDa), involved in promoter binding and RNA polymerase II transcription initiation
0.085 8.50E-7 YPL096W PNG1 hom Conserved peptide N-glycanase required for deglycosylation of misfolded glycoproteins during proteasome-dependent degradation; localizes to the cytoplasm and nucleus; activity is enhanced by interaction with Rad23p
0.083 1.64E-6 YAL034C-B_d YAL034C-B_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.082 1.74E-6 YBR155W CNS1 het TPR-containing co-chaperone; binds both Hsp82p (Hsp90) and Ssa1p (Hsp70) and stimulates the ATPase activity of SSA1, ts mutants reduce Hsp82p function while over expression suppresses the phenotypes of an HSP82 ts allele and a cpr7 deletion
0.082 1.82E-6 YAR050W FLO1 hom Lectin-like protein involved in flocculation, cell wall protein that binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin sensitive and heat resistant; similar to Flo5p
0.082 1.93E-6 YDR235W PRP42 het U1 snRNP protein involved in splicing, required for U1 snRNP biogenesis; contains multiple tetriatricopeptide repeats
0.081 2.88E-6 YGR274C TAF1 het TFIID subunit (145 kDa), involved in RNA polymerase II transcription initiation; possesses in vitro histone acetyltransferase activity but its role in vivo appears to be minor; involved in promoter binding and G1/S progression
0.078 6.37E-6 YAL032C PRP45 het Protein required for pre-mRNA splicing; associates with the spliceosome and interacts with splicing factors Prp22p and Prp46p; orthologous to human transcriptional coactivator SKIP and can activate transcription of a reporter gene
0.078 6.77E-6 YNL262W POL2 het Catalytic subunit of DNA polymerase (II) epsilon, a chromosomal DNA replication polymerase that exhibits processivity and proofreading exonuclease activity; also involved in DNA synthesis during DNA repair; interacts extensively with Mrc1p
0.076 1.07E-5 YJL051W IRC8 hom Bud tip localized protein of unknown function; mRNA is targeted to the bud by a She2p dependent transport system; mRNA is cell cycle regulated via Fkh2p, peaking in G2/M phase; null mutant displays increased levels of spontaneous Rad52p foc