HIPHOP chemogenomics database
YJR045C / SSC1 
Hsp70 family ATPase; constituent of the import motor component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); involved in protein translocation and folding; subunit of SceI endonuclease; SSC1 has a paralog, ECM10, that arose from the whole genome duplication
Zygosity: Heterozygous strain
fixedexpanded
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Top fitness defect scores for YJR045C deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.130 | 3.55E-14 | YER053C-A | YER053C-A | hom | Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; protein abundance increases in response to DNA replication stress |
| 0.116 | 1.83E-11 | YCR008W | SAT4 | hom | Ser/Thr protein kinase involved in salt tolerance; funtions in regulation of Trk1p-Trk2p potassium transporter; partially redundant with Hal5p; has similarity to Npr1p |
| 0.107 | 5.86E-10 | YJR023C_d | YJR023C_d | het | Putative protein of unknown function; open reading frame overlaps LSM8/YJR022W encoding an essential snRNP protein required for RNA processing and splicing |
| 0.095 | 3.25E-8 | YDR399W | HPT1 | hom | Dimeric hypoxanthine-guanine phosphoribosyltransferase, catalyzes the transfer of the phosphoribosyl portion of 5-phosphoribosyl-alpha-1-pyrophosphate to a purine base (either guanine or hypoxanthine) to form pyrophosphate and a purine nucleotide (either guanosine monophosphate or inosine monophosphate); mutations in the human homolog HPRT1 can cause Lesch-Nyhan syndrome and Kelley-Seegmiller syndrome |
| 0.090 | 1.69E-7 | YPL061W | ALD6 | hom | Cytosolic aldehyde dehydrogenase, activated by Mg2+ and utilizes NADP+ as the preferred coenzyme; required for conversion of acetaldehyde to acetate; constitutively expressed; locates to the mitochondrial outer surface upon oxidative stress |
| 0.085 | 7.45E-7 | YPL011C | TAF3 | het | TFIID subunit (47 kDa), involved in promoter binding and RNA polymerase II transcription initiation |
| 0.085 | 8.50E-7 | YPL096W | PNG1 | hom | Conserved peptide N-glycanase required for deglycosylation of misfolded glycoproteins during proteasome-dependent degradation; localizes to the cytoplasm and nucleus; activity is enhanced by interaction with Rad23p |
| 0.083 | 1.64E-6 | YAL034C-B_d | YAL034C-B_d | het | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data |
| 0.082 | 1.74E-6 | YBR155W | CNS1 | het | TPR-containing co-chaperone; binds both Hsp82p (Hsp90) and Ssa1p (Hsp70) and stimulates the ATPase activity of SSA1, ts mutants reduce Hsp82p function while over expression suppresses the phenotypes of an HSP82 ts allele and a cpr7 deletion |
| 0.082 | 1.82E-6 | YAR050W | FLO1 | hom | Lectin-like protein involved in flocculation, cell wall protein that binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin sensitive and heat resistant; similar to Flo5p |
| 0.082 | 1.93E-6 | YDR235W | PRP42 | het | U1 snRNP protein involved in splicing, required for U1 snRNP biogenesis; contains multiple tetriatricopeptide repeats |
| 0.081 | 2.88E-6 | YGR274C | TAF1 | het | TFIID subunit (145 kDa), involved in RNA polymerase II transcription initiation; possesses in vitro histone acetyltransferase activity but its role in vivo appears to be minor; involved in promoter binding and G1/S progression |
| 0.078 | 6.37E-6 | YAL032C | PRP45 | het | Protein required for pre-mRNA splicing; associates with the spliceosome and interacts with splicing factors Prp22p and Prp46p; orthologous to human transcriptional coactivator SKIP and can activate transcription of a reporter gene |
| 0.078 | 6.77E-6 | YNL262W | POL2 | het | Catalytic subunit of DNA polymerase (II) epsilon, a chromosomal DNA replication polymerase that exhibits processivity and proofreading exonuclease activity; also involved in DNA synthesis during DNA repair; interacts extensively with Mrc1p |
| 0.076 | 1.07E-5 | YJL051W | IRC8 | hom | Bud tip localized protein of unknown function; mRNA is targeted to the bud by a She2p dependent transport system; mRNA is cell cycle regulated via Fkh2p, peaking in G2/M phase; null mutant displays increased levels of spontaneous Rad52p foc |