YJR049C / UTR1

ATP-NADH kinase; phosphorylates both NAD and NADH; active as a hexamer; enhances the activity of ferric reductase (Fre1p); UTR1 has a paralog, YEF1, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YJR049C / UTR1

Click on Significant Values for Screen Details ID:SGTC_9|Compound:0092-0002|FD-Score:4.63|P-value:1.41E-5 ID:SGTC_16|Compound:erodoxin|FD-Score:4.43|P-value:3.03E-5 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:15.50|P-value:2.26E-45 ID:SGTC_57|Compound:miconazole|FD-Score:5.99|P-value:2.87E-8 ID:SGTC_63|Compound:0099-0242|FD-Score:6.56|P-value:1.45E-9 ID:SGTC_64|Compound:000l-0018|FD-Score:4.35|P-value:4.15E-5 ID:SGTC_86|Compound:0417-1630|FD-Score:4.01|P-value:1.42E-4 ID:SGTC_88|Compound:0180-0332|FD-Score:4.40|P-value:3.46E-5 ID:SGTC_141|Compound:0443-0274|FD-Score:4.54|P-value:2.01E-5 ID:SGTC_158|Compound:k038-0087|FD-Score:5.61|P-value:1.89E-7 ID:SGTC_177|Compound:1327-0068|FD-Score:36.40|P-value:3.38E-239 ID:SGTC_182|Compound:3448-4371|FD-Score:6.08|P-value:1.85E-8 ID:SGTC_184|Compound:1494-0393|FD-Score:5.44|P-value:4.18E-7 ID:SGTC_200|Compound:k038-0079|FD-Score:3.94|P-value:1.82E-4 ID:SGTC_210|Compound:3551-0445|FD-Score:6.20|P-value:9.88E-9 ID:SGTC_212|Compound:3807-4682|FD-Score:5.76|P-value:9.00E-8 ID:SGTC_216|Compound:k038-0035|FD-Score:5.80|P-value:7.49E-8 ID:SGTC_217|Compound:ketoconazole|FD-Score:7.70|P-value:1.51E-12 ID:SGTC_227|Compound:fluconazole|FD-Score:25.60|P-value:5.71E-120 ID:SGTC_256|Compound:clotrimazole|FD-Score:5.63|P-value:1.69E-7 ID:SGTC_266|Compound:formosanin C|FD-Score:-6.11|P-value:1.31E-8 ID:SGTC_270|Compound:tamoxifen|FD-Score:-3.68|P-value:3.93E-4 ID:SGTC_279|Compound:1273-0055|FD-Score:6.44|P-value:2.71E-9 ID:SGTC_294|Compound:k038-0071|FD-Score:5.19|P-value:1.30E-6 ID:SGTC_310|Compound:1273-0058|FD-Score:4.07|P-value:1.16E-4 ID:SGTC_320|Compound:4092-0846|FD-Score:4.31|P-value:4.80E-5 ID:SGTC_327|Compound:1273-0057|FD-Score:8.12|P-value:9.16E-14 ID:SGTC_340|Compound:k038-0059|FD-Score:4.36|P-value:4.00E-5 ID:SGTC_346|Compound:4513-0042|FD-Score:3.91|P-value:2.04E-4 ID:SGTC_383|Compound:2324-0395|FD-Score:5.89|P-value:4.87E-8 ID:SGTC_398|Compound:bronopol|FD-Score:-3.43|P-value:8.85E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:11.10|P-value:4.54E-24 ID:SGTC_528|Compound:3492-0019|FD-Score:7.69|P-value:1.63E-12 ID:SGTC_540|Compound:1187-0821|FD-Score:4.27|P-value:5.55E-5 ID:SGTC_547|Compound:1120-0019|FD-Score:7.84|P-value:6.15E-13 ID:SGTC_548|Compound:1436-0017|FD-Score:7.24|P-value:2.79E-11 ID:SGTC_555|Compound:4296-0685|FD-Score:3.96|P-value:1.71E-4 ID:SGTC_611|Compound:3453-1652|FD-Score:9.77|P-value:4.25E-19 ID:SGTC_639|Compound:0833-0042|FD-Score:7.39|P-value:1.09E-11 ID:SGTC_676|Compound:falcarinol|FD-Score:8.94|P-value:2.75E-16 ID:SGTC_682|Compound:0kpi-0099|FD-Score:5.44|P-value:4.19E-7 ID:SGTC_687|Compound:k029-0044|FD-Score:3.73|P-value:3.72E-4 ID:SGTC_695|Compound:3505-6186|FD-Score:4.19|P-value:7.57E-5 ID:SGTC_704|Compound:1310-0270|FD-Score:3.54|P-value:7.00E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:6.09|P-value:1.71E-8 ID:SGTC_799|Compound:1310-0557|FD-Score:6.30|P-value:5.82E-9 ID:SGTC_852|Compound:0418-0143|FD-Score:3.93|P-value:1.91E-4 ID:SGTC_862|Compound:0452-0056|FD-Score:5.62|P-value:1.82E-7 ID:SGTC_902|Compound:1120-0002|FD-Score:8.32|P-value:2.40E-14 ID:SGTC_1019|Compound:4262-0212|FD-Score:5.59|P-value:2.04E-7 ID:SGTC_1057|Compound:3448-5381|FD-Score:7.12|P-value:5.68E-11 ID:SGTC_1066|Compound:ketoconazole|FD-Score:3.49|P-value:8.17E-4 ID:SGTC_1084|Compound:voriconazole|FD-Score:8.21|P-value:5.19E-14 ID:SGTC_1086|Compound:cerivastatin|FD-Score:5.05|P-value:2.41E-6 ID:SGTC_1097|Compound:itavastatin|FD-Score:6.74|P-value:5.13E-10 ID:SGTC_1239|Compound:0337-0584|FD-Score:8.07|P-value:1.32E-13 ID:SGTC_1317|Compound:1273-0028|FD-Score:11.90|P-value:1.93E-27 ID:SGTC_1347|Compound:1493-0251|FD-Score:5.50|P-value:3.24E-7 ID:SGTC_1381|Compound:2324-0066|FD-Score:11.90|P-value:1.91E-27 ID:SGTC_1424|Compound:4048-1941|FD-Score:3.48|P-value:8.37E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:4.59|P-value:1.64E-5 ID:SGTC_1608|Compound:st001473|FD-Score:6.20|P-value:9.60E-9 ID:SGTC_1740|Compound:st038286|FD-Score:3.63|P-value:5.19E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:5.16|P-value:1.54E-6 ID:SGTC_1788|Compound:fluconazole|FD-Score:7.50|P-value:5.39E-12 ID:SGTC_1831|Compound:st055328|FD-Score:3.45|P-value:9.23E-4 ID:SGTC_1845|Compound:st056753|FD-Score:3.44|P-value:9.28E-4 ID:SGTC_1847|Compound:st056231|FD-Score:-3.52|P-value:6.64E-4 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:5.03|P-value:2.68E-6 ID:SGTC_1919|Compound:st067113|FD-Score:9.24|P-value:2.74E-17 ID:SGTC_2085|Compound:5307070|FD-Score:9.11|P-value:7.60E-17 ID:SGTC_2089|Compound:5281248|FD-Score:8.56|P-value:4.45E-15 ID:SGTC_2110|Compound:5483698|FD-Score:7.74|P-value:1.15E-12 ID:SGTC_2112|Compound:5488546|FD-Score:4.08|P-value:1.14E-4 ID:SGTC_2139|Compound:5578692|FD-Score:11.20|P-value:2.27E-24 ID:SGTC_2214|Compound:7179297|FD-Score:6.48|P-value:2.17E-9 ID:SGTC_2223|Compound:6903751|FD-Score:14.40|P-value:3.36E-39 ID:SGTC_2233|Compound:sulbentine|FD-Score:12.00|P-value:6.24E-28 ID:SGTC_2325|Compound:6158266|FD-Score:7.09|P-value:6.57E-11 ID:SGTC_2344|Compound:7990960|FD-Score:5.50|P-value:3.22E-7 ID:SGTC_2350|Compound:9023895|FD-Score:5.68|P-value:1.33E-7 ID:SGTC_2408|Compound:sulbentine|FD-Score:6.44|P-value:2.76E-9 ID:SGTC_2430|Compound:5571206|FD-Score:6.31|P-value:5.38E-9 ID:SGTC_2442|Compound:5158906|FD-Score:3.60|P-value:5.75E-4 ID:SGTC_2451|Compound:5856223|FD-Score:7.02|P-value:9.88E-11 ID:SGTC_2510|Compound:benzyl isothiocyanate|FD-Score:10.80|P-value:4.51E-23 ID:SGTC_2523|Compound:spermine|FD-Score:3.46|P-value:8.97E-4 ID:SGTC_2533|Compound:agelasine|FD-Score:3.79|P-value:3.07E-4 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:14.60|P-value:2.33E-40 ID:SGTC_2576|Compound:guaiol|FD-Score:-3.40|P-value:9.62E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:3.72|P-value:3.88E-4 ID:SGTC_2592|Compound:piperlongumine|FD-Score:4.27|P-value:5.69E-5 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:-3.44|P-value:8.42E-4 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:4.44|P-value:2.95E-5 ID:SGTC_2647|Compound:atorvastatin|FD-Score:17.40|P-value:1.48E-56 ID:SGTC_2648|Compound:atorvastatin|FD-Score:16.20|P-value:2.10E-49 ID:SGTC_2700|Compound:st077718|FD-Score:-4.09|P-value:9.50E-5 ID:SGTC_2710|Compound:st078562|FD-Score:-3.72|P-value:3.41E-4 ID:SGTC_2753|Compound:fluvastatin|FD-Score:9.72|P-value:6.39E-19 ID:SGTC_2765|Compound:myclobutanil|FD-Score:4.51|P-value:2.28E-5 ID:SGTC_2777|Compound:climbazole|FD-Score:6.49|P-value:2.12E-9 ID:SGTC_2778|Compound:tioconazole|FD-Score:6.40|P-value:3.47E-9 ID:SGTC_2788|Compound:5282734|FD-Score:8.37|P-value:1.66E-14 ID:SGTC_2790|Compound:5423970|FD-Score:4.22|P-value:6.88E-5 ID:SGTC_2799|Compound:7812892|FD-Score:8.03|P-value:1.74E-13 ID:SGTC_2832|Compound:7992762|FD-Score:-5.97|P-value:2.71E-8 ID:SGTC_2834|Compound:9001755|FD-Score:18.60|P-value:7.22E-64 ID:SGTC_2836|Compound:9010338|FD-Score:-4.69|P-value:9.42E-6 ID:SGTC_2858|Compound:9025781|FD-Score:-4.96|P-value:3.13E-6 ID:SGTC_2925|Compound:9010536|FD-Score:5.76|P-value:9.19E-8 ID:SGTC_2928|Compound:9011484|FD-Score:5.05|P-value:2.39E-6 ID:SGTC_2971|Compound:9092186|FD-Score:3.62|P-value:5.32E-4 ID:SGTC_2974|Compound:9094440|FD-Score:6.11|P-value:1.59E-8 ID:SGTC_2983|Compound:9022671|FD-Score:3.69|P-value:4.29E-4 ID:SGTC_2985|Compound:9022375|FD-Score:3.52|P-value:7.38E-4 ID:SGTC_3006|Compound:9075424|FD-Score:3.50|P-value:7.88E-4 ID:SGTC_3086|Compound:9117350|FD-Score:4.01|P-value:1.42E-4 ID:SGTC_3154|Compound:9100113|FD-Score:5.20|P-value:1.27E-6 ID:SGTC_3231|Compound:9132313|FD-Score:-4.49|P-value:2.17E-5 ID:SGTC_3286|Compound:9117135|FD-Score:3.82|P-value:2.78E-4 ID:SGTC_3314|Compound:9135860|FD-Score:3.60|P-value:5.68E-4 ID:SGTC_9|Compound:0092-0002|FD-Score:4.63|P-value:1.41E-5 ID:SGTC_16|Compound:erodoxin|FD-Score:4.43|P-value:3.03E-5 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:15.50|P-value:2.26E-45 ID:SGTC_57|Compound:miconazole|FD-Score:5.99|P-value:2.87E-8 ID:SGTC_63|Compound:0099-0242|FD-Score:6.56|P-value:1.45E-9 ID:SGTC_64|Compound:000l-0018|FD-Score:4.35|P-value:4.15E-5 ID:SGTC_86|Compound:0417-1630|FD-Score:4.01|P-value:1.42E-4 ID:SGTC_88|Compound:0180-0332|FD-Score:4.40|P-value:3.46E-5 ID:SGTC_141|Compound:0443-0274|FD-Score:4.54|P-value:2.01E-5 ID:SGTC_158|Compound:k038-0087|FD-Score:5.61|P-value:1.89E-7 ID:SGTC_177|Compound:1327-0068|FD-Score:36.40|P-value:3.38E-239 ID:SGTC_182|Compound:3448-4371|FD-Score:6.08|P-value:1.85E-8 ID:SGTC_184|Compound:1494-0393|FD-Score:5.44|P-value:4.18E-7 ID:SGTC_200|Compound:k038-0079|FD-Score:3.94|P-value:1.82E-4 ID:SGTC_210|Compound:3551-0445|FD-Score:6.20|P-value:9.88E-9 ID:SGTC_212|Compound:3807-4682|FD-Score:5.76|P-value:9.00E-8 ID:SGTC_216|Compound:k038-0035|FD-Score:5.80|P-value:7.49E-8 ID:SGTC_217|Compound:ketoconazole|FD-Score:7.70|P-value:1.51E-12 ID:SGTC_227|Compound:fluconazole|FD-Score:25.60|P-value:5.71E-120 ID:SGTC_256|Compound:clotrimazole|FD-Score:5.63|P-value:1.69E-7 ID:SGTC_266|Compound:formosanin C|FD-Score:-6.11|P-value:1.31E-8 ID:SGTC_270|Compound:tamoxifen|FD-Score:-3.68|P-value:3.93E-4 ID:SGTC_279|Compound:1273-0055|FD-Score:6.44|P-value:2.71E-9 ID:SGTC_294|Compound:k038-0071|FD-Score:5.19|P-value:1.30E-6 ID:SGTC_310|Compound:1273-0058|FD-Score:4.07|P-value:1.16E-4 ID:SGTC_320|Compound:4092-0846|FD-Score:4.31|P-value:4.80E-5 ID:SGTC_327|Compound:1273-0057|FD-Score:8.12|P-value:9.16E-14 ID:SGTC_340|Compound:k038-0059|FD-Score:4.36|P-value:4.00E-5 ID:SGTC_346|Compound:4513-0042|FD-Score:3.91|P-value:2.04E-4 ID:SGTC_383|Compound:2324-0395|FD-Score:5.89|P-value:4.87E-8 ID:SGTC_398|Compound:bronopol|FD-Score:-3.43|P-value:8.85E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:11.10|P-value:4.54E-24 ID:SGTC_528|Compound:3492-0019|FD-Score:7.69|P-value:1.63E-12 ID:SGTC_540|Compound:1187-0821|FD-Score:4.27|P-value:5.55E-5 ID:SGTC_547|Compound:1120-0019|FD-Score:7.84|P-value:6.15E-13 ID:SGTC_548|Compound:1436-0017|FD-Score:7.24|P-value:2.79E-11 ID:SGTC_555|Compound:4296-0685|FD-Score:3.96|P-value:1.71E-4 ID:SGTC_611|Compound:3453-1652|FD-Score:9.77|P-value:4.25E-19 ID:SGTC_639|Compound:0833-0042|FD-Score:7.39|P-value:1.09E-11 ID:SGTC_676|Compound:falcarinol|FD-Score:8.94|P-value:2.75E-16 ID:SGTC_682|Compound:0kpi-0099|FD-Score:5.44|P-value:4.19E-7 ID:SGTC_687|Compound:k029-0044|FD-Score:3.73|P-value:3.72E-4 ID:SGTC_695|Compound:3505-6186|FD-Score:4.19|P-value:7.57E-5 ID:SGTC_704|Compound:1310-0270|FD-Score:3.54|P-value:7.00E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:6.09|P-value:1.71E-8 ID:SGTC_799|Compound:1310-0557|FD-Score:6.30|P-value:5.82E-9 ID:SGTC_852|Compound:0418-0143|FD-Score:3.93|P-value:1.91E-4 ID:SGTC_862|Compound:0452-0056|FD-Score:5.62|P-value:1.82E-7 ID:SGTC_902|Compound:1120-0002|FD-Score:8.32|P-value:2.40E-14 ID:SGTC_1019|Compound:4262-0212|FD-Score:5.59|P-value:2.04E-7 ID:SGTC_1057|Compound:3448-5381|FD-Score:7.12|P-value:5.68E-11 ID:SGTC_1066|Compound:ketoconazole|FD-Score:3.49|P-value:8.17E-4 ID:SGTC_1084|Compound:voriconazole|FD-Score:8.21|P-value:5.19E-14 ID:SGTC_1086|Compound:cerivastatin|FD-Score:5.05|P-value:2.41E-6 ID:SGTC_1097|Compound:itavastatin|FD-Score:6.74|P-value:5.13E-10 ID:SGTC_1239|Compound:0337-0584|FD-Score:8.07|P-value:1.32E-13 ID:SGTC_1317|Compound:1273-0028|FD-Score:11.90|P-value:1.93E-27 ID:SGTC_1347|Compound:1493-0251|FD-Score:5.50|P-value:3.24E-7 ID:SGTC_1381|Compound:2324-0066|FD-Score:11.90|P-value:1.91E-27 ID:SGTC_1424|Compound:4048-1941|FD-Score:3.48|P-value:8.37E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:4.59|P-value:1.64E-5 ID:SGTC_1608|Compound:st001473|FD-Score:6.20|P-value:9.60E-9 ID:SGTC_1740|Compound:st038286|FD-Score:3.63|P-value:5.19E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:5.16|P-value:1.54E-6 ID:SGTC_1788|Compound:fluconazole|FD-Score:7.50|P-value:5.39E-12 ID:SGTC_1831|Compound:st055328|FD-Score:3.45|P-value:9.23E-4 ID:SGTC_1845|Compound:st056753|FD-Score:3.44|P-value:9.28E-4 ID:SGTC_1847|Compound:st056231|FD-Score:-3.52|P-value:6.64E-4 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:5.03|P-value:2.68E-6 ID:SGTC_1919|Compound:st067113|FD-Score:9.24|P-value:2.74E-17 ID:SGTC_2085|Compound:5307070|FD-Score:9.11|P-value:7.60E-17 ID:SGTC_2089|Compound:5281248|FD-Score:8.56|P-value:4.45E-15 ID:SGTC_2110|Compound:5483698|FD-Score:7.74|P-value:1.15E-12 ID:SGTC_2112|Compound:5488546|FD-Score:4.08|P-value:1.14E-4 ID:SGTC_2139|Compound:5578692|FD-Score:11.20|P-value:2.27E-24 ID:SGTC_2214|Compound:7179297|FD-Score:6.48|P-value:2.17E-9 ID:SGTC_2223|Compound:6903751|FD-Score:14.40|P-value:3.36E-39 ID:SGTC_2233|Compound:sulbentine|FD-Score:12.00|P-value:6.24E-28 ID:SGTC_2325|Compound:6158266|FD-Score:7.09|P-value:6.57E-11 ID:SGTC_2344|Compound:7990960|FD-Score:5.50|P-value:3.22E-7 ID:SGTC_2350|Compound:9023895|FD-Score:5.68|P-value:1.33E-7 ID:SGTC_2408|Compound:sulbentine|FD-Score:6.44|P-value:2.76E-9 ID:SGTC_2430|Compound:5571206|FD-Score:6.31|P-value:5.38E-9 ID:SGTC_2442|Compound:5158906|FD-Score:3.60|P-value:5.75E-4 ID:SGTC_2451|Compound:5856223|FD-Score:7.02|P-value:9.88E-11 ID:SGTC_2510|Compound:benzyl isothiocyanate|FD-Score:10.80|P-value:4.51E-23 ID:SGTC_2523|Compound:spermine|FD-Score:3.46|P-value:8.97E-4 ID:SGTC_2533|Compound:agelasine|FD-Score:3.79|P-value:3.07E-4 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:14.60|P-value:2.33E-40 ID:SGTC_2576|Compound:guaiol|FD-Score:-3.40|P-value:9.62E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:3.72|P-value:3.88E-4 ID:SGTC_2592|Compound:piperlongumine|FD-Score:4.27|P-value:5.69E-5 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:-3.44|P-value:8.42E-4 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:4.44|P-value:2.95E-5 ID:SGTC_2647|Compound:atorvastatin|FD-Score:17.40|P-value:1.48E-56 ID:SGTC_2648|Compound:atorvastatin|FD-Score:16.20|P-value:2.10E-49 ID:SGTC_2700|Compound:st077718|FD-Score:-4.09|P-value:9.50E-5 ID:SGTC_2710|Compound:st078562|FD-Score:-3.72|P-value:3.41E-4 ID:SGTC_2753|Compound:fluvastatin|FD-Score:9.72|P-value:6.39E-19 ID:SGTC_2765|Compound:myclobutanil|FD-Score:4.51|P-value:2.28E-5 ID:SGTC_2777|Compound:climbazole|FD-Score:6.49|P-value:2.12E-9 ID:SGTC_2778|Compound:tioconazole|FD-Score:6.40|P-value:3.47E-9 ID:SGTC_2788|Compound:5282734|FD-Score:8.37|P-value:1.66E-14 ID:SGTC_2790|Compound:5423970|FD-Score:4.22|P-value:6.88E-5 ID:SGTC_2799|Compound:7812892|FD-Score:8.03|P-value:1.74E-13 ID:SGTC_2832|Compound:7992762|FD-Score:-5.97|P-value:2.71E-8 ID:SGTC_2834|Compound:9001755|FD-Score:18.60|P-value:7.22E-64 ID:SGTC_2836|Compound:9010338|FD-Score:-4.69|P-value:9.42E-6 ID:SGTC_2858|Compound:9025781|FD-Score:-4.96|P-value:3.13E-6 ID:SGTC_2925|Compound:9010536|FD-Score:5.76|P-value:9.19E-8 ID:SGTC_2928|Compound:9011484|FD-Score:5.05|P-value:2.39E-6 ID:SGTC_2971|Compound:9092186|FD-Score:3.62|P-value:5.32E-4 ID:SGTC_2974|Compound:9094440|FD-Score:6.11|P-value:1.59E-8 ID:SGTC_2983|Compound:9022671|FD-Score:3.69|P-value:4.29E-4 ID:SGTC_2985|Compound:9022375|FD-Score:3.52|P-value:7.38E-4 ID:SGTC_3006|Compound:9075424|FD-Score:3.50|P-value:7.88E-4 ID:SGTC_3086|Compound:9117350|FD-Score:4.01|P-value:1.42E-4 ID:SGTC_3154|Compound:9100113|FD-Score:5.20|P-value:1.27E-6 ID:SGTC_3231|Compound:9132313|FD-Score:-4.49|P-value:2.17E-5 ID:SGTC_3286|Compound:9117135|FD-Score:3.82|P-value:2.78E-4 ID:SGTC_3314|Compound:9135860|FD-Score:3.60|P-value:5.68E-4

Top fitness defect scores for YJR049C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_177 1327-0068 36.40 8.4 µM 3.38E-239 1 7.67E-290
2 SGTC_227 fluconazole 25.60 33.5 µM 5.71E-120 azole & statin 2 3.39E-145
3 SGTC_2834 9001755 18.60 58.4 µM 7.22E-64 1 3.91E-77
4 SGTC_2647 atorvastatin 17.40 60.2 µM 1.48E-56 azole & statin 2 2.89E-68
5 SGTC_2648 atorvastatin 16.20 78.7 µM 2.10E-49 azole & statin 2 1.37E-59
6 SGTC_28 pentachloropyridine N-oxide 15.50 1.6 µM 2.26E-45 TSC3-RPN4 3 1.07E-54
7 SGTC_2566 crystal violet carbinol 14.60 226.0 nM 2.33E-40 1 1.29E-48
8 SGTC_2223 6903751 14.40 107.6 µM 3.36E-39 superoxide 1 3.28E-47
9 SGTC_2233 sulbentine 12.00 40.4 µM 6.24E-28 5 1.52E-33
10 SGTC_1381 2324-0066 11.90 62.1 µM 1.91E-27 1 5.91E-33
11 SGTC_1317 1273-0028 11.90 910.0 nM 1.93E-27 azole & statin 9 5.99E-33
12 SGTC_2139 5578692 11.20 56.5 µM 2.27E-24 superoxide 3 3.17E-29
13 SGTC_513 4245-1575 11.10 41.7 µM 4.54E-24 unfolded protein response 11 7.34E-29
14 SGTC_2510 benzyl isothiocyanate 10.80 8.3 µM 4.51E-23 3 1.19E-27
15 SGTC_611 3453-1652 9.77 23.7 µM 4.25E-19 1 7.84E-23
16 SGTC_2753 fluvastatin 9.72 17.1 µM 6.39E-19 azole & statin 3 1.28E-22
17 SGTC_1919 st067113 9.24 52.3 µM 2.74E-17 TSC3-RPN4 3 1.22E-20
18 SGTC_2085 5307070 9.11 144.1 µM 7.60E-17 superoxide 1 4.21E-20
19 SGTC_676 falcarinol 8.94 140.0 µM 2.75E-16 6 2.00E-19
20 SGTC_2089 5281248 8.56 129.7 µM 4.45E-15 superoxide 4 5.84E-18

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.438 2.18E-157 YML075C HMG1 hom HMG-CoA reductase; catalyzes the conversion of HMG-CoA to mevalonate, which is a rate-limiting step in sterol biosynthesis; one of two isozymes; localizes to the nuclear envelope; overproduction induces the formation of karmellae; forms foci at the nuclear periphery upon DNA replication stress
0.305 5.19E-73 YML081W TDA9 hom DNA-binding protein, putative transcription factor; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; null mutant is sensitive to expression of the top1-T722A allele; not an essential gene; TDA9 has a paralog, RSF2, that arose from the whole genome duplication
0.263 2.63E-54 YPL061W ALD6 hom Cytosolic aldehyde dehydrogenase, activated by Mg2+ and utilizes NADP+ as the preferred coenzyme; required for conversion of acetaldehyde to acetate; constitutively expressed; locates to the mitochondrial outer surface upon oxidative stress
0.250 7.23E-49 YGR122W YGR122W hom Protein that may be involved in pH regulation; probable ortholog of A. nidulans PalC, which is involved in pH regulation and binds to the ESCRT-III complex; null mutant does not properly process Rim101p and has decreased resistance to rapamycin; GFP-fusion protein is cytoplasmic; relative distribution to cytoplasm increases upon DNA replication stress
0.246 1.57E-47 YPR074C TKL1 hom Transketolase; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids; TKL1 has a paralog, TKL2, that arose from the whole genome duplication
0.241 2.22E-45 YPL062W_d YPL062W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YPL062W is not an essential gene; homozygous diploid mutant shows a decrease in glycogen accumulation
0.233 1.69E-42 YKL195W MIA40 het Oxidoreductase that mediates mitochondrial intermembrane space import; substrates include small proteins containing twin cysteine motifs; acts in concert with Erv1p, which oxidizes the cysteine residues of Mia40p to comprise a disulfide relay system that catalyzes import; also mediates folding of Atp23p
0.230 1.27E-41 YHR045W_p YHR045W_p hom Putative protein of unknown function; possible role in iron metabolism and/or amino acid and carbohydrate metabolism; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum
0.230 2.49E-41 YMR154C RIM13 hom Calpain-like cysteine protease; involved in proteolytic activation of Rim101p in response to alkaline pH; localizes to punctate structures in alkaline conditions and in vps4 mutant; has similarity to A. nidulans palB
0.212 2.16E-35 YHL027W RIM101 hom Cys2His2 zinc-finger transcriptional repressor; involved in alkaline responsive gene repression as part of adaptation to a alkaline conditions; involved in cell wall assembly; required for alkaline pH-stimulated haploid invasive growth and sporulation; activated by alkaline-dependent proteolytic processing which results in removal of the C-terminal tail; similar to A. nidulans PacC
0.206 1.64E-33 YJL121C RPE1 hom D-ribulose-5-phosphate 3-epimerase, catalyzes a reaction in the non-oxidative part of the pentose-phosphate pathway; mutants are sensitive to oxidative stress
0.198 6.60E-31 YDL118W_d YDL118W_d hom Dubious open reading frame, unlikely to encode a protein; overlaps almost completely with YDL119C; mutations that would affect both YDL118W and YDL119C confer defective telomere maintenance and are synthetically sick or lethal with alpha-synuclein
0.197 8.66E-31 YOR207C RET1 het Second-largest subunit of RNA polymerase III, which is responsible for the transcription of tRNA and 5S RNA genes, and other low molecular weight RNAs
0.196 1.57E-30 YDL119C_p YDL119C_p hom Putative mitochondrial transport protein; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; the authentic, non-tagged protein is detected in purified mitochondria
0.192 2.59E-29 YJL120W_d YJL120W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL121C/RPE1; deletion confers sensitivity to GSAO