YJR051W / OSM1

Fumarate reductase, catalyzes the reduction of fumarate to succinate; required for the reoxidation of intracellular NADH under anaerobic conditions; mutations cause osmotic sensitivity; OSM1 has a paralog, FRD1, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YJR051W / OSM1

Click on Significant Values for Screen Details ID:SGTC_95|Compound:0471-0001|FD-Score:4.54|P-value:1.06E-6 ID:SGTC_105|Compound:0111-0055|FD-Score:-3.14|P-value:5.15E-4 ID:SGTC_108|Compound:0509-0257|FD-Score:-4.21|P-value:5.68E-6 ID:SGTC_122|Compound:0236-0016|FD-Score:4.91|P-value:1.48E-7 ID:SGTC_139|Compound:0099-0334|FD-Score:-5.03|P-value:7.45E-8 ID:SGTC_147|Compound:4466-0538|FD-Score:3.13|P-value:5.37E-4 ID:SGTC_182|Compound:3448-4371|FD-Score:-3.42|P-value:1.80E-4 ID:SGTC_286|Compound:k060-0067|FD-Score:3.16|P-value:4.84E-4 ID:SGTC_292|Compound:k038-0015|FD-Score:3.07|P-value:6.70E-4 ID:SGTC_348|Compound:k064-0012|FD-Score:3.48|P-value:1.43E-4 ID:SGTC_408|Compound:cantharidin|FD-Score:3.00|P-value:8.81E-4 ID:SGTC_409|Compound:arachidonic acid|FD-Score:3.02|P-value:7.97E-4 ID:SGTC_442|Compound:cape|FD-Score:3.13|P-value:5.40E-4 ID:SGTC_541|Compound:4513-1321|FD-Score:-3.42|P-value:1.79E-4 ID:SGTC_618|Compound:k072-0232|FD-Score:3.77|P-value:4.25E-5 ID:SGTC_688|Compound:0527-0193|FD-Score:3.01|P-value:8.29E-4 ID:SGTC_736|Compound:0958-0254|FD-Score:3.23|P-value:3.73E-4 ID:SGTC_749|Compound:1000-0129|FD-Score:6.67|P-value:1.67E-12 ID:SGTC_758|Compound:0868-0029|FD-Score:2.97|P-value:9.68E-4 ID:SGTC_766|Compound:1391-0721|FD-Score:4.12|P-value:8.58E-6 ID:SGTC_802|Compound:4112-3352|FD-Score:3.18|P-value:4.55E-4 ID:SGTC_812|Compound:4251-0442|FD-Score:-3.08|P-value:6.46E-4 ID:SGTC_884|Compound:0851-0618|FD-Score:3.40|P-value:1.96E-4 ID:SGTC_912|Compound:3474-0017|FD-Score:-3.29|P-value:3.01E-4 ID:SGTC_918|Compound:glabranin|FD-Score:-3.15|P-value:5.07E-4 ID:SGTC_954|Compound:1189-0853|FD-Score:-4.64|P-value:6.34E-7 ID:SGTC_963|Compound:1269-2853|FD-Score:-3.53|P-value:1.14E-4 ID:SGTC_978|Compound:1416-0512|FD-Score:-3.03|P-value:7.69E-4 ID:SGTC_1027|Compound:k015-0025|FD-Score:-4.38|P-value:2.45E-6 ID:SGTC_1040|Compound:k898-0338|FD-Score:3.82|P-value:3.35E-5 ID:SGTC_1198|Compound:1612-1005|FD-Score:3.01|P-value:8.41E-4 ID:SGTC_1206|Compound:3978-0017|FD-Score:3.01|P-value:8.50E-4 ID:SGTC_1270|Compound:0831-1170|FD-Score:3.64|P-value:7.25E-5 ID:SGTC_1536|Compound:cytidine-2',3'-monophosphoric acid;  3'-cytidylic acid|FD-Score:3.84|P-value:3.03E-5 ID:SGTC_1806|Compound:st050005|FD-Score:3.57|P-value:9.67E-5 ID:SGTC_1892|Compound:st058411|FD-Score:3.34|P-value:2.49E-4 ID:SGTC_1916|Compound:st067606|FD-Score:3.31|P-value:2.72E-4 ID:SGTC_2040|Compound:5100729|FD-Score:-4.04|P-value:1.23E-5 ID:SGTC_2042|Compound:p-Dimethylaminoacetophenone|FD-Score:-3.04|P-value:7.53E-4 ID:SGTC_2047|Compound:4141938|FD-Score:-3.97|P-value:1.70E-5 ID:SGTC_2215|Compound:7188065|FD-Score:3.35|P-value:2.39E-4 ID:SGTC_2230|Compound:bromochlorosalicylanilide|FD-Score:2.97|P-value:9.55E-4 ID:SGTC_2292|Compound:7671323|FD-Score:5.62|P-value:2.26E-9 ID:SGTC_2298|Compound:7976326|FD-Score:4.15|P-value:7.38E-6 ID:SGTC_2299|Compound:7976368|FD-Score:-3.65|P-value:6.90E-5 ID:SGTC_2330|Compound:7979373|FD-Score:5.77|P-value:8.71E-10 ID:SGTC_2333|Compound:9017922|FD-Score:3.35|P-value:2.36E-4 ID:SGTC_2334|Compound:9017922|FD-Score:-4.43|P-value:1.91E-6 ID:SGTC_2336|Compound:9001819|FD-Score:-3.92|P-value:2.12E-5 ID:SGTC_2338|Compound:7999974|FD-Score:5.47|P-value:5.76E-9 ID:SGTC_2362|Compound:9071156|FD-Score:3.95|P-value:1.88E-5 ID:SGTC_2381|Compound:9035592|FD-Score:-3.76|P-value:4.34E-5 ID:SGTC_2397|Compound:5161689|FD-Score:3.50|P-value:1.28E-4 ID:SGTC_2439|Compound:5492030|FD-Score:2.98|P-value:9.39E-4 ID:SGTC_2472|Compound:5377652|FD-Score:3.76|P-value:4.30E-5 ID:SGTC_2596|Compound:sinensetin|FD-Score:4.05|P-value:1.19E-5 ID:SGTC_2716|Compound:st080858|FD-Score:4.03|P-value:1.28E-5 ID:SGTC_2793|Compound:7325131|FD-Score:4.96|P-value:1.15E-7 ID:SGTC_2795|Compound:7780010|FD-Score:5.13|P-value:4.29E-8 ID:SGTC_2797|Compound:7859098|FD-Score:-3.90|P-value:2.36E-5 ID:SGTC_2798|Compound:7813637|FD-Score:-5.97|P-value:2.32E-10 ID:SGTC_2801|Compound:7907800|FD-Score:-5.19|P-value:2.96E-8 ID:SGTC_2830|Compound:7992007|FD-Score:-3.96|P-value:1.81E-5 ID:SGTC_3000|Compound:9075062|FD-Score:3.60|P-value:8.70E-5 ID:SGTC_95|Compound:0471-0001|FD-Score:4.54|P-value:1.06E-6 ID:SGTC_105|Compound:0111-0055|FD-Score:-3.14|P-value:5.15E-4 ID:SGTC_108|Compound:0509-0257|FD-Score:-4.21|P-value:5.68E-6 ID:SGTC_122|Compound:0236-0016|FD-Score:4.91|P-value:1.48E-7 ID:SGTC_139|Compound:0099-0334|FD-Score:-5.03|P-value:7.45E-8 ID:SGTC_147|Compound:4466-0538|FD-Score:3.13|P-value:5.37E-4 ID:SGTC_182|Compound:3448-4371|FD-Score:-3.42|P-value:1.80E-4 ID:SGTC_286|Compound:k060-0067|FD-Score:3.16|P-value:4.84E-4 ID:SGTC_292|Compound:k038-0015|FD-Score:3.07|P-value:6.70E-4 ID:SGTC_348|Compound:k064-0012|FD-Score:3.48|P-value:1.43E-4 ID:SGTC_408|Compound:cantharidin|FD-Score:3.00|P-value:8.81E-4 ID:SGTC_409|Compound:arachidonic acid|FD-Score:3.02|P-value:7.97E-4 ID:SGTC_442|Compound:cape|FD-Score:3.13|P-value:5.40E-4 ID:SGTC_541|Compound:4513-1321|FD-Score:-3.42|P-value:1.79E-4 ID:SGTC_618|Compound:k072-0232|FD-Score:3.77|P-value:4.25E-5 ID:SGTC_688|Compound:0527-0193|FD-Score:3.01|P-value:8.29E-4 ID:SGTC_736|Compound:0958-0254|FD-Score:3.23|P-value:3.73E-4 ID:SGTC_749|Compound:1000-0129|FD-Score:6.67|P-value:1.67E-12 ID:SGTC_758|Compound:0868-0029|FD-Score:2.97|P-value:9.68E-4 ID:SGTC_766|Compound:1391-0721|FD-Score:4.12|P-value:8.58E-6 ID:SGTC_802|Compound:4112-3352|FD-Score:3.18|P-value:4.55E-4 ID:SGTC_812|Compound:4251-0442|FD-Score:-3.08|P-value:6.46E-4 ID:SGTC_884|Compound:0851-0618|FD-Score:3.40|P-value:1.96E-4 ID:SGTC_912|Compound:3474-0017|FD-Score:-3.29|P-value:3.01E-4 ID:SGTC_918|Compound:glabranin|FD-Score:-3.15|P-value:5.07E-4 ID:SGTC_954|Compound:1189-0853|FD-Score:-4.64|P-value:6.34E-7 ID:SGTC_963|Compound:1269-2853|FD-Score:-3.53|P-value:1.14E-4 ID:SGTC_978|Compound:1416-0512|FD-Score:-3.03|P-value:7.69E-4 ID:SGTC_1027|Compound:k015-0025|FD-Score:-4.38|P-value:2.45E-6 ID:SGTC_1040|Compound:k898-0338|FD-Score:3.82|P-value:3.35E-5 ID:SGTC_1198|Compound:1612-1005|FD-Score:3.01|P-value:8.41E-4 ID:SGTC_1206|Compound:3978-0017|FD-Score:3.01|P-value:8.50E-4 ID:SGTC_1270|Compound:0831-1170|FD-Score:3.64|P-value:7.25E-5 ID:SGTC_1536|Compound:cytidine-2',3'-monophosphoric acid;  3'-cytidylic acid|FD-Score:3.84|P-value:3.03E-5 ID:SGTC_1806|Compound:st050005|FD-Score:3.57|P-value:9.67E-5 ID:SGTC_1892|Compound:st058411|FD-Score:3.34|P-value:2.49E-4 ID:SGTC_1916|Compound:st067606|FD-Score:3.31|P-value:2.72E-4 ID:SGTC_2040|Compound:5100729|FD-Score:-4.04|P-value:1.23E-5 ID:SGTC_2042|Compound:p-Dimethylaminoacetophenone|FD-Score:-3.04|P-value:7.53E-4 ID:SGTC_2047|Compound:4141938|FD-Score:-3.97|P-value:1.70E-5 ID:SGTC_2215|Compound:7188065|FD-Score:3.35|P-value:2.39E-4 ID:SGTC_2230|Compound:bromochlorosalicylanilide|FD-Score:2.97|P-value:9.55E-4 ID:SGTC_2292|Compound:7671323|FD-Score:5.62|P-value:2.26E-9 ID:SGTC_2298|Compound:7976326|FD-Score:4.15|P-value:7.38E-6 ID:SGTC_2299|Compound:7976368|FD-Score:-3.65|P-value:6.90E-5 ID:SGTC_2330|Compound:7979373|FD-Score:5.77|P-value:8.71E-10 ID:SGTC_2333|Compound:9017922|FD-Score:3.35|P-value:2.36E-4 ID:SGTC_2334|Compound:9017922|FD-Score:-4.43|P-value:1.91E-6 ID:SGTC_2336|Compound:9001819|FD-Score:-3.92|P-value:2.12E-5 ID:SGTC_2338|Compound:7999974|FD-Score:5.47|P-value:5.76E-9 ID:SGTC_2362|Compound:9071156|FD-Score:3.95|P-value:1.88E-5 ID:SGTC_2381|Compound:9035592|FD-Score:-3.76|P-value:4.34E-5 ID:SGTC_2397|Compound:5161689|FD-Score:3.50|P-value:1.28E-4 ID:SGTC_2439|Compound:5492030|FD-Score:2.98|P-value:9.39E-4 ID:SGTC_2472|Compound:5377652|FD-Score:3.76|P-value:4.30E-5 ID:SGTC_2596|Compound:sinensetin|FD-Score:4.05|P-value:1.19E-5 ID:SGTC_2716|Compound:st080858|FD-Score:4.03|P-value:1.28E-5 ID:SGTC_2793|Compound:7325131|FD-Score:4.96|P-value:1.15E-7 ID:SGTC_2795|Compound:7780010|FD-Score:5.13|P-value:4.29E-8 ID:SGTC_2797|Compound:7859098|FD-Score:-3.90|P-value:2.36E-5 ID:SGTC_2798|Compound:7813637|FD-Score:-5.97|P-value:2.32E-10 ID:SGTC_2801|Compound:7907800|FD-Score:-5.19|P-value:2.96E-8 ID:SGTC_2830|Compound:7992007|FD-Score:-3.96|P-value:1.81E-5 ID:SGTC_3000|Compound:9075062|FD-Score:3.60|P-value:8.70E-5

Top fitness defect scores for YJR051W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_749 1000-0129 6.67 128.0 µM 1.67E-12 amide catabolism 2 1.27E-11
2 SGTC_2330 7979373 5.77 200.0 µM 8.71E-10 60S ribosome export 13 4.01E-9
3 SGTC_2292 7671323 5.62 168.1 µM 2.26E-9 RNA processing & uracil transport 10 9.63E-9
4 SGTC_2338 7999974 5.47 200.0 µM 5.76E-9 4 2.28E-8
5 SGTC_2795 7780010 5.13 54.5 µM 4.29E-8 7 1.45E-7
6 SGTC_2793 7325131 4.96 81.8 µM 1.15E-7 8 3.59E-7
7 SGTC_122 0236-0016 4.91 402.4 µM 1.48E-7 RNA processing & uracil transport 16 4.52E-7
8 SGTC_95 0471-0001 4.54 561.1 µM 1.06E-6 14 2.77E-6
9 SGTC_2298 7976326 4.15 193.8 µM 7.38E-6 6 1.66E-5
10 SGTC_766 1391-0721 4.12 126.0 µM 8.58E-6 12 1.90E-5
11 SGTC_2596 sinensetin 4.05 100.0 µM 1.19E-5 32 2.58E-5
12 SGTC_2716 st080858 4.03 38.6 µM 1.28E-5 60S ribosome export 18 2.74E-5
13 SGTC_2362 9071156 3.95 126.0 µM 1.88E-5 11 3.92E-5
14 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 3.84 61.9 µM 3.03E-5 20 6.09E-5
15 SGTC_1040 k898-0338 3.82 155.0 µM 3.35E-5 24 6.69E-5
16 SGTC_618 k072-0232 3.77 33.2 µM 4.25E-5 60S ribosome export 9 8.31E-5
17 SGTC_2472 5377652 3.76 49.4 µM 4.30E-5 TRP & mitochondrial translation 66 8.42E-5
18 SGTC_1270 0831-1170 3.64 17.3 µM 7.25E-5 16 1.36E-4
19 SGTC_3000 9075062 3.60 71.4 µM 8.70E-5 33 1.61E-4
20 SGTC_1806 st050005 3.57 60.3 µM 9.67E-5 22 1.78E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.144 3.99E-17 YDR037W KRS1 het Lysyl-tRNA synthetase
0.106 7.62E-10 YBR186W PCH2 hom Nucleolar component of the pachytene checkpoint, which prevents chromosome segregation when recombination and chromosome synapsis are defective; also represses meiotic interhomolog recombination in the rDNA; required for meiotic double-stranded break formation
0.094 4.60E-8 YEL001C IRC22 hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion localizes to the ER; YEL001C is non-essential; null mutant displays increased levels of spontaneous Rad52p foci
0.088 2.94E-7 YJL108C PRM10 hom Pheromone-regulated protein, proposed to be involved in mating; predicted to have 5 transmembrane segments; induced by treatment with 8-methoxypsoralen and UVA irradiation
0.085 7.64E-7 YIL164C NIT1 hom Nitrilase, member of the nitrilase branch of the nitrilase superfamily; in closely related species and other S. cerevisiae strain backgrounds YIL164C and adjacent ORF, YIL165C, likely constitute a single ORF encoding a nitrilase gene
0.079 4.15E-6 YNL281W HCH1 hom Heat shock protein regulator; binds to Hsp90p and may stimulate ATPase activity; originally identified as a high-copy number suppressor of a HSP90 loss-of-function mutation; GFP-fusion protein localizes to the cytoplasm and nucleus; protein abundance increases in response to DNA replication stress
0.078 5.88E-6 YPR075C OPY2 hom Integral membrane protein that acts as a membrane anchor for Ste50p; involved in the signaling branch of the high-osmolarity glycerol (HOG) pathway and as a regulator of the filamentous growth pathway; overproduction blocks cell cycle arrest in the presence of mating pheromone; relocalizes from vacuole to plasma membrane upon DNA replication stress
0.078 6.68E-6 YDL214C PRR2 hom Serine/threonine protein kinase that inhibits pheromone induced signalling downstream of MAPK, possibly at the level of the Ste12p transcription factor; mutant has increased aneuploidy tolerance
0.077 7.75E-6 YNL049C SFB2 hom Component of the Sec23p-Sfb2p heterodimer of the COPII vesicle coat, required for cargo selection during vesicle formation in ER to Golgi transport; homologous to Sec24p and Sfb3p
0.072 3.18E-5 YMR017W SPO20 hom Meiosis-specific subunit of the t-SNARE complex, required for prospore membrane formation during sporulation; similar to but not functionally redundant with Sec9p; SNAP-25 homolog
0.072 3.23E-5 YOR316C COT1 hom Vacuolar transporter that mediates zinc transport into the vacuole; overexpression confers resistance to cobalt and rhodium; protein abundance increases in response to DNA replication stress; COT1 has a paralog, ZRC1, that arose from the whole genome duplication
0.070 4.75E-5 YML069W POB3 het Subunit of the heterodimeric FACT complex (Spt16p-Pob3p); FACT associates with chromatin via interaction with Nhp6Ap and Nhp6Bp, and reorganizes nucleosomes to facilitate access to DNA by RNA and DNA polymerases; protein abundance increases in response to DNA replication stress
0.070 5.44E-5 YGR149W_p YGR149W_p hom Putative protein of unknown function; predicted to be an integal membrane protein
0.068 7.50E-5 YAL042W ERV46 hom Protein localized to COPII-coated vesicles, forms a complex with Erv41p; involved in the membrane fusion stage of transport
0.067 9.14E-5 YGR239C PEX21 hom Peroxin required for peroxisomal matrix protein targeting; acts on proteins containing the PTS2 targeting sequence; interacts with Pex7p; partially redundant with Pex18p; relative distribution to cytoplasmic foci increases upon DNA replication stress