YJR053W / BFA1

Component of the GTPase-activating Bfa1p-Bub2p complex involved in multiple cell cycle checkpoint pathways that control exit from mitosis

Zygosity: Homozygous strain
fixedexpanded
Profile for YJR053W / BFA1

Click on Significant Values for Screen Details ID:SGTC_35|Compound:0133-0054|FD-Score:-3.87|P-value:8.34E-6 ID:SGTC_43|Compound:0570-0105|FD-Score:-3.85|P-value:9.13E-6 ID:SGTC_52|Compound:0329-0193|FD-Score:-2.86|P-value:7.50E-4 ID:SGTC_68|Compound:0986-0284|FD-Score:-7.14|P-value:9.46E-16 ID:SGTC_74|Compound:000s-0487|FD-Score:2.84|P-value:7.16E-4 ID:SGTC_265|Compound:mycophenolic acid|FD-Score:2.86|P-value:6.76E-4 ID:SGTC_379|Compound:3970-0972|FD-Score:4.46|P-value:2.87E-7 ID:SGTC_637|Compound:1181-0519|FD-Score:3.66|P-value:2.01E-5 ID:SGTC_656|Compound:4090-1979|FD-Score:2.97|P-value:4.30E-4 ID:SGTC_697|Compound:0508-1955|FD-Score:6.45|P-value:2.56E-13 ID:SGTC_865|Compound:0488-0499|FD-Score:2.86|P-value:6.60E-4 ID:SGTC_994|Compound:3910-0338|FD-Score:3.44|P-value:5.84E-5 ID:SGTC_997|Compound:3996-0078|FD-Score:2.75|P-value:9.98E-4 ID:SGTC_1004|Compound:4084-0029|FD-Score:3.74|P-value:1.36E-5 ID:SGTC_1094|Compound:duloxetine|FD-Score:4.26|P-value:9.03E-7 ID:SGTC_1246|Compound:0422-0085|FD-Score:2.93|P-value:5.00E-4 ID:SGTC_1258|Compound:0671-0043|FD-Score:5.19|P-value:3.17E-9 ID:SGTC_1259|Compound:0671-0132|FD-Score:-3.98|P-value:4.92E-6 ID:SGTC_1267|Compound:0828-0272|FD-Score:3.29|P-value:1.14E-4 ID:SGTC_1306|Compound:1185-0270|FD-Score:2.85|P-value:6.99E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.07|P-value:3.19E-4 ID:SGTC_1625|Compound:st003711|FD-Score:5.89|P-value:2.24E-11 ID:SGTC_1626|Compound:st003712|FD-Score:3.50|P-value:4.30E-5 ID:SGTC_1656|Compound:st012921|FD-Score:3.93|P-value:5.42E-6 ID:SGTC_1729|Compound:st035615|FD-Score:3.27|P-value:1.21E-4 ID:SGTC_1734|Compound:st037168|FD-Score:3.40|P-value:6.90E-5 ID:SGTC_1816|Compound:st051957|FD-Score:-3.72|P-value:1.73E-5 ID:SGTC_1838|Compound:st055369|FD-Score:-5.10|P-value:6.97E-9 ID:SGTC_1839|Compound:st053978|FD-Score:-3.26|P-value:1.44E-4 ID:SGTC_1842|Compound:st055362|FD-Score:-4.24|P-value:1.18E-6 ID:SGTC_1844|Compound:rapamycin|FD-Score:-3.05|P-value:3.58E-4 ID:SGTC_1896|Compound:st058441|FD-Score:-4.15|P-value:1.96E-6 ID:SGTC_1980|Compound:st071811|FD-Score:3.41|P-value:6.57E-5 ID:SGTC_1996|Compound:st072960|FD-Score:3.51|P-value:4.10E-5 ID:SGTC_2018|Compound:5133068|FD-Score:-3.60|P-value:3.10E-5 ID:SGTC_2294|Compound:7971431|FD-Score:-4.34|P-value:6.91E-7 ID:SGTC_2303|Compound:7774051|FD-Score:3.43|P-value:6.01E-5 ID:SGTC_2307|Compound:7538926|FD-Score:-3.00|P-value:4.31E-4 ID:SGTC_2308|Compound:7584454|FD-Score:4.03|P-value:3.19E-6 ID:SGTC_2310|Compound:7668677|FD-Score:3.16|P-value:1.99E-4 ID:SGTC_2341|Compound:7987486|FD-Score:3.73|P-value:1.49E-5 ID:SGTC_2363|Compound:9053361|FD-Score:2.79|P-value:8.81E-4 ID:SGTC_2480|Compound:5767542|FD-Score:2.78|P-value:9.10E-4 ID:SGTC_2543|Compound:pimpinellin|FD-Score:2.93|P-value:5.02E-4 ID:SGTC_2908|Compound:7930301|FD-Score:2.81|P-value:8.15E-4 ID:SGTC_3013|Compound:9080133|FD-Score:-3.01|P-value:4.22E-4 ID:SGTC_3051|Compound:9093778|FD-Score:-3.15|P-value:2.38E-4 ID:SGTC_3053|Compound:9095903|FD-Score:-2.85|P-value:7.83E-4 ID:SGTC_3302|Compound:9125395|FD-Score:3.65|P-value:2.17E-5 ID:SGTC_3309|Compound:9129340|FD-Score:3.29|P-value:1.13E-4 ID:SGTC_35|Compound:0133-0054|FD-Score:-3.87|P-value:8.34E-6 ID:SGTC_43|Compound:0570-0105|FD-Score:-3.85|P-value:9.13E-6 ID:SGTC_52|Compound:0329-0193|FD-Score:-2.86|P-value:7.50E-4 ID:SGTC_68|Compound:0986-0284|FD-Score:-7.14|P-value:9.46E-16 ID:SGTC_74|Compound:000s-0487|FD-Score:2.84|P-value:7.16E-4 ID:SGTC_265|Compound:mycophenolic acid|FD-Score:2.86|P-value:6.76E-4 ID:SGTC_379|Compound:3970-0972|FD-Score:4.46|P-value:2.87E-7 ID:SGTC_637|Compound:1181-0519|FD-Score:3.66|P-value:2.01E-5 ID:SGTC_656|Compound:4090-1979|FD-Score:2.97|P-value:4.30E-4 ID:SGTC_697|Compound:0508-1955|FD-Score:6.45|P-value:2.56E-13 ID:SGTC_865|Compound:0488-0499|FD-Score:2.86|P-value:6.60E-4 ID:SGTC_994|Compound:3910-0338|FD-Score:3.44|P-value:5.84E-5 ID:SGTC_997|Compound:3996-0078|FD-Score:2.75|P-value:9.98E-4 ID:SGTC_1004|Compound:4084-0029|FD-Score:3.74|P-value:1.36E-5 ID:SGTC_1094|Compound:duloxetine|FD-Score:4.26|P-value:9.03E-7 ID:SGTC_1246|Compound:0422-0085|FD-Score:2.93|P-value:5.00E-4 ID:SGTC_1258|Compound:0671-0043|FD-Score:5.19|P-value:3.17E-9 ID:SGTC_1259|Compound:0671-0132|FD-Score:-3.98|P-value:4.92E-6 ID:SGTC_1267|Compound:0828-0272|FD-Score:3.29|P-value:1.14E-4 ID:SGTC_1306|Compound:1185-0270|FD-Score:2.85|P-value:6.99E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.07|P-value:3.19E-4 ID:SGTC_1625|Compound:st003711|FD-Score:5.89|P-value:2.24E-11 ID:SGTC_1626|Compound:st003712|FD-Score:3.50|P-value:4.30E-5 ID:SGTC_1656|Compound:st012921|FD-Score:3.93|P-value:5.42E-6 ID:SGTC_1729|Compound:st035615|FD-Score:3.27|P-value:1.21E-4 ID:SGTC_1734|Compound:st037168|FD-Score:3.40|P-value:6.90E-5 ID:SGTC_1816|Compound:st051957|FD-Score:-3.72|P-value:1.73E-5 ID:SGTC_1838|Compound:st055369|FD-Score:-5.10|P-value:6.97E-9 ID:SGTC_1839|Compound:st053978|FD-Score:-3.26|P-value:1.44E-4 ID:SGTC_1842|Compound:st055362|FD-Score:-4.24|P-value:1.18E-6 ID:SGTC_1844|Compound:rapamycin|FD-Score:-3.05|P-value:3.58E-4 ID:SGTC_1896|Compound:st058441|FD-Score:-4.15|P-value:1.96E-6 ID:SGTC_1980|Compound:st071811|FD-Score:3.41|P-value:6.57E-5 ID:SGTC_1996|Compound:st072960|FD-Score:3.51|P-value:4.10E-5 ID:SGTC_2018|Compound:5133068|FD-Score:-3.60|P-value:3.10E-5 ID:SGTC_2294|Compound:7971431|FD-Score:-4.34|P-value:6.91E-7 ID:SGTC_2303|Compound:7774051|FD-Score:3.43|P-value:6.01E-5 ID:SGTC_2307|Compound:7538926|FD-Score:-3.00|P-value:4.31E-4 ID:SGTC_2308|Compound:7584454|FD-Score:4.03|P-value:3.19E-6 ID:SGTC_2310|Compound:7668677|FD-Score:3.16|P-value:1.99E-4 ID:SGTC_2341|Compound:7987486|FD-Score:3.73|P-value:1.49E-5 ID:SGTC_2363|Compound:9053361|FD-Score:2.79|P-value:8.81E-4 ID:SGTC_2480|Compound:5767542|FD-Score:2.78|P-value:9.10E-4 ID:SGTC_2543|Compound:pimpinellin|FD-Score:2.93|P-value:5.02E-4 ID:SGTC_2908|Compound:7930301|FD-Score:2.81|P-value:8.15E-4 ID:SGTC_3013|Compound:9080133|FD-Score:-3.01|P-value:4.22E-4 ID:SGTC_3051|Compound:9093778|FD-Score:-3.15|P-value:2.38E-4 ID:SGTC_3053|Compound:9095903|FD-Score:-2.85|P-value:7.83E-4 ID:SGTC_3302|Compound:9125395|FD-Score:3.65|P-value:2.17E-5 ID:SGTC_3309|Compound:9129340|FD-Score:3.29|P-value:1.13E-4

Top fitness defect scores for YJR053W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_697 0508-1955 6.45 564.0 µM 2.56E-13 5 5.42E-11
2 SGTC_1625 st003711 5.89 30.1 µM 2.24E-11 calcium & mitochondrial duress 10 1.98E-9
3 SGTC_1258 0671-0043 5.19 57.1 µM 3.17E-9 5 1.07E-7
4 SGTC_379 3970-0972 4.46 5.9 µM 2.87E-7 tubulin folding & SWR complex 25 4.03E-6
5 SGTC_1094 duloxetine 4.26 25.4 µM 9.03E-7 RPP1 & pyrimidine depletion 10 1.02E-5
6 SGTC_2308 7584454 4.03 197.6 µM 3.19E-6 19 2.81E-5
7 SGTC_1656 st012921 3.93 11.0 µM 5.42E-6 30 4.32E-5
8 SGTC_1004 4084-0029 3.74 199.0 µM 1.36E-5 19 9.07E-5
9 SGTC_2341 7987486 3.73 176.7 µM 1.49E-5 22 9.76E-5
10 SGTC_637 1181-0519 3.66 7.3 µM 2.01E-5 fatty acid desaturase (OLE1) 119 1.24E-4
11 SGTC_3302 9125395 3.65 16.4 µM 2.17E-5 20 1.32E-4
12 SGTC_1996 st072960 3.51 66.8 µM 4.10E-5 31 2.22E-4
13 SGTC_1626 st003712 3.50 1.8 µM 4.30E-5 37 2.30E-4
14 SGTC_994 3910-0338 3.44 138.0 µM 5.84E-5 calcium & mitochondrial duress 73 2.95E-4
15 SGTC_2303 7774051 3.43 200.0 µM 6.01E-5 37 3.02E-4
16 SGTC_1980 st071811 3.41 45.7 µM 6.57E-5 RPP1 & pyrimidine depletion 35 3.24E-4
17 SGTC_1734 st037168 3.40 69.4 µM 6.90E-5 44 3.38E-4
18 SGTC_3309 9129340 3.29 25.8 µM 1.13E-4 39 5.05E-4
19 SGTC_1267 0828-0272 3.29 9.5 µM 1.14E-4 45 5.08E-4
20 SGTC_1729 st035615 3.27 46.0 µM 1.21E-4 59 5.31E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.132 1.36E-14 YGR209C TRX2 hom Cytoplasmic thioredoxin isoenzyme; part of the thioredoxin system which protects cells against oxidative and reductive stress; forms LMA1 complex with Pbi2p; acts as a cofactor for Tsa1p; required for ER-Golgi transport and vacuole inheritance; protein abundance increases in response to DNA replication stress
0.124 5.73E-13 YLL042C ATG10 hom Conserved E2-like conjugating enzyme that mediates formation of the Atg12p-Atg5p conjugate, which is a critical step in autophagy
0.117 1.09E-11 YOR059C YOR059C hom Lipid particle protein of unknown function; contains a putative lipase serine active site; induced by transcription factor Rpn4p; protein abundance increases in response to DNA replication stress
0.109 3.14E-10 YMR114C YMR114C hom Protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and cytoplasm; YMR114C is not an essential gene
0.107 4.92E-10 YLR233C EST1 hom TLC1 RNA-associated factor involved in telomere length regulation as recruitment subunit of telomerase; has G-quadruplex promoting activity that is required for telomere elongation; possible role in activating telomere-bound Est2p-TLC1-RNA
0.102 3.00E-9 YER043C SAH1 het S-adenosyl-L-homocysteine hydrolase, catabolizes S-adenosyl-L-homocysteine which is formed after donation of the activated methyl group of S-adenosyl-L-methionine (AdoMet) to an acceptor
0.101 4.37E-9 YLR272C YCS4 het Subunit of the condensin complex; required for establishment and maintenance of chromosome condensation, chromosome segregation, chromatin binding of condensin, tRNA gene clustering at the nucleolus, and silencing at the mating type locus; required for replication slow zone (RSZ) breakage following Mec1p inactivation
0.099 8.18E-9 YGL210W YPT32 hom Rab family GTPase involved in the exocytic pathway; mediates intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi; protein abundance increases in response to DNA replication stress; YPT32 has a paralog, YPT31, that arose from the whole genome duplication
0.096 2.61E-8 YLR146C SPE4 hom Spermine synthase, required for the biosynthesis of spermine and also involved in biosynthesis of pantothenic acid
0.092 9.22E-8 YGL147C RPL9A hom Ribosomal 60S subunit protein L9A; nearly identical to paralog Rpl9Bp; homologous to mammalian ribosomal protein L9 and bacterial L6
0.091 1.22E-7 YHR103W SBE22 hom Protein involved in the transport of cell wall components from the Golgi to the cell surface; similar in structure and functionally redundant with Sbe2p; involved in bud growth
0.086 5.32E-7 YNR033W ABZ1 hom Para-aminobenzoate (PABA) synthase; has similarity to Escherichia coli PABA synthase components PabA and PabB; required for the synthesis of para-aminobenzoic acid, an important intermediate for folate and ubiquinone Q biosynthesis; protein abundance increases in response to DNA replication stress
0.086 6.61E-7 YOR335C ALA1 het Cytoplasmic and mitochondrial alanyl-tRNA synthetase, required for protein synthesis; point mutation (cdc64-1 allele) causes cell cycle arrest at G1; lethality of null mutation is functionally complemented by human homolog
0.083 1.34E-6 YIR019C FLO11 hom GPI-anchored cell surface glycoprotein (flocculin); required for pseudohyphal formation, invasive growth, flocculation, and biofilms; transcriptionally regulated by the MAPK pathway (via Ste12p and Tec1p) and the cAMP pathway (via Flo8p); required for the formation of fibrous interconnections between cells in a colony of a wild S. cerevisiae strain
0.080 3.19E-6 YDL234C GYP7 hom GTPase-activating protein for yeast Rab family members including: Ypt7p (most effective), Ypt1p, Ypt31p, and Ypt32p (in vitro); involved in vesicle mediated protein trafficking