YJR055W / HIT1

Protein of unknown function, required for growth at high temperature

Zygosity: Homozygous strain
fixedexpanded
Profile for YJR055W / HIT1

Click on Significant Values for Screen Details ID:SGTC_87|Compound:0100-0052|FD-Score:3.01|P-value:6.75E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:5.78|P-value:8.80E-10 ID:SGTC_154|Compound:3389-1638|FD-Score:4.44|P-value:1.53E-6 ID:SGTC_287|Compound:k060-0039|FD-Score:3.04|P-value:5.87E-4 ID:SGTC_462|Compound:ag-879|FD-Score:2.95|P-value:8.06E-4 ID:SGTC_464|Compound:bw-b 70c|FD-Score:4.88|P-value:1.62E-7 ID:SGTC_511|Compound:blebbistatin|FD-Score:3.18|P-value:3.57E-4 ID:SGTC_518|Compound:1021-0119|FD-Score:3.20|P-value:3.33E-4 ID:SGTC_550|Compound:4123-0385|FD-Score:3.28|P-value:2.44E-4 ID:SGTC_633|Compound:0437-0093|FD-Score:2.90|P-value:9.79E-4 ID:SGTC_674|Compound:0498-0004|FD-Score:-3.44|P-value:4.18E-4 ID:SGTC_676|Compound:falcarinol|FD-Score:-5.06|P-value:3.03E-7 ID:SGTC_710|Compound:3448-4187|FD-Score:3.02|P-value:6.44E-4 ID:SGTC_733|Compound:4069-0007|FD-Score:-3.31|P-value:6.69E-4 ID:SGTC_752|Compound:1896-0090|FD-Score:4.47|P-value:1.38E-6 ID:SGTC_753|Compound:1322-0200|FD-Score:3.15|P-value:4.03E-4 ID:SGTC_765|Compound:1319-0117|FD-Score:2.91|P-value:9.48E-4 ID:SGTC_791|Compound:1348-1292|FD-Score:3.69|P-value:4.77E-5 ID:SGTC_800|Compound:3448-7362|FD-Score:5.43|P-value:7.28E-9 ID:SGTC_830|Compound:4076-0286|FD-Score:2.98|P-value:7.39E-4 ID:SGTC_832|Compound:4083-0019|FD-Score:4.94|P-value:1.15E-7 ID:SGTC_851|Compound:0394-0702|FD-Score:2.92|P-value:9.13E-4 ID:SGTC_855|Compound:0428-0020|FD-Score:5.57|P-value:3.15E-9 ID:SGTC_921|Compound:1561-0023|FD-Score:3.96|P-value:1.50E-5 ID:SGTC_937|Compound:3122-0005|FD-Score:3.11|P-value:4.68E-4 ID:SGTC_992|Compound:3909-8734|FD-Score:4.53|P-value:9.94E-7 ID:SGTC_1189|Compound:1431-2119|FD-Score:3.37|P-value:1.75E-4 ID:SGTC_1221|Compound:2958-7315|FD-Score:3.32|P-value:2.15E-4 ID:SGTC_1369|Compound:1866-0067|FD-Score:3.28|P-value:2.49E-4 ID:SGTC_1373|Compound:2887-0003|FD-Score:-3.96|P-value:5.53E-5 ID:SGTC_1375|Compound:2910-0797|FD-Score:3.71|P-value:4.46E-5 ID:SGTC_1376|Compound:2910-0861|FD-Score:3.56|P-value:8.31E-5 ID:SGTC_1380|Compound:2291-0730|FD-Score:4.32|P-value:2.85E-6 ID:SGTC_1509|Compound:1326-1131|FD-Score:3.01|P-value:6.55E-4 ID:SGTC_1512|Compound:0259-0544|FD-Score:3.55|P-value:8.44E-5 ID:SGTC_1543|Compound:azetidyl-2-carboxylic acid|FD-Score:2.93|P-value:8.89E-4 ID:SGTC_1544|Compound:7-methoxy-4-methylcoumarin|FD-Score:7.06|P-value:1.25E-13 ID:SGTC_1869|Compound:3',7'-dimethoxyflavone|FD-Score:3.50|P-value:1.03E-4 ID:SGTC_1870|Compound:st057514|FD-Score:3.88|P-value:2.09E-5 ID:SGTC_1923|Compound:st058458|FD-Score:-3.85|P-value:8.64E-5 ID:SGTC_1935|Compound:st074532|FD-Score:3.61|P-value:6.77E-5 ID:SGTC_1963|Compound:st076565|FD-Score:4.01|P-value:1.17E-5 ID:SGTC_2006|Compound:4011487|FD-Score:-3.29|P-value:7.04E-4 ID:SGTC_2026|Compound:5148700|FD-Score:3.02|P-value:6.50E-4 ID:SGTC_2128|Compound:5255449|FD-Score:3.31|P-value:2.22E-4 ID:SGTC_2183|Compound:6420625|FD-Score:2.95|P-value:8.28E-4 ID:SGTC_2296|Compound:7971656|FD-Score:3.23|P-value:2.99E-4 ID:SGTC_2336|Compound:9001819|FD-Score:-3.73|P-value:1.38E-4 ID:SGTC_2361|Compound:9034121|FD-Score:3.54|P-value:9.08E-5 ID:SGTC_2377|Compound:9073351|FD-Score:3.25|P-value:2.73E-4 ID:SGTC_2413|Compound:inermin|FD-Score:-5.23|P-value:1.23E-7 ID:SGTC_2416|Compound:tofa|FD-Score:3.90|P-value:1.94E-5 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:3.17|P-value:3.73E-4 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:3.85|P-value:2.44E-5 ID:SGTC_2664|Compound:lyso-paf C-16|FD-Score:4.12|P-value:7.15E-6 ID:SGTC_2680|Compound:butyl paraben|FD-Score:3.20|P-value:3.30E-4 ID:SGTC_2793|Compound:7325131|FD-Score:-3.30|P-value:6.90E-4 ID:SGTC_2795|Compound:7780010|FD-Score:-3.67|P-value:1.73E-4 ID:SGTC_2807|Compound:7945238|FD-Score:3.35|P-value:1.86E-4 ID:SGTC_2809|Compound:7964133|FD-Score:3.54|P-value:8.86E-5 ID:SGTC_2896|Compound:9052656|FD-Score:-4.22|P-value:1.82E-5 ID:SGTC_2983|Compound:9022671|FD-Score:3.50|P-value:1.03E-4 ID:SGTC_3016|Compound:9080866|FD-Score:2.89|P-value:9.96E-4 ID:SGTC_3101|Compound:9120531|FD-Score:3.09|P-value:5.07E-4 ID:SGTC_3210|Compound:9128157|FD-Score:6.03|P-value:1.74E-10 ID:SGTC_3266|Compound:9136860|FD-Score:-4.36|P-value:9.48E-6 ID:SGTC_3269|Compound:9137823|FD-Score:3.57|P-value:7.79E-5 ID:SGTC_3282|Compound:9108498|FD-Score:2.90|P-value:9.88E-4 ID:SGTC_3296|Compound:9122258|FD-Score:-3.88|P-value:7.75E-5 ID:SGTC_87|Compound:0100-0052|FD-Score:3.01|P-value:6.75E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:5.78|P-value:8.80E-10 ID:SGTC_154|Compound:3389-1638|FD-Score:4.44|P-value:1.53E-6 ID:SGTC_287|Compound:k060-0039|FD-Score:3.04|P-value:5.87E-4 ID:SGTC_462|Compound:ag-879|FD-Score:2.95|P-value:8.06E-4 ID:SGTC_464|Compound:bw-b 70c|FD-Score:4.88|P-value:1.62E-7 ID:SGTC_511|Compound:blebbistatin|FD-Score:3.18|P-value:3.57E-4 ID:SGTC_518|Compound:1021-0119|FD-Score:3.20|P-value:3.33E-4 ID:SGTC_550|Compound:4123-0385|FD-Score:3.28|P-value:2.44E-4 ID:SGTC_633|Compound:0437-0093|FD-Score:2.90|P-value:9.79E-4 ID:SGTC_674|Compound:0498-0004|FD-Score:-3.44|P-value:4.18E-4 ID:SGTC_676|Compound:falcarinol|FD-Score:-5.06|P-value:3.03E-7 ID:SGTC_710|Compound:3448-4187|FD-Score:3.02|P-value:6.44E-4 ID:SGTC_733|Compound:4069-0007|FD-Score:-3.31|P-value:6.69E-4 ID:SGTC_752|Compound:1896-0090|FD-Score:4.47|P-value:1.38E-6 ID:SGTC_753|Compound:1322-0200|FD-Score:3.15|P-value:4.03E-4 ID:SGTC_765|Compound:1319-0117|FD-Score:2.91|P-value:9.48E-4 ID:SGTC_791|Compound:1348-1292|FD-Score:3.69|P-value:4.77E-5 ID:SGTC_800|Compound:3448-7362|FD-Score:5.43|P-value:7.28E-9 ID:SGTC_830|Compound:4076-0286|FD-Score:2.98|P-value:7.39E-4 ID:SGTC_832|Compound:4083-0019|FD-Score:4.94|P-value:1.15E-7 ID:SGTC_851|Compound:0394-0702|FD-Score:2.92|P-value:9.13E-4 ID:SGTC_855|Compound:0428-0020|FD-Score:5.57|P-value:3.15E-9 ID:SGTC_921|Compound:1561-0023|FD-Score:3.96|P-value:1.50E-5 ID:SGTC_937|Compound:3122-0005|FD-Score:3.11|P-value:4.68E-4 ID:SGTC_992|Compound:3909-8734|FD-Score:4.53|P-value:9.94E-7 ID:SGTC_1189|Compound:1431-2119|FD-Score:3.37|P-value:1.75E-4 ID:SGTC_1221|Compound:2958-7315|FD-Score:3.32|P-value:2.15E-4 ID:SGTC_1369|Compound:1866-0067|FD-Score:3.28|P-value:2.49E-4 ID:SGTC_1373|Compound:2887-0003|FD-Score:-3.96|P-value:5.53E-5 ID:SGTC_1375|Compound:2910-0797|FD-Score:3.71|P-value:4.46E-5 ID:SGTC_1376|Compound:2910-0861|FD-Score:3.56|P-value:8.31E-5 ID:SGTC_1380|Compound:2291-0730|FD-Score:4.32|P-value:2.85E-6 ID:SGTC_1509|Compound:1326-1131|FD-Score:3.01|P-value:6.55E-4 ID:SGTC_1512|Compound:0259-0544|FD-Score:3.55|P-value:8.44E-5 ID:SGTC_1543|Compound:azetidyl-2-carboxylic acid|FD-Score:2.93|P-value:8.89E-4 ID:SGTC_1544|Compound:7-methoxy-4-methylcoumarin|FD-Score:7.06|P-value:1.25E-13 ID:SGTC_1869|Compound:3',7'-dimethoxyflavone|FD-Score:3.50|P-value:1.03E-4 ID:SGTC_1870|Compound:st057514|FD-Score:3.88|P-value:2.09E-5 ID:SGTC_1923|Compound:st058458|FD-Score:-3.85|P-value:8.64E-5 ID:SGTC_1935|Compound:st074532|FD-Score:3.61|P-value:6.77E-5 ID:SGTC_1963|Compound:st076565|FD-Score:4.01|P-value:1.17E-5 ID:SGTC_2006|Compound:4011487|FD-Score:-3.29|P-value:7.04E-4 ID:SGTC_2026|Compound:5148700|FD-Score:3.02|P-value:6.50E-4 ID:SGTC_2128|Compound:5255449|FD-Score:3.31|P-value:2.22E-4 ID:SGTC_2183|Compound:6420625|FD-Score:2.95|P-value:8.28E-4 ID:SGTC_2296|Compound:7971656|FD-Score:3.23|P-value:2.99E-4 ID:SGTC_2336|Compound:9001819|FD-Score:-3.73|P-value:1.38E-4 ID:SGTC_2361|Compound:9034121|FD-Score:3.54|P-value:9.08E-5 ID:SGTC_2377|Compound:9073351|FD-Score:3.25|P-value:2.73E-4 ID:SGTC_2413|Compound:inermin|FD-Score:-5.23|P-value:1.23E-7 ID:SGTC_2416|Compound:tofa|FD-Score:3.90|P-value:1.94E-5 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:3.17|P-value:3.73E-4 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:3.85|P-value:2.44E-5 ID:SGTC_2664|Compound:lyso-paf C-16|FD-Score:4.12|P-value:7.15E-6 ID:SGTC_2680|Compound:butyl paraben|FD-Score:3.20|P-value:3.30E-4 ID:SGTC_2793|Compound:7325131|FD-Score:-3.30|P-value:6.90E-4 ID:SGTC_2795|Compound:7780010|FD-Score:-3.67|P-value:1.73E-4 ID:SGTC_2807|Compound:7945238|FD-Score:3.35|P-value:1.86E-4 ID:SGTC_2809|Compound:7964133|FD-Score:3.54|P-value:8.86E-5 ID:SGTC_2896|Compound:9052656|FD-Score:-4.22|P-value:1.82E-5 ID:SGTC_2983|Compound:9022671|FD-Score:3.50|P-value:1.03E-4 ID:SGTC_3016|Compound:9080866|FD-Score:2.89|P-value:9.96E-4 ID:SGTC_3101|Compound:9120531|FD-Score:3.09|P-value:5.07E-4 ID:SGTC_3210|Compound:9128157|FD-Score:6.03|P-value:1.74E-10 ID:SGTC_3266|Compound:9136860|FD-Score:-4.36|P-value:9.48E-6 ID:SGTC_3269|Compound:9137823|FD-Score:3.57|P-value:7.79E-5 ID:SGTC_3282|Compound:9108498|FD-Score:2.90|P-value:9.88E-4 ID:SGTC_3296|Compound:9122258|FD-Score:-3.88|P-value:7.75E-5

Top fitness defect scores for YJR055W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1544 7-methoxy-4-methylcoumarin 7.06 105.0 µM 1.25E-13 1 8.54E-13
2 SGTC_3210 9128157 6.03 49.5 µM 1.74E-10 14 8.27E-10
3 SGTC_118 0083-0097 5.78 135.3 µM 8.80E-10 translation 31 3.83E-9
4 SGTC_855 0428-0020 5.57 25.0 µM 3.15E-9 Golgi 6 1.28E-8
5 SGTC_800 3448-7362 5.43 155.0 µM 7.28E-9 translation 70 2.83E-8
6 SGTC_832 4083-0019 4.94 164.0 µM 1.15E-7 translation 44 3.85E-7
7 SGTC_464 bw-b 70c 4.88 158.0 µM 1.62E-7 7 5.29E-7
8 SGTC_992 3909-8734 4.53 162.0 µM 9.94E-7 7 2.94E-6
9 SGTC_752 1896-0090 4.47 130.0 µM 1.38E-6 TSC3-RPN4 9 4.00E-6
10 SGTC_154 3389-1638 4.44 511.1 µM 1.53E-6 15 4.42E-6
11 SGTC_1380 2291-0730 4.32 164.0 µM 2.85E-6 16 7.90E-6
12 SGTC_2664 lyso-paf C-16 4.12 73.5 µM 7.15E-6 9 1.88E-5
13 SGTC_1963 st076565 4.01 50.3 µM 1.17E-5 8 2.97E-5
14 SGTC_921 1561-0023 3.96 372.0 µM 1.50E-5 17 3.77E-5
15 SGTC_2416 tofa 3.90 880.0 nM 1.94E-5 sphingolipid biosynthesis & PDR1 52 4.79E-5
16 SGTC_1870 st057514 3.88 26.5 µM 2.09E-5 RSC & ERG11 24 5.15E-5
17 SGTC_2573 2',4'-dihydroxychalcone 3.85 15.0 µM 2.44E-5 54 5.95E-5
18 SGTC_1375 2910-0797 3.71 186.0 µM 4.46E-5 32 1.05E-4
19 SGTC_791 1348-1292 3.69 225.0 µM 4.77E-5 43 1.11E-4
20 SGTC_1935 st074532 3.61 41.6 µM 6.77E-5 43 1.55E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.171 1.52E-23 YLR048W RPS0B hom Protein component of the small (40S) ribosomal subunit; RPS0B has a paralog, RPS0A, that arose from the whole genome duplication; required for maturation of 18S rRNA along with Rps0Ap; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal; homologous to human ribosomal protein SA and bacterial S2
0.150 2.22E-18 YGL246C RAI1 hom Nuclear protein with decapping endonuclease activity targeted toward mRNAs with unmethylated 7-methylguanosine cap structures; binds to and stabilizes the exoribonuclease Rat1p; required for pre-rRNA processing; homologous to human DOM3Z
0.138 8.81E-16 YEL054C RPL12A hom Ribosomal 60S subunit protein L12A; rpl12a rpl12b double mutant exhibits slow growth and slow translation; homologous to mammalian ribosomal protein L12 and bacterial L11; RPL12A has a paralog, RPL12B, that arose from the whole genome duplication
0.132 1.45E-14 YLR068W FYV7 hom Essential protein required for maturation of 18S rRNA; required for survival upon exposure to K1 killer toxin
0.129 8.00E-14 YLR287C-A RPS30A hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S30, no bacterial homolog; RPS30A has a paralog, RPS30B, that arose from the whole genome duplication
0.126 2.37E-13 YLR061W RPL22A hom Ribosomal 60S subunit protein L22A; required for the oxidative stress response in yeast; homologous to mammalian ribosomal protein L22, no bacterial homolog; RPL22A has a paralog, RPL22B, that arose from the whole genome duplication
0.126 2.70E-13 YJL189W RPL39 hom Ribosomal 60S subunit protein L39; required for ribosome biogenesis; loss of both Rpl31p and Rpl39p confers lethality; also exhibits genetic interactions with SIS1 and PAB1; homologous to mammalian ribosomal protein L39, no bacterial homolog
0.123 8.10E-13 YJL188C_d BUD19_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 88% of ORF overlaps the verified gene RPL39; diploid mutant displays a weak budding pattern phenotype in a systematic assay
0.114 3.54E-11 YDR140W MTQ2 hom S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; subunit of complex with Trm112p that methylates translation release factor Sup45p (eRF1) in the ternary complex eRF1-eRF3-GTP; similar to E.coli PrmC
0.113 4.82E-11 YIR026C YVH1 hom Protein phosphatase involved in vegetative growth at low temperatures, sporulation, and glycogen accumulation; mutants are defective in 60S ribosome assembly; member of the dual-specificity family of protein phosphatases
0.110 1.41E-10 YGL076C RPL7A hom Ribosomal 60S subunit protein L7A; contains a conserved C-terminal Nucleic acid Binding Domain (NDB2); homologous to mammalian ribosomal protein L7 and bacterial L30; RPL7A has a paralog, RPL7B, that arose from the whole genome duplication
0.110 1.51E-10 YBR191W RPL21A hom Ribosomal 60S subunit protein L21A; homologous to mammalian ribosomal protein L21, no bacterial homolog; RPL21A has a paralog, RPL21B, that arose from the whole genome duplication
0.105 8.83E-10 YJR010W MET3 hom ATP sulfurylase, catalyzes the primary step of intracellular sulfate activation, essential for assimilatory reduction of sulfate to sulfide, involved in methionine metabolism
0.105 1.21E-9 YDL082W RPL13A hom Ribosomal 60S subunit protein L13A; not essential for viability; homologous to mammalian ribosomal protein L13, no bacterial homolog; RPL13A has a paralog, RPL13B, that arose from the whole genome duplication
0.104 1.29E-9 YGR162W TIF4631 hom Translation initiation factor eIF4G; subunit of the mRNA cap-binding protein complex (eIF4F) that also contains eIF4E (Cdc33p); interacts with Pab1p and with eIF4A (Tif1p); also has a role in biogenesis of the large ribosomal subunit; TIF4631 has a paralog, TIF4632, that arose from the whole genome duplication